AP693A - A method of preparing an undifferentiated cell. - Google Patents
A method of preparing an undifferentiated cell. Download PDFInfo
- Publication number
- AP693A AP693A APAP/P/1997/001031A AP9701031A AP693A AP 693 A AP693 A AP 693A AP 9701031 A AP9701031 A AP 9701031A AP 693 A AP693 A AP 693A
- Authority
- AP
- ARIPO
- Prior art keywords
- cell
- cells
- committed
- undifferentiated
- antigen
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 117
- 210000004027 cell Anatomy 0.000 claims description 511
- 239000000427 antigen Substances 0.000 claims description 128
- 102000036639 antigens Human genes 0.000 claims description 128
- 108091007433 antigens Proteins 0.000 claims description 128
- 238000011282 treatment Methods 0.000 claims description 123
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 64
- 102000006354 HLA-DR Antigens Human genes 0.000 claims description 58
- 108010058597 HLA-DR Antigens Proteins 0.000 claims description 58
- 239000003795 chemical substances by application Substances 0.000 claims description 50
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 47
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 40
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 40
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 36
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 36
- 210000000130 stem cell Anatomy 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 15
- 230000014509 gene expression Effects 0.000 claims description 13
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 10
- 210000003714 granulocyte Anatomy 0.000 claims description 9
- 208000026278 immune system disease Diseases 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 102000043129 MHC class I family Human genes 0.000 claims description 6
- 108091054437 MHC class I family Proteins 0.000 claims description 6
- 230000008512 biological response Effects 0.000 claims description 6
- 239000003607 modifier Substances 0.000 claims description 6
- 102000043131 MHC class II family Human genes 0.000 claims description 4
- 108091054438 MHC class II family Proteins 0.000 claims description 4
- 229940100198 alkylating agent Drugs 0.000 claims description 4
- 239000002168 alkylating agent Substances 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 101150076359 Mhc gene Proteins 0.000 claims description 2
- 239000010754 BS 2869 Class F Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 description 135
- 239000008280 blood Substances 0.000 description 135
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 62
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 description 61
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 description 61
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 50
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 50
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 36
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 36
- 102000005962 receptors Human genes 0.000 description 31
- 108020003175 receptors Proteins 0.000 description 31
- 210000004698 lymphocyte Anatomy 0.000 description 28
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 26
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 26
- 230000008569 process Effects 0.000 description 26
- 230000007423 decrease Effects 0.000 description 23
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 19
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 19
- 238000004458 analytical method Methods 0.000 description 17
- 210000001616 monocyte Anatomy 0.000 description 14
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 13
- 108010027412 Histocompatibility Antigens Class II Proteins 0.000 description 13
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 13
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 13
- 238000013394 immunophenotyping Methods 0.000 description 13
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 description 12
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 description 12
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 description 12
- 230000003247 decreasing effect Effects 0.000 description 12
- 102000000844 Cell Surface Receptors Human genes 0.000 description 11
- 108010001857 Cell Surface Receptors Proteins 0.000 description 11
- 108700018351 Major Histocompatibility Complex Proteins 0.000 description 11
- 230000004069 differentiation Effects 0.000 description 11
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 11
- 102100027208 T-cell antigen CD7 Human genes 0.000 description 10
