AR009666A1 - Compuestos derivados de carboxamida ciclicos sustituidos con carboxi, composicion farmaceutica, usos en la fabricacion de composiciones farmaceuticas para el asma, la tos y la bronquitis y procedimiento de preparacion - Google Patents
Compuestos derivados de carboxamida ciclicos sustituidos con carboxi, composicion farmaceutica, usos en la fabricacion de composiciones farmaceuticas para el asma, la tos y la bronquitis y procedimiento de preparacionInfo
- Publication number
- AR009666A1 AR009666A1 ARP970105924A ARP970105924A AR009666A1 AR 009666 A1 AR009666 A1 AR 009666A1 AR P970105924 A ARP970105924 A AR P970105924A AR P970105924 A ARP970105924 A AR P970105924A AR 009666 A1 AR009666 A1 AR 009666A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- hydrogen
- bronchitis
- asthma
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se describen compuestos de formula (I), donde G1 es CH2, o C(O); G2 es CH2 o C(O); m es 2 o 3; n es 0 o 1; R1 es de 1 a 3 sustituyentes seleccionados cadauno independientemente del grupo formado por hidrogeno, halogeno, -CF3, alquilo C1-C6,y alcoxi C1-C6; R2 es de 1 a 3 sustituyentes seleccionados cadauno independientemente del grupo formado por hidrogeno, halogeno, ciano, -CF3, alquilo C1-C6, y alcoxi C1-C6; R3 es hidrogeno o el radical seleccionado delgrupo formado por formulas(II) , donde R4 es seleccionado del grupo formado por hidrogeno, alquilo C1-C4, y -CF3; Ar1 es un radical seleccionado del grupoformado por formulas (III), donde R8 es de 1 a 3 sustituyentes seleccionados cada uno independientemente del grupoformado p or hidrogeno, halogeno, -CF3,alquilo C1-C6, y alcoxi C1-C6; R9 es de 1 a 2 sustituyentes seleccionados cada uno independientemente del grupo formado por hidrogeno, halogeno, alquiloC1-C6, y alcoxi C1-C6; A es un radical seleccionado delgrupo formad o por formulas (IV), donde p es 1, 2, 3 o 4; X es -O-, -S(O)k- o -CH2- donde k es0, 1, o 2; R10 es hidrogeno, alquilo C1-C6 o un radical seleccionado del grupo formado por formulas (V), donde q es 2 o 3; R5 es alquilo C1-C4 o -(CH2)2OH; R6es a lquilo C1-C4, -(CH2)2OH, o -(CH2)2N(CH3)2; R5 es alquilo C1-C4; R6 es alquilo C1-C4; R7 es alquilo C1-C6; siempre que cuando G1 sea -C(O)- G2 es-CH2-; adicionalmente siempre que cuando G2 sea -C(O)- G1 es -CH2-; y losestereoisomeros, y l as sales farmacéuticamente aceptables del mismo. Dichoscompuestos son utiles como antagonistas de receptores de taquiquinas. Se describen composiciones farmacéuticas que incluyen dichos compuestos y su usoen lafabricacion de composiciones far macéuticas para el tratamiento de asma, tos y bronquitis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79415796A | 1996-12-19 | 1996-12-19 | |
US08/971,891 US5977139A (en) | 1996-12-15 | 1997-11-17 | Carboxysubstituted cyclic carboxamide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
AR009666A1 true AR009666A1 (es) | 2000-04-26 |
Family
ID=27121482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970105924A AR009666A1 (es) | 1996-12-19 | 1997-12-17 | Compuestos derivados de carboxamida ciclicos sustituidos con carboxi, composicion farmaceutica, usos en la fabricacion de composiciones farmaceuticas para el asma, la tos y la bronquitis y procedimiento de preparacion |
Country Status (27)
Country | Link |
---|---|
EP (1) | EP0946545B1 (es) |
JP (1) | JP4195513B2 (es) |
KR (1) | KR100468552B1 (es) |
CN (1) | CN1098259C (es) |
AR (1) | AR009666A1 (es) |
AT (1) | ATE205200T1 (es) |
AU (1) | AU718984B2 (es) |
BR (1) | BR9714156A (es) |
CA (1) | CA2275602C (es) |
CL (1) | CL2003002750A1 (es) |
DE (1) | DE69706564T2 (es) |
DK (1) | DK0946545T3 (es) |
EE (1) | EE04117B1 (es) |
