AR004679A1 - Clorhidrato de n-metil-n-[(1s)-1-fenil-2-((3s)-3-hidroxipirrolidin-1-il)-etil]-2,2-difenilacetamida en una forma cristalina termoestable, un procedimiento para obtener este compuesto en su nueva forma, una composicion farmaceutica que lo contiene, y el uso del mismo para la preparacion de composiciones farmaceuticas . - Google Patents

Clorhidrato de n-metil-n-[(1s)-1-fenil-2-((3s)-3-hidroxipirrolidin-1-il)-etil]-2,2-difenilacetamida en una forma cristalina termoestable, un procedimiento para obtener este compuesto en su nueva forma, una composicion farmaceutica que lo contiene, y el uso del mismo para la preparacion de composiciones farmaceuticas .

Info

Publication number
AR004679A1
AR004679A1 ARP960104088A AR10408896A AR004679A1 AR 004679 A1 AR004679 A1 AR 004679A1 AR P960104088 A ARP960104088 A AR P960104088A AR 10408896 A AR10408896 A AR 10408896A AR 004679 A1 AR004679 A1 AR 004679A1
Authority
AR
Argentina
Prior art keywords
pain
compound
phenyl
ethyl
methyl
Prior art date
Application number
ARP960104088A
Other languages
English (en)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR004679A1 publication Critical patent/AR004679A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una nueva forma termoestable de clorhidrato de N-metil-N-[/1S)-1-fenil-2- ((3S)-3-hidroxipirrolidin-1-il)-etil]-2,2-difenil-acetamida, de fórmula (I), unprocedimiento para obtener y aislar este compuesto en su nueva forma, y composicionesf armacéuticas que contienen este compuesto y/o de sus salesinobjetables desde el punto de vista fisiológico y que tienen acción farmacológica de kappa-opiatagonistas y/o sirven para el tratamiento deenfermedades inflamatorias delintestino, para el tratamiento de los dolores y la hipersensibilidad al dolor que aparecen con los padecimientos de laespalda, para el tratamiento de los dolores y la hipersensibilidad al dolor y reacciones inflamatorias de enfermedadesreumáticas, lesion es por quemaduras,quemaduras de sol o neurodermatitis, y/o para el tratamiento de los dolores y la hipersensibilidad al dolor, postoperatorios, y de ileo postoperatorio.
ARP960104088A 1995-08-26 1996-08-23 Clorhidrato de n-metil-n-[(1s)-1-fenil-2-((3s)-3-hidroxipirrolidin-1-il)-etil]-2,2-difenilacetamida en una forma cristalina termoestable, un procedimiento para obtener este compuesto en su nueva forma, una composicion farmaceutica que lo contiene, y el uso del mismo para la preparacion de composiciones farmaceuticas . AR004679A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19531464A DE19531464A1 (de) 1995-08-26 1995-08-26 N-Methyl-N-[(1S-)-1-phenyl-2-((3S)-3-hydroxypyrrolidin 1-yl-)-ethyl]-2,2-diphenyl-acetamid

Publications (1)

Publication Number Publication Date
AR004679A1 true AR004679A1 (es) 1999-03-10

Family

ID=7770485

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960104088A AR004679A1 (es) 1995-08-26 1996-08-23 Clorhidrato de n-metil-n-[(1s)-1-fenil-2-((3s)-3-hidroxipirrolidin-1-il)-etil]-2,2-difenilacetamida en una forma cristalina termoestable, un procedimiento para obtener este compuesto en su nueva forma, una composicion farmaceutica que lo contiene, y el uso del mismo para la preparacion de composiciones farmaceuticas .

Country Status (25)