- 238000011534 incubation Methods 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 108010013709 Leukocyte Common Antigens Proteins 0.000 description 9
- 102000017095 Leukocyte Common Antigens Human genes 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 206010028980 Neoplasm Diseases 0.000 description 8
- 210000000265 leukocyte Anatomy 0.000 description 8
- 210000003738 lymphoid progenitor cell Anatomy 0.000 description 8
- 108091008874 T cell receptors Proteins 0.000 description 7
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 7
- 230000002950 deficient Effects 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 210000004185 liver Anatomy 0.000 description 7
- 239000003550 marker Substances 0.000 description 7
- 102000013925 CD34 antigen Human genes 0.000 description 6
- 108050003733 CD34 antigen Proteins 0.000 description 6
- 108010041397 CD4 Antigens Proteins 0.000 description 6
- 238000006711 Chan reduction reaction Methods 0.000 description 6
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 6
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 6
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 description 6
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 6
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 6
- 238000011161 development Methods 0.000 description 6
- 230000018109 developmental process Effects 0.000 description 6
- 210000003743 erythrocyte Anatomy 0.000 description 6
- 210000005259 peripheral blood Anatomy 0.000 description 6
- 239000011886 peripheral blood Substances 0.000 description 6
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 5
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 description 5
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 5
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 description 5
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 5
- 229960004397 cyclophosphamide Drugs 0.000 description 5
- 208000030507 AIDS Diseases 0.000 description 4
- 102100022749 Aminopeptidase N Human genes 0.000 description 4
- 102100032768 Complement receptor type 2 Human genes 0.000 description 4
- 102100033215 DNA nucleotidylexotransferase Human genes 0.000 description 4
- 108010008286 DNA nucleotidylexotransferase Proteins 0.000 description 4
- 102100021260 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Human genes 0.000 description 4
- 102100036242 HLA class II histocompatibility antigen, DQ alpha 2 chain Human genes 0.000 description 4
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 description 4
- 101000941929 Homo sapiens Complement receptor type 2 Proteins 0.000 description 4
- 101000894906 Homo sapiens Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Proteins 0.000 description 4
- 101000930801 Homo sapiens HLA class II histocompatibility antigen, DQ alpha 2 chain Proteins 0.000 description 4
- 210000003651 basophil Anatomy 0.000 description 4
- 210000001185 bone marrow Anatomy 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 210000003979 eosinophil Anatomy 0.000 description 4
- 238000000684 flow cytometry Methods 0.000 description 4
- 230000003394 haemopoietic effect Effects 0.000 description 4
- 210000002751 lymph Anatomy 0.000 description 4
- 210000002540 macrophage Anatomy 0.000 description 4
- 210000003643 myeloid progenitor cell Anatomy 0.000 description 4
- 210000000822 natural killer cell Anatomy 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000008929 regeneration Effects 0.000 description 4
- 238000011069 regeneration method Methods 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 230000000284 resting effect Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 102000010910 CD28 Antigens Human genes 0.000 description 3
- 108010062433 CD28 Antigens Proteins 0.000 description 3
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 description 3
- 102000003729 Neprilysin Human genes 0.000 description 3
- 108090000028 Neprilysin Proteins 0.000 description 3
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 208000032839 leukemia Diseases 0.000 description 3
- 210000003593 megakaryocyte Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 210000000440 neutrophil Anatomy 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 230000036962 time dependent Effects 0.000 description 3
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 description 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 2
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 2
- 208000005623 Carcinogenesis Diseases 0.000 description 2
- 208000031886 HIV Infections Diseases 0.000 description 2
