AR039629A1 - Antagonistas de proteinas mcp - Google Patents
Antagonistas de proteinas mcpInfo
- Publication number
- AR039629A1 AR039629A1 ARP030101253A ARP030101253A AR039629A1 AR 039629 A1 AR039629 A1 AR 039629A1 AR P030101253 A ARP030101253 A AR P030101253A AR P030101253 A ARP030101253 A AR P030101253A AR 039629 A1 AR039629 A1 AR 039629A1
- Authority
- AR
- Argentina
- Prior art keywords
- mcp
- protein
- protein antagonists
- mutants
- proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Antagonistas novedosos de proteínas MCP, en particular de proteína MCP-1, pueden ser obtenidos generando mutantes MCP en los cuales al menos un sitio de unión GAG ubicado en la terminal-N de proteínas MCP es eliminado siguiendo sustituciones no conservativas. Los compuestos preparados de acuerdo con la presente invención pueden utilizarse en el tratamiento o prevención de enfermedades relacionadas con una actividad indeseable de proteínas MCP, tal como enfermedad inflamatoria, enfermedades autoinmunes, enfermedades vasculares, y cáncer. Reivindicación 1: antagonistas de proteínas MCP que consisten de mutantes de proteínas MCP en las cuales las siguientes combinaciones de residuos, numeradas en la secuencia de MCP-1 madura humana, son sustituidas a Alanina, Glicina, Serina, Treonina, Prolina, ácido Aspártico, ácido Glutámico, o Glutamina: a- 18 y 19; b- 18 y/o 19, junto con 58; c- 18 y/o 19, junto con 66; d-18 y/o 19, junto con 58 y 66; e- 18 y/o 19, junto con uno o más de los siguientes: 24, 44, 49, 75.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37144202P | 2002-04-10 | 2002-04-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR039629A1 true AR039629A1 (es) | 2005-03-02 |
Family
ID=28792054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030101253A AR039629A1 (es) | 2002-04-10 | 2003-04-09 | Antagonistas de proteinas mcp |
Country Status (18)
Country | Link |
---|---|
US (1) | US7425324B2 (es) |
EP (1) | EP1495050A1 (es) |
JP (1) | JP2006505243A (es) |
KR (1) | KR20040101426A (es) |
CN (1) | CN1665839A (es) |
AR (1) | AR039629A1 (es) |
AU (1) | AU2003240765A1 (es) |
BR (1) | BR0309238A (es) |
CA (1) | CA2509767A1 (es) |
EA (1) | EA200401342A1 (es) |
HR (1) | HRP20040946A2 (es) |
IL (1) | IL164464A0 (es) |
MX (1) | MXPA04009874A (es) |
NO (1) | NO20044850L (es) |
PL (1) | PL373007A1 (es) |
RS (1) | RS89104A (es) |
WO (1) | WO2003084993A1 (es) |
ZA (1) | ZA200409062B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR046594A1 (es) * | 2003-10-16 | 2005-12-14 | Applied Research Systems | Usos terapeuticos de variantes de quemoquina |
US20050232923A1 (en) * | 2003-11-05 | 2005-10-20 | Li Yan | Methods and compositions for treating MCP-1 related pathologies |
US20050106740A1 (en) * | 2003-11-13 | 2005-05-19 | Boyes Barry E. | Methods, systems and devices for performing analytical protocols |
AT412785B (de) * | 2003-12-04 | 2005-07-25 | Kungl Andreas J Dr | Gag-bindungsproteine |
GB0412400D0 (en) * | 2004-06-03 | 2004-07-07 | Univ Newcastle | Treatment of inflammatory conditions |
CA2618951A1 (en) | 2005-08-12 | 2007-02-22 | Schering Corporation | Mcp1 fusions |
EP2041568A4 (en) * | 2006-06-15 | 2009-08-12 | CCR2 ANTAGONISTS FOR CHRONIC BREATHING REACTIONS IN ORGAN TRANSPLANTATIONS | |
US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
US10745701B2 (en) | 2007-06-28 | 2020-08-18 | The Trustees Of Princeton University | Methods of identifying and treating poor-prognosis cancers |
