AP3597A - Imidazopyridazines as akt kinase inhibitors - Google Patents

Imidazopyridazines as akt kinase inhibitors

Info

Publication number
AP3597A
AP3597A AP2013007215A AP2013007215A AP3597A AP 3597 A AP3597 A AP 3597A AP 2013007215 A AP2013007215 A AP 2013007215A AP 2013007215 A AP2013007215 A AP 2013007215A AP 3597 A AP3597 A AP 3597A
Authority
AP
ARIPO
Prior art keywords
imidazopyridazines
kinase inhibitors
akt kinase
akt
inhibitors
Prior art date
Application number
AP2013007215A
Other languages
English (en)
Other versions
AP2013007215A0 (en
Inventor
Lars Barfacker
William Johnston Scott
Andrea Hagebarth
Stuart Ince
Hartmut Rehwinkel
Oliver Politz
Roland Neuhaus
Hans Briem
Ulf Bomer
Original Assignee
Bayer Ip Gmbh
Bayer Pharma Aktiengellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh, Bayer Pharma Aktiengellschaft filed Critical Bayer Ip Gmbh
Publication of AP2013007215A0 publication Critical patent/AP2013007215A0/xx
Application granted granted Critical
Publication of AP3597A publication Critical patent/AP3597A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AP2013007215A 2011-04-07 2012-04-05 Imidazopyridazines as akt kinase inhibitors AP3597A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161472732P 2011-04-07 2011-04-07
PCT/EP2012/056300 WO2012136776A1 (en) 2011-04-07 2012-04-05 Imidazopyridazines as akt kinase inhibitors

Publications (2)

Publication Number Publication Date
AP2013007215A0 AP2013007215A0 (en) 2013-10-31
AP3597A true AP3597A (en) 2016-02-19

Family

ID=45953129

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2013007215A AP3597A (en) 2011-04-07 2012-04-05 Imidazopyridazines as akt kinase inhibitors

Country Status (42)

Country Link
US (2) US9206185B2 (ar)
EP (1) EP2694510B1 (ar)
JP (1) JP5906303B2 (ar)
KR (1) KR20140022057A (ar)
CN (1) CN103596957B (ar)
AP (1) AP3597A (ar)
AR (1) AR087148A1 (ar)
AU (1) AU2012238589B2 (ar)
BR (1) BR112013025777A2 (ar)
CA (1) CA2832374A1 (ar)
CL (1) CL2013002878A1 (ar)
CO (1) CO6862145A2 (ar)
CR (1) CR20130515A (ar)
CU (1) CU24263B1 (ar)
CY (1) CY1117163T1 (ar)
DK (1) DK2694510T3 (ar)
DO (1) DOP2013000226A (ar)
EA (1) EA024890B1 (ar)
EC (1) ECSP13013008A (ar)
ES (1) ES2558780T3 (ar)
GT (1) GT201300238A (ar)
HR (1) HRP20160011T1 (ar)
HU (1) HUE026323T2 (ar)
IL (1) IL228567A0 (ar)
JO (1) JO3068B1 (ar)
MA (1) MA35016B1 (ar)
ME (1) ME02316B (ar)
MX (1) MX336865B (ar)
NI (1) NI201300105A (ar)
PE (1) PE20141380A1 (ar)
PL (1) PL2694510T3 (ar)
PT (1) PT2694510E (ar)
RS (1) RS54480B1 (ar)
SG (1) SG193631A1 (ar)
SI (1) SI2694510T1 (ar)
SM (1) SMT201600001B (ar)
TN (1) TN2013000400A1 (ar)
TW (1) TWI535719B (ar)
UA (1) UA111739C2 (ar)
UY (1) UY34006A (ar)
WO (1) WO2012136776A1 (ar)
ZA (1) ZA201307223B (ar)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
TR201903981T4 (tr) 2008-06-16 2019-04-22 Univ Ohio State Res Found Kanser tedavisi için bileşikler.
US11084811B2 (en) 2010-03-01 2021-08-10 Oncternal Therapeutics, Inc. Compounds for treatment of cancer
JP5879273B2 (ja) 2010-03-01 2016-03-08 ジーティーエックス・インコーポレイテッド 癌を処置するための化合物
EA024890B1 (ru) * 2011-04-07 2016-10-31 Байер Интеллектчуал Проперти Гмбх Имидазопиридазины в качестве ингибиторов akt киназы
JP6106694B2 (ja) * 2012-01-10 2017-04-05 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ Ａｋｔキナーゼ阻害剤としての置換ピラゾロピリミジン類
US9260435B2 (en) * 2012-01-10 2016-02-16 Bayer Pharma Aktiengesellschaft Substituted imidazopyrazines as Akt kinase inhibitors
ES2686730T3 (es) * 2012-11-30 2018-10-19 Novartis Ag Composición farmacéutica novedosa
CN109568312A (zh) 2013-03-05 2019-04-05 田纳西大学研究基金会 用于治疗癌症的化合物
WO2014158467A1 (en) * 2013-03-12 2014-10-02 Glaxosmithkline Llc Combination
EP2968343A4 (en) * 2013-03-14 2016-11-02 Epizyme Inc POLY THERAPY FOR TREATING CANCER
CN105899512A (zh) * 2014-01-09 2016-08-24 拜耳医药股份公司 可用于治疗过度增殖性和/或血管生成疾病的酰胺基团取代的咪唑并哒嗪
KR102611539B1 (ko) * 2016-11-28 2023-12-06 브리스톨-마이어스 스큅 컴퍼니 Gsk-3 억제제
EP3453706A1 (en) 2017-09-08 2019-03-13 Basf Se Pesticidal imidazole compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010091808A1 (en) * 2009-02-13 2010-08-19 Bayer Schering Pharma Aktiengesellschaft Fused pyrimidines
WO2011033265A1 (en) * 2009-09-18 2011-03-24 Almac Discovery Limited Pharmaceutical compounds