- 208000017604 Hodgkin disease Diseases 0.000 description 2
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 description 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 2
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 description 2
- 208000028018 Lymphocytic leukaemia Diseases 0.000 description 2
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000030741 antigen processing and presentation Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 230000036952 cancer formation Effects 0.000 description 2
- 231100000504 carcinogenesis Toxicity 0.000 description 2
- 210000004970 cd4 cell Anatomy 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 239000002158 endotoxin Substances 0.000 description 2
- 210000004700 fetal blood Anatomy 0.000 description 2
- 210000002443 helper t lymphocyte Anatomy 0.000 description 2
- 230000004730 hepatocarcinogenesis Effects 0.000 description 2
- 210000003494 hepatocyte Anatomy 0.000 description 2
- 210000003630 histaminocyte Anatomy 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 229920006008 lipopolysaccharide Polymers 0.000 description 2
- 230000036210 malignancy Effects 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 238000000386 microscopy Methods 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 2
- 239000002644 phorbol ester Substances 0.000 description 2
- 210000004180 plasmocyte Anatomy 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000004043 responsiveness Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 210000001541 thymus gland Anatomy 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 231100000167 toxic agent Toxicity 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 101150090724 3 gene Proteins 0.000 description 1
- 108010027122 ADP-ribosyl Cyclase 1 Proteins 0.000 description 1
- 102000018667 ADP-ribosyl Cyclase 1 Human genes 0.000 description 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
- 208000008190 Agammaglobulinemia Diseases 0.000 description 1
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 description 1
- 101000980996 Arabidopsis thaliana Phosphatidate cytidylyltransferase 3 Proteins 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 201000008162 B cell deficiency Diseases 0.000 description 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 description 1
- 108010003639 CD56 Antigen Proteins 0.000 description 1
- 102000004652 CD56 Antigen Human genes 0.000 description 1
- 108010001017 CD71 antigen Proteins 0.000 description 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
- 102000016289 Cell Adhesion Molecules Human genes 0.000 description 1
- 239000004381 Choline salt Substances 0.000 description 1
- 102100030886 Complement receptor type 1 Human genes 0.000 description 1
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 206010011831 Cytomegalovirus infection Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108010087819 Fc receptors Proteins 0.000 description 1
- 102000009109 Fc receptors Human genes 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 1
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 description 1
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 description 1
- 102100028970 HLA class I histocompatibility antigen, alpha chain E Human genes 0.000 description 1
- 102100028966 HLA class I histocompatibility antigen, alpha chain F Human genes 0.000 description 1
- 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 description 1
- 108010075704 HLA-A Antigens Proteins 0.000 description 1
- 108010058607 HLA-B Antigens Proteins 0.000 description 1
- 108010052199 HLA-C Antigens Proteins 0.000 description 1
- 108010024164 HLA-G Antigens Proteins 0.000 description 1
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 description 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 description 1
- 101000727061 Homo sapiens Complement receptor type 1 Proteins 0.000 description 1
- 101000986085 Homo sapiens HLA class I histocompatibility antigen, alpha chain E Proteins 0.000 description 1
- 101000986080 Homo sapiens HLA class I histocompatibility antigen, alpha chain F Proteins 0.000 description 1
- 101000623713 Homo sapiens Motile sperm domain-containing protein 3 Proteins 0.000 description 1
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 description 1
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 description 1
- 208000007924 IgA Deficiency Diseases 0.000 description 1
- 108010073807 IgG Receptors Proteins 0.000 description 1
