AP1A - Polycyclic aromatic compounds - Google Patents

Polycyclic aromatic compounds Download PDF

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Publication number
AP1A
AP1A APAP/P/1984/000003A AP8400003A AP1A AP 1 A AP1 A AP 1A AP 8400003 A AP8400003 A AP 8400003A AP 1 A AP1 A AP 1A
Authority
AP
ARIPO
Prior art keywords
propanediol
methyl
amino
methy
thy
Prior art date
Application number
APAP/P/1984/000003A
Other languages
English (en)
Other versions
AP8400003A0 (en
Inventor
Kenneth Walter Bair
Original Assignee
The Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB838313571A priority Critical patent/GB8313571D0/en
Priority to US06/499,813 priority patent/US4530800A/en
Priority to NO841954A priority patent/NO157416C/no
Priority to SU843744951A priority patent/SU1535377A3/ru
Priority to GB08412485A priority patent/GB2140416B/en
Priority to DD84263086A priority patent/DD223439A5/de
Priority to GR74735A priority patent/GR82278B/el
Priority to EP84105584A priority patent/EP0125701B1/en
Priority to PT78586A priority patent/PT78586A/pt
Priority to KR1019840002647A priority patent/KR910000854B1/ko
Priority to JP59099656A priority patent/JPS59225150A/ja
Priority to CS364584A priority patent/CS273314B2/cs
Priority to AU28098/84A priority patent/AU572509B2/en
Priority to DK242284A priority patent/DK242284A/da
Priority to ZA843708A priority patent/ZA843708B/xx
Priority to IE120384A priority patent/IE58416B1/en
Priority to EP84105585A priority patent/EP0125702B1/en
Priority to CA000454514A priority patent/CA1222750A/en
Priority to NZ208168A priority patent/NZ208168A/en
Priority to FI841966A priority patent/FI85263C/fi
Priority to ES532512A priority patent/ES8603376A1/es
Priority to JP59099655A priority patent/JPS59225149A/ja
Priority to DE8484105584T priority patent/DE3473141D1/de
Priority to MC841705A priority patent/MC1595A1/xx
Priority to DE8484105585T priority patent/DE3465296D1/de
Priority to IL71854A priority patent/IL71851A/xx
Priority to EG315/84A priority patent/EG17595A/xx
Priority to HU841886A priority patent/HU197875B/hu
Priority to PH30683A priority patent/PH22265A/en
Priority to PL1984254244A priority patent/PL145420B1/pl
Priority to PL1984247759A priority patent/PL144294B1/pl
Priority to PL1984254245A priority patent/PL145421B1/pl
Application filed by The Wellcome Foundation Ltd filed Critical The Wellcome Foundation Ltd
Priority to APAP/P/1984/000003A priority patent/AP1A/en
Priority to US06/661,802 priority patent/US4719049A/en
Priority to US06/661,803 priority patent/US4719236A/en
Priority to US06/661,674 priority patent/US4720587A/en
Publication of AP8400003A0 publication Critical patent/AP8400003A0/xx
Priority to ES540161A priority patent/ES8603801A1/es
Priority to ES540160A priority patent/ES8604487A1/es
Priority to US06/725,157 priority patent/US4719047A/en
Application granted granted Critical
Publication of AP1A publication Critical patent/AP1A/en
Priority to SU853947162A priority patent/SU1466648A3/ru
Priority to SU853982431A priority patent/SU1447277A3/ru
Priority to US07/102,275 priority patent/US4820873A/en
Priority to AU13052/88A priority patent/AU599215B2/en
Priority to SG223/89A priority patent/SG22389G/en
Priority to HK450/89A priority patent/HK45089A/en
Priority to CY1486A priority patent/CY1486A/xx
Priority to JP2144246A priority patent/JPH0684336B2/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/14—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to acyclic carbon atoms
    • C07C205/15—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/62—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings
    • C07D263/64—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings linked in positions 2 and 2' by chains containing six-membered aromatic rings or ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/48—Chrysenes; Hydrogenated chrysenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/50—Pyrenes; Hydrogenated pyrenes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
APAP/P/1984/000003A 1983-05-17 1984-07-16 Polycyclic aromatic compounds AP1A (en)

Priority Applications (47)

