AP459A - Substituted 6-azaandrostenones. - Google Patents
Substituted 6-azaandrostenones. Download PDFInfo
- Publication number
- AP459A AP459A APAP/P/1993/000599A AP9300599A AP459A AP 459 A AP459 A AP 459A AP 9300599 A AP9300599 A AP 9300599A AP 459 A AP459 A AP 459A
- Authority
- AP
- ARIPO
- Prior art keywords
- alk
- azaandrost
- carbamoyl
- compound
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/45—Monoamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/46—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing nine carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99393092A | 1992-12-18 | 1992-12-18 | |
| US8066593A | 1993-06-18 | 1993-06-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP9300599A0 AP9300599A0 (en) | 1994-01-31 |
| AP459A true AP459A (en) | 1996-02-14 |
Family
ID=26763785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1993/000599A AP459A (en) | 1992-12-18 | 1993-12-13 | Substituted 6-azaandrostenones. |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0674651B1 (xx) |
| JP (1) | JPH08504825A (xx) |
| CN (1) | CN1095383A (xx) |
| AP (1) | AP459A (xx) |
| AT (1) | ATE172738T1 (xx) |
| AU (1) | AU673899B2 (xx) |
| BG (1) | BG99729A (xx) |
| CA (1) | CA2152053A1 (xx) |
| CZ (1) | CZ157695A3 (xx) |
| DE (1) | DE69321849D1 (xx) |
| FI (1) | FI953009A (xx) |
| HU (1) | HUT72083A (xx) |
| IL (1) | IL108073A0 (xx) |
| IS (1) | IS4106A (xx) |
| LV (1) | LV10958B (xx) |
| MX (1) | MX9308015A (xx) |
| NO (1) | NO952402L (xx) |
| NZ (1) | NZ261415A (xx) |
| OA (1) | OA10167A (xx) |
| PL (1) | PL314532A1 (xx) |
| SI (1) | SI9300665A (xx) |
| SK (1) | SK79495A3 (xx) |
| TW (1) | TW293824B (xx) |
| WO (1) | WO1994014833A2 (xx) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW369521B (en) * | 1993-09-17 | 1999-09-11 | Smithkline Beecham Corp | Androstenone derivative |
| US5516779A (en) * | 1994-06-08 | 1996-05-14 | Merck & Co., Inc. | 17β-substituted-6-azasteroid derivatives useful as 5α-reductase inhibitors |
| US5817818A (en) * | 1994-09-16 | 1998-10-06 | Glaxo Wellcome Inc. | Androstenones |
| US5541322A (en) * | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
| US5543417A (en) * | 1994-10-21 | 1996-08-06 | Merck & Co., Inc. | Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents |
| US5595996A (en) * | 1994-10-25 | 1997-01-21 | Merck & Co., Inc. | 7-substituted 4-aza cholanic acid derivatives and their use |
| GB9506678D0 (en) * | 1995-03-31 | 1995-05-24 | Glaxo Inc | Substituted 6-azacholesten-3-ones |
| AU704933B2 (en) * | 1995-10-19 | 1999-05-06 | Merck & Co., Inc. | 16-substituted-6-aza-steroid 5-alpha-reductase inhibitors |
| US5935968A (en) | 1997-03-17 | 1999-08-10 | Merck & Co., Inc. | Methods for treating polycystic ovary syndrome |
| BRPI0409376A (pt) | 2003-04-15 | 2006-04-25 | Inflazyme Pharm Ltd | derivados de indeno como agentes farmacêuticos |
| US7790770B2 (en) | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| KR20220110337A (ko) | 2013-03-14 | 2022-08-05 | 에퀴녹스 파머수티칼스 (캐나다) 인코포레이티드 | Ship1 조절제 및 그와 관련된 방법 |
| WO2014143561A1 (en) | 2013-03-14 | 2014-09-18 | Aquinox Pharmaceuticals Inc. | Ship1 modulators and methods related thereto |
| CA2986790A1 (en) | 2015-06-26 | 2016-12-29 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| US10053415B2 (en) | 2016-01-20 | 2018-08-21 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
| BR112018072255B1 (pt) * | 2016-04-29 | 2024-02-06 | The Research Foundation For The State University Of New York | Azasteroides para tratamento de tuberculose |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE165368T1 (de) * | 1991-12-20 | 1998-05-15 | Glaxo Wellcome Inc | Inhibitoren von testosteron-5-alpha reductase. |
