AR030426A1 - Proteinas sinteticas de tela de arana y su expresion en plantas transgenicas - Google Patents

Proteinas sinteticas de tela de arana y su expresion en plantas transgenicas

Info

Publication number
AR030426A1
AR030426A1 ARP010102752A ARP010102752A AR030426A1 AR 030426 A1 AR030426 A1 AR 030426A1 AR P010102752 A ARP010102752 A AR P010102752A AR P010102752 A ARP010102752 A AR P010102752A AR 030426 A1 AR030426 A1 AR 030426A1
Authority
AR
Argentina
Prior art keywords
arana
cloth
protein
synthetic
proteins
Prior art date
Application number
ARP010102752A
Other languages
English (en)
Inventor
Scheller Jurgen Dr
Conrad Udo Dr
Dr Grosse Frank Prof
Guehrs Karl-Heinz Dr
Original Assignee
Ipk Inst Fuer Pflanzengenetik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10113781A external-priority patent/DE10113781A1/de
Application filed by Ipk Inst Fuer Pflanzengenetik filed Critical Ipk Inst Fuer Pflanzengenetik
Publication of AR030426A1 publication Critical patent/AR030426A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43586—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from silkworms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Insects & Arthropods (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

El invento se refiere a una secuencia de ADN que codifica una proteína de tela de arana sintética, a las proteínas de tela de arana recombinantes que son codificadas por dicha secuencia de ADN, a los métodos para obtener plantas o células vegetales que contienen proteína de tela de arana recombinante, así como a las células vegetales y las plantas transgénicas que contienen una secuencia de ADN que codifica una proteína de tela de arana sintética. También se refiere a un método para obtener una proteína de tela de arana vegetal a partir de plantas transgénicas, así como a las proteínas de tela de arana vegetales que se obtienen con un método de este tipo. De esta manera se logra poner a disposicion secuencias de ADN que codifican una proteína sintética de tela de arana que presenta la mayor similitud posible con las secuencias naturales de las proteínas fibrosas de tela de arana conocidas. Además, se ofrece un procedimiento con el que se pueden producir proteínas sintéticas de tela de arana en gran escala. Las proteínas de tela de arana conforme a la invencion pueden utilizarse para preparar hilos sintéticos así como láminas y membranas. Estos productos son apropiados especialmente para aplicaciones médicas, sobre todo para suturar heridas y/o como estructuras o como recubrimiento de organos artificiales. Además, las láminas y membranas fabricadas a partir de estas proteínas de tela de arana pueden emplearse, por ejemplo, como superficies de soporte para células cultivadas y para filtrado.
ARP010102752A 2000-06-09 2001-06-11 Proteinas sinteticas de tela de arana y su expresion en plantas transgenicas AR030426A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10028212 2000-06-09
DE10053478 2000-10-24
DE10113781A DE10113781A1 (de) 2000-06-09 2001-03-21 Synthetische Spinnenseidenproteine und deren Expression in transgenen Pflanzen

Publications (1)

Publication Number Publication Date
AR030426A1 true AR030426A1 (es) 2003-08-20

Family

ID=27213905

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010102752A AR030426A1 (es) 2000-06-09 2001-06-11 Proteinas sinteticas de tela de arana y su expresion en plantas transgenicas

Country Status (6)

Country Link
US (1) US20060248615A1 (es)
EP (1) EP1287139B1 (es)
AR (1) AR030426A1 (es)
AU (1) AU2001285735A1 (es)
CA (1) CA2411600A1 (es)
WO (1) WO2001094393A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608242B1 (en) 2000-05-25 2003-08-19 E. I. Du Pont De Nemours And Company Production of silk-like proteins in plants
US7057023B2 (en) 2002-01-11 2006-06-06 Nexia Biotechnologies Inc. Methods and apparatus for spinning spider silk protein
US20070260039A1 (en) * 2002-01-11 2007-11-08 Karatzas Costas N Methods of Producing Silk Polypeptides and Products Thereof
DE102007002222A1 (de) 2007-01-10 2008-07-17 Gustav Pirazzi & Comp. Kg Verwendung von künstlich hergestellter Spinnenseide
BRPI0701826B1 (pt) 2007-03-16 2021-02-17 Embrapa - Empresa Brasileira De Pesquisa Agropecuária proteínas da teia de aranha nephilengys cruentata, avicularia juruensis e parawixia bistriata isoladas da biodiversidade brasileira
WO2008151405A1 (en) * 2007-06-15 2008-12-18 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Expression of fusion proteins containing a single chain antibody fragment linked to elastin-like repeating units in transgenic plants
KR101317420B1 (ko) * 2010-03-11 2013-10-10 한국과학기술원 고분자량의 재조합 실크 또는 실크 유사 단백질 및 이를 이용하여 제조된 마이크로 또는 나노 크기의 거미줄 또는 거미줄 유사 섬유
SG190088A1 (en) * 2010-11-01 2013-06-28 Peptimed Inc Compositions of a peptide targeting system for treating cancer
EP2518081B1 (en) 2011-04-28 2017-11-29 Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK) Method of producing and purifying polymeric proteins in transgenic plants
US20180271939A1 (en) * 2017-03-24 2018-09-27 Milton J. Silverman, JR. Genetic method to kill cancer cells by suffocation
CN116425848B (zh) * 2023-04-11 2024-05-24 北京新诚中科技术有限公司 重组嵌合蛛丝蛋白、生物蛋白纤维及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770697A (en) * 1986-11-04 1998-06-23 Protein Polymer Technologies, Inc. Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
EP0707645B1 (en) * 1993-06-15 2003-11-05 E.I. Du Pont De Nemours And Company Novel, recombinantly produced spider silk analogs
EP0848754A1 (en) * 1995-08-22 1998-06-24 Richard M. Basel Cloning methods for high strength spider silk proteins
US6608242B1 (en) * 2000-05-25 2003-08-19 E. I. Du Pont De Nemours And Company Production of silk-like proteins in plants

Also Published As

Publication number Publication date
WO2001094393A3 (de) 2002-06-20
AU2001285735A1 (en) 2001-12-17
EP1287139A2 (de) 2003-03-05
EP1287139B1 (de) 2010-08-25
CA2411600A1 (en) 2001-12-13
US20060248615A1 (en) 2006-11-02
WO2001094393A2 (de) 2001-12-13

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