AR037826A1 - Derivados de piridazina fusionada - Google Patents

Derivados de piridazina fusionada

Info

Publication number
AR037826A1
AR037826A1 ARP020104845A ARP020104845A AR037826A1 AR 037826 A1 AR037826 A1 AR 037826A1 AR P020104845 A ARP020104845 A AR P020104845A AR P020104845 A ARP020104845 A AR P020104845A AR 037826 A1 AR037826 A1 AR 037826A1
Authority
AR
Argentina
Prior art keywords
nr4r5
alkyl
cycloalkyl
alkenyl
aryl
Prior art date
Application number
ARP020104845A
Other languages
English (en)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AR037826A1 publication Critical patent/AR037826A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Los derivados de piridazina fusionada, que son útiles como inhibidores de CDK se describen en la presente. La presente descrita también incluye métodos para elaborar tales derivados de piridazinas fusionadas así como también métodos para utilizar los mismos en el tratamiento de enfermedades hiperproliferativas. Reivindicación 1: Un compuesto de la fórmula (1) o una sal, solvato o derivado fisiológicamente funcional del mismo, en donde: D es N o CH; R1 es hidrógeno, alquilo C1-6, alquenilo C2-4, alquinilo C2-4, alcoxi C1-3, halógeno, -CF3, hidroxi, ciano, -S(O)yalquilo C1-3, o -NR4R5; y es 0, 1 ó 2; a es 1 ó 2; R2 es hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, haloalquilo C1-6, cicloalquilo C3-7, halógeno, heterociclilo, arilo, heteroarilo, ciano, azido, nitro, -OR8, -OR6R8, -R6R7, -R6R'', -OS(O)2R9, -S(O)yR10, -C(O)R7, -C(O)OR7, -C(O)NR4R5, -N(H)R'C(=NR4)NR4R5, -OC(O)NR4R5, -OC(O)OR7, -C(=NR4)NR4R5, -NR4R5, -OC(O)R7 o -N(R8)C(O)R8; R3 es -(Q)p-(Q1), en donde Q es O, N(R8) o S(O)y, p es 0 ó 1; y es 0, 1 ó 2 y Q1 es alquilo C1-6, cicloalquilo C3-7, haloalquilo C1-6, arilo, arilo sustituido con -C(O)N(H)R6NR4R5 o -OC(H)(OH)R6NR4R6, heteroarilo, aralquilo, o R6NR4R5; R4 y R5 son independientemente hidrógeno, alquilo C1-3, cicloalquilo C3-7, -C(O)R9, o R4 y R5, junto con el átomo de nitrógeno al cual se unen, forman un heterociclilo; R6 es alquenilo, arileno, heteroarileno, cicloalquileno C3-7, alquenileno, cicloalquenileno C3-7, o alquinileno; R7 es hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, -NR4R5, arilo, aralquilo, heteroarilo, cicloalquilo, heterociclilo, -S(O)yR10, -C(O)R8, -C(O)OR8, -C(O)NR4R5, -S(O)2NR4R5, -N(H)R'C(=NR4)NR4R5, -OC(O)NR4R5, -OC(O)OR8, -C(=NR4)NR4R5, -NR4R5, o -N(R8)C(O)R8; R8 es hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, -NR4R5, arilo, aralquilo, heteroarilo, cicloalquilo, heterociclilo, o -S(O)2R9; R9 es alquilo C1-6 o haloalquilo C1-6; R10 es hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, -NR4R5, arilo, aralquilo, heteroarilo, cicloalquilo, heterociclilo, -C(O)R8, -C(O)OR8, -C(O)NR4R5, -N(H)R'C(=NR4)NR4R5, -OC(O)NR4R5, -OC(O)OR8, -C(=NR4)NR4R5, -NR4R5, o -N(R8)C(O)R8; R' es alquileno C1-3 y R'' es -OR7, -OC(O)NR4R5, -OC(O)OR7, o -OC(O)R7.
ARP020104845A 2001-12-17 2002-12-13 Derivados de piridazina fusionada AR037826A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34179801P 2001-12-17 2001-12-17

Publications (1)

Publication Number Publication Date
AR037826A1 true AR037826A1 (es) 2004-12-09

Family

ID=23339081

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020104845A AR037826A1 (es) 2001-12-17 2002-12-13 Derivados de piridazina fusionada

Country Status (10)