| US5438061A (en) * | 1993-07-16 | 1995-08-01 | Merck & Co., Inc. | 7-substituted-δ4-6-azasteroid derivatives as 5α-reductase inhibitors |
-
1993
- 1993-12-13 AP APAP/P/1993/000599A patent/AP459A/en active
- 1993-12-15 TW TW082110624A patent/TW293824B/zh active
- 1993-12-15 MX MX9308015A patent/MX9308015A/es unknown
- 1993-12-15 IS IS4106A patent/IS4106A/is unknown
- 1993-12-17 NZ NZ261415A patent/NZ261415A/en unknown
- 1993-12-17 HU HU9501775A patent/HUT72083A/hu unknown
- 1993-12-17 CZ CZ951576A patent/CZ157695A3/cs unknown
- 1993-12-17 DE DE69321849T patent/DE69321849D1/de not_active Expired - Lifetime
- 1993-12-17 EP EP94906449A patent/EP0674651B1/en not_active Expired - Lifetime
- 1993-12-17 CA CA002152053A patent/CA2152053A1/en not_active Abandoned
- 1993-12-17 SI SI9300665A patent/SI9300665A/sl unknown
- 1993-12-17 SK SK794-95A patent/SK79495A3/sk unknown
- 1993-12-17 JP JP6515375A patent/JPH08504825A/ja active Pending
- 1993-12-17 AU AU60150/94A patent/AU673899B2/en not_active Ceased
- 1993-12-17 PL PL93314532A patent/PL314532A1/xx unknown
- 1993-12-17 AT AT94906449T patent/ATE172738T1/de not_active IP Right Cessation
- 1993-12-17 IL IL10807393A patent/IL108073A0/xx unknown
- 1993-12-17 WO PCT/US1993/012419 patent/WO1994014833A2/en active IP Right Grant
- 1993-12-18 CN CN93119914A patent/CN1095383A/zh active Pending
-
1995
- 1995-06-14 OA OA60676A patent/OA10167A/en unknown
- 1995-06-16 NO NO952402A patent/NO952402L/no unknown
- 1995-06-16 FI FI953009A patent/FI953009A/fi unknown
- 1995-06-16 LV LVP-95-179A patent/LV10958B/en unknown
- 1995-06-19 BG BG99729A patent/BG99729A/xx unknown
Non-Patent Citations (1)
| Title |
|---|
| TETRAHEDRON, vol.24, no.2, January 1968, OXFORD, GB pages 845 - 857 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CZ157695A3 (en) | 1995-12-13 |
| PL314532A1 (en) | 1996-09-16 |
| OA10167A (en) | 1996-12-18 |
| NO952402D0 (no) | 1995-06-16 |
| EP0674651A1 (en) | 1995-10-04 |
| MX9308015A (es) | 1994-08-31 |
| CN1095383A (zh) | 1994-11-23 |
| SI9300665A (en) | 1994-06-30 |
| CA2152053A1 (en) | 1994-07-07 |
| EP0674651B1 (en) | 1998-10-28 |
| NO952402L (no) | 1995-08-16 |
| BG99729A (en) | 1996-01-31 |
| AP9300599A0 (en) | 1994-01-31 |
| WO1994014833A2 (en) | 1994-07-07 |
| JPH08504825A (ja) | 1996-05-28 |
| FI953009A (fi) | 1995-08-15 |
| AU673899B2 (en) | 1996-11-28 |
| IL108073A0 (en) | 1994-04-12 |
| TW293824B (xx) | 1996-12-21 |
| LV10958B (en) | 1996-10-20 |
| HUT72083A (en) | 1996-03-28 |
| WO1994014833A3 (en) | 1994-09-29 |
| NZ261415A (en) | 1997-03-24 |
| DE69321849D1 (de) | 1998-12-03 |
| FI953009A0 (fi) | 1995-06-16 |
| SK79495A3 (en) | 1995-11-08 |
| IS4106A (is) | 1994-06-19 |
| HU9501775D0 (en) | 1995-08-28 |
| ATE172738T1 (de) | 1998-11-15 |
| LV10958A (lv) | 1995-12-20 |
| AU6015094A (en) | 1994-07-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AP494A (en) | Androstenone derivative. | |
| AP459A (en) | Substituted 6-azaandrostenones. | |
| EP0641356B1 (en) | Inhibitors of 5-alpha-testosterone reductase | |
| AU685167B2 (en) | Androstenones | |
| EP0880540B1 (en) | 17-beta-cyclopropyl(amino/oxy) 4-aza steroids as active inhibitors of testosterone 5-alpha-reductase and c17-20-lyase | |
| US5998427A (en) | Androstenones | |
| US5708001A (en) | Substituted 6-azaandrostenones | |
| US6365597B1 (en) | 4-aza steroids | |
| WO1996030391A1 (en) | Substituted 6-azacholesten-3-ones | |
| JP3824636B2 (ja) | アンドロステノン | |
| US5817818A (en) | Androstenones |