AR043003A1 - Compuestos (benzoimidazol-2-il) fenilaminas n-sustituidas, procedimiento para su preparacion, su uso como farmacos o como ayuda en diagnostico, y los medicamentos que las contienen - Google Patents
Compuestos (benzoimidazol-2-il) fenilaminas n-sustituidas, procedimiento para su preparacion, su uso como farmacos o como ayuda en diagnostico, y los medicamentos que las contienenInfo
- Publication number
- AR043003A1 AR043003A1 ARP040100315A ARP040100315A AR043003A1 AR 043003 A1 AR043003 A1 AR 043003A1 AR P040100315 A ARP040100315 A AR P040100315A AR P040100315 A ARP040100315 A AR P040100315A AR 043003 A1 AR043003 A1 AR 043003A1
- Authority
- AR
- Argentina
- Prior art keywords
- atoms
- substituted
- alkyl
- independently
- alkoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
La presente se refiere a (benzoimidazol-2-il)fenilaminas N-sustituidas y los medicamentos que contienen compuestos de este tipo que son útiles en la prevención o tratamiento de varios trastornos, Así, los compuestos pueden emplearse inter alia para trastornos renales tales como insuficiencia aguda o crónica del rinón, trastornos de la función biliar, trastornos respiratorios tales como ronquidos o apneas del sueno o para el ictus. Reivindicación 1: Un compuesto de fórmula (1) en la que: R1 y R4 son independientemente H, F, Cl, Br, alquilo de 1,2,3, o 4 átomos de C o alcoxilo de 1,2,3,o 4átomos de C, en la que los grupos alquilo y alcoxilo no están sustituidos o están independientemente sustituidos con 1,2,3,4,5,6,7,8,o 9 átomos de F; R2 y R3 son independientemente H, F, alquilo de 1,2 o 3 átomos de C, alcoxilo de 1,2, o 3 átomos de C o OH, en la que los grupo alquilo y alcoxilo no están sustituidos o están independientemente sustituidos con 1,2,3,4,5,6 o 7 átomos de F; R5 es un grupo alquilo de 1,2,3,4 o 4 átomos de C, alquenilo de 2,3 o 4 átomos de C o cicloalquilo de 3,4, o5 átomos de C, en la que los grupos alquilo, alquenilo y cicloalquilo no están sustituidos o están sustituidos con 1,2,3,4,5,6,7,8 o.9 átomos de F; R6 y R7 son independientemente H, F, Cl, Br, alquilo de 1,2,3, o 4 átomos de C o alcoxilo de 1,2, o 3, átomos de C, en la que los grupos alquilo y alcoxilo no están sustituidos o están independientemente sustituidos con 1,2,3,4,5,6,7,8 o 9 átomos de F; y al menos uno de los dos radicales R6 o R7 no es H; y las sales farmacéuticamente aceptables y sus sales con ácido trifluoroacético.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10304294A DE10304294A1 (de) | 2003-02-04 | 2003-02-04 | N-Substituierte(Benzoimidazol-2-yl)-phenyl, Verfahren zu ihrer Herstellung , ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
Publication Number | Publication Date |
---|---|
AR043003A1 true AR043003A1 (es) | 2005-07-13 |
Family
ID=32695159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040100315A AR043003A1 (es) | 2003-02-04 | 2004-02-02 | Compuestos (benzoimidazol-2-il) fenilaminas n-sustituidas, procedimiento para su preparacion, su uso como farmacos o como ayuda en diagnostico, y los medicamentos que las contienen |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1592671B1 (es) |
JP (1) | JP4630270B2 (es) |
AR (1) | AR043003A1 (es) |
AT (1) | ATE391714T1 (es) |
AU (1) | AU2004208871A1 (es) |
BR (1) | BRPI0407199A (es) |
CA (1) | CA2513821A1 (es) |
