AR024573A1 - Calpainas y su utilizacion. - Google Patents
Calpainas y su utilizacion.Info
- Publication number
- AR024573A1 AR024573A1 ARP000102995A ARP000102995A AR024573A1 AR 024573 A1 AR024573 A1 AR 024573A1 AR P000102995 A ARP000102995 A AR P000102995A AR P000102995 A ARP000102995 A AR P000102995A AR 024573 A1 AR024573 A1 AR 024573A1
- Authority
- AR
- Argentina
- Prior art keywords
- enzymatic activity
- capn11
- compounds
- inhibit
- measure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Una calpaína de mamífero CAPN11, procedimiento para identificar compuestos que inhiben la actividad enzimática de la misma y su uso. Polipéptido que tienela secuencia de aminoácidos SEQ ID Ns 2 y secuencia de polinucleotidos que codifica dichopolipé ptido. Secuencia de polinucleotidos que tiene la secuencia SEQID Ns1. Uso de un polipéptido de acuerdo con el descripto para la identificacion de sustancias que pueden inhibir la actividad enzimática de este polipéptido.Un procedimiento parala ident ificacion de compuestos que inhiben la actividad enzimática de un polipéptido de acuerdo con el descripto, que comprende: (a) lacomparacion de la medida de la actividad enzimática de CAPN11 en presencia del compuesto con la medida de laactividad enz imática de CAPN11 en ausencia delcompuesto y (b)la seleccion de compuestos que modifican la medida de la actividad enzimática de CAPN11 con respecto a la actividad enzimática de CAPN11 enausencia del compuesto. Uso de compuestos quefueron identifica dos por medio del procedimiento anterior para el tratamiento de trastornos de la fertilidad enel hombre.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19928021A DE19928021A1 (de) | 1999-06-18 | 1999-06-18 | Neue Calpaine und deren Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR024573A1 true AR024573A1 (es) | 2002-10-16 |
Family
ID=7911777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000102995A AR024573A1 (es) | 1999-06-18 | 2000-06-16 | Calpainas y su utilizacion. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1185673A2 (es) |
| JP (1) | JP2003503023A (es) |
| KR (1) | KR20020011140A (es) |
| CN (1) | CN1373808A (es) |
| AR (1) | AR024573A1 (es) |
| AU (1) | AU5970600A (es) |
| BG (1) | BG106186A (es) |
| BR (1) | BR0011721A (es) |
| CA (1) | CA2375477A1 (es) |
| DE (1) | DE19928021A1 (es) |
| HU (1) | HUP0201800A2 (es) |
| IL (1) | IL146940A0 (es) |
| MX (1) | MXPA01012937A (es) |
| NO (1) | NO20015922L (es) |
| PL (1) | PL353004A1 (es) |
| SK (1) | SK18262001A3 (es) |
| TR (1) | TR200103662T2 (es) |
| WO (1) | WO2000078933A2 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001016336A1 (en) * | 1999-09-02 | 2001-03-08 | Lexicon Genetics Incorporated | Human calcium dependent proteases and polynucleotides encoding the same |
| CN102939126B (zh) | 2010-04-30 | 2015-09-16 | 雅培心脏血管系统股份有限公司 | 呈现迅速膨胀和收缩的改进型球囊导管 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19737105A1 (de) * | 1997-08-26 | 1999-03-04 | Basf Ag | Neue gewebsspezifische Calpaine, ihre Herstellung und Verwendung |
| WO2000058473A2 (en) * | 1999-03-31 | 2000-10-05 | Curagen Corporation | Nucleic acids including open reading frames encoding polypeptides; 'orfx' |
-
1999
- 1999-06-18 DE DE19928021A patent/DE19928021A1/de not_active Withdrawn
-
2000
- 2000-06-07 EP EP00945716A patent/EP1185673A2/de not_active Withdrawn
- 2000-06-07 MX MXPA01012937A patent/MXPA01012937A/es unknown
- 2000-06-07 KR KR1020017016244A patent/KR20020011140A/ko not_active Application Discontinuation
- 2000-06-07 IL IL14694000A patent/IL146940A0/xx unknown
- 2000-06-07 CN CN00808932A patent/CN1373808A/zh active Pending
- 2000-06-07 HU HU0201800A patent/HUP0201800A2/hu unknown
- 2000-06-07 WO PCT/EP2000/005261 patent/WO2000078933A2/de not_active Application Discontinuation
- 2000-06-07 BR BR0011721-8A patent/BR0011721A/pt not_active IP Right Cessation
- 2000-06-07 AU AU59706/00A patent/AU5970600A/en not_active Abandoned
- 2000-06-07 CA CA002375477A patent/CA2375477A1/en not_active Abandoned
- 2000-06-07 SK SK1826-2001A patent/SK18262001A3/sk unknown
- 2000-06-07 JP JP2001505676A patent/JP2003503023A/ja active Pending
- 2000-06-07 PL PL00353004A patent/PL353004A1/xx unknown
- 2000-06-07 TR TR2001/03662T patent/TR200103662T2/xx unknown
- 2000-06-16 AR ARP000102995A patent/AR024573A1/es unknown
-
2001
- 2001-12-04 NO NO20015922A patent/NO20015922L/no not_active Application Discontinuation
- 2001-12-06 BG BG106186A patent/BG106186A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003503023A (ja) | 2003-01-28 |
| WO2000078933A2 (de) | 2000-12-28 |
| AU5970600A (en) | 2001-01-09 |
| BR0011721A (pt) | 2002-03-05 |
| BG106186A (bg) | 2002-12-29 |
| NO20015922D0 (no) | 2001-12-04 |
| SK18262001A3 (sk) | 2002-09-10 |
| WO2000078933A3 (de) | 2001-07-26 |
| TR200103662T2 (tr) | 2002-05-21 |
| PL353004A1 (en) | 2003-09-22 |
| NO20015922L (no) | 2002-02-12 |
| KR20020011140A (ko) | 2002-02-07 |
| MXPA01012937A (es) | 2002-07-30 |
| IL146940A0 (en) | 2002-08-14 |
| CN1373808A (zh) | 2002-10-09 |
| HUP0201800A2 (en) | 2002-09-28 |
| DE19928021A1 (de) | 2000-12-21 |
| EP1185673A2 (de) | 2002-03-13 |
| CA2375477A1 (en) | 2000-12-28 |
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