AR025694A1 - Composiciones de condrocitos, preparacion y usos. - Google Patents

Composiciones de condrocitos, preparacion y usos.

Info

Publication number
AR025694A1
AR025694A1 ARP000104869A ARP000104869A AR025694A1 AR 025694 A1 AR025694 A1 AR 025694A1 AR P000104869 A ARP000104869 A AR P000104869A AR P000104869 A ARP000104869 A AR P000104869A AR 025694 A1 AR025694 A1 AR 025694A1
Authority
AR
Argentina
Prior art keywords
preparation
refers
defects
cartilaginous
compositions
Prior art date
Application number
ARP000104869A
Other languages
English (en)
Original Assignee
Univ Paris Curie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Paris Curie filed Critical Univ Paris Curie
Publication of AR025694A1 publication Critical patent/AR025694A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3852—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se refiere a composiciones de células condrocitarias, en especial humanas, y también se refiere a métodos para su preparacion y a sus utilizaciones. Másparticularmente, describe la produccion de suspensiones de condrocitos humanos autologos, en la cual se utilizan enzimas recombinantes y/o medios compatiblescon un uso farmacéutico. Los condrocitos producidos pueden ser utilizados in vivo para restaurar estructuras cartilaginosas afectadas, tales como los defectoscartilaginosos post-traumáticoso la osteocondritris disecante de las rodillas o, en términos más generales, para el tratamiento y retencion de los defectossignificativos del cartílago, en especial de cartílago articular.
ARP000104869A 1999-09-16 2000-09-15 Composiciones de condrocitos, preparacion y usos. AR025694A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9911564A FR2798671A1 (fr) 1999-09-16 1999-09-16 Compositions de chondrocytes, preparation et utilisations

Publications (1)

Publication Number Publication Date
AR025694A1 true AR025694A1 (es) 2002-12-11

Family

ID=9549897

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP000104868A AR025693A1 (es) 1999-09-16 2000-09-15 Composiciones de condrocitos, preparacion y usos
ARP000104869A AR025694A1 (es) 1999-09-16 2000-09-15 Composiciones de condrocitos, preparacion y usos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP000104868A AR025693A1 (es) 1999-09-16 2000-09-15 Composiciones de condrocitos, preparacion y usos

Country Status (7)

Country Link
US (1) US6365405B1 (es)
EP (2) EP1085082A1 (es)
AR (2) AR025693A1 (es)
AU (2) AU7429200A (es)
CA (1) CA2384768A1 (es)
FR (1) FR2798671A1 (es)
WO (2) WO2001019965A1 (es)

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US8480754B2 (en) 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8545569B2 (en) 2001-05-25 2013-10-01 Conformis, Inc. Patient selectable knee arthroplasty devices
US8066708B2 (en) 2001-05-25 2011-11-29 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US8771365B2 (en) 2009-02-25 2014-07-08 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs, and related tools
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US8083745B2 (en) * 2001-05-25 2011-12-27 Conformis, Inc. Surgical tools for arthroplasty
US8735773B2 (en) 2007-02-14 2014-05-27 Conformis, Inc. Implant device and method for manufacture
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US7534263B2 (en) 2001-05-25 2009-05-19 Conformis, Inc. Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
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US7239908B1 (en) 1998-09-14 2007-07-03 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
US9289153B2 (en) * 1998-09-14 2016-03-22 The Board Of Trustees Of The Leland Stanford Junior University Joint and cartilage diagnosis, assessment and modeling
DE10038700B4 (de) * 2000-07-31 2006-09-07 Michael Priv.-Doz. Dr. Sittinger Autologe Bindegewebe, Verfahren zu ihrer Herstellung und ihre Verwendung
WO2002022014A1 (en) * 2000-09-14 2002-03-21 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
EP2036495A1 (en) 2000-09-14 2009-03-18 The Board of Trustees of The Leland Stanford Junior University Assessing condition of a joint and cartilage loss
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US8439926B2 (en) 2001-05-25 2013-05-14 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
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US20050147959A1 (en) * 2002-03-25 2005-07-07 Frondoza Carmelita G. Tissue analogs for in vitro testing and method of use therefor
ATE497740T1 (de) 2002-10-07 2011-02-15 Conformis Inc Minimal invasives gelenkimplantat mit einer den gelenkflächen angepassten dreidimensionalen geometrie
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
JP2006505366A (ja) 2002-11-07 2006-02-16 コンフォーミス・インコーポレイテッド 半月板サイズおよび形状の決定および工夫した処置の方法
US7642092B2 (en) * 2003-03-03 2010-01-05 Technion Research & Development Foundation Ltd. Cultured cartilage/bone cells/tissue, method of generating same and uses thereof
US7067123B2 (en) * 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
EP1529543A1 (fr) * 2003-11-04 2005-05-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Utilisation d'un hydrogel pour la culture de chondrocytes
US20060063141A1 (en) * 2004-09-17 2006-03-23 Mcgann Locksley E Method of cryopreserving cells
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US7837740B2 (en) * 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
EP1928359A4 (en) 2005-09-30 2010-10-13 Conformis Inc JOINT ARTHROPLASTIEVORRICHTUNGEN
EP1954802B1 (en) * 2005-10-31 2017-05-31 Bio Solution Co., Ltd. Artificial cartilage containing chondrocytes obtained from costal cartilage and preparation process thereof
EP2302037A1 (en) * 2005-11-10 2011-03-30 Carticure Ltd. Method for non-autologous cartilage regeneration
JP2009516545A (ja) 2005-11-21 2009-04-23 フィリップ ラング， 面関節、錐体鉤状関節、肋椎関節、および他の関節を治療する装置および方法
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Also Published As

Publication number Publication date
US6365405B1 (en) 2002-04-02
AU7429200A (en) 2001-04-17
CA2384768A1 (fr) 2001-03-22
AU7429100A (en) 2001-04-17
WO2001019964A1 (fr) 2001-03-22
EP1085082A1 (fr) 2001-03-21
EP1085084A1 (fr) 2001-03-21
WO2001019965A1 (fr) 2001-03-22
FR2798671A1 (fr) 2001-03-23
AR025693A1 (es) 2002-12-11

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