DE (2) | DE10304294A1 (es) |
MX (1) | MXPA05007247A (es) |
PE (1) | PE20041041A1 (es) |
TW (1) | TW200507837A (es) |
WO (1) | WO2004069811A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0401334D0 (en) * | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
US7960561B2 (en) | 2005-06-21 | 2011-06-14 | Neurosearch A/S | 2-(phenylamino) benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
HUE026025T2 (en) * | 2008-05-09 | 2016-05-30 | Merck Patent Gmbh | A pharmaceutical composition comprising rimeporide for the treatment of diseases associated with beta cell dysfunction |
RS58378B1 (sr) | 2014-07-25 | 2019-04-30 | Taisho Pharmaceutical Co Ltd | Fenil tetrahidroizokvinolinsko jedinjenje supstituisano heteroarilom |
WO2024028893A1 (en) * | 2022-08-01 | 2024-02-08 | Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) | Substituted benzimidazoles for treating viral diseases |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR900100380A (el) * | 1989-05-20 | 1991-10-10 | Fisons Plc | Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης. |
JP2869561B2 (ja) * | 1989-05-22 | 1999-03-10 | 大塚製薬株式会社 | 血小板粘着抑制剤 |
PT966465E (pt) * | 1997-03-14 | 2003-11-28 | Vertex Pharma | Inibidores do enzima imfdh |
JPH10330369A (ja) * | 1997-04-04 | 1998-12-15 | Sumitomo Pharmaceut Co Ltd | 複素環化合物 |
WO2001021160A2 (en) * | 1999-09-23 | 2001-03-29 | Axxima Pharmaceuticals Aktiengesellschaft | Carboxymide and aniline derivatives as selective inhibitors of pathogens |
DE10060292A1 (de) * | 2000-12-05 | 2002-06-20 | Aventis Pharma Gmbh | Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament |
-
2003
- 2003-02-04 DE DE10304294A patent/DE10304294A1/de not_active Withdrawn
-
2004
- 2004-01-20 DE DE502004006770T patent/DE502004006770D1/de not_active Expired - Lifetime
- 2004-01-20 AU AU2004208871A patent/AU2004208871A1/en not_active Abandoned
- 2004-01-20 BR BRPI0407199-9A patent/BRPI0407199A/pt not_active IP Right Cessation
- 2004-01-20 MX MXPA05007247A patent/MXPA05007247A/es not_active Application Discontinuation
- 2004-01-20 JP JP2006501562A patent/JP4630270B2/ja not_active Expired - Fee Related
- 2004-01-20 WO PCT/EP2004/000395 patent/WO2004069811A1/de active IP Right Grant
- 2004-01-20 EP EP04703374A patent/EP1592671B1/de not_active Expired - Lifetime
- 2004-01-20 AT AT04703374T patent/ATE391714T1/de not_active IP Right Cessation
- 2004-01-20 CA CA002513821A patent/CA2513821A1/en not_active Abandoned
- 2004-01-28 PE PE2004000107A patent/PE20041041A1/es not_active Application Discontinuation
- 2004-02-02 AR ARP040100315A patent/AR043003A1/es unknown
- 2004-02-02 TW TW093102253A patent/TW200507837A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
TW200507837A (en) | 2005-03-01 |
DE502004006770D1 (de) | 2008-05-21 |
MXPA05007247A (es) | 2005-09-08 |
ATE391714T1 (de) | 2008-04-15 |
JP2006516577A (ja) | 2006-07-06 |
PE20041041A1 (es) | 2005-02-04 |
JP4630270B2 (ja) | 2011-02-09 |
BRPI0407199A (pt) | 2006-02-14 |
AU2004208871A1 (en) | 2004-08-19 |
DE10304294A1 (de) | 2004-08-12 |
CA2513821A1 (en) | 2004-08-19 |
EP1592671A1 (de) | 2005-11-09 |
EP1592671B1 (de) | 2008-04-09 |
WO2004069811A1 (de) | 2004-08-19 |
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Legal Events
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FB | Suspension of granting procedure |