AR022798A1 - Indolinas n-sustituidas como agentes estrogenicos - Google Patents
Indolinas n-sustituidas como agentes estrogenicosInfo
- Publication number
- AR022798A1 AR022798A1 ARP000100899A ARP000100899A AR022798A1 AR 022798 A1 AR022798 A1 AR 022798A1 AR P000100899 A ARP000100899 A AR P000100899A AR P000100899 A ARP000100899 A AR P000100899A AR 022798 A1 AR022798 A1 AR 022798A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- straight
- compounds
- indolinas
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente provee compuestos de la formula (1) donde: R1 es H o bencilo; R2 es H, -OH, o -O-bencilo; R3, R4 y R5 se seleccionan independientemente de H,ciano, alquilo C1-6 (cadena recta o ramificada), trifluorometilo, -OH o ésteres C1-12 (cadena recta o ramificada), o sus alquil éteres C1-12 (cadena recta oramificada o cíclica), halogenos, o éteres halogenados C1-6; R6 es H o alquilo C1-6; R7 es alquilo C1-6; n es 2 o 3; Y es O o S; y X es la porcion (2) donde Rse selecciona de alquilo inferior C1-6 o las porciones (3), (4), (5) o (6); o sus sales farmacéuticamente aceptables, así como también las composicionesfarmacéuticas y los métodos que utilizan a los compuestos para tratar o prevenir los estados o síndromes de enfermedades que estánprovocados o asociados conla deficiencia de estrogeno o un exceso de estrogeno que utilizan a estos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26256999A | 1999-03-04 | 1999-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR022798A1 true AR022798A1 (es) | 2002-09-04 |
Family
ID=22998068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000100899A AR022798A1 (es) | 1999-03-04 | 2000-03-01 | Indolinas n-sustituidas como agentes estrogenicos |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1159267B1 (es) |
| JP (1) | JP2002538140A (es) |
| CN (1) | CN1152861C (es) |
| AR (1) | AR022798A1 (es) |
| AT (1) | ATE268754T1 (es) |
| AU (1) | AU3497700A (es) |
| CA (1) | CA2364911A1 (es) |
| DE (1) | DE60011401T2 (es) |
| DK (1) | DK1159267T3 (es) |
| ES (1) | ES2220434T3 (es) |
| HK (1) | HK1038922B (es) |
| PT (1) | PT1159267E (es) |
| TW (1) | TWI220898B (es) |
| WO (1) | WO2000051982A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016518449A (ja) * | 2013-05-15 | 2016-06-23 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インドール製剤を調製するためのプロセスおよび中間体 |
| CN103664733B (zh) * | 2013-12-10 | 2016-04-20 | 邯郸惠达化工有限公司 | 一种吲哚啉的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0802183T3 (da) * | 1996-04-19 | 2002-02-04 | American Home Prod | Østrogenforbindelser |
-
2000
- 2000-02-18 TW TW089102843A patent/TWI220898B/zh not_active IP Right Cessation
- 2000-02-22 WO PCT/US2000/004343 patent/WO2000051982A1/en active IP Right Grant
- 2000-02-22 DE DE60011401T patent/DE60011401T2/de not_active Expired - Fee Related
- 2000-02-22 PT PT00913549T patent/PT1159267E/pt unknown
- 2000-02-22 JP JP2000602210A patent/JP2002538140A/ja active Pending
- 2000-02-22 CA CA002364911A patent/CA2364911A1/en not_active Abandoned
- 2000-02-22 DK DK00913549T patent/DK1159267T3/da active
- 2000-02-22 AT AT00913549T patent/ATE268754T1/de not_active IP Right Cessation
- 2000-02-22 CN CNB008044619A patent/CN1152861C/zh not_active Expired - Fee Related
- 2000-02-22 AU AU34977/00A patent/AU3497700A/en not_active Abandoned
- 2000-02-22 ES ES00913549T patent/ES2220434T3/es not_active Expired - Lifetime
- 2000-02-22 EP EP00913549A patent/EP1159267B1/en not_active Expired - Lifetime
- 2000-03-01 AR ARP000100899A patent/AR022798A1/es not_active Application Discontinuation
-
2002
- 2002-01-22 HK HK02100496.7A patent/HK1038922B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2364911A1 (en) | 2000-09-08 |
| CN1342143A (zh) | 2002-03-27 |
| HK1038922A1 (en) | 2002-04-04 |
| ES2220434T3 (es) | 2004-12-16 |
| HK1038922B (zh) | 2004-12-03 |
| ATE268754T1 (de) | 2004-06-15 |
| EP1159267B1 (en) | 2004-06-09 |
| CN1152861C (zh) | 2004-06-09 |
| DK1159267T3 (da) | 2004-08-09 |
| PT1159267E (pt) | 2004-09-30 |
| EP1159267A1 (en) | 2001-12-05 |
| DE60011401T2 (de) | 2005-07-14 |
| TWI220898B (en) | 2004-09-11 |
| DE60011401D1 (de) | 2004-07-15 |
| AU3497700A (en) | 2000-09-21 |
| JP2002538140A (ja) | 2002-11-12 |
| WO2000051982A1 (en) | 2000-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |