AR035982A1 - Derivados de c-furano-2-il-metilamina y c-tiofeno-2-il-metilamina sustituidos y metodo de preparacion - Google Patents

Derivados de c-furano-2-il-metilamina y c-tiofeno-2-il-metilamina sustituidos y metodo de preparacion

Info

Publication number
AR035982A1
AR035982A1 ARP020101843A ARP020101843A AR035982A1 AR 035982 A1 AR035982 A1 AR 035982A1 AR P020101843 A ARP020101843 A AR P020101843A AR P020101843 A ARP020101843 A AR P020101843A AR 035982 A1 AR035982 A1 AR 035982A1
Authority
AR
Argentina
Prior art keywords
alkyl
aryl
cycloalkyl
heterocyclyl
cyclopropyl
Prior art date
Application number
ARP020101843A
Other languages
English (en)
Inventor
Corinna Maul
Michael Przewosny
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of AR035982A1 publication Critical patent/AR035982A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Derivados de C-furano-2-il-metilamina y C-tiofeno-2-il-metilamina sustituidos, de la fórmula general (1), en la cual: A representa O ó S; R1 representa arilo, heterociclilo, -(alquil C1-6)-arilo o -(alquil C1-6)-heterociclilo; R2 representa -C(=O)R6 o cicloalquilo C3-8; R3, R4 y R5 representan independientemente entre sí H, F, Cl, Br, I, CN, OR7, SR8, NO2, alquilo C1-12, cicloalquilo C3-8, -(alquil C1-6)-cicloalquilo C3-8, arilo, -(alquil C1-6)-arilo, heterociclilo, -(alquil C1-6)-heterociclilo, -(CH2)m-O-(CH2)n-R9, siendo m = 1, 2, 3 ó 4 y n = 0, 1, 2, 3 ó 4, -(CH2)p-Sq-(CH2)r-R10, siendo p = 1, 2, 3 ó 4, q = 1 ó 2 y r = 0, 1, 2, 3 ó 4, -(CH2)s-C(=O)OR11 siendo s = 0, 1, 2, 3 ó 4, -C(=O)R12 o C(=S)R13; R6 representa arilo, heterociclilo, -(alquil C1-6)-arilo o -(alquil C1-6)-heterociclilo; R7 y R8 representan independientemente entre sí H, alquilo C1-6 o cicloalquilo C3-8; R9 y R10 representan independientemente entre sí H, alquilo C1-6, cicloalquilo C3-8, arilo, heterociclilo o -C(=O)R14; R11 representa H, alquilo C1-6 o cicloalquilo C3-8; R12 y R13 representan independientemente entre sí alquilo C1-6, cicloalquilo C3-8, -(alquil C1-6)-cicloalquilo C3-8, arilo, -(alquil C1-6)-arilo, heterociclilo, -(alquil C1-6)-heterociclilo o -NR15R16; R14 representa independientemente de los demás sustituyentes alquilo C1-6, cicloalquilo C3-8, -(alquil C1-6)-cicloalquilo C3-8, arilo o -(alquil C1-6)-arilo; y R15 y R16 representan independientemente entre sí H, alquilo C1-8, cicloalquilo C1-8, -(alquil C1-6)-cicloalquilo C3-8, arilo, -(alquil C1-6)-arilo, heterociclilo o -(alquil C1-6)-heterociclilo; o -NR15R16 forman un anillo de heterociclilo; en forma de sus racematos, en forma de sus enantiómeros o diastereómeros puros o en forma de mezclas de los enantiómeros y diastereómeros en cualquier proporción; con excepción de N-(ciclopropil-2-tienilmetil)-4,5-dihidro-2-oxazolamina; N-(ciclopropil-2-furanilmetil)-4,5-dihidro-2-oxazolamina; 1,2-di-2-furanil-2-(fenilamino)-etanona; 1,2-di-2-furanil-2-(pirazinilamino)-etanona; 5-cloro-N-[ciclopropil[5(2-etoxietil)-2-tienil]metil]-6-metil-4-piridinamina; N-(ciclopropil-2-tienilmetil)-3,4,5,6-tetrahidro-2-piridinamina; N-(ciclopropil-2-tienilmetil)-3,4,5,6-tetrahidro-2H-azepinamina; y N-(ciclopropil-2-tienilmetil)-3,4,5,7-tetrahidro-2-azocinamina; procedimiento para su preparación, y medicamentos y composiciones farmacéuticas de efecto analgésico, anestésico local, antiarrítmico, antiemético, nootrópico y/o un medicamento para el tratamiento y/o profilaxis de enfermedades cardiovasculares, incontinencia urinaria, diarrea, prurito y/o inflamaciones y/o un medicamento para el tratamiento de depresiones y/o abuso de alcohol y/o drogas y/o medicamentos y/o un medicamento para el incremento de la vigilia, que los contienen. Preparación de un compuesto de fórmula (1) en la que una amina de la fórmula general R1-NH2 en la cual R1 tiene el significado arriba definido, se hace reaccionar con un compuesto de la fórmula general R2-C(O)H, en la que R2 tiene el significado arriba definido, y un heterociclo de la fórmula general (2), en la cual A, R3, R4 y R5 tienen los significados arriba definidos, en presencia de un ácido.
ARP020101843A 2001-05-22 2002-05-17 Derivados de c-furano-2-il-metilamina y c-tiofeno-2-il-metilamina sustituidos y metodo de preparacion AR035982A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10125145A DE10125145A1 (de) 2001-05-22 2001-05-22 Substituierte C-Furan-2-yl-methylamin- und C-Thiophen-2-yl-methylamin-Derivate

