AR040446A1 - Defensinas de plantas - Google Patents
Defensinas de plantasInfo
- Publication number
- AR040446A1 AR040446A1 AR20030102214A ARP030102214A AR040446A1 AR 040446 A1 AR040446 A1 AR 040446A1 AR 20030102214 A AR20030102214 A AR 20030102214A AR P030102214 A ARP030102214 A AR P030102214A AR 040446 A1 AR040446 A1 AR 040446A1
- Authority
- AR
- Argentina
- Prior art keywords
- nucleotide sequence
- seq
- sequence
- amino acid
- depicted
- Prior art date
Links
- 239000002773 nucleotide Substances 0.000 abstract 9
- 125000003729 nucleotide group Chemical group 0.000 abstract 9
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 102000000541 Defensins Human genes 0.000 abstract 2
- 108010002069 Defensins Proteins 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 230000007123 defense Effects 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8285—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for nematode resistance
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Acidos nucleicos aislados que codifican defensinas vegetales. La presente tambíén se relaciona con la construcción de un gen quimérico que codifica todo o una porción de la defensina vegetal, orientado en el sentido del marco de lectura o antisentido, donde la expresión del gen quimérico da como resultado la producción de niveles alternados de defensinas vegetales en una célula huésped transformada. Reivindicación1: Una molécula de ácido nucleico, caracterizada porque comprende una secuencia de nucleótidos seleccionada del grupo formado por: (a) una secuencia de nucleótidos representada en la SEQ ID Ns. 29, 31, 34, 46 ó 48; (b) una secuencia de nucleótidos que codifica un polipéptido que comprende la secuencia de aminoácidos representada en la SEQ ID Ns: 32, 35, 47 ó 49; (c) una secuencia de nucleótidos caracterizada por al menos un 90% de identidad de secuencia con la secuencia de nucleótidos representada en la SEQ ID Ns: 31, 34 ó 48; (d) una secuencia de nucleótidos caracterizada por al menos un 96% de identidad de secuencia con la secuencia de nucleótidos representada en la SEQ ID Ns: 46; (e) una secuencia de nucleótidos que codifica un polipéptido que comprende una secuencia de aminoácidos que posee al menos un 93% de identidad de secuencia con la secuencia de aminoácidos representada en la SEQ ID Ns:47; (f) una secuencia de nucleótidos que comprende el complemento de cualquiera de (a) a (e).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/178,449 US6855865B2 (en) | 1999-05-07 | 2002-06-21 | Nucleic acids encoding plant defensins and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR040446A1 true AR040446A1 (es) | 2005-04-06 |
Family
ID=29999121
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR20030102214A AR040446A1 (es) | 2002-06-21 | 2003-06-20 | Defensinas de plantas |
| ARP030102213A AR044736A1 (es) | 2002-06-21 | 2003-06-20 | Metodo para aumentar la resistencia de una planta frente a por lo menos un patogeno de plantas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030102213A AR044736A1 (es) | 2002-06-21 | 2003-06-20 | Metodo para aumentar la resistencia de una planta frente a por lo menos un patogeno de plantas |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6855865B2 (es) |
| EP (1) | EP1534829B1 (es) |
| AR (2) | AR040446A1 (es) |
| AT (1) | ATE419272T1 (es) |
| AU (1) | AU2003245651B2 (es) |
| BR (1) | BR0312151A (es) |
| CA (1) | CA2490098C (es) |
| DE (1) | DE60325608D1 (es) |
| MX (1) | MXPA04012645A (es) |
| WO (1) | WO2004001012A2 (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012030759A1 (en) * | 2010-09-01 | 2012-03-08 | Pioneer Hi-Bred International, Inc. | Vacuole targeting peptides and methods of use |
| US7785828B1 (en) * | 2003-02-06 | 2010-08-31 | Pioneer Hi-Bred International, Inc. | Production of antimicrobial proteins in fusion proteins |
| BRPI0512904A (pt) * | 2004-06-30 | 2008-04-15 | Pioneer Hi Bred Int | método para o aumento da resistência de plantas a patógenos de fungo |
| US7306946B2 (en) | 2004-07-02 | 2007-12-11 | Pioneer Hi-Bred International, Inc. | Antifungal polypeptides |
| US20070277263A1 (en) * | 2006-05-25 | 2007-11-29 | Hexima Ltd. | Multi-gene expression vehicle |
| AU2008241364B2 (en) | 2007-04-20 | 2013-03-21 | Hexima Limited | Modified plant defensin |
| AR075257A1 (es) | 2008-02-01 | 2011-03-23 | Hexima Ltd | Sistema de proteccion de plantas contra la infeccion por agentes patogenos |