Country Link
US (1) US7279473B2 (es)
EP (1) EP1463730B1 (es)
JP (1) JP2005524609A (es)
AR (1) AR037826A1 (es)
AT (1) ATE323706T1 (es)
AU (1) AU2002357164A1 (es)
DE (1) DE60210819T2 (es)
ES (1) ES2262899T3 (es)
TW (1) TW200301119A (es)
WO (1) WO2003051886A1 (es)

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DK1470124T3 (da) 2002-01-22 2006-04-18 Warner Lambert Co 2-(Pyridin-2-yl amino)-pyrido[2,3]pyrimidin-7-oner
JP2006504755A (ja) * 2002-10-15 2006-02-09 スミスクライン ビーチャム コーポレーション Ｇｓｋ−３阻害薬としてのピリダジン化合物
CN1835951B (zh) * 2003-07-11 2010-06-02 沃尼尔·朗伯有限责任公司 选择性cdk4抑制剂的羟乙基磺酸盐
DE10344223A1 (de) * 2003-09-24 2005-04-21 Merck Patent Gmbh 1,3-Benzoxazolylderivate als Kinase-Inhibitoren
US7855205B2 (en) 2004-10-29 2010-12-21 Janssen Pharmaceutica Nv Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders
TW200800213A (en) 2005-09-02 2008-01-01 Abbott Lab Novel imidazo based heterocycles
WO2008068171A1 (en) * 2006-12-08 2008-06-12 F. Hoffmann-La Roche Ag Substituted pyrimidines and their use as jnk modulators
PT2231636E (pt) * 2007-12-07 2012-01-02 Novartis Ag Derivados de pirazole e a sua utilização a título de inibidores de quinases dependentes de ciclina
EP2265607B1 (en) 2008-02-15 2016-12-14 Rigel Pharmaceuticals, Inc. Pyrimidine-2-amine compounds and their use as inhibitors of jak kinases
ME02154B (me) * 2008-06-30 2015-10-20 Janssen Pharmaceutica Nv Proces za pripremu supstituisanih derivata pirimidina
AR074870A1 (es) * 2008-12-24 2011-02-16 Palau Pharma Sa Derivados de pirazolo (1,5-a ) piridina
WO2012101013A1 (en) * 2011-01-28 2012-08-02 Boehringer Ingelheim International Gmbh Substituted pyridinyl-pyrimidines and their use as medicaments
US20150203812A1 (en) * 2014-01-20 2015-07-23 Francesco Tombola Inhibitors of Voltage Gated Ion Channels
GB201605126D0 (en) 2016-03-24 2016-05-11 Univ Nottingham Inhibitors and their uses
CN106699608A (zh) * 2016-12-26 2017-05-24 常州大学 一种含有强吸电子基团的苯胍及其盐的制备方法
GB201715342D0 (en) 2017-09-22 2017-11-08 Univ Nottingham Compounds
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
WO2020180959A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
TW202115024A (zh) 2019-08-14 2021-04-16 美商英塞特公司 作為cdk2 抑制劑之咪唑基嘧啶基胺化合物
CA3157681A1 (en) 2019-10-11 2021-04-15 Incyte Corporation Bicyclic amines as cdk2 inhibitors
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

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AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
WO1998054093A1 (en) * 1997-05-30 1998-12-03 Merck & Co., Inc. Novel angiogenesis inhibitors
EP1510519B1 (en) 1997-09-05 2006-02-15 Glaxo Group Limited Pharmaceutical compositions comprising 2,3-diarylpyrazolo[1,5-B]pyridazine derivatives
AU3352899A (en) 1997-12-11 1999-07-12 American Home Products Corporation 2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof
GB9919778D0 (en) 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
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GB0103926D0 (en) 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds

Also Published As

Publication number Publication date
EP1463730A1 (en) 2004-10-06
DE60210819D1 (en) 2006-05-24
JP2005524609A (ja) 2005-08-18
WO2003051886A1 (en) 2003-06-26
ATE323706T1 (de) 2006-05-15
AU2002357164A1 (en) 2003-06-30
AU2002357164A8 (en) 2003-06-30
EP1463730B1 (en) 2006-04-19
US20050090507A1 (en) 2005-04-28
WO2003051886A8 (en) 2004-08-19
DE60210819T2 (de) 2007-04-19
TW200301119A (en) 2003-07-01
US7279473B2 (en) 2007-10-09
ES2262899T3 (es) 2006-12-01

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