AP508A - Novel opioid analogs that are 9 (delta) opioid receptor antagonists, their syntheis and their use as analgesic and immunosupressive compounds. - Google Patents

Novel opioid analogs that are 9 (delta) opioid receptor antagonists, their syntheis and their use as analgesic and immunosupressive compounds. Download PDF

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Publication number
AP508A
AP508A APAP/P/1994/000605A AP9400605A AP508A AP 508 A AP508 A AP 508A AP 9400605 A AP9400605 A AP 9400605A AP 508 A AP508 A AP 508A
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AP
ARIPO
Prior art keywords
phe
tic
tyr
compound according
boc
Prior art date
Application number
APAP/P/1994/000605A
Other languages
English (en)
Other versions
AP9400605A0 (en
Inventor
Peter Schiller
Original Assignee
Ab Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ab Astra filed Critical Ab Astra
Publication of AP9400605A0 publication Critical patent/AP9400605A0/xx
Application granted granted Critical
Publication of AP508A publication Critical patent/AP508A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
APAP/P/1994/000605A 1993-01-05 1994-01-05 Novel opioid analogs that are 9 (delta) opioid receptor antagonists, their syntheis and their use as analgesic and immunosupressive compounds. AP508A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9300012A SE9300012D0 (sv) 1993-01-05 1993-01-05 New peptides

Publications (2)

Publication Number Publication Date
AP9400605A0 AP9400605A0 (en) 1994-01-31
AP508A true AP508A (en) 1996-07-22

Family

ID=20388466

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1994/000605A AP508A (en) 1993-01-05 1994-01-05 Novel opioid analogs that are 9 (delta) opioid receptor antagonists, their syntheis and their use as analgesic and immunosupressive compounds.

Country Status (25)

Country Link
US (1) US5602099A (sk)
EP (1) EP0678099A1 (sk)
JP (1) JPH08505386A (sk)
KR (1) KR960700269A (sk)
CN (1) CN1096515A (sk)
AP (1) AP508A (sk)
AU (1) AU681372B2 (sk)
CA (1) CA2152380A1 (sk)
CZ (1) CZ171195A3 (sk)
EE (1) EE9400326A (sk)
FI (1) FI953302A0 (sk)
HU (1) HUT72597A (sk)
IL (1) IL108169A0 (sk)
IS (1) IS4115A (sk)
LV (1) LV10962B (sk)
MX (1) MX9400255A (sk)
NO (1) NO952650L (sk)
NZ (1) NZ259597A (sk)
PL (1) PL309778A1 (sk)
SE (1) SE9300012D0 (sk)
SI (1) SI9400005A (sk)
SK (1) SK83995A3 (sk)
WO (1) WO1994015959A1 (sk)
YU (1) YU394A (sk)
ZA (1) ZA9455B (sk)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854211A (en) * 1993-12-23 1998-12-29 Novo Nordisk A/S Compounds with growth hormone releasing properties
IS4261A (is) * 1994-02-21 1995-08-22 Astra Aktiebolag Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra
IL114046A0 (en) * 1994-06-20 1995-10-31 Astra Ab New opioid peptide antagonists
RU2067000C1 (ru) * 1994-06-29 1996-09-27 Владислав Исакович Дейгин Пептид и способ его получения
US6184208B1 (en) 1994-06-29 2001-02-06 Immunotech Developments Inc. Peptide, a method for its preparation and a pharmaceutical composition containing the peptide
SE9402880D0 (sv) * 1994-08-30 1994-08-30 Astra Ab New peptide derivatives
US5780589A (en) * 1994-11-30 1998-07-14 The United States Of America As Represented By The Department Of Health And Human Services Ultraselective opioidmimetic peptides and pharmacological and therapeutic uses thereof
AU708620B2 (en) * 1995-03-29 1999-08-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0837857A4 (en) * 1995-03-29 1998-08-05 Merck & Co Inc FARNESYL-PROTEIN TRANSFERASE INHIBITORS
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
SE9600769D0 (sv) * 1996-02-28 1996-02-28 Astra Ab Compounds useful as analgesic
JP2002512625A (ja) * 1997-05-29 2002-04-23 メルク エンド カンパニー インコーポレーテッド 細胞接着阻害薬としての複素環アミド化合物
US6903075B1 (en) 1997-05-29 2005-06-07 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
US6703381B1 (en) 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US6306576B1 (en) * 1999-02-19 2001-10-23 Cleveland Clinic Foundation Diagnostic methods for asthma
US7601739B2 (en) 2003-08-08 2009-10-13 Virgina Commonwealth University Compounds having antiestrogenic and tissue selective estrogenic properties, and compounds with anti-androgenic properties for treatment of prostate cancer and androgen receptor dependent diseases
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
CA2580694A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
EP3160497A4 (en) * 2014-06-27 2018-01-17 H. Lee Moffitt Cancer Center And Research Institute, Inc. Conjugates for immunotherapy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NONE *

Also Published As

Publication number Publication date
LV10962A (lv) 1995-12-20
CN1096515A (zh) 1994-12-21
LV10962B (en) 1997-04-20
FI953302A (fi) 1995-07-04
IL108169A0 (en) 1994-04-12
CA2152380A1 (en) 1994-07-21
FI953302A0 (fi) 1995-07-04
YU394A (sh) 1997-07-31
SI9400005A (en) 1994-12-31
SK83995A3 (en) 1996-09-04
NZ259597A (en) 1996-07-26
CZ171195A3 (en) 1996-09-11
EE9400326A (et) 1996-04-15
AU681372B2 (en) 1997-08-28
HU9502041D0 (en) 1995-09-28
ZA9455B (en) 1994-07-05
PL309778A1 (en) 1995-11-13
IS4115A (is) 1994-07-06
WO1994015959A1 (en) 1994-07-21
JPH08505386A (ja) 1996-06-11
AP9400605A0 (en) 1994-01-31
HUT72597A (en) 1996-05-28
NO952650L (no) 1995-08-30
NO952650D0 (no) 1995-07-04
AU5844894A (en) 1994-08-15
KR960700269A (ko) 1996-01-19
MX9400255A (es) 1994-07-29
EP0678099A1 (en) 1995-10-25
SE9300012D0 (sv) 1993-01-05
US5602099A (en) 1997-02-11

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