Publications (1)

Publication Number Publication Date
AR035982A1 true AR035982A1 (es) 2004-07-28

Family

ID=7685874

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020101843A AR035982A1 (es) 2001-05-22 2002-05-17 Derivados de c-furano-2-il-metilamina y c-tiofeno-2-il-metilamina sustituidos y metodo de preparacion

Country Status (17)

Country Link
US (2) US6878740B2 (es)
EP (1) EP1392670B1 (es)
JP (1) JP2004532246A (es)
AR (1) AR035982A1 (es)
AT (1) ATE299873T1 (es)
AU (1) AU2002338989B2 (es)
CA (1) CA2448038C (es)
DE (2) DE10125145A1 (es)
DK (1) DK1392670T3 (es)
ES (1) ES2242869T3 (es)
HU (1) HUP0401162A3 (es)
MX (1) MXPA03010601A (es)
PE (1) PE20021099A1 (es)
PL (1) PL367535A1 (es)
PT (1) PT1392670E (es)
SI (1) SI1392670T1 (es)
WO (1) WO2002094802A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0302094D0 (en) * 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
KR100553398B1 (ko) 2004-03-12 2006-02-16 한미약품 주식회사 티에노[3,2-ｃ]피리딘 유도체의 제조 방법 및 이에사용되는 중간체
US8884034B2 (en) 2009-07-08 2014-11-11 Dermira (Canada), Inc. TOFA analogs useful in treating dermatological disorders or conditions
MX2016006376A (es) * 2013-11-22 2016-10-28 Teva Branded Pharmaceutical Products R&D Inc Un medicamento inhalable.
WO2017209322A1 (ko) * 2016-05-31 2017-12-07 한림대학교 산학협력단 5원 헤테로사이클릭 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물
CN112521357B (zh) * 2020-08-31 2021-10-08 深圳瑞健生物科技有限公司 一种长效低成瘾性hnk衍生物及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3816457A (en) * 1973-01-05 1974-06-11 Richardson Merrell Inc Lactamimide derivatives
US3890445A (en) * 1973-01-05 1975-06-17 Richardson Merrell Inc Lactamimide derivatives useful as hypoglycemic agents
WO2001068816A1 (en) 2000-03-13 2001-09-20 Smithkline Beecham Corporation Human histamine h3 gene variant-3
DE10012820A1 (de) * 2000-03-16 2001-09-20 Bayer Ag Substituierte 1-Aryl-cyclopropylmethylamino-1,3,5-triazine
DE10059864A1 (de) * 2000-11-30 2002-06-13 Gruenenthal Gmbh Substituierte Amino-furan-2-yl-essigsäure- und Amino-thien-2-yl-essigsäure-Derivate

Also Published As

Publication number Publication date
US6878740B2 (en) 2005-04-12
AU2002338989B2 (en) 2007-06-07
HUP0401162A3 (en) 2007-05-02
DK1392670T3 (da) 2005-08-08
JP2004532246A (ja) 2004-10-21
CA2448038A1 (en) 2002-11-28
PT1392670E (pt) 2005-10-31
PL367535A1 (en) 2005-02-21
WO2002094802A1 (de) 2002-11-28
US20040152734A1 (en) 2004-08-05
EP1392670B1 (de) 2005-07-20
EP1392670A1 (de) 2004-03-03
DE10125145A1 (de) 2002-11-28
ES2242869T3 (es) 2005-11-16
DE50203686D1 (en) 2005-08-25
ATE299873T1 (de) 2005-08-15
PE20021099A1 (es) 2003-01-25
SI1392670T1 (sl) 2005-12-31
US7317034B2 (en) 2008-01-08
US20050148550A1 (en) 2005-07-07
HUP0401162A2 (hu) 2004-10-28
MXPA03010601A (es) 2004-03-09
CA2448038C (en) 2010-09-28

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