| US9889184B2 (en) | 2008-08-05 | 2018-02-13 | Hexima Limited | Anti-pathogen systems |
| AR072910A1 (es) * | 2008-08-05 | 2010-09-29 | Hexima Ltd | Sistemas anti -patogeno |
| MX349741B (es) | 2011-02-07 | 2017-08-10 | Hexima Ltd * | Defensinas de planta modificadas utiles como agentes antipatogenos. |
| WO2013096818A1 (en) | 2011-12-21 | 2013-06-27 | The Curators Of The University Of Missouri | Soybean variety s05-11268 |
| WO2013096810A1 (en) | 2011-12-21 | 2013-06-27 | The Curators Of The University Of Missouri | Soybean variety s05-11482 |
| WO2013112997A1 (en) * | 2012-01-27 | 2013-08-01 | The Texas A&M University System | Pathogen resistant citrus compositions, organisms, systems, and methods |
| CA2905743C (en) | 2013-03-13 | 2021-09-28 | Pioneer Hi-Bred International, Inc. | Glyphosate application for weed control in brassica |
| EA029279B1 (ru) | 2013-03-14 | 2018-03-30 | Пайонир Хай-Бред Интернэшнл Инк. | Композиции и способы контроля насекомых-вредителей |
| BR112015023709A2 (pt) | 2013-03-15 | 2017-07-18 | Pioneer Hi Bred Int | polipeptídeo phi-4, polinucleotídeo, composição, método para inibir o crescimento, método para controlar uma população, planta, semente, cassete de expressão, método para expressar em uma planta um polinucleotídeo, método para proteger uma planta, proteína de fusão |
| BR112016003225B1 (pt) | 2013-08-16 | 2022-10-25 | Pioneer Hi-Bred International, Inc. | Polipeptídeo pip-47, polipeptídeo pip-47 quimérico, composição, proteína de fusão, método para controlar uma população de inseto-praga, método para inibir o crescimento ou matar um inseto-praga, construto de dna, polinucleotídeo isolado, cassete de expressão, método de obtenção de uma planta transgênica e método para controlar infestação de inseto |
| BR122020001770B1 (pt) | 2013-09-13 | 2022-11-29 | Pioneer Hi-Bred International, Inc | Construto de dna, método de obtenção de planta transgênica, proteína de fusão, método para controlar uma população de praga de inseto, método para inibir o crescimento ou matar uma praga de inseto |
| CN103911384B (zh) * | 2014-01-21 | 2016-05-25 | 江苏大学 | 一种控制油菜菌核病的基因及其应用 |
| BR112016018103B1 (pt) | 2014-02-07 | 2024-01-16 | E.I. Du Pont De Nemours And Company | Polipeptídeo e seu uso, polinucleotídeo, composição, proteína de fusão, método para controlar uma população, método para inibir o crescimento, método para controlar a infestação, método para obtenção de uma planta ou célula vegetal, construto |
| US10227608B2 (en) | 2014-02-07 | 2019-03-12 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
| US20170247719A1 (en) | 2014-09-17 | 2017-08-31 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| UA126192C2 (uk) | 2014-10-16 | 2022-08-31 | Піонір Хай-Бред Інтернешнл, Інк. | Інсектицидний білок та спосіб його застосування |
| WO2016099916A1 (en) | 2014-12-19 | 2016-06-23 | E. I. Du Pont De Nemours And Company | Polylactic acid compositions with accelerated degradation rate and increased heat stability |
| MX369475B (es) | 2015-01-15 | 2019-11-08 | Pioneer Hi Bred Int | Proteinas insecticidas y metodos para sus usos. |
| CN108064233B (zh) | 2015-05-19 | 2022-07-15 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
| EP3310803A1 (en) | 2015-06-16 | 2018-04-25 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| CN109475096B (zh) | 2015-08-06 | 2022-08-23 | 先锋国际良种公司 | 植物来源的杀昆虫蛋白及其使用方法 |
| CA3002995A1 (en) | 2015-12-18 | 2017-06-22 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
| BR112018072417B1 (pt) | 2016-05-04 | 2023-03-14 | E. I. Du Pont De Nemours And Company | Polipeptídeo inseticida recombinante, polipeptídeo quimérico, composição, polinucleotídeo recombinante, construtos de dna, métodos para obter uma planta transgênica, métodos para inibir o crescimento ou extermínio de uma praga de inseto ou população de praga, método para obter uma célula procariótica transformada, célula procariótica transformada e método para modificar geneticamente o polipeptídeo inseticida |
| CA3022858A1 (en) | 2016-06-16 | 2017-12-21 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| PH12018502706B1 (en) | 2016-07-01 | 2024-05-24 | Pioneer Hi Bred Int | Insecticidal proteins from plants and methods for their use |
| WO2018013333A1 (en) | 2016-07-12 | 2018-01-18 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| WO2018084936A1 (en) | 2016-11-01 | 2018-05-11 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