- 102000009490 IgG Receptors Human genes 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 101710177649 Low affinity immunoglobulin gamma Fc region receptor III Proteins 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 102000012750 Membrane Glycoproteins Human genes 0.000 description 1
- 108010090054 Membrane Glycoproteins Proteins 0.000 description 1
- 102100023091 Motile sperm domain-containing protein 3 Human genes 0.000 description 1
- 102000016979 Other receptors Human genes 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 102000002727 Protein Tyrosine Phosphatase Human genes 0.000 description 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
- 206010039915 Selective IgA immunodeficiency Diseases 0.000 description 1
- 108010029180 Sialic Acid Binding Ig-like Lectin 3 Proteins 0.000 description 1
- 102000001555 Sialic Acid Binding Ig-like Lectin 3 Human genes 0.000 description 1
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 241000269370 Xenopus <genus> Species 0.000 description 1
- 101000910954 Xenopus laevis F-actin-capping protein subunit alpha-1 Proteins 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 230000000961 alloantigen Effects 0.000 description 1
- 230000019552 anatomical structure morphogenesis Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 210000003567 ascitic fluid Anatomy 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000002960 bfu-e Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000005907 cancer growth Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 210000001043 capillary endothelial cell Anatomy 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 230000020411 cell activation Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000011712 cell development Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 210000003104 cytoplasmic structure Anatomy 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 210000003162 effector t lymphocyte Anatomy 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000000267 erythroid cell Anatomy 0.000 description 1
- 230000000925 erythroid effect Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 210000004524 haematopoietic cell Anatomy 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000000760 immunoelectrophoresis Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 201000007156 immunoglobulin alpha deficiency Diseases 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 230000002584 immunomodulator Effects 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 208000016245 inborn errors of metabolism Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 208000003747 lymphoid leukemia Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 210000000066 myeloid cell Anatomy 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000004287 null lymphocyte Anatomy 0.000 description 1
- 230000005868 ontogenesis Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000033667 organ regeneration Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 210000002741 palatine tonsil Anatomy 0.000 description 1
- 210000004738 parenchymal cell Anatomy 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 238000012753 partial hepatectomy Methods 0.000 description 1
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 210000004910 pleural fluid Anatomy 0.000 description 1
- 230000001855 preneoplastic effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 108020000494 protein-tyrosine phosphatase Proteins 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000009703 regulation of cell differentiation Effects 0.000 description 1
- 230000021014 regulation of cell growth Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 208000029138 selective IgA deficiency disease Diseases 0.000 description 1
- 238000012882 sequential analysis Methods 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002536 stromal cell Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000002992 thymic effect Effects 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/06—Anti-neoplasic drugs, anti-retroviral drugs, e.g. azacytidine, cyclophosphamide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9502022.8A GB9502022D0 (en) | 1995-02-02 | 1995-02-02 | A method for preparing lymphohaematopoietic progenitor cells |
| PCT/GB1996/000208 WO1996023870A1 (fr) | 1995-02-02 | 1996-01-31 | Technique d'elaboration d'une cellule indifferenciee |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP9701031A0 AP9701031A0 (en) | 1997-07-31 |
| AP693A true AP693A (en) | 1998-11-11 |
Family
