AR010666A1 - Un sistema multifuncional de ligandos para transferencia celular especifica de acido nucleico - Google Patents

Un sistema multifuncional de ligandos para transferencia celular especifica de acido nucleico

Info

Publication number
AR010666A1
AR010666A1 ARP970105591A ARP970105591A AR010666A1 AR 010666 A1 AR010666 A1 AR 010666A1 AR P970105591 A ARP970105591 A AR P970105591A AR P970105591 A ARP970105591 A AR P970105591A AR 010666 A1 AR010666 A1 AR 010666A1
Authority
AR
Argentina
Prior art keywords
ligand
specific
multifunctional
nucleic acid
specific cell
Prior art date
Application number
ARP970105591A
Other languages
English (en)
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AR010666A1 publication Critical patent/AR010666A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Se refiere a un sistema multifuncional de ligandos que no es inmunogeno y que realiza la transferencia de secuencias de nucleotidos específica de lacélula. El sistema comprende al menos un ligando específico de la célula diana, al menos un enlazador y al menos un ligando específico de la construcciongénica, comprendiendo ventajosamente el ligando específico de la construccion génica un anticuerpo, o una parte del mismo, que se une directa oindirectamente a la construcccion génica. Se refieretambién a sistemas de ligandos para preparar un producto farmacéutico o una vacuna para eltratamiento o la prevencion de una enfermedad de la piel, de la membrana mucosa, del sistema nervioso, de organos internos, de la coagulacion de lasangre, del sistema hemopoyético, del sistema inmunitario, de la musculatura, del tejido sustentacular o de las articulaciones.
ARP970105591A 1996-11-29 1997-11-27 Un sistema multifuncional de ligandos para transferencia celular especifica de acido nucleico AR010666A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19649645A DE19649645A1 (de) 1996-11-29 1996-11-29 Mehrfach funktionelles Ligandensystem zur zielzellspezifischen Übertragung von Nukleotidsequenzen

Publications (1)

Publication Number Publication Date
AR010666A1 true AR010666A1 (es) 2000-06-28

Family

ID=7813211

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970105591A AR010666A1 (es) 1996-11-29 1997-11-27 Un sistema multifuncional de ligandos para transferencia celular especifica de acido nucleico

Country Status (11)

Country Link
EP (1) EP0846772A1 (es)
JP (1) JPH11169A (es)
AR (1) AR010666A1 (es)
AU (1) AU729798B2 (es)
BR (1) BR9706032A (es)
CA (1) CA2217159A1 (es)
CZ (1) CZ377697A3 (es)
DE (1) DE19649645A1 (es)
HU (1) HUP9702251A3 (es)
PL (1) PL323434A1 (es)
TR (1) TR199701444A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62177909A (ja) * 1986-01-31 1987-08-04 Hitachi Ltd 半導体装置の製造方法
US6465253B1 (en) 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US6127525A (en) * 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
DE19743135A1 (de) 1997-09-30 1999-04-01 Hoechst Marion Roussel De Gmbh Biologisch verträgliche niedermolekular Polyethylenimine
CZ121599A3 (cs) 1998-04-09 1999-10-13 Aventis Pharma Deutschland Gmbh Jednořetězcová molekula vázající několik antigenů, způsob její přípravy a léčivo obsahující tuto molekulu
JP2002525065A (ja) 1998-09-11 2002-08-13 ジェンベク、インコーポレイティッド 選択的にターゲッティングされるアデノウイルス
DE19910419A1 (de) * 1999-03-10 2000-09-21 Aventis Pharma Gmbh Zielzellspezifische, multivalente Proteine (MVP)
DE19929104A1 (de) * 1999-06-24 2000-12-28 Aventis Pharma Gmbh Neue Vektorkomplexe und deren Verwendung für die Gentherapie
US7053187B2 (en) 2000-03-28 2006-05-30 Gioagri Corporation Sperm-specific monoclonal antibody, mAbC
WO2002022154A2 (en) * 2000-09-13 2002-03-21 Praecis Pharmaceuticals Incorporated Pharmaceutical compositions for sustained drug delivery
CN1304305C (zh) * 2003-03-31 2007-03-14 株式会社荏原制作所 含有硫化合物的废水的甲烷发酵处理方法及装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529700A (en) * 1982-08-20 1985-07-16 University Of Miami Hybridoma cells secreting a monoclonal antibody specific for 5-bromo and 5-iodoeoxyuridine and reagents for measuring cellular proliferation
US5166320A (en) * 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
IL103059A0 (en) * 1991-09-30 1993-02-21 Boehringer Ingelheim Int Conjugates for introducing nucleic acid into higher eucaryotic cells
SE503225C2 (sv) * 1991-10-30 1996-04-22 Leif Lindholm Konsult Ab Virus-antikroppskomplex för införing av virus i mammalieceller
IL106760A (en) * 1992-08-25 1999-12-31 Miles Inc Nuclear Acid Protein Hybrid Structure for Transferring Nucleic Acid from External Source to Cell and Target Nucleus
EP0753069A1 (en) * 1994-04-15 1997-01-15 Targeted Genetics Corporation Gene delivery fusion proteins
ATE202145T1 (de) * 1994-11-01 2001-06-15 Winfried Wels Nukleinsäure-einbringungssystem
AU4690596A (en) * 1994-12-30 1996-07-24 Chiron Viagene, Inc. Nucleic acid condensing agents with reduced immunogenicity

Also Published As

Publication number Publication date
JPH11169A (ja) 1999-01-06
AU729798B2 (en) 2001-02-08
PL323434A1 (en) 1998-06-08
HUP9702251A3 (en) 2000-08-28
AU4540797A (en) 1998-06-04
EP0846772A1 (en) 1998-06-10
HU9702251D0 (en) 1998-01-28
TR199701444A2 (xx) 1998-06-22
CA2217159A1 (en) 1998-05-29
BR9706032A (pt) 1999-04-27
HUP9702251A2 (hu) 1999-06-28
MX9709226A (es) 1998-06-28
CZ377697A3 (cs) 1998-06-17
DE19649645A1 (de) 1998-06-04

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