AP2014007399A0 - Phenyl-3-AZA-bicycloÄ3.1.0Ühex-3-YL-methanones andthe use thereof as medicament - Google Patents
Phenyl-3-AZA-bicycloÄ3.1.0Ühex-3-YL-methanones andthe use thereof as medicamentInfo
- Publication number
- AP2014007399A0 AP2014007399A0 AP2014007399A AP2014007399A AP2014007399A0 AP 2014007399 A0 AP2014007399 A0 AP 2014007399A0 AP 2014007399 A AP2014007399 A AP 2014007399A AP 2014007399 A AP2014007399 A AP 2014007399A AP 2014007399 A0 AP2014007399 A0 AP 2014007399A0
- Authority
- AP
- ARIPO
- Prior art keywords
- methanones
- aza
- medicament
- phenyl
- andthe use
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11176468 | 2011-08-03 | ||
| PCT/EP2012/065140 WO2013017657A1 (en) | 2011-08-03 | 2012-08-02 | Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AP2014007399A0 true AP2014007399A0 (en) | 2014-01-31 |
Family
ID=46598566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2014007399A AP2014007399A0 (en) | 2011-08-03 | 2012-08-02 | Phenyl-3-AZA-bicycloÄ3.1.0Ühex-3-YL-methanones andthe use thereof as medicament |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US9012489B2 (lt) |
| EP (1) | EP2739615B1 (lt) |
| JP (1) | JP5850589B2 (lt) |
| KR (1) | KR101944686B1 (lt) |
| CN (2) | CN103797005B (lt) |
| AP (1) | AP2014007399A0 (lt) |
| AR (1) | AR087436A1 (lt) |
| AU (1) | AU2012292036C1 (lt) |
| BR (1) | BR112014001642B1 (lt) |
| CA (1) | CA2843805C (lt) |
| CL (1) | CL2014000246A1 (lt) |
| CO (1) | CO6870037A2 (lt) |
| CY (1) | CY1119326T1 (lt) |
| DK (1) | DK2739615T3 (lt) |
| EA (1) | EA024933B1 (lt) |
| EC (1) | ECSP14013221A (lt) |
| ES (1) | ES2623006T3 (lt) |
| GE (1) | GEP20166483B (lt) |
| HK (1) | HK1193100A1 (lt) |
| HR (1) | HRP20170695T1 (lt) |
| HU (1) | HUE033134T2 (lt) |
| IL (1) | IL229962A (lt) |
| LT (1) | LT2739615T (lt) |
| MA (1) | MA35286B1 (lt) |
| ME (1) | ME02672B (lt) |
| MX (1) | MX347828B (lt) |
| MY (1) | MY167396A (lt) |
| PE (1) | PE20141352A1 (lt) |
| PL (1) | PL2739615T3 (lt) |
| PT (1) | PT2739615T (lt) |
| RS (1) | RS55927B1 (lt) |
| SI (1) | SI2739615T1 (lt) |
| TN (1) | TN2014000044A1 (lt) |
| TW (1) | TWI543974B (lt) |
| UA (1) | UA114405C2 (lt) |
| UY (1) | UY34239A (lt) |
| WO (1) | WO2013017657A1 (lt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR122021017872B1 (pt) | 2014-06-06 | 2021-11-23 | Basf Se | Uso dos compostos, composição agroquímica e método para o combate dos fungos fitopatogênicos |
| AR106679A1 (es) | 2015-11-13 | 2018-02-07 | Basf Se | Oxadiazoles sustituidos para combatir hongos fitopatógenos |
| US10492494B2 (en) | 2015-11-13 | 2019-12-03 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| JP2018537457A (ja) | 2015-11-19 | 2018-12-20 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | 植物病原菌を駆除するための置換オキサジアゾール |
| US10986839B2 (en) | 2016-04-11 | 2021-04-27 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| WO2018224455A1 (en) | 2017-06-07 | 2018-12-13 | Basf Se | Substituted cyclopropyl derivatives |
| CN113784966B (zh) | 2019-05-01 | 2024-07-19 | 勃林格殷格翰国际有限公司 | Glyt1抑制剂的固体形式 |
| CN115279372A (zh) | 2020-01-09 | 2022-11-01 | 迪斯克医药公司 | 用甘氨酸转运蛋白抑制剂治疗红细胞生成性原卟啉病、x连锁原卟啉病或先天性红细胞生成性卟啉病的方法 |
| JP2023537963A (ja) | 2020-08-13 | 2023-09-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 統合失調症に伴う認知機能障害に対する処置法 |
| MX2023004293A (es) | 2020-10-13 | 2023-05-03 | Boehringer Ingelheim Int | Proceso de reelaboracion. |
| IL313067A (en) * | 2021-11-24 | 2024-07-01 | Maplight Therapeutics Inc | Methods for treating neurological disorders |
| CN114957087A (zh) * | 2022-04-13 | 2022-08-30 | 湖南复瑞生物医药技术有限责任公司 | 一种帕罗韦德中间体制备方法 |
| WO2023237103A1 (zh) * | 2022-06-10 | 2023-12-14 | 成都百裕制药股份有限公司 | 吡咯烷衍生物、药物组合物及其在医药上的应用 |
| WO2024042043A1 (en) | 2022-08-24 | 2024-02-29 | Boehringer Ingelheim International Gmbh | A scalable process for the preparation of a glyt-1 inhibitor |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003214535B2 (en) * | 2003-04-10 | 2009-09-03 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| DK1680124T3 (en) | 2003-10-14 | 2017-08-21 | Pfizer Prod Inc | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors |
| DE102004035280A1 (de) | 2004-07-21 | 2006-03-16 | Robert Bosch Gmbh | Kraftstoffinjektor mit direkter mehrstufiger Einspritzventilgliedansteuerung |