ID=10768971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1997/001031A AP693A (en) | 1995-02-02 | 1996-01-31 | A method of preparing an undifferentiated cell. |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US6090625A (fr) |
| EP (1) | EP0807166B1 (fr) |
| JP (4) | JPH10513053A (fr) |
| KR (1) | KR100630591B1 (fr) |
| CN (1) | CN1289660C (fr) |
| AP (1) | AP693A (fr) |
| AT (1) | ATE396253T1 (fr) |
| AU (1) | AU4545196A (fr) |
| BR (1) | BR9606866A (fr) |
| CA (1) | CA2211147C (fr) |
| CY (1) | CY2206B1 (fr) |
| DE (1) | DE69637534D1 (fr) |
| DK (1) | DK0807166T3 (fr) |
| ES (1) | ES2308774T3 (fr) |
| GB (1) | GB9502022D0 (fr) |
| IL (2) | IL116994A (fr) |
| NZ (1) | NZ300650A (fr) |
| PT (1) | PT807166E (fr) |
| RU (2) | RU2215539C2 (fr) |
| SI (1) | SI0807166T1 (fr) |
| WO (1) | WO1996023870A1 (fr) |
| ZA (1) | ZA96727B (fr) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9068164B1 (en) | 1995-02-02 | 2015-06-30 | Tristem Trading (Cyprus) Limited | Method of preparing an undifferentiated cell |
| GB9502022D0 (en) * | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
| US8252280B1 (en) | 1999-08-05 | 2012-08-28 | Regents Of The University Of Minnesota | MAPC generation of muscle |
| US10638734B2 (en) | 2004-01-05 | 2020-05-05 | Abt Holding Company | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| US7927587B2 (en) * | 1999-08-05 | 2011-04-19 | Regents Of The University Of Minnesota | MAPC administration for the treatment of lysosomal storage disorders |
| US8609412B2 (en) * | 1999-08-05 | 2013-12-17 | Regents Of The University Of Minnesota | Mapc generation of lung tissue |
| US7015037B1 (en) * | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| US8075881B2 (en) | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
| EP1226233B1 (fr) | 1999-08-05 | 2011-06-29 | ABT Holding Company | Cellules souches adultes multipotentes et procede d'isolement |
| CN101538551A (zh) * | 2000-05-10 | 2009-09-23 | 特里施泰姆贸易(塞浦路斯)有限公司 | 一种设备 |
| NL1017973C2 (nl) * | 2000-05-10 | 2002-11-08 | Tristem Trading Cyprus Ltd | Inrichting. |
| CA2438501C (fr) * | 2001-02-14 | 2014-09-16 | Leo T. Furcht | Cellules souches adultes totipotentes, sources de ces cellules, procedes d'obtention et de maintien de ces dernieres, procedes de differentiation de ces cellules, procedes d'utilisation correspondants et cellules derivees des cellules susmentionnees |
| CN102302493B (zh) * | 2001-07-31 | 2015-08-12 | 健赞股份有限公司 | 活化祖细胞/干细胞的方法 |
| DE10144326B4 (de) * | 2001-09-10 | 2005-09-22 | Siemens Ag | Verfahren und System zur Überwachung eines Reifenluftdrucks |
| TWI288779B (en) * | 2002-03-28 | 2007-10-21 | Blasticon Biotech Forschung | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
| DE10231655A1 (de) * | 2002-07-12 | 2004-02-26 | Blasticon Biotechnologische Forschung Gmbh | Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung |
| WO2004050859A2 (fr) | 2002-11-27 | 2004-06-17 | Regents Of The University Of Minnesota | Recombinaison homologue dans des cellules souches adultes multipotentes |
| AU2004256154A1 (en) * | 2003-07-11 | 2005-01-20 | Blasticon Biotechnologische Forschung Gmbh | Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical proparations |
| PL1653994T3 (pl) * | 2003-08-12 | 2010-05-31 | Tigenix Nv | Zastosowanie chemokiny CXCL6 w profilaktyce lub naprawie ubytków chrząstki |
| EP1694345A1 (fr) | 2003-12-04 | 2006-08-30 | Regents Of The University Of Minnesota | Compositions et methodes de traitement des maladies lysosomales |
| RU2272810C2 (ru) * | 2004-01-14 | 2006-03-27 | Государственное учреждение Российский научно-исследовательский институт гематологии и трансфузиологии Министерства здравоохранения Российской Федерации (ГУ РосНИИГТ) | Средство для активации стволовых клеток |
| WO2006047743A2 (fr) | 2004-10-26 | 2006-05-04 | Regents Of The University Of Minnesota | Cellules souches adultes de porc |
| EP1859028B1 (fr) * | 2005-02-10 | 2015-12-02 | Regents Of The University Of Minnesota | Cellules endothéliales vasculaires |
| WO2006121454A2 (fr) * | 2005-05-05 | 2006-11-16 | Regents Of The University Of Minnesota | Utilisation de mapc ou de sa descendance pour peupler des tissus lympho-hematopoietiques |
| AU2005331559B2 (en) * | 2005-05-05 | 2012-04-19 | Regents Of The University Of Minnesota | Use of NK cell inhibition to facilitate persistence of engrafted MHC-I negative cells |
| US20080194024A1 (en) * | 2005-07-29 | 2008-08-14 | Mays Robert W | Culture of Non-Embryonic Cells at High Cell Density |
| CA2625883A1 (fr) * | 2005-10-14 | 2007-04-26 | Regents Of The University Of Minnesota | Differenciation de cellules souches non-embryonnaires avec des cellules possedant un phenotype pancreatique |
