AP174A - Antiviral tetrahydroimidazo (1,4) benzodiazepines. - Google Patents

Antiviral tetrahydroimidazo (1,4) benzodiazepines. Download PDF

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Publication number
AP174A
AP174A APAP/P/1990/000205A AP9000205A AP174A AP 174 A AP174 A AP 174A AP 9000205 A AP9000205 A AP 9000205A AP 174 A AP174 A AP 174A
Authority
AP
ARIPO
Prior art keywords
formula
hydrogen
alkyl
reaction
aryl
Prior art date
Application number
APAP/P/1990/000205A
Other languages
English (en)
Other versions
AP9000205A0 (en
Inventor
Michael Joseph Kukla
Henry Joseph Breslin
Alfons Herman Margaretha Raeymaekers
GELDER Josephus Ludovicus Huberstus VAN
Paul Adriaan Jan Janssen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AP9000205A0 publication Critical patent/AP9000205A0/xx
Application granted granted Critical
Publication of AP174A publication Critical patent/AP174A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
APAP/P/1990/000205A 1989-09-13 1990-09-11 Antiviral tetrahydroimidazo (1,4) benzodiazepines. AP174A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40662589A 1989-09-13 1989-09-13

Publications (2)

Publication Number Publication Date
AP9000205A0 AP9000205A0 (en) 1990-10-31
AP174A true AP174A (en) 1992-03-16

Family

ID=23608794

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1990/000205A AP174A (en) 1989-09-13 1990-09-11 Antiviral tetrahydroimidazo (1,4) benzodiazepines.

Country Status (30)

Country Link
EP (2) EP0417840B1 (fi)
JP (1) JPH05500053A (fi)
KR (1) KR927003596A (fi)
CN (1) CN1029971C (fi)
AP (1) AP174A (fi)
AT (1) ATE115144T1 (fi)
AU (1) AU635328B2 (fi)
BG (1) BG60681B1 (fi)
CA (1) CA2064782A1 (fi)
DE (1) DE69014784T2 (fi)
DK (1) DK0417840T3 (fi)
ES (1) ES2067652T3 (fi)
FI (1) FI98816C (fi)
GR (1) GR3015270T3 (fi)
HU (1) HUT62297A (fi)
IE (1) IE65357B1 (fi)
IL (3) IL108074A (fi)
MA (1) MA21948A1 (fi)
MY (1) MY106961A (fi)
NO (1) NO300328B1 (fi)
NZ (1) NZ235137A (fi)
OA (1) OA09565A (fi)
PT (1) PT95303B (fi)
RO (1) RO109199B1 (fi)
RU (1) RU2099341C1 (fi)
TN (1) TNSN90121A1 (fi)
TW (1) TW199160B (fi)
WO (1) WO1991004255A1 (fi)
YU (1) YU169090A (fi)
ZA (1) ZA907278B (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ238664A (en) * 1990-07-06 1992-12-23 Janssen Pharmaceutica Nv Substituted tetrahydroimidazo(1,4)benzodiazepin-2-(thi)ones and pharmaceutical anti-viral compositions
GB9018601D0 (en) * 1990-08-24 1990-10-10 Fujisawa Pharmaceutical Co Tricyclic compounds
EP0475231A1 (en) * 1990-09-10 1992-03-18 F. Hoffmann-La Roche Ag Benzodiazepines

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1595745A (en) * 1977-02-25 1981-08-19 Lilly Co Eli Pyrroloquinoxalinones and pyrrolobenzodiazepinones
EP0336466A1 (en) * 1988-03-18 1989-10-11 Janssen Pharmaceutica N.V. Antiviral tetrahydroimidazo (1,4) benzodiazepin-2-ones
EP0384522A1 (en) * 1989-02-23 1990-08-29 Janssen Pharmaceutica N.V. Antiviral tetrahydroimidazo[1,4]benzodiazepin-2-thiones

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1595745A (en) * 1977-02-25 1981-08-19 Lilly Co Eli Pyrroloquinoxalinones and pyrrolobenzodiazepinones
EP0336466A1 (en) * 1988-03-18 1989-10-11 Janssen Pharmaceutica N.V. Antiviral tetrahydroimidazo (1,4) benzodiazepin-2-ones
EP0384522A1 (en) * 1989-02-23 1990-08-29 Janssen Pharmaceutica N.V. Antiviral tetrahydroimidazo[1,4]benzodiazepin-2-thiones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NATURE, Vol. 343, 01.02.90, pp. 470-474 *

Also Published As

Publication number Publication date
CA2064782A1 (en) 1991-03-14
DK0417840T3 (da) 1995-02-13
IL95638A0 (en) 1991-06-30
DE69014784T2 (de) 1995-04-13
RO109199B1 (ro) 1994-12-30
TW199160B (fi) 1993-02-01
NO300328B1 (no) 1997-05-12
IL95638A (en) 1995-01-24
FI98816C (fi) 1997-08-25
NO920505L (no) 1992-02-07
TNSN90121A1 (fr) 1991-03-05
ATE115144T1 (de) 1994-12-15
EP0417840A1 (en) 1991-03-20
CN1050192A (zh) 1991-03-27
YU169090A (sh) 1993-10-20
OA09565A (fr) 1993-01-31
EP0417840B1 (en) 1994-12-07
ES2067652T3 (es) 1995-04-01
FI98816B (fi) 1997-05-15
AU635328B2 (en) 1993-03-18
AP9000205A0 (en) 1990-10-31
NO920505D0 (no) 1992-02-07
JPH05500053A (ja) 1993-01-14
CN1029971C (zh) 1995-10-11
MY106961A (en) 1995-08-30
NZ235137A (en) 1992-02-25
IE903313A1 (en) 1991-04-10
HUT62297A (en) 1993-04-28
AU6293490A (en) 1991-04-18
BG96041A (bg) 1993-12-24
PT95303A (pt) 1991-05-22
BG60681B1 (bg) 1995-12-29
KR927003596A (ko) 1992-12-18
DE69014784D1 (de) 1995-01-19
RU2099341C1 (ru) 1997-12-20
WO1991004255A1 (en) 1991-04-04
IL108074A (en) 1995-06-29
MA21948A1 (fr) 1991-04-01
IE65357B1 (en) 1995-10-18
ZA907278B (en) 1992-05-27
PT95303B (pt) 1997-06-30
GR3015270T3 (en) 1995-06-30
IL108074A0 (en) 1994-04-12
EP0491751A1 (en) 1992-07-01
FI921070A0 (fi) 1992-03-12

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