Application Number Priority Date Filing Date Title
GB838313571A GB8313571D0 (en) 1983-05-17 1983-05-17 Chemical compounds
US06/499,813 US4530800A (en) 1983-05-17 1983-06-01 Perylene derivatives
NO841954A NO157416C (no) 1983-05-17 1984-05-16 Analogifremgangsmaate for fremstilling av polycykliske aromatiske alkanolderivater med biocid virkning.
SU843744951A SU1535377A3 (ru) 1983-05-17 1984-05-16 Способ получени производных ароматических аминоспиртов или их фармакологически приемлемых солей
GB08412485A GB2140416B (en) 1983-05-17 1984-05-16 Polycyclic aromatic compounds
DD84263086A DD223439A5 (de) 1983-05-17 1984-05-16 Verfahren zur herstellung von alkanolderivaten
GR74735A GR82278B (en, 2012) 1983-05-17 1984-05-16
EP84105584A EP0125701B1 (en) 1983-05-17 1984-05-16 Polycyclic aromatic compounds
PT78586A PT78586A (en) 1983-05-17 1984-05-16 Polycyclic aromatic compounds
KR1019840002647A KR910000854B1 (ko) 1983-05-17 1984-05-16 살균성 화합물의 제조방법
JP59099656A JPS59225150A (ja) 1983-05-17 1984-05-16 殺生物性芳香族化合物、その合成および医薬としてのその使用
CS364584A CS273314B2 (en) 1983-05-17 1984-05-16 Method of polycyclic aromatic alkanol derivatives preparation
AU28098/84A AU572509B2 (en) 1983-05-17 1984-05-16 Polycylic aromatic alkanol derivatives with anti-tumour activity
DK242284A DK242284A (da) 1983-05-17 1984-05-16 Polycycliske aromatiske forbindelser, fremstilling heraf og mellemprodukter herfor
ZA843708A ZA843708B (en) 1983-05-17 1984-05-16 Polycyclic aromatic compounds
IE120384A IE58416B1 (en) 1983-05-17 1984-05-16 Polycyclic aromatic compounds
EP84105585A EP0125702B1 (en) 1983-05-17 1984-05-16 Polycyclic aromatic compounds
CA000454514A CA1222750A (en) 1983-05-17 1984-05-16 Polycyclic aromatic compounds
NZ208168A NZ208168A (en) 1983-05-17 1984-05-16 Polycyclic aromatic alkanol derivatives and pharmaceutical compositions
FI841966A FI85263C (fi) 1983-05-17 1984-05-16 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara polykarbocykliska aromatiska alkanolderivat och nya mellanprodukter.
ES532512A ES8603376A1 (es) 1983-05-17 1984-05-16 Un metodo para preparar derivados de alcanol aromaticos policiclicos
JP59099655A JPS59225149A (ja) 1983-05-17 1984-05-16 殺生物性多環化合物，その合成法，その中間体，それを含有する製剤および医薬としてのその使用
DE8484105584T DE3473141D1 (en) 1983-05-17 1984-05-16 Polycyclic aromatic compounds
MC841705A MC1595A1 (fr) 1983-05-17 1984-05-16 Derives d'alcanols aromatiques polycycliques doues d'activite biocide
DE8484105585T DE3465296D1 (en) 1983-05-17 1984-05-16 Polycyclic aromatic compounds
IL71854A IL71851A (en) 1983-05-17 1984-05-16 Polycyclic aromatic alkanol derivatives,their preparation and pharmaceutical compositions containing them
EG315/84A EG17595A (en) 1983-05-17 1984-05-16 Aromatic biocidal compounds,their sunthesis and intermediates therefor,formulations containing them,and their use in medicine
HU841886A HU197875B (en) 1983-05-17 1984-05-16 Process for producing polycyclic aromatic amino-alcanol derivatives and pharmaceutical compositions containing themas active components
PH30683A PH22265A (en) 1983-05-17 1984-05-16 Biocidal polycyclic aromatic amino alkanol derivatives
PL1984254244A PL145420B1 (en) 1983-05-17 1984-05-17 Method of obtaining novel substituted polycarbocyclic aromatic amine alkanoles
PL1984247759A PL144294B1 (en) 1983-05-17 1984-05-17 Method of obtaining novel polycyclic aromatic compounds
PL1984254245A PL145421B1 (en) 1983-05-17 1984-05-17 Method of obtaining novel substituted polycarbocyclic aromatic amine alkanoles
APAP/P/1984/000003A AP1A (en) 1983-05-17 1984-07-16 Polycyclic aromatic compounds
US06/661,802 US4719049A (en) 1983-05-17 1984-10-17 Anthracene derivatives
US06/661,803 US4719236A (en) 1983-05-17 1984-10-17 Perylene derivatives
US06/661,674 US4720587A (en) 1983-05-17 1984-10-17 Fluoranthene derivatives
ES540161A ES8603801A1 (es) 1983-05-17 1985-02-06 Un metodo para preparar derivados de alcanoles aromaticos policiclicos
ES540160A ES8604487A1 (es) 1983-05-17 1985-02-06 Un metodo para preparar derivados de alcanoles aromaticos policiclicos
US06/725,157 US4719047A (en) 1983-05-17 1985-04-22 Anthracene derivatives
SU853947162A SU1466648A3 (ru) 1983-05-17 1985-08-30 Способ получени полициклических ароматических производных алканола или его моноалкилового С @ -С @ простого эфира, или его соли кислоты
SU853982431A SU1447277A3 (ru) 1983-05-17 1985-12-02 Способ получени полициклических ароматических производных алканола или их солей
US07/102,275 US4820873A (en) 1983-05-17 1987-09-28 Pyrene derivatives
AU13052/88A AU599215B2 (en) 1983-05-17 1988-03-11 A novel chemical intermediate of the synthesis of aromatic biocidal compounds
SG223/89A SG22389G (en) 1983-05-17 1989-04-08 Polycyclic aromatic compounds
HK450/89A HK45089A (en) 1983-05-17 1989-06-01 Polycyclic aromatic compounds
CY1486A CY1486A (en) 1983-05-17 1989-12-08 Polycyclic aromatic compounds
JP2144246A JPH0684336B2 (ja) 1983-05-17 1990-06-01 殺生物性芳香族化合物、その合成および医薬としてのその使用

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GB838313571A GB8313571D0 (en) 1983-05-17 1983-05-17 Chemical compounds
APAP/P/1984/000003A AP1A (en) 1983-05-17 1984-07-16 Polycyclic aromatic compounds

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US4720587A (en) 1988-01-19
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GB8313571D0 (en) 1983-06-22
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US4719236A (en) 1988-01-12
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US4820873A (en) 1989-04-11
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