| WO2008063675A2 (fr) | 2006-11-24 | 2008-05-29 | Regents Of The University Of Minnesota | Cellules progénitrices endothermiques |
| SG187493A1 (en) | 2008-01-18 | 2013-02-28 | Univ Minnesota | Stem cell aggregates and methods for making and using |
| EP2362899A1 (fr) | 2008-10-31 | 2011-09-07 | Katholieke Universiteit Leuven | Procédés optimisés pour la différenciation de cellules en cellules présentant des phénotypes d'hépatocytes et de cellules souches d'hépatocytes, cellules produites par ces procédés et procédés pour l'utilisation des cellules |
| CN105925535A (zh) | 2009-06-05 | 2016-09-07 | 细胞动力国际有限公司 | 重编程t细胞和造血细胞的方法 |
| AU2010276264B2 (en) * | 2009-07-21 | 2013-09-19 | Abt Holding Company | Use of stem cells to reduce leukocyte extravasation |
| SG10201404280XA (en) * | 2009-07-21 | 2014-10-30 | Abt Holding Co | Use of stem cells to reduce leukocyte extravasation |
| BR122013008030B8 (pt) * | 2009-09-15 | 2021-07-27 | Univ Tokyo | método para produzir células eritroides e método para produzir um produto sanguíneo |
| JP6073135B2 (ja) * | 2009-10-19 | 2017-02-01 | トライステム・トレイディング・（キプロス）・リミテッドＴｒｉＳｔｅｍ Ｔｒａｄｉｎｇ （Ｃｙｐｒｕｓ） Ｌｉｍｉｔｅｄ | 再プログラム化成熟成体細胞を用いる治療 |
| WO2011106476A1 (fr) * | 2010-02-25 | 2011-09-01 | Abt Holding Company | Modulation de l'activation des microglies |
| BR112012021451B8 (pt) * | 2010-02-25 | 2021-05-25 | Abt Holding Co | uso de células que apresentam uma eficiência desejada para a expressão e/ou secreção dos fatores pró-angiogênicos vegf, cxcl5 e il8, métodos para construir um banco de células, para desenvolver fármaco, e para aumentar a expressão de um ou mais fatores pró-angiogênicos em uma célula realizado in vitro, e, composição |
| US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
| DK2568991T6 (en) | 2010-05-12 | 2019-03-18 | Abt Holding Co | MODULATION OF SPLENOCYTES IN CELL THERAPY |
| US9090878B2 (en) | 2010-06-17 | 2015-07-28 | Katholieke Universiteit Leuven | Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells |
| WO2012027474A1 (fr) | 2010-08-24 | 2012-03-01 | Regents Of The University Of Minnesota | Culture en suspension non statique d'agrégats cellulaires |
| AU2013251649B2 (en) * | 2012-04-24 | 2019-04-04 | Vcell Therapeutics, Inc. | Generating pluripotent cells de novo |
| RU2497947C1 (ru) * | 2012-08-15 | 2013-11-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства зравоохранения и социального развития Российской Федерации (ГБОУ ВПО СибГМУ Минздравсоцразвития России) | Способ модификации моноцитов периферической крови для повышения их паракринной активности при аутологической трансплантации |
| KR102161726B1 (ko) | 2013-04-12 | 2020-10-06 | 사베리오 라프란체스카 | 이식용 장기의 개선 |
| WO2017127123A1 (fr) | 2016-01-21 | 2017-07-27 | Abt Holding Company | Cellules souches pour la cicatrisation de plaie |
| JP2017008049A (ja) * | 2016-07-04 | 2017-01-12 | トライステム・トレイディング・（キプロス）・リミテッドＴｒｉＳｔｅｍ Ｔｒａｄｉｎｇ （Ｃｙｐｒｕｓ） Ｌｉｍｉｔｅｄ | 再プログラム化成熟成体細胞を用いる治療 |
| US20220125852A1 (en) * | 2020-10-27 | 2022-04-28 | Therapeutic Solutions International, Inc. | Protection and regeneration of neurological function by using stem cells |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993025216A1 (fr) * | 1992-06-08 | 1993-12-23 | Becton, Dickinson And Company | Cellules souches primitives humaines |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0763361B2 (ja) * | 1985-10-15 | 1995-07-12 | 三井東圧化学株式会社 | 培養株化細胞株 |
| US5004681B1 (en) * | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| AU5678890A (en) * | 1989-05-11 | 1990-11-29 | Public Health Research Institute Of The City Of New York, Inc., The | A method for the activation of t cells |
| US5061620A (en) * | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5229115A (en) * | 1990-07-26 | 1993-07-20 | Immunex Corporation | Adoptive immunotherapy with interleukin-7 |
| US6194376B1 (en) * | 1991-03-11 | 2001-02-27 | Creative Biomolecules, Inc. | Method for modulating inflammatory response comprising administering morphogen |
| US5199942A (en) * | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
| WO1993009815A1 (fr) * | 1991-11-22 | 1993-05-27 | The General Hospital Corporation | Tolerance specifique lors d'une transplantation |
| US5436151A (en) * | 1992-04-03 | 1995-07-25 | Regents Of The University Of Minnesota | Method for culturing human hematopoietic stem cells in vitro |
| AU5594994A (en) * | 1992-11-16 | 1994-06-08 | Schering Corporation | Modulators of hematopoietic progenitor cells |
