AR002984A1 - Derivados de 1,3-dihidro-2h-imidazol-2-ona, procedimiento para su preparacion, composicion que los comprende, procedimiento para preparar dicha composicion y el uso de dichos derivados para fabricar medicamentos. - Google Patents
Derivados de 1,3-dihidro-2h-imidazol-2-ona, procedimiento para su preparacion, composicion que los comprende, procedimiento para preparar dicha composicion y el uso de dichos derivados para fabricar medicamentos.Info
- Publication number
- AR002984A1 AR002984A1 ARP960102075A AR10207596A AR002984A1 AR 002984 A1 AR002984 A1 AR 002984A1 AR P960102075 A ARP960102075 A AR P960102075A AR 10207596 A AR10207596 A AR 10207596A AR 002984 A1 AR002984 A1 AR 002984A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkyl
- piperidinyl
- derivatives
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se relaciona con derivados de 1,3-dihidro-2H-imidazol -2-ona de la fórmula (I), las formas de N-óxido, las sales de adición de ácidoo base farmacéuticamente aceptables y las formas estereoquímicamente isoméricas de las mismas,e n las cuales:R1 y R2 consisten independientemente en hidrógeno,alquilo C1-6, difluorometilo, trifluorometilo, cicloalquilo C2-6,un heterociclo saturado de 5-, 6- ó 7- elementos que contiene uno o dos heteroátomosseleccionados entre oxígeno, azufreo nitrógeno; indanilo, biciclo [2.2.1]-2- heptenilo; biciclo [2.2.1] heptanilo; alquilsulfonilo C1-6; arilsulfonilo; óalquilo C1-10 sustituido;R3 es H, halo o alquiloxi C1-16;donde X es O; alquilo; >C = NOR5; un anillo de metilenos; Alc esalcanodiil o C1-4;-A-B- es un radicalbivalente de la fórmula: -CR6=CR7-; ó -CHR6-CHR7-; L es H, alquilo C1-6; optativamente sustituido alquilcarbonilo C1-6;alquiloxicarbonilo C1-6,alqueniloC3-6; optativamente sustituido; piperidinilooptativamente sustit uido; alquilsulfonilo C1-6 o arilsulfonilo; arilo es fenilo optativamente sustituido.Het 1 es piridinilo, piridinilo sustituido con alquilo C1-4; furanilo, furanilo sustituido con alquilo C1-4;tienilo, tienilosustituido con alquilcarbonilam inoC1-4; hidroxipiridinilo, hidroxipiridinilo sustituido con alquilo C1-4 ó C1-4 alcoxi C1-4 alquilo, imidazolilo, imidazolilo sustituido con alquilo C1-4;tiazolilo,tiazolilo sustituido con alquilo C1-4;oxazolilo;oxazolilo sustituido con alquilo C 1-4; isoquinolinilo; isoquinolinilo sustituido con alquilo C1-4;quinolinonilo; quinolinonilo sustituido con alquilo C1-4; morfolinilo; piperidinilo; piperidinilo sustituido con alquilo C1-4,alquiloxicarbonilo C1-4ó aril C1-4alquilo;y Het2 e s morfolinilo;piperidinilo, piperidinilo sustituido con alquilo C1-4; o aril C1-4alquilo; piperazinilo; piperazinilo sustituido con
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95200870 | 1995-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR002984A1 true AR002984A1 (es) | 1998-05-27 |
Family
ID=8220175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960102075A AR002984A1 (es) | 1995-04-06 | 1996-04-03 | Derivados de 1,3-dihidro-2h-imidazol-2-ona, procedimiento para su preparacion, composicion que los comprende, procedimiento para preparar dicha composicion y el uso de dichos derivados para fabricar medicamentos. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5869515A (es) |
| EP (1) | EP0832071B1 (es) |
| JP (1) | JP4115519B2 (es) |
| KR (1) | KR100400159B1 (es) |
| CN (1) | CN1103760C (es) |
| AR (1) | AR002984A1 (es) |
| AT (1) | ATE305455T1 (es) |
| CA (1) | CA2216542C (es) |
| DE (1) | DE69635224T2 (es) |
| ES (1) | ES2250988T3 (es) |
| IL (1) | IL117806A (es) |
| MY (1) | MY117936A (es) |
| TW (1) | TW375612B (es) |
| WO (1) | WO1996031487A1 (es) |
| ZA (1) | ZA962753B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
| IL129298A0 (en) * | 1996-10-02 | 2000-02-17 | Janssen Pharmaceutica Nv | PDE iv inhibiting 2-cyanoiminoimidazole derivatives |
| WO1999050262A1 (en) * | 1998-04-01 | 1999-10-07 | Janssen Pharmaceutica N.V. | Pde iv inhibiting pyridine derivatives |
