AR009311A1 - Procedimiento para la preparacion de carbamato de fisostigmina a partir de eteres de eserolina y procedimiento de obtencion de un intermediario en dichoprocedimiento - Google Patents

Procedimiento para la preparacion de carbamato de fisostigmina a partir de eteres de eserolina y procedimiento de obtencion de un intermediario en dichoprocedimiento

Info

Publication number
AR009311A1
AR009311A1 ARP970103837A ARP970103837A AR009311A1 AR 009311 A1 AR009311 A1 AR 009311A1 AR P970103837 A ARP970103837 A AR P970103837A AR P970103837 A ARP970103837 A AR P970103837A AR 009311 A1 AR009311 A1 AR 009311A1
Authority
AR
Argentina
Prior art keywords
formula
procedure
alkyl
compound
cycloalkyl
Prior art date
Application number
ARP970103837A
Other languages
English (en)
Original Assignee
Hoechst Marion Rousell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Rousell Inc filed Critical Hoechst Marion Rousell Inc
Publication of AR009311A1 publication Critical patent/AR009311A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se obtienen compuestos de formula (I) donde R es alquilo; R1 es hidrogeno, alquilo, cicloalquilo, cicloalquil alquilo, bicicloalquilo, arilo oarilalquilo; R2 es alquilo, cicloalquilo, cicloalquil alquilo, bicicloalquilo, arilo o arilalquilo; o R1 yR2, tomados junto con el átomo de nitrogeno al queestán unidos, forman un grupo de formula (Ia), donde Y es hidrogeno o alquilo y Z es hidrogeno, alquilo, halogeno, alcoxi o hidroxi; X es alquilo inferior,alcoxi, halogeno o trifluorometilo, y m es 0, 1 o 2, o una sal del mismo farmacéuticamente aceptable. El procedimiento consiste en (a) poner en contactoun compuesto de formula (II) segun se ha definido aquí con bromuro de hidrogeno acuoso y haluro de litio para obtener un compuesto de formula (III)segun se ha definido aquí; poner en contacto la mezcla de reaccion que contiene un compuesto de formula (III) con (1) un isocianato de formula R1NCO o (2) uncompuesto de formula (IV) segun se ha definido para obtener un compuesto de formula (V) segun se ha definido aquí y poner en contacto la mezcla de reaccionque contiene el compuesto de formula (V) con una amina de formula R1R2NH aquí en presencia de un ácido carboxílico de formula R5COOH y formar y aislar elproducto de formula (I). También se describe un procedimiento para la obtencion de los compuestos de formula (III).
ARP970103837A 1996-12-19 1997-08-25 Procedimiento para la preparacion de carbamato de fisostigmina a partir de eteres de eserolina y procedimiento de obtencion de un intermediario en dichoprocedimiento AR009311A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/769,409 US5677457A (en) 1996-12-19 1996-12-19 Method of preparation of physostigmine carbamate derivatives from eseroline ethers

Publications (1)

Publication Number Publication Date
AR009311A1 true AR009311A1 (es) 2000-04-12

Family

ID=25085359

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970103837A AR009311A1 (es) 1996-12-19 1997-08-25 Procedimiento para la preparacion de carbamato de fisostigmina a partir de eteres de eserolina y procedimiento de obtencion de un intermediario en dichoprocedimiento

Country Status (13)

Country Link
US (1) US5677457A (es)
EP (1) EP0946560A1 (es)
JP (1) JP2001506259A (es)
KR (1) KR20000062263A (es)
AR (1) AR009311A1 (es)
AU (1) AU715483B2 (es)
BR (1) BR9714046A (es)
CA (1) CA2273180C (es)
HU (1) HUP0000046A3 (es)
IL (1) IL130460A0 (es)
NO (1) NO993011L (es)
WO (1) WO1998027096A1 (es)
ZA (1) ZA976713B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1023297A1 (en) * 1997-10-10 2000-08-02 CHIESI FARMACEUTICI S.p.A. A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity
US6495700B1 (en) 2002-01-09 2002-12-17 Axonyx, Inc. Process for producing phenserine and its analog
US7795307B2 (en) 2003-10-21 2010-09-14 Colucid Pharmaceuticals, Inc. Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents
CA2677241A1 (en) * 2007-02-02 2008-08-14 Colucid Pharmaceuticals, Inc. Compounds that inhibit cholinesterase
SE531698C2 (sv) 2007-07-12 2009-07-07 Respiratorius Ab Nya bronkdilaterande a,b-omättade amider
JP2010533717A (ja) * 2007-07-18 2010-10-28 コルシド・ファーマシューティカルズ・インコーポレイテッド 覚醒を促進する方法
US8593728B2 (en) * 2009-02-19 2013-11-26 Toyota Motor Engineering & Manufacturing North America, Inc. Multilayer photonic structures

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DE2905054C3 (de) * 1979-02-08 1982-04-29 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 4-Hydroxyindolen
IT1199076B (it) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
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US4937341A (en) * 1989-09-28 1990-06-26 Hoechst-Roussel Pharmaceuticals Inc. Process for preparing N-aminocarbarbamates related to physostigmine
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5260452A (en) * 1989-11-03 1993-11-09 Hoechst-Roussel Pharmaceuticals Inc. 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
US5177101A (en) * 1989-11-30 1993-01-05 Hoechst-Roussel Pharmaceuticals Incorporated Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine
US5077289A (en) * 1989-11-30 1991-12-31 Hoechst Roussel Pharmaceuticals Inc. Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine
US5274117A (en) * 1990-01-22 1993-12-28 Hoechst-Roussel Pharmaceuticals, Inc. Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine
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US5216017A (en) * 1990-05-11 1993-06-01 Hoechst-Roussel Pharmaceuticals Incorporated Pyrrolo[2,3-b]indole-ketones and analogs
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US5264587A (en) * 1990-05-17 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Method of preparing α-oxopyrrolo[2,3-b]indole acetic acids and derivatives
MC2287A1 (fr) * 1990-06-27 1993-07-14 Hoechst Roussel Pharma Tetrahydroisoquinoleinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,31,8-trimethylpyrrolo(2,3,-b)indole
US5231093A (en) * 1991-10-01 1993-07-27 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US5153193A (en) * 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US5234941A (en) * 1991-10-01 1993-08-10 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US5302721A (en) * 1992-07-21 1994-04-12 Hoechst-Roussel Pharmaceuticals Incorporated Method of preparation of physostigmine carbamate derivatives from eseretholes
NZ248180A (en) * 1992-07-21 1995-02-24 Hoechst Roussel Pharma Process for the preparation of physostigmine carbamate derivatives
US5350762A (en) * 1993-03-08 1994-09-27 Hoechst-Roussel Pharmaceuticals Incorporated Tetrahydrocyclopent[B]indole methanamines and related compounds

Also Published As

Publication number Publication date
AU715483B2 (en) 2000-02-03
EP0946560A1 (en) 1999-10-06
CA2273180C (en) 2002-10-29
JP2001506259A (ja) 2001-05-15
BR9714046A (pt) 2000-05-09
US5677457A (en) 1997-10-14
AU3800897A (en) 1998-07-15
NO993011D0 (no) 1999-06-18
NO993011L (no) 1999-08-18
WO1998027096A1 (en) 1998-06-25
HUP0000046A3 (en) 2000-09-28
CA2273180A1 (en) 1998-06-25
IL130460A0 (en) 2000-06-01
KR20000062263A (ko) 2000-10-25
HUP0000046A2 (hu) 2000-06-28
ZA976713B (en) 1998-06-19

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