| DE4240635C2 (de) * | 1992-12-03 | 1997-07-10 | Lothar Prof Dr Kanz | Vermehrung hämatopoetischer Vorläuferzellen ex vivo sowieZusammensetzungen hämatopoetischer Wachstumsfaktoren |
| US5654186A (en) * | 1993-02-26 | 1997-08-05 | The Picower Institute For Medical Research | Blood-borne mesenchymal cells |
| CA2164226C (fr) * | 1993-06-04 | 2011-02-08 | Carl H. June | Methodes pour stimuler de facon selective la proliferation de cellules t |
| US5843780A (en) * | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| GB9502022D0 (en) * | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
| US5877299A (en) * | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| US5843633A (en) * | 1996-04-26 | 1998-12-01 | Amcell Corporation | Characterization of a human hematopoietic progenitor cell antigen |
| US6227202B1 (en) * | 1996-09-03 | 2001-05-08 | Maulana Azad Medical College | Method of organogenesis and tissue regeneration/repair using surgical techniques |
| US6468794B1 (en) * | 1999-02-12 | 2002-10-22 | Stemcells, Inc. | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations |
| TWI288779B (en) * | 2002-03-28 | 2007-10-21 | Blasticon Biotech Forschung | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
-
1995
- 1995-02-02 GB GBGB9502022.8A patent/GB9502022D0/en active Pending
-
1996
- 1996-01-31 DK DK96901432T patent/DK0807166T3/da active
- 1996-01-31 RU RU2000130595/14A patent/RU2215539C2/ru active IP Right Revival
- 1996-01-31 KR KR1019970705346A patent/KR100630591B1/ko not_active Expired - Lifetime
- 1996-01-31 WO PCT/GB1996/000208 patent/WO1996023870A1/fr not_active Ceased
- 1996-01-31 DE DE69637534T patent/DE69637534D1/de not_active Expired - Lifetime
- 1996-01-31 ZA ZA96727A patent/ZA96727B/xx unknown
- 1996-01-31 NZ NZ300650A patent/NZ300650A/en not_active IP Right Cessation
- 1996-01-31 AT AT96901432T patent/ATE396253T1/de active
- 1996-01-31 RU RU97114802/14A patent/RU2177996C2/ru active
- 1996-01-31 IL IL11699496A patent/IL116994A/xx not_active IP Right Cessation
- 1996-01-31 SI SI9630761T patent/SI0807166T1/sl unknown
- 1996-01-31 ES ES96901432T patent/ES2308774T3/es not_active Expired - Lifetime
- 1996-01-31 BR BR9606866A patent/BR9606866A/pt not_active Application Discontinuation
- 1996-01-31 PT PT96901432T patent/PT807166E/pt unknown
- 1996-01-31 US US08/594,164 patent/US6090625A/en not_active Expired - Lifetime
- 1996-01-31 CN CNB961930217A patent/CN1289660C/zh not_active Expired - Lifetime
- 1996-01-31 AU AU45451/96A patent/AU4545196A/en not_active Abandoned
- 1996-01-31 IL IL139244A patent/IL139244A/en not_active IP Right Cessation
- 1996-01-31 EP EP96901432A patent/EP0807166B1/fr not_active Expired - Lifetime
- 1996-01-31 JP JP8523345A patent/JPH10513053A/ja active Pending
- 1996-01-31 AP APAP/P/1997/001031A patent/AP693A/en active
- 1996-01-31 CA CA2211147A patent/CA2211147C/fr not_active Expired - Lifetime
-
2000
- 2000-03-09 US US09/521,700 patent/US20020076812A1/en not_active Abandoned
- 2000-12-21 CY CY0000061A patent/CY2206B1/xx unknown
-
2007
- 2007-07-12 JP JP2007183193A patent/JP2007259868A/ja active Pending
-
2008
- 2008-12-25 JP JP2008330347A patent/JP2009148266A/ja active Pending
-
2011
- 2011-02-23 US US13/033,093 patent/US20110143431A1/en not_active Abandoned
- 2011-10-05 JP JP2011220926A patent/JP2012040011A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993025216A1 (fr) * | 1992-06-08 | 1993-12-23 | Becton, Dickinson And Company | Cellules souches primitives humaines |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0807166B1 (fr) | Technique d'elaboration d'une cellule indifferenciee | |
| US7410773B2 (en) | Method of preparing an undifferentiated cell | |
| KR100875089B1 (ko) | 수임 세포를 포함한 세포 집단에서 미분화 세포의 상대적인 수를 증가시키기 위한 장치 | |
| US7220412B2 (en) | Method of preparing an undifferentiated cell | |
| US7112440B2 (en) | Method of increasing the relative number of CD45 low cells in a cell population | |
| GB2297558A (en) | Conversion of a more committed cell into an undifferentiated cell | |
| AU751866B2 (en) | A method of preparing an undifferentiated cell | |
| AU751928B2 (en) | A method of preparing an undifferentiated cell | |
| CA2395452A1 (fr) | Technique d'elaboration d'une cellule indifferenciee | |
| AU7243100A (en) | A method of preparing an undifferentiated cell | |
| IL133155A (en) | Method for producing a medicament comprising retrodifferentiated cells | |
| CN100390264C (zh) | 一种设备 | |
| MXPA97005919A (en) | A method for preparing an indiferencial cell | |
| AU2005201200A1 (en) | A Method of Preparing an Undifferentiated Cell |