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1246621A4 (en) 1999-12-23 2004-11-24 Nitromed Inc NITROSED AND NITROSYLATED CYCLOOXYGENASE-2 INHIBITORS, COMPOSITIONS AND METHODS FOR THEIR USE
EP1268478B1 (en) 2000-03-31 2007-05-02 Ortho-McNeil Pharmaceutical, Inc. Phenyl-substituted imidazopyridines
CN1173975C (zh) 2000-04-27 2004-11-03 山之内制药株式会社 咪唑并吡啶衍生物
US7381825B2 (en) 2003-03-17 2008-06-03 Takeda San Diego, Inc. Histone deacetylase inhibitors
AU2004233828B2 (en) 2003-04-24 2009-05-28 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
ATE380816T1 (de) 2003-07-30 2007-12-15 S A L V A T Lab Sa Substituierte imidazopyrimidine zur prävention und behandlung von krebs
EP1737843B1 (en) 2004-04-09 2011-02-23 Merck Sharp & Dohme Corp. Inhibitors of akt activity
US7544677B2 (en) 2004-08-23 2009-06-09 Merck & Co., Inc. Inhibitors of Akt activity
CN101006062A (zh) 2004-08-24 2007-07-25 巴斯福股份公司 用作生产离子液体的起始化合物的咪唑甲基亚硫酸盐
CA2589084A1 (en) 2004-12-15 2006-06-22 Merck & Co., Inc. Inhibitors of akt activity
CA2609299A1 (en) 2005-05-20 2006-11-23 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
ES2409168T3 (es) 2005-06-10 2013-06-25 Merck Sharp & Dohme Corp. Inhibidores de la actividad Akt
WO2007025090A2 (en) 2005-08-25 2007-03-01 Kalypsys, Inc. Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase
PE20070978A1 (es) 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
US7530313B2 (en) 2006-05-12 2009-05-12 Day & Zimmerman, Inc. Self-destruct fuze delay mechanism
AR064010A1 (es) 2006-12-06 2009-03-04 Merck & Co Inc Inhibidores de la actividad de la akt
CN101790526A (zh) * 2007-06-08 2010-07-28 雅培制药有限公司 用作激酶抑制剂的5-杂芳基取代的吲唑化合物
EP2176259B1 (en) 2007-08-14 2011-03-30 Bayer Schering Pharma Aktiengesellschaft Fused imidazoles for cancer treatment
PE20090944A1 (es) 2007-08-14 2009-08-09 Bayer Schering Pharma Ag PIRIMIDINAS BICICLICAS FUSIONADAS COMO INHIBIDORES DE LA VIA Pi3K/AKT
WO2009086130A1 (en) 2007-12-21 2009-07-09 Wyeth Imidazo [1,2-b] pyridazine compounds as modulators of liver x receptors
WO2009148916A1 (en) 2008-06-03 2009-12-10 Merck & Co., Inc. Inhibitors of akt activity
JP2011522047A (ja) 2008-06-03 2011-07-28 メルク・シャープ・エンド・ドーム・コーポレイション Ａｋｔ活性の阻害剤
AR074072A1 (es) 2008-11-11 2010-12-22 Lilly Co Eli Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme
PA8854101A1 (es) 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
AU2010208480A1 (en) 2009-02-02 2011-07-28 Msd K.K. Inhibitors of Akt activity
US8614221B2 (en) 2009-03-11 2013-12-24 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
AR076936A1 (es) 2009-06-02 2011-07-20 Vitae Pharmaceuticals Inc Inhibidores de carbamato y urea de la 11 beta hidroxiesteroide deshidrogenasa 1
WO2012007345A2 (en) * 2010-07-12 2012-01-19 Bayer Pharma Aktiengesellschaft Substituted imidazo[1,2-a]pyrimidines and -pyridines
US8987273B2 (en) * 2010-07-28 2015-03-24 Bayer Intellectual Property Gmbh Substituted imidazo[1,2-B]pyridazines
EA024890B1 (ru) * 2011-04-07 2016-10-31 Байер Интеллектчуал Проперти Гмбх Имидазопиридазины в качестве ингибиторов akt киназы

