MX2010009850A - Analogos de insulina acilados y etabilizados contra proteasas. - Google Patents

Analogos de insulina acilados y etabilizados contra proteasas.

Info

Publication number
MX2010009850A
MX2010009850A MX2010009850A MX2010009850A MX2010009850A MX 2010009850 A MX2010009850 A MX 2010009850A MX 2010009850 A MX2010009850 A MX 2010009850A MX 2010009850 A MX2010009850 A MX 2010009850A MX 2010009850 A MX2010009850 A MX 2010009850A
Authority
MX
Mexico
Prior art keywords
insulin analogues
acylated insulin
protease stabilized
protease
stabilized
Prior art date
Application number
MX2010009850A
Other languages
English (en)
Inventor
Palle Jakobsen
Peter Madsen
Janos Tibor Kodra
Patrick William Garibay
Thomas Hoeg-Jensen
Tina Moller Tagmose
Thomas Borglum Kjeldsen
Tine Glendorf
Jacob Sten Petersen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of MX2010009850A publication Critical patent/MX2010009850A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describen análogos de insulina acilados novedosos que tienen resistencia hacia proteasas que pueden, de manera efectiva, administrarse pulmonar u oralmente. Los análogos de insulina contienen B25H y A14E o A14H.
MX2010009850A 2008-03-18 2009-03-13 Analogos de insulina acilados y etabilizados contra proteasas. MX2010009850A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08102708 2008-03-18
EP08170231 2008-11-28
PCT/EP2009/053017 WO2009115469A1 (en) 2008-03-18 2009-03-13 Protease stabilized, acylated insulin analogues

Publications (1)

Publication Number Publication Date
MX2010009850A true MX2010009850A (es) 2010-09-30

Family

ID=40673840

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010009850A MX2010009850A (es) 2008-03-18 2009-03-13 Analogos de insulina acilados y etabilizados contra proteasas.

Country Status (18)

Country Link
US (5) US8691759B2 (es)
EP (4) EP2254906B1 (es)
JP (4) JP5749155B2 (es)
KR (3) KR101755529B1 (es)
CN (1) CN102037008B (es)
AU (1) AU2009226910B2 (es)
BR (1) BRPI0910348B1 (es)
CA (1) CA2718738C (es)
DK (2) DK2254906T3 (es)
ES (2) ES2609288T3 (es)
HU (2) HUE032287T2 (es)
IL (3) IL207748A0 (es)
MX (1) MX2010009850A (es)
PL (2) PL2254906T3 (es)
PT (2) PT2910570T (es)
RU (1) RU2571857C2 (es)
WO (1) WO2009115469A1 (es)
ZA (1) ZA201006126B (es)

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US20190112348A1 (en) 2019-04-18
AU2009226910A1 (en) 2009-09-24
EP2910570B1 (en) 2016-10-12
DK2254906T3 (en) 2017-01-23
BRPI0910348B1 (pt) 2021-06-29
US20150210748A1 (en) 2015-07-30
EP2254906A1 (en) 2010-12-01
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US10259856B2 (en) 2019-04-16
CN102037008A (zh) 2011-04-27
PT2254906T (pt) 2017-01-03
ES2611007T3 (es) 2017-05-04
US20150210747A1 (en) 2015-07-30
US8691759B2 (en) 2014-04-08
CA2718738C (en) 2019-05-07
DK2910570T3 (en) 2017-01-30
KR20110004366A (ko) 2011-01-13
EP2254906B1 (en) 2016-10-05
JP2015155421A (ja) 2015-08-27
PT2910570T (pt) 2017-01-24
KR20160073431A (ko) 2016-06-24
RU2571857C2 (ru) 2015-12-20
KR101755529B1 (ko) 2017-07-07
US9045560B2 (en) 2015-06-02
CN102037008B (zh) 2016-08-31
HUE032284T2 (en) 2017-09-28
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ZA201006126B (en) 2011-11-30
IL250549B (en) 2018-12-31
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US20140073564A1 (en) 2014-03-13

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