ES (1) | ES2162686T3 (es) |
HK (1) | HK1020571A1 (es) |
IL (1) | IL130222A0 (es) |
NO (1) | NO318196B1 (es) |
NZ (1) | NZ335883A (es) |
OA (1) | OA11070A (es) |
PL (1) | PL189777B1 (es) |
PT (1) | PT946545E (es) |
RU (1) | RU2199535C2 (es) |
SK (1) | SK82799A3 (es) |
TR (1) | TR199901395T2 (es) |
TW (1) | TW544452B (es) |
UA (1) | UA58529C2 (es) |
WO (1) | WO1998027085A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2296428A1 (en) * | 1997-07-14 | 1999-01-28 | John Neilsen | Piperidine oligomers and combinatorial libraries thereof |
ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
WO2001029027A1 (fr) * | 1999-10-22 | 2001-04-26 | Sankyo Company, Limited | Dérivés de 2-alcoxybenzène |
AU2001290743A1 (en) * | 2000-09-14 | 2002-03-26 | Ortho-Mcneil Pharmaceutical, Inc. | Solid salt forms of n-(2-(4-(2-(1-methylethoxy)phenyl)-1-piperazinyl)ethyl)-2-oxo-1-piperidineacetamide |
GB0217447D0 (en) * | 2002-07-29 | 2002-09-04 | Betts John A | Personal deodorant |
CN101928284A (zh) | 2003-03-14 | 2010-12-29 | 小野药品工业株式会社 | 含氮杂环衍生物以及包含所述化合物作为活性成分的药物 |
US8143404B2 (en) | 2004-09-13 | 2012-03-27 | Ono Pharmaceutical Co., Ltd | Nitrogenous heterocylic derivative and medicine containing the same as an active ingredient |
US8003642B2 (en) | 2006-03-10 | 2011-08-23 | Ono Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU224496B1 (hu) * | 1993-05-06 | 2005-10-28 | Merrel Dow Pharmaceuticals Inc. | Pirrolidin-3-il-alkil-piperidin-származékok és e vegyületeket tartalmazó gyógyászati készítmények |
-
1997
- 1997-11-21 PL PL97334077A patent/PL189777B1/pl not_active IP Right Cessation
- 1997-11-21 UA UA99074152A patent/UA58529C2/uk unknown
- 1997-11-21 EP EP97950690A patent/EP0946545B1/en not_active Expired - Lifetime
- 1997-11-21 WO PCT/US1997/021586 patent/WO1998027085A1/en not_active Application Discontinuation
- 1997-11-21 JP JP52772098A patent/JP4195513B2/ja not_active Expired - Lifetime
- 1997-11-21 RU RU99115883/04A patent/RU2199535C2/ru not_active IP Right Cessation
- 1997-11-21 DK DK97950690T patent/DK0946545T3/da active
- 1997-11-21 TR TR1999/01395T patent/TR199901395T2/xx unknown
- 1997-11-21 ES ES97950690T patent/ES2162686T3/es not_active Expired - Lifetime
- 1997-11-21 AU AU53627/98A patent/AU718984B2/en not_active Ceased
- 1997-11-21 CN CN97180774A patent/CN1098259C/zh not_active Expired - Fee Related
- 1997-11-21 SK SK827-99A patent/SK82799A3/sk unknown
- 1997-11-21 BR BR9714156-9A patent/BR9714156A/pt unknown
- 1997-11-21 EE EEP199900254A patent/EE04117B1/xx not_active IP Right Cessation
- 1997-11-21 NZ NZ335883A patent/NZ335883A/en unknown
- 1997-11-21 IL IL13022297A patent/IL130222A0/xx not_active IP Right Cessation
- 1997-11-21 KR KR10-1999-7005495A patent/KR100468552B1/ko not_active IP Right Cessation
- 1997-11-21 DE DE69706564T patent/DE69706564T2/de not_active Expired - Lifetime
- 1997-11-21 PT PT97950690T patent/PT946545E/pt unknown
- 1997-11-21 AT AT97950690T patent/ATE205200T1/de not_active IP Right Cessation
- 1997-11-21 CA CA002275602A patent/CA2275602C/en not_active Expired - Lifetime
- 1997-12-17 AR ARP970105924A patent/AR009666A1/es active IP Right Grant
- 1997-12-19 TW TW086119362A patent/TW544452B/zh not_active IP Right Cessation
-
1999
- 1999-06-18 NO NO19993012A patent/NO318196B1/no not_active IP Right Cessation
- 1999-06-18 OA OA9900138A patent/OA11070A/en unknown
- 1999-11-30 HK HK99105551A patent/HK1020571A1/xx not_active IP Right Cessation
-
2003
- 2003-12-24 CL CL200302750A patent/CL2003002750A1/es unknown
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Legal Events
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FG | Grant, registration |