| BRPI0519744A2 (pt) * | 2005-01-06 | 2009-03-10 | Hoffmann La Roche | metanonas de fenila substituÍda por sulfanila como inibidores de transportador de glicina 1 (glyt-1) para o tratamento de distérbios neurolàgicos e neuropsiquiÁtricos |
| BRPI0519794A2 (pt) * | 2005-01-07 | 2009-03-17 | Hoffmann La Roche | derivados de [4-(heteroaril)piperazin-1-il]-(fenil 2,5-substituìdo)metanona como inibidores de transportador de glicina 1 (glyt-1) para o tratamento de distúrbios neurológicos e neuropsiquiátricos |
| RS51204B (sr) * | 2005-02-07 | 2010-12-31 | F. Hoffmann-La Roche Ag. | Heterociklični supstituisani fenil metanoni kao inhibitori glicin transportera 1 |
| CA2653355C (en) * | 2006-06-22 | 2014-04-15 | F. Hoffmann-La Roche Ag | Substituted phenyl methanone derivatives |
| DK2041088T3 (da) | 2006-06-28 | 2014-04-07 | Amgen Inc | Glycintransporter-1 inhibitorer |
| AR064561A1 (es) * | 2006-12-28 | 2009-04-08 | Actelion Pharmaceuticals Ltd | Derivados de 2-aza-biciclo[3.1.0]hexano y su uso en la preparacion de un medicamento para el tratamiento de enfermedades relacionadas con disfunciones generales del sistema de la orexina. |
| UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| JP2012514006A (ja) * | 2008-12-29 | 2012-06-21 | バンダービルト ユニバーシティ | ３．１．０二環式ＧｌｙＴ１阻害剤ならびにその作製および使用の方法 |
| AU2010209816A1 (en) | 2009-01-27 | 2011-08-11 | F. Hoffmann-La Roche Ag | Aroylamino - and heteroaroylamino-substituted piperidines as GlyT-1 inhibitors |
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2012
- 2012-07-27 US US13/560,063 patent/US9012489B2/en active Active
- 2012-08-01 TW TW101127831A patent/TWI543974B/zh active
- 2012-08-02 UA UAA201402017A patent/UA114405C2/uk unknown
- 2012-08-02 PT PT127410223T patent/PT2739615T/pt unknown
- 2012-08-02 DK DK12741022.3T patent/DK2739615T3/en active
- 2012-08-02 KR KR1020147002515A patent/KR101944686B1/ko active IP Right Grant
- 2012-08-02 CN CN201280042794.7A patent/CN103797005B/zh active Active
- 2012-08-02 AU AU2012292036A patent/AU2012292036C1/en active Active
- 2012-08-02 HU HUE12741022A patent/HUE033134T2/en unknown
- 2012-08-02 JP JP2014523332A patent/JP5850589B2/ja active Active
- 2012-08-02 AR ARP120102828 patent/AR087436A1/es active IP Right Grant
- 2012-08-02 MY MYPI2014000271A patent/MY167396A/en unknown
- 2012-08-02 EA EA201400183A patent/EA024933B1/ru not_active IP Right Cessation
- 2012-08-02 PE PE2014000158A patent/PE20141352A1/es active IP Right Grant
- 2012-08-02 CN CN201610214305.1A patent/CN105837562B/zh active Active
- 2012-08-02 RS RS20170472A patent/RS55927B1/sr unknown
- 2012-08-02 AP AP2014007399A patent/AP2014007399A0/xx unknown
- 2012-08-02 ES ES12741022.3T patent/ES2623006T3/es active Active
- 2012-08-02 PL PL12741022T patent/PL2739615T3/pl unknown
- 2012-08-02 WO PCT/EP2012/065140 patent/WO2013017657A1/en active Application Filing
- 2012-08-02 EP EP12741022.3A patent/EP2739615B1/en active Active
- 2012-08-02 LT LTEP12741022.3T patent/LT2739615T/lt unknown
- 2012-08-02 MX MX2014001252A patent/MX347828B/es active IP Right Grant
- 2012-08-02 ME MEP-2017-92A patent/ME02672B/me unknown
- 2012-08-02 CA CA2843805A patent/CA2843805C/en active Active
- 2012-08-02 BR BR112014001642-9A patent/BR112014001642B1/pt active IP Right Grant
- 2012-08-02 GE GEAP201213402A patent/GEP20166483B/en unknown
- 2012-08-02 SI SI201230968A patent/SI2739615T1/sl unknown
- 2012-08-03 UY UY34239A patent/UY34239A/es unknown
-
2013
- 2013-12-17 IL IL229962A patent/IL229962A/en active IP Right Grant
-
2014
- 2014-01-31 MA MA36719A patent/MA35286B1/fr unknown
- 2014-01-31 TN TNP2014000044A patent/TN2014000044A1/en unknown
- 2014-01-31 CL CL2014000246A patent/CL2014000246A1/es unknown
- 2014-02-03 CO CO14022058A patent/CO6870037A2/es active IP Right Grant
- 2014-02-26 EC ECSP14013221 patent/ECSP14013221A/es unknown
- 2014-07-02 HK HK14106631.6A patent/HK1193100A1/zh unknown
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2017
- 2017-05-10 HR HRP20170695TT patent/HRP20170695T1/hr unknown
- 2017-06-06 CY CY20171100591T patent/CY1119326T1/el unknown
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