ATE556137T1 - Durch einen polyelektrolytkomplex von hyaluronsäure und chitosan verstärkte biomimetische zusammensetzung - Google Patents

Durch einen polyelektrolytkomplex von hyaluronsäure und chitosan verstärkte biomimetische zusammensetzung

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Publication number
ATE556137T1
ATE556137T1 AT04812547T AT04812547T ATE556137T1 AT E556137 T1 ATE556137 T1 AT E556137T1 AT 04812547 T AT04812547 T AT 04812547T AT 04812547 T AT04812547 T AT 04812547T AT E556137 T1 ATE556137 T1 AT E556137T1
Authority
AT
Austria
Prior art keywords
chitosan
hyaluronic acid
polyelectrolyte complex
composition reinforced
biomimetic composition
Prior art date
Application number
AT04812547T
Other languages
English (en)
Inventor
John Brekke
Original Assignee
Tissue Engineering Consultants Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tissue Engineering Consultants Inc filed Critical Tissue Engineering Consultants Inc
Application granted granted Critical
Publication of ATE556137T1 publication Critical patent/ATE556137T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/72—Chitin, chitosan

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT04812547T 2003-12-01 2004-12-01 Durch einen polyelektrolytkomplex von hyaluronsäure und chitosan verstärkte biomimetische zusammensetzung ATE556137T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52596503P 2003-12-01 2003-12-01
US10/999,848 US7524514B2 (en) 2003-12-01 2004-11-30 Biomimetic composition reinforced by a polyelectrolytic complex of hyaluronic acid and chitosan
PCT/US2004/040051 WO2005054440A2 (en) 2003-12-01 2004-12-01 A biomimetic composition reinforced by a polyelectrolytic complex of hyaluronic acid and chitosan

Publications (1)

Publication Number Publication Date
ATE556137T1 true ATE556137T1 (de) 2012-05-15

Family

ID=34657208

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04812547T ATE556137T1 (de) 2003-12-01 2004-12-01 Durch einen polyelektrolytkomplex von hyaluronsäure und chitosan verstärkte biomimetische zusammensetzung

Country Status (8)