US20090324596A1 (en) | 2008-06-30 | 2009-12-31 | The Trustees Of Princeton University | Methods of identifying and treating poor-prognosis cancers |
EP2042516A1 (en) | 2007-09-27 | 2009-04-01 | Protaffin Biotechnologie AG | Glycosaminoglycan-antagonising MCP-1 mutants and methods of using same |
EP2391645A1 (en) | 2009-01-30 | 2011-12-07 | Protaffin Biotechnologie AG | Glycosaminoglycan-antagonising mcp-i mutants and methods of using same |
US8524217B2 (en) | 2010-05-11 | 2013-09-03 | Merck Sharp & Dohme Corp. | MCP1-Ig fusion variants |
KR101238196B1 (ko) * | 2010-12-16 | 2013-02-28 | 사회복지법인 삼성생명공익재단 | 대장암의 간 전이 진단용 조성물 및 그 용도 |
US20180206726A1 (en) | 2016-12-07 | 2018-07-26 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
WO2018112264A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
US20220249814A1 (en) | 2018-11-19 | 2022-08-11 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
WO2021119482A1 (en) | 2019-12-13 | 2021-06-17 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5094941A (en) * | 1987-12-31 | 1992-03-10 | Zymogenetics, Inc. | Monoclonal antibodies to PDGF |
US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
-
2003
- 2003-04-09 AU AU2003240765A patent/AU2003240765A1/en not_active Abandoned
- 2003-04-09 RS YU89104A patent/RS89104A/sr unknown
- 2003-04-09 CA CA002509767A patent/CA2509767A1/en not_active Abandoned
- 2003-04-09 WO PCT/EP2003/050097 patent/WO2003084993A1/en active Application Filing
- 2003-04-09 PL PL03373007A patent/PL373007A1/xx not_active Application Discontinuation
- 2003-04-09 KR KR10-2004-7016121A patent/KR20040101426A/ko not_active Application Discontinuation
- 2003-04-09 JP JP2003582187A patent/JP2006505243A/ja active Pending
- 2003-04-09 CN CN038130076A patent/CN1665839A/zh active Pending
- 2003-04-09 EP EP03730178A patent/EP1495050A1/en not_active Withdrawn
- 2003-04-09 EA EA200401342A patent/EA200401342A1/ru unknown
- 2003-04-09 US US10/510,658 patent/US7425324B2/en not_active Expired - Fee Related
- 2003-04-09 AR ARP030101253A patent/AR039629A1/es unknown
- 2003-04-09 BR BR0309238-0A patent/BR0309238A/pt not_active IP Right Cessation
- 2003-04-09 MX MXPA04009874A patent/MXPA04009874A/es not_active Application Discontinuation
-
2004
- 2004-10-10 IL IL16446404A patent/IL164464A0/xx unknown
- 2004-10-11 HR HR20040946A patent/HRP20040946A2/hr not_active Application Discontinuation
- 2004-11-08 NO NO20044850A patent/NO20044850L/no not_active Application Discontinuation
- 2004-11-09 ZA ZA200409062A patent/ZA200409062B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2003240765A1 (en) | 2003-10-20 |
CN1665839A (zh) | 2005-09-07 |
BR0309238A (pt) | 2005-02-15 |
US20070004906A1 (en) | 2007-01-04 |
ZA200409062B (en) | 2005-11-09 |
HRP20040946A2 (en) | 2005-06-30 |
WO2003084993A1 (en) | 2003-10-16 |
MXPA04009874A (es) | 2005-10-19 |
EP1495050A1 (en) | 2005-01-12 |
JP2006505243A (ja) | 2006-02-16 |
EA200401342A1 (ru) | 2005-08-25 |
US7425324B2 (en) | 2008-09-16 |
NO20044850L (no) | 2004-12-09 |
KR20040101426A (ko) | 2004-12-02 |
PL373007A1 (en) | 2005-08-08 |
CA2509767A1 (en) | 2003-10-16 |
IL164464A0 (en) | 2005-12-18 |
RS89104A (en) | 2006-12-15 |
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Legal Events
Date | Code | Title | Description |
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FB | Suspension of granting procedure |