Country Link
US (1) US6060504A (es)
EP (1) EP0761650B1 (es)
JP (3) JP5023273B2 (es)
KR (1) KR100436254B1 (es)
CN (1) CN1081631C (es)
AR (1) AR004679A1 (es)
AT (1) ATE207895T1 (es)
AU (1) AU716615B2 (es)
BR (1) BR9603540A (es)
CA (1) CA2184049C (es)
CZ (1) CZ287783B6 (es)
DE (2) DE19531464A1 (es)
DK (1) DK0761650T3 (es)
ES (1) ES2165948T3 (es)
HU (1) HU226667B1 (es)
MX (1) MX9603606A (es)
NO (1) NO307048B1 (es)
PL (1) PL187691B1 (es)
PT (1) PT761650E (es)
RU (1) RU2174976C2 (es)
SI (1) SI0761650T1 (es)
SK (1) SK282437B6 (es)
TW (1) TW513407B (es)
UA (1) UA41978C2 (es)
ZA (1) ZA967200B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999032096A1 (en) * 1997-12-22 1999-07-01 Alza Corporation Novel formulations for the transdermal administration of asimadoline
DE19827633A1 (de) * 1998-04-20 1999-10-21 Merck Patent Gmbh Verfahren zur Herstellung von enantiomerenreinem N-Methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamid
US6174878B1 (en) * 1999-08-31 2001-01-16 Alcon Laboratories, Inc. Topical use of kappa opioid agonists to treat otic pain
DE10116978A1 (de) * 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
EP1505974B1 (en) * 2002-05-17 2009-04-22 Tioga Pharmaceuticals, Inc. Use of compounds that are effective as selective opiate receptor modulators
DE10259245A1 (de) * 2002-12-17 2004-07-01 Merck Patent Gmbh Derivate des Asimadolins mit kovalent gebundenen Säuren
WO2005046687A1 (en) * 2003-10-30 2005-05-26 Tioga Pharmaceuticals, Inc. Use of selective opiate receptor modulators in the treatment of neuropathy
ES2393815T3 (es) 2007-03-30 2012-12-28 Tioga Pharmaceuticals, Inc. Agonistas opioides kappa para el tratamiento de síndrome del intestino irritable con diarrea predominante y alternante
EP2284987B1 (en) * 2009-08-12 2019-02-06 Braun GmbH Method and device for adjusting the frequency of a drive current of an electric motor
WO2011136905A2 (en) * 2010-04-07 2011-11-03 Onyx Therapeutics, Inc. Crystalline peptide epoxyketone immunoproteasome inhibitor
US9675587B2 (en) 2013-03-14 2017-06-13 Allergan Holdings Unlimited Company Opioid receptor modulator dosage formulations
CN103664727A (zh) * 2013-12-19 2014-03-26 无锡万全医药技术有限公司 一种一锅法制备1-[(3s)-3-羟基吡咯烷-1-基]-(2s)-2-甲氨基-2-苯基乙烷的工艺
ES2906979T3 (es) * 2016-12-21 2022-04-21 Tioga Pharmaceuticals Inc Formulaciones farmacéuticas sólidas de asimadolina
EP3932390A1 (en) 2020-07-02 2022-01-05 Dr. August Wolff GmbH & Co. KG Arzneimittel Topical gel formulation containing asimadoline

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4215213A1 (de) * 1992-05-09 1993-11-11 Merck Patent Gmbh Arylacetamide

Also Published As

Publication number Publication date
KR970010744A (ko) 1997-03-27
TW513407B (en) 2002-12-11
DK0761650T3 (da) 2002-02-18
JP5023273B2 (ja) 2012-09-12
HUP9602346A2 (en) 1997-09-29
AU6214996A (en) 1997-03-06
MX9603606A (es) 1997-03-29
HU9602346D0 (en) 1996-10-28
EP0761650A1 (de) 1997-03-12
CZ243496A3 (en) 1997-03-12
DE59608050D1 (de) 2001-12-06
JPH09110830A (ja) 1997-04-28
NO963526L (no) 1997-02-27
PL315799A1 (en) 1997-03-03
RU2174976C2 (ru) 2001-10-20
ES2165948T3 (es) 2002-04-01
HU226667B1 (en) 2009-06-29
EP0761650B1 (de) 2001-10-31
SI0761650T1 (en) 2002-04-30
SK108996A3 (en) 1997-06-04
BR9603540A (pt) 1998-05-12
AU716615B2 (en) 2000-03-02
PL187691B1 (pl) 2004-09-30
PT761650E (pt) 2002-04-29
ATE207895T1 (de) 2001-11-15
JP2012246321A (ja) 2012-12-13
JP2009046501A (ja) 2009-03-05
US6060504A (en) 2000-05-09
CZ287783B6 (en) 2001-02-14
UA41978C2 (uk) 2001-10-15
CN1151986A (zh) 1997-06-18
CA2184049C (en) 2007-10-02
CN1081631C (zh) 2002-03-27
NO307048B1 (no) 2000-01-31
NO963526D0 (no) 1996-08-23
KR100436254B1 (ko) 2005-01-25
DE19531464A1 (de) 1997-02-27
SK282437B6 (sk) 2002-02-05
CA2184049A1 (en) 1997-02-27
ZA967200B (en) 1997-03-03
HUP9602346A3 (en) 1998-01-28

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