| DE60043318D1 (de) | 1999-08-21 | 2010-01-14 | Nycomed Gmbh | Synergistische kombination von pumafentrine und salmeterol |
| US20030175314A1 (en) * | 2001-11-19 | 2003-09-18 | Didriksen Erik Johannes | Pharmaceutical composition for dermal application |
| FR2860514A1 (fr) | 2003-10-03 | 2005-04-08 | Sanofi Synthelabo | Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique |
| BRPI0510453A (pt) | 2004-04-30 | 2007-10-30 | Warner Lambert Co | composto substituìdos com morfolina para o tratamento de distúrbios do sistema nervoso central |
| WO2006078698A1 (en) * | 2005-01-19 | 2006-07-27 | Cengent Therapeutics, Inc. | 2-imidazolone and 2-imidazolidinone heterocyclic inhibitors of tyrosine phosphatases |
| WO2007085357A1 (en) * | 2006-01-30 | 2007-08-02 | Euro-Celtique S.A. | Cyclourea compounds as calcium channel blockers |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4636516A (en) * | 1981-02-19 | 1987-01-13 | Yamanouchi Pharmaceutical Co., Ltd. | 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds |
| CA1309096C (en) * | 1985-08-13 | 1992-10-20 | Sumitomo Chemical Co., Ltd. | Butenoic acid derivatives, and their production and use |
| US4845233A (en) * | 1987-09-11 | 1989-07-04 | Iprx, Inc. | Imidazolin-2-ones |
| US5401851A (en) * | 1992-06-03 | 1995-03-28 | Eli Lilly And Company | Angiotensin II antagonists |
| JP3775684B2 (ja) * | 1992-07-28 | 2006-05-17 | ローン−プーラン・ロレ・リミテツド | 脂肪族−またはヘテロ原子−含有連結基によりアリールまたはヘテロアリールに連結されたフェニル含有化合物 |
| EP0711282B1 (en) * | 1993-07-28 | 2002-06-05 | Aventis Pharma Limited | Compounds as pde iv and tnf inhibitors |
| GB9401460D0 (en) * | 1994-01-26 | 1994-03-23 | Rhone Poulenc Rorer Ltd | Compositions of matter |
| GB9412672D0 (en) * | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| EP0766676B1 (en) * | 1994-06-24 | 2002-05-22 | Euroceltique S.A. | Compounds for inhibiting phosphodiesterase iv |
-
1996
- 1996-03-22 TW TW085103445A patent/TW375612B/zh not_active IP Right Cessation
- 1996-03-28 EP EP96911969A patent/EP0832071B1/en not_active Expired - Lifetime
- 1996-03-28 ES ES96911969T patent/ES2250988T3/es not_active Expired - Lifetime
- 1996-03-28 AT AT96911969T patent/ATE305455T1/de active
- 1996-03-28 US US08/930,478 patent/US5869515A/en not_active Expired - Lifetime
- 1996-03-28 DE DE69635224T patent/DE69635224T2/de not_active Expired - Lifetime
- 1996-03-28 CA CA002216542A patent/CA2216542C/en not_active Expired - Lifetime
- 1996-03-28 KR KR1019970706852A patent/KR100400159B1/ko not_active IP Right Cessation
- 1996-03-28 JP JP52995896A patent/JP4115519B2/ja not_active Expired - Lifetime
- 1996-03-28 WO PCT/EP1996/001393 patent/WO1996031487A1/en active IP Right Grant
- 1996-03-28 CN CN96193104A patent/CN1103760C/zh not_active Expired - Lifetime
- 1996-04-03 IL IL11780696A patent/IL117806A/xx not_active IP Right Cessation
- 1996-04-03 AR ARP960102075A patent/AR002984A1/es active IP Right Grant
- 1996-04-04 ZA ZA9602753A patent/ZA962753B/xx unknown
- 1996-04-05 MY MYPI96001299A patent/MY117936A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1181073A (zh) | 1998-05-06 |
| JPH11504003A (ja) | 1999-04-06 |
| IL117806A (en) | 2000-02-17 |
| AU697390B2 (en) | 1998-10-01 |
| ZA962753B (en) | 1997-10-06 |
| TW375612B (en) | 1999-12-01 |
| JP4115519B2 (ja) | 2008-07-09 |
| CN1103760C (zh) | 2003-03-26 |
| CA2216542A1 (en) | 1996-10-10 |
| ES2250988T3 (es) | 2006-04-16 |
| ATE305455T1 (de) | 2005-10-15 |
| AU5497996A (en) | 1996-10-23 |
| DE69635224T2 (de) | 2006-06-22 |
| US5869515A (en) | 1999-02-09 |
| KR100400159B1 (ko) | 2003-12-31 |
| EP0832071A1 (en) | 1998-04-01 |
| WO1996031487A1 (en) | 1996-10-10 |
| EP0832071B1 (en) | 2005-09-28 |
| MY117936A (en) | 2004-08-30 |
| KR19980703448A (ko) | 1998-11-05 |
| DE69635224D1 (de) | 2006-02-09 |
| IL117806A0 (en) | 1996-08-04 |
| CA2216542C (en) | 2009-01-13 |
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant, registration | ||
| FG | Grant, registration |