| CN116410286A (zh) | 2018-03-14 | 2023-07-11 | 先锋国际良种公司 | 来自植物的杀昆虫蛋白及其使用方法 |
| EP3764798B1 (en) | 2018-03-14 | 2025-12-17 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
| US12168774B2 (en) | 2020-07-14 | 2024-12-17 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US14732A (en) * | 1856-04-22 | Coal-breaker | ||
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| ATE118788T1 (de) * | 1990-06-15 | 1995-03-15 | Hoechst Schering Agrevo Gmbh | Antifungisches polypeptid, verfahren zu seiner herstellung. |
| GB9104617D0 (en) * | 1991-03-05 | 1991-04-17 | Nickerson Int Seed | Pest control |
| US5538525A (en) | 1991-08-29 | 1996-07-23 | Zeneca Limited | Biocidal proteins |
| NZ244091A (en) | 1991-08-29 | 1994-10-26 | Zeneca Ltd | Biocidal proteins derived from plants, their manufacture, coding sequences and uses |
| GB9300281D0 (en) | 1993-01-08 | 1993-03-03 | Zeneca Ltd | Antimicrobial-protein-producing endosymbiotic micro-organisms |
| US5847047A (en) | 1993-06-22 | 1998-12-08 | E. I. Du Pont De Nemours And Company | Antimicrobial composition of a polymer and a peptide forming amphiphilic helices of the magainin-type |
| AU677407B2 (en) | 1993-08-04 | 1997-04-24 | Zeneca Limited | Antimicrobial proteins |
| GB9326424D0 (en) | 1993-12-24 | 1994-02-23 | Zeneca Ltd | Biocidal proteins |
| US5412839A (en) | 1994-01-07 | 1995-05-09 | General Electric Company | Soft touch appliance handle assembly |
| GB9404807D0 (en) | 1994-03-11 | 1994-04-27 | Zeneca Ltd | Biocidal proteins |
| CA2239731A1 (en) | 1995-12-13 | 1997-06-19 | Zeneca Limited | Antifungal proteins |
| GB9525474D0 (en) | 1995-12-13 | 1996-02-14 | Zeneca Ltd | Antifungal proteins |
| US5773696A (en) | 1996-03-29 | 1998-06-30 | Monsanto Company | Antifungal polypeptide and methods for controlling plant pathogenic fungi |
| GB9613753D0 (en) | 1996-07-01 | 1996-09-04 | Broekaert Willem F | Plant protection method |
| GB9714564D0 (en) | 1997-07-10 | 1997-09-17 | Zeneca Ltd | Composition |
| AU4494599A (en) * | 1998-07-03 | 2000-01-24 | University Of Manitoba | Method for genetic engineering of disease resistance using the drr206 class of proteins |
| GB9818003D0 (en) | 1998-08-18 | 1998-10-14 | Zeneca Ltd | Polynucleotide sequences |
| CA2370017A1 (en) | 1999-05-07 | 2000-11-16 | E.I. Du Pont De Nemours And Company | Plant defensins |
| US6677503B1 (en) | 1999-06-23 | 2004-01-13 | Pioneer Hi-Bred International, Inc. | Sunflower anti-pathogene proteins and genes and their uses |
| EP1101771A1 (en) * | 1999-11-15 | 2001-05-23 | Korea Kumho Petrochemical Co. Ltd. | Pathogen-induced genes from Capsicum annuum |
| WO2002063011A1 (en) | 2001-02-08 | 2002-08-15 | Hexima Ltd | Plant-derived molecules and genetic sequences encoding same and uses therefor |
-
2002
- 2002-06-21 US US10/178,449 patent/US6855865B2/en not_active Expired - Lifetime
-
2003
- 2003-06-20 CA CA2490098A patent/CA2490098C/en not_active Expired - Fee Related
- 2003-06-20 BR BRPI0312151-8A patent/BR0312151A/pt not_active Application Discontinuation
- 2003-06-20 MX MXPA04012645A patent/MXPA04012645A/es active IP Right Grant
- 2003-06-20 AR AR20030102214A patent/AR040446A1/es unknown
- 2003-06-20 AT AT03739278T patent/ATE419272T1/de not_active IP Right Cessation
- 2003-06-20 WO PCT/US2003/019800 patent/WO2004001012A2/en not_active Ceased
- 2003-06-20 AR ARP030102213A patent/AR044736A1/es unknown
- 2003-06-20 DE DE60325608T patent/DE60325608D1/de not_active Expired - Lifetime
- 2003-06-20 AU AU2003245651A patent/AU2003245651B2/en not_active Ceased
- 2003-06-20 EP EP03739278A patent/EP1534829B1/en not_active Expired - Lifetime
-
2004
- 2004-09-30 US US10/954,790 patent/US7238781B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1534829A2 (en) | 2005-06-01 |
| US20050076407A1 (en) | 2005-04-07 |
| US20030140368A1 (en) | 2003-07-24 |
| EP1534829B1 (en) | 2008-12-31 |
| AU2003245651B2 (en) | 2007-06-28 |
| MXPA04012645A (es) | 2005-07-01 |
| US7238781B2 (en) | 2007-07-03 |
| WO2004001012A3 (en) | 2004-09-02 |
| ATE419272T1 (de) | 2009-01-15 |
| CA2490098C (en) | 2011-11-29 |
| WO2004001012A2 (en) | 2003-12-31 |
| BR0312151A (pt) | 2007-05-29 |
| CA2490098A1 (en) | 2003-12-31 |
| AR044736A1 (es) | 2005-10-05 |
| AU2003245651A1 (en) | 2004-01-06 |
| DE60325608D1 (de) | 2009-02-12 |
| EP1534829A4 (en) | 2007-08-22 |
| US6855865B2 (en) | 2005-02-15 |
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