AR039041A1 - Derivados de ciclopenteno - Google Patents

Derivados de ciclopenteno

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Publication number
AR039041A1
AR039041A1 ARP030100983A ARP030100983A AR039041A1 AR 039041 A1 AR039041 A1 AR 039041A1 AR P030100983 A ARP030100983 A AR P030100983A AR P030100983 A ARP030100983 A AR P030100983A AR 039041 A1 AR039041 A1 AR 039041A1
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AR
Argentina
Prior art keywords
alkyl
alkoxy
hydrogen
amino
group
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ARP030100983A
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English (en)
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Bayer Ag
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Publication of AR039041A1 publication Critical patent/AR039041A1/es

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    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07C205/08—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms
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    • C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
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    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group
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    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
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    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
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    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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Abstract

La presente se refiere a derivados de ciclopenteno sustituidos, a un procedimiento para su preparación, así como a su uso para la preparación de medicamentos, especialmente para el tratamiento y/o la prevención de enfermedades tromboembólicas. Reivindicación 1: Compuestos de fórmula (1) en la que: R1 designa arilo (C6-10) o heteroarilo de 5 ó 6 miembros con hasta dos heteroátomos del grupo de N, O y/o S, que pueden estar sustituidos respectivamente de una a tres veces independientemente entre sí con restos seleccionados del grupo de halógeno, alquilo (C1-6), trifluorometilo, ciano, hidroxi, alcoxi (C1-6), trifluorometoxi, carboxilo, alcoxi(C1-4)-carbonilo, -C(O)-NR9R10, amino, mono- y dialquil(C1-6)-amino, en los que los restos alquilo y alcoxi anteriormente citados pueden estar sustituidos respectivamente a su vez con hidroxi, alcoxi (C1-4), carboxilo, alcoxi(C1-4)-carbonilo, amino, mono-, o dialquil(C1-4)-amino; y R9 y R10 significan independientemente entre sí hidrógeno o alquilo (C1-6); A designa un enlace o alcano(C1-4)-diilo, alqueno(C2-4)-diilo o alquino(C2-4)-diilo; R2 y R5 designan independientemente entre sí piridilo, tienilo, furilo, benzofuranilo, tetrahidropiranilo, ciclohexilo, o fenilo, que pueden estar sustituidos respectivamente una o dos veces independientemente entre sí con halógeno, alquilo (C1-6), trifluorometilo, ciano, amino, alcoxi (C1-6) o trifluorometoxi, en los que los restos alquilo y alcoxi anteriormente citados pueden estar sustituidos a su vez respectivamente con hidroxi, alcoxi (C1-4), carboxilo, alcoxi(C1-4)-carbonilo, amino, mono- o dialquil(C1-4)-amino; R3 y R4 designan independientemente entre sí hidrógeno, alquilo (C1-6), alquenilo (C2-6) ,alquinilo (C2-6) o cicloalquilo (C3-8), que pueden estar sustituidos respectivamente de una a tres veces independientemente entre sí con restos seleccionados del grupo de hidroxi, alcoxi (C1-6), ciano, flúor, cloro, -NR11R12, -C(O)-OR13, -C(O)-NR11R12, -SO2-OR13 y -SO2-OR3, en los que R11, R12 y R13 significan independientemente entre sí hidrógeno o alquilo (C1-6), o R3 y R4 junto con el átomo de carbono al que están unidos forman un anillo cicloalquilo con enlace espiro de 3 a 6 miembros; R6 designa hidrógeno, alquilo (C1-6), alcanoilo (C1-6) o un grupo de fórmula -C(O)-C(O)-OR14, en la que R14 significa hidrógeno o alquilo (C1-6); R7 designa hidrógeno; R8 designa hidroxi; o R7 y R8 junto con el átomo de carbono al que están unidos forman un grupo carbonilo o un grupo de fórmula C=N-O-R15, en la que R15 designa hidrógeno o alquilo (C1-6), que puede estar sustituido con hidroxi, alcoxi (C1-6), carboxilo, alcoxi(C1-4)-carbonilo o un grupo de fórmula -NR16R17 o -C(O)-NR16R17, en al que R16 y R17 significan independientemente entre sí hidrógeno o alquilo (C1-6); y sus sales, solvatos y solvatos de las sales para combatir enfermedades.
ARP030100983A 2002-03-25 2003-03-20 Derivados de ciclopenteno AR039041A1 (es)

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DE10213228A DE10213228A1 (de) 2002-03-25 2002-03-25 Cyclopenten-Derivate

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AR039041A1 true AR039041A1 (es) 2005-02-02

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US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
ATE499370T1 (de) 2005-01-19 2011-03-15 Bristol Myers Squibb Co 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3- aminderivate und verwandte verbindungen als p2y1- rezeptor-hemmer zur behandlung thromboembolischer erkrankungen
US7728008B2 (en) 2005-06-27 2010-06-01 Bristol-Myers Squibb Company N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US7714002B2 (en) 2005-06-27 2010-05-11 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
ES2352796T3 (es) 2005-06-27 2011-02-23 Bristol-Myers Squibb Company Antagonistas cíclicos unidos a c del receptor p2y1 útiles en el tratamiento de afecciones trombóticas.
DE602006020871D1 (de) 2005-06-27 2011-05-05 Bristol Myers Squibb Co Lineare harnstoffmimetika-antagonisten des p2y1-rezeptors zur behandlung von thromboseleiden
TWI499414B (zh) 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
WO2008109591A1 (en) 2007-03-08 2008-09-12 Lexicon Pharmaceuticals, Inc. Phlorizin analogs as inhibitors of sodium glucose co-transporter 2
US11884640B2 (en) * 2021-06-02 2024-01-30 Chirogate International Inc. Processes and intermediates for the preparations of benzoprostacyclin analogues and benzoprostacyclin analogues prepared therefrom

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US3888905A (en) * 1969-02-17 1975-06-10 Searle & Co Prostaglandin intermediates and optically active isomers thereof
GB1461789A (en) * 1973-04-12 1977-01-19 Lilly Industries Ltd 3-substituted propanoic acid derivatives

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