Country Link
US (2) US7524514B2 (de)
EP (1) EP1702064B1 (de)
AT (1) ATE556137T1 (de)
AU (1) AU2004295705A1 (de)
CA (1) CA2547668A1 (de)
MX (1) MXPA06006124A (de)
NZ (1) NZ548177A (de)
WO (1) WO2005054440A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524514B2 (en) * 2003-12-01 2009-04-28 Tissue Engineering Consultants, Inc. Biomimetic composition reinforced by a polyelectrolytic complex of hyaluronic acid and chitosan
GB0329907D0 (en) * 2003-12-23 2004-01-28 Innomed Ltd Compositions
EP1791523B1 (de) * 2004-09-21 2013-10-23 AMO Groningen B.V. Methode zur herstellung einer viskoelastischen lösung
SE0402272D0 (sv) 2004-09-21 2004-09-21 Amo Groningen Bv Methods of treating a body site with a viscoelastic preparation
EP1962920A4 (de) * 2005-12-01 2012-03-21 Agency Science Tech & Res Dreidimensionale rekonstituierte extrazelluläre matrizen als gerüste für gewebetechnologie
CN100431624C (zh) * 2005-12-07 2008-11-12 浙江大学 可注射聚乳酸微载体/壳聚糖水凝胶复合支架的制备方法
CN1330386C (zh) * 2005-12-07 2007-08-08 浙江大学 用于组织工程的可注射性壳聚糖水凝胶的制备方法
US8690957B2 (en) 2005-12-21 2014-04-08 Warsaw Orthopedic, Inc. Bone graft composition, method and implant
JP5864429B2 (ja) 2009-11-09 2016-02-17 スポットライト テクノロジー パートナーズ エルエルシーＳｐｏｔｌｉｇｈｔ Ｔｅｃｈｎｏｌｏｇｙ Ｐａｒｔｎｅｒｓ Ｌｌｃ 架橋ヒドロゲル組成物、ヒドロゲル組成物の形成方法、及びキット
EP2498764B1 (de) 2009-11-09 2017-09-06 Spotlight Technology Partners LLC Fragmentierte hydrogele
FR2967580A1 (fr) * 2010-11-18 2012-05-25 Centre Nat Rech Scient Materiau comprenant un polysaccharide acide et un biopolymere cationique
USH2271H1 (en) * 2010-12-13 2012-07-03 James Thomas Sears Production and application of an aircraft spreadable, cyanobacterial based biological soil crust inoculant for soil fertilization, soil stablization and atmospheric CO2 drawdown and sequestration
ES2770498T3 (es) 2012-08-28 2020-07-01 Univ Geneve Hidrogeles híbridos
WO2015048774A2 (en) 2013-09-30 2015-04-02 Bioactive Regenerative Therapeutics, Inc. Biomimetic hybrid gel compositions and methods of use
FR3029116B1 (fr) * 2014-12-01 2018-03-30 Advanced Chitosan Solutions Biotech Procede d'obtention d'un gel de cartilage pour la reparation cartilagineuse, comprenant du chitosane et des chondrocytes
CN105903087A (zh) * 2015-12-14 2016-08-31 上海其胜生物制剂有限公司 一种兼具内聚性和弥散性的粘弹剂的制备方法
US11576925B2 (en) * 2016-04-25 2023-02-14 Mizhou Hui Application of low-molecular-weight hyaluronic acid (LMW-HA) fragments
EP3675922A1 (de) * 2017-10-12 2020-07-08 Solyplus Berlin GmbH Vernetzung von biopolymeren in halbfestem zustand
TWI732132B (zh) * 2018-09-05 2021-07-01 國立臺灣大學 製造模擬血管新生的細胞球的方法及其應用
US20200095540A1 (en) * 2018-09-25 2020-03-26 Bioactive Regenerative Therapeutics, Inc. Methods of producing three-dimensional cell culture microenvironments
CN114191608B (zh) * 2021-12-17 2022-07-29 暨南大学附属第一医院（广州华侨医院） 一种温敏凝胶材料组合及其制备方法和应用
CN115105464B (zh) * 2022-08-31 2022-12-02 山东大学齐鲁医院 一种纳米复合水凝胶及其制备方法和应用

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FR2616318A1 (fr) * 1987-06-15 1988-12-16 Centre Nat Rech Scient Peau artificielle et son procede de preparation
US5306311A (en) * 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
EP0544259A1 (de) 1991-11-27 1993-06-02 Lignyte Co., Ltd. Wasserlöslicher biokompatibler Hyaluron- und Polyionen-Komplex und Herstellungsverfahren
CA2130295A1 (en) 1993-08-26 1995-02-27 Richard A. Berg Ionically crosslinked glycosaminoglycan gels for soft tissue augmentation and drug delivery
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US7524514B2 (en) * 2003-12-01 2009-04-28 Tissue Engineering Consultants, Inc. Biomimetic composition reinforced by a polyelectrolytic complex of hyaluronic acid and chitosan

Also Published As

Publication number Publication date
EP1702064A2 (de) 2006-09-20
US20090238874A1 (en) 2009-09-24
WO2005054440A2 (en) 2005-06-16
EP1702064B1 (de) 2012-05-02
US7524514B2 (en) 2009-04-28
NZ548177A (en) 2009-06-26
CA2547668A1 (en) 2005-06-16
EP1702064A4 (de) 2008-05-07
AU2004295705A1 (en) 2005-06-16
US8137696B2 (en) 2012-03-20
MXPA06006124A (es) 2006-08-23
US20050214341A1 (en) 2005-09-29
WO2005054440A3 (en) 2005-09-29

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