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010091808A1 (en) * 2009-02-13 2010-08-19 Bayer Schering Pharma Aktiengesellschaft Fused pyrimidines
WO2011033265A1 (en) * 2009-09-18 2011-03-24 Almac Discovery Limited Pharmaceutical compounds

Also Published As

Publication number Publication date
KR20140022057A (ko) 2014-02-21
EA024890B1 (ru) 2016-10-31
EA201301130A1 (ru) 2014-07-30
WO2012136776A1 (en) 2012-10-11
ECSP13013008A (es) 2013-12-31
PL2694510T3 (pl) 2016-03-31
HRP20160011T1 (hr) 2016-02-12
ZA201307223B (en) 2014-12-23
SMT201600001B (it) 2016-02-25
ES2558780T3 (es) 2016-02-08
EP2694510A1 (en) 2014-02-12
CR20130515A (es) 2013-12-04
AU2012238589A1 (en) 2013-11-07
CO6862145A2 (es) 2014-02-10
CN103596957B (zh) 2016-12-07
PT2694510E (pt) 2016-02-08
SI2694510T1 (sl) 2016-02-29
US9604989B2 (en) 2017-03-28
AP2013007215A0 (en) 2013-10-31
JO3068B1 (ar) 2017-03-15
TW201245204A (en) 2012-11-16
CU20130135A7 (es) 2014-02-28
DOP2013000226A (es) 2013-11-15
TN2013000400A1 (en) 2015-03-30
MX2013011699A (es) 2014-01-31
JP5906303B2 (ja) 2016-04-20
HUE026323T2 (en) 2016-05-30
DK2694510T3 (en) 2016-01-18
UY34006A (es) 2012-10-31
AR087148A1 (es) 2014-02-26
SG193631A1 (en) 2013-11-29
ME02316B (me) 2016-06-20
GT201300238A (es) 2015-04-06
IL228567A0 (en) 2013-12-31
RS54480B1 (en) 2016-06-30
CL2013002878A1 (es) 2014-05-02
UA111739C2 (uk) 2016-06-10
CU24263B1 (es) 2017-07-04
EP2694510B1 (en) 2015-10-14
CN103596957A (zh) 2014-02-19
US9206185B2 (en) 2015-12-08
PE20141380A1 (es) 2014-10-18
MA35016B1 (fr) 2014-04-03
TWI535719B (zh) 2016-06-01
US20140113901A1 (en) 2014-04-24
NZ616270A (en) 2015-09-25
BR112013025777A2 (pt) 2016-12-20
MX336865B (es) 2016-02-04
AU2012238589B2 (en) 2017-02-16
US20150368250A1 (en) 2015-12-24
JP2014510127A (ja) 2014-04-24
NI201300105A (es) 2014-07-14
CA2832374A1 (en) 2012-10-11
CY1117163T1 (el) 2017-04-05

Similar Documents

Publication Publication Date Title
HK1210775A1 (en) Imidazotriazinecarbonitriles useful as kinase inhibitors
HK1200828A1 (en) Kinase inhibitors
HUE048834T2 (hu) Kináz inhibitorok
AP3597A (en) Imidazopyridazines as akt kinase inhibitors
HK1199880A1 (en) Benzonitrile derivatives as kinase inhibitors
EP2552208A4 (en) IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS
IL228103A0 (en) Amino-quinolines as kinase inhibitors
EP2552214A4 (en) PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS
EP2552211A4 (en) INDAZOLYL-PYRIMIDINE AS KINASEHEMMER
EP2685992A4 (en) AMINO-QUINOLINES AS KINASE INHIBITORS
IL229028A0 (en) Kinase inhibitors
HK1199873A1 (en) Kinase inhibitors
HK1201830A1 (en) Substituted imidazopyrazines as akt kinase inhibitors akt
SG11201500973WA (en) Amino-quinolines as kinase inhibitors
HK1201831A1 (en) Substituted pyrazolopyrimidines as akt kinase inhibitors akt
EP2763535A4 (en) AZAINDOLES AS INHIBITORS OF JANUS KINASE