AP406A - Substituted benzenemethanamine derivatives. - Google Patents

Substituted benzenemethanamine derivatives. Download PDF

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Publication number
AP406A
AP406A APAP/P/1992/000469A AP9200469A AP406A AP 406 A AP406 A AP 406A AP 9200469 A AP9200469 A AP 9200469A AP 406 A AP406 A AP 406A
Authority
AP
ARIPO
Prior art keywords
formula
hydrogen
halo
radical
compound
Prior art date
Application number
APAP/P/1992/000469A
Other languages
English (en)
Other versions
AP9200469A0 (en
Inventor
Janssen
DAELE Georges Henri Paul VAN (Deceased)
Jean-Paul Rene Marie Andre Bosmans
Den Keybus Frans Maria Alfons Van
Karin Josepha Malvina Maria Nuyens
Paul Adriaan Jan Janssen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AP9200469A0 publication Critical patent/AP9200469A0/xx
Application granted granted Critical
Publication of AP406A publication Critical patent/AP406A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
APAP/P/1992/000469A 1991-12-30 1992-12-29 Substituted benzenemethanamine derivatives. AP406A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91203430 1991-12-30

Publications (2)

Publication Number Publication Date
AP9200469A0 AP9200469A0 (en) 1993-01-31
AP406A true AP406A (en) 1995-09-22

Family

ID=8208118

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1992/000469A AP406A (en) 1991-12-30 1992-12-29 Substituted benzenemethanamine derivatives.

Country Status (17)

Country Link
US (2) US5407961A (de)
EP (1) EP0620809B1 (de)
JP (1) JPH07502524A (de)
CN (1) CN1033451C (de)
AP (1) AP406A (de)
AT (1) ATE149484T1 (de)
AU (1) AU664874B2 (de)
CA (1) CA2125676A1 (de)
DE (1) DE69217992T2 (de)
FI (1) FI943120A7 (de)
HU (1) HUT67030A (de)
IL (1) IL104258A (de)
MX (1) MX9207620A (de)
NO (1) NO942481D0 (de)
TW (1) TW249227B (de)
WO (1) WO1993013052A1 (de)
ZA (1) ZA9210079B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE75693B1 (en) * 1990-07-10 1997-09-10 Janssen Pharmaceutica Nv HIV-inhibiting benzeneacetamide derivatives
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5767310A (en) * 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
US5686478A (en) * 1993-07-20 1997-11-11 Merck & Co. Inc. Endothelin antagonists
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
NZ297157A (en) 1994-10-21 1999-08-30 Nps Pharma Inc Amine derivatives with calcium ion receptor activity; medicaments containing such compounds
AU731146C (en) 1996-05-01 2005-02-03 Nps Pharmaceuticals, Inc. Inorganic ion receptor-active compounds
BR9911385A (pt) * 1998-06-19 2001-03-13 Us Health Composição, processos para dissociar um ìon de metal de uma proteìna contendo dedo de zinco, para inativar um vìrus e para selecionar um composto capaz de dissociar um ìon de metal quelado com um dedo de zinco de uma proteìna viral, vìrus isolado e inativado, kit para selecionar um composto capaz de dissociar um ìon de metal de um dedo de zinco de uma proteìna viral, composição viricida, e, formulação farmacêutica.
DK1104239T3 (da) 1998-08-13 2004-06-21 Bayer Cropscience Gmbh Herbicide midler med acylerede aminophenylsulfonylurinstoffer
JP2004525109A (ja) 2001-02-15 2004-08-19 キング・ファーマシューティカルズ・インコーポレイティッド 安定化された甲状腺ホルモン医薬組成物、及びその製法
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
US9403789B2 (en) 2008-02-21 2016-08-02 Sequoia Pharmaceuticals, Inc. Benzofuran-containing amino acid inhibitors of cytochrome P450

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006713A1 (de) * 1978-06-23 1980-01-09 Janssen Pharmaceutica N.V. Alpha-Aminophenylessigsäurederivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Herbizide, Algizide und das Pflanzenwachstum regulierende Mittel und sie enthaltende herbizide, algizide und das Pflanzenwachstum regulierende Zusammensetzungen
US4939295A (en) * 1988-07-26 1990-07-03 Zambon Group S.P.A. Process for the preparation of intermediates for the synthesis of diltiazem
WO1992000952A1 (en) * 1990-07-10 1992-01-23 Janssen Pharmaceutica N.V. Hiv-inhibiting benzeneacetamide derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006713A1 (de) * 1978-06-23 1980-01-09 Janssen Pharmaceutica N.V. Alpha-Aminophenylessigsäurederivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Herbizide, Algizide und das Pflanzenwachstum regulierende Mittel und sie enthaltende herbizide, algizide und das Pflanzenwachstum regulierende Zusammensetzungen
US4939295A (en) * 1988-07-26 1990-07-03 Zambon Group S.P.A. Process for the preparation of intermediates for the synthesis of diltiazem
WO1992000952A1 (en) * 1990-07-10 1992-01-23 Janssen Pharmaceutica N.V. Hiv-inhibiting benzeneacetamide derivatives

Also Published As

Publication number Publication date
CN1033451C (zh) 1996-12-04
IL104258A (en) 1997-04-15
AP9200469A0 (en) 1993-01-31
IL104258A0 (en) 1993-05-13
US5480912A (en) 1996-01-02
AU664874B2 (en) 1995-12-07
HUT67030A (en) 1995-01-30
FI943120A0 (fi) 1994-06-29
HU9401381D0 (en) 1994-08-29
CN1073936A (zh) 1993-07-07
FI943120L (fi) 1994-06-29
US5407961A (en) 1995-04-18
JPH07502524A (ja) 1995-03-16
DE69217992T2 (de) 1997-06-12
MX9207620A (es) 1993-06-01
NO942481L (de) 1994-06-30
EP0620809A1 (de) 1994-10-26
FI943120A7 (fi) 1994-06-29
CA2125676A1 (en) 1993-07-08
EP0620809B1 (de) 1997-03-05
ZA9210079B (en) 1994-06-29
NO942481D0 (de) 1994-06-30
TW249227B (de) 1995-06-11
WO1993013052A1 (en) 1993-07-08
DE69217992D1 (de) 1997-04-10
ATE149484T1 (de) 1997-03-15
AU3258193A (en) 1993-07-28

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