JPS5767548A - Insulin analog and its preparation - Google Patents
Insulin analog and its preparationInfo
- Publication number
- JPS5767548A JPS5767548A JP14403280A JP14403280A JPS5767548A JP S5767548 A JPS5767548 A JP S5767548A JP 14403280 A JP14403280 A JP 14403280A JP 14403280 A JP14403280 A JP 14403280A JP S5767548 A JPS5767548 A JP S5767548A
- Authority
- JP
- Japan
- Prior art keywords
- insulin
- amino acid
- insulin analog
- derivative
- diabetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
NEW MATERIAL:An insulin analog in which the B chain at the 30-position is substituted by an amino acid or a derivative thereof.
EXAMPLE: [B30-Leucine]-hog insulin.
USE: A remedy for diabetes, particularly useful for diabetic patiens resistant to insulin. The antibody production can be reduced to a small amount by using in general diabetic partients.
PROCESS: Des-B30-insulin obtained from various animals is condensed with a desired ≥5C D- or L-amino acid or a derivative thereof to give the aimed insulin analog. The condensation reaction is carried out by using a protease having the ability to cleave the carboxyl side of a basic amino acid residue, e.g. trypsin.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14403280A JPS5767548A (en) | 1980-10-14 | 1980-10-14 | Insulin analog and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14403280A JPS5767548A (en) | 1980-10-14 | 1980-10-14 | Insulin analog and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5767548A true JPS5767548A (en) | 1982-04-24 |
Family
ID=15352735
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14403280A Pending JPS5767548A (en) | 1980-10-14 | 1980-10-14 | Insulin analog and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5767548A (en) |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0137361A2 (en) * | 1983-09-23 | 1985-04-17 | Hoechst Aktiengesellschaft | Insulin derivatives modified in position B 30, process for their preparation, their vuse and pharmaceutical agents for the treatment of diabetes mellitus |
EP0884053A1 (en) * | 1997-06-13 | 1998-12-16 | Eli Lilly And Company | Stable insulin formulations |
US6011007A (en) * | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
US6251856B1 (en) | 1995-03-17 | 2001-06-26 | Novo Nordisk A/S | Insulin derivatives |
WO2001052937A1 (en) * | 2000-01-24 | 2001-07-26 | Medtronic Minimed, Inc. | Mixed buffer system for stabilizing polypeptide formulations |
EP1283051A1 (en) * | 1997-06-13 | 2003-02-12 | Eli Lilly And Company | Stable insulin formulations |
US6869930B1 (en) | 1993-09-17 | 2005-03-22 | Novo Nordisk A/S | Acylated insulin |
WO2006082204A1 (en) | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
EP2033662A1 (en) | 2004-01-21 | 2009-03-11 | Novo Nordisk Health Care AG | Transglutaminase mediated conjugation of peptides |
EP2107069A2 (en) | 2003-08-05 | 2009-10-07 | Novo Nordisk A/S | Novel insulin derivatives |
EP2264066A2 (en) | 2003-08-05 | 2010-12-22 | Novo Nordisk A/S | Novel insulin derivatives |
EP2292653A1 (en) | 2005-02-02 | 2011-03-09 | Novo Nordisk A/S | Novel insulin derivatives |
US8710001B2 (en) | 2006-07-31 | 2014-04-29 | Novo Nordisk A/S | PEGylated, extended insulins |
US9018161B2 (en) | 2006-09-22 | 2015-04-28 | Novo Nordisk A/S | Protease resistant insulin analogues |
US9034818B2 (en) | 2007-06-13 | 2015-05-19 | Novo Nordisk A/S | Pharmaceutical formulations comprising an insulin derivative |
US9260502B2 (en) | 2008-03-14 | 2016-02-16 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
US9387176B2 (en) | 2007-04-30 | 2016-07-12 | Novo Nordisk A/S | Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein |
US9481721B2 (en) | 2012-04-11 | 2016-11-01 | Novo Nordisk A/S | Insulin formulations |
US9603904B2 (en) | 2008-10-30 | 2017-03-28 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
US9688737B2 (en) | 2008-03-18 | 2017-06-27 | Novo Nordisk A/S | Protease stabilized acylated insulin analogues |
US9896496B2 (en) | 2013-10-07 | 2018-02-20 | Novo Nordisk A/S | Derivative of an insulin analogue |
US10137172B2 (en) | 2013-04-30 | 2018-11-27 | Novo Nordisk A/S | Administration regime |
US10265385B2 (en) | 2016-12-16 | 2019-04-23 | Novo Nordisk A/S | Insulin containing pharmaceutical compositions |
US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
US10596229B2 (en) | 2010-10-27 | 2020-03-24 | Novo Nordisk A/S | Method of treating diabetes mellitus by administration, at specifically defined intervals, of a derivative of a naturally occurring insulin or insulin analogue, the derivative having a prolonged profile of action |
US11167035B2 (en) | 2005-12-28 | 2021-11-09 | Novo Nordisk A/S | Insulin compositions and method of making a composition |
-
1980
- 1980-10-14 JP JP14403280A patent/JPS5767548A/en active Pending
Cited By (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6094999A (en) * | 1983-09-23 | 1985-05-28 | ヘキスト・アクチエンゲゼルシヤフト | Insulin derivative and manufacture |
EP0137361B1 (en) * | 1983-09-23 | 1990-05-16 | Hoechst Aktiengesellschaft | Insulin derivatives modified in position b 30, process for their preparation, their vuse and pharmaceutical agents for the treatment of diabetes mellitus |
EP0137361A2 (en) * | 1983-09-23 | 1985-04-17 | Hoechst Aktiengesellschaft | Insulin derivatives modified in position B 30, process for their preparation, their vuse and pharmaceutical agents for the treatment of diabetes mellitus |
US6011007A (en) * | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
US6869930B1 (en) | 1993-09-17 | 2005-03-22 | Novo Nordisk A/S | Acylated insulin |
US6620780B2 (en) | 1995-03-17 | 2003-09-16 | Novo Nordisk A/S | Insulin derivatives |
US7229964B2 (en) | 1995-03-17 | 2007-06-12 | Novo Nordisk A/S | Insulin derivatives |
US6251856B1 (en) | 1995-03-17 | 2001-06-26 | Novo Nordisk A/S | Insulin derivatives |
US6034054A (en) * | 1997-06-13 | 2000-03-07 | Eli Lilly And Company | Stable insulin formulations |
CZ299637B6 (en) * | 1997-06-13 | 2008-10-01 | Eli Lilly And Company | Stable insulin formulations |
EP1283051A1 (en) * | 1997-06-13 | 2003-02-12 | Eli Lilly And Company | Stable insulin formulations |
US6551992B1 (en) | 1997-06-13 | 2003-04-22 | Eli Lilly And Company | Stable insulin formulations |
EP0884053A1 (en) * | 1997-06-13 | 1998-12-16 | Eli Lilly And Company | Stable insulin formulations |
WO2001052937A1 (en) * | 2000-01-24 | 2001-07-26 | Medtronic Minimed, Inc. | Mixed buffer system for stabilizing polypeptide formulations |
EP2264066A2 (en) | 2003-08-05 | 2010-12-22 | Novo Nordisk A/S | Novel insulin derivatives |
EP2107069A2 (en) | 2003-08-05 | 2009-10-07 | Novo Nordisk A/S | Novel insulin derivatives |
US8828923B2 (en) | 2003-08-05 | 2014-09-09 | Novo Nordisk A/S | Insulin derivatives |
EP2264065A2 (en) | 2003-08-05 | 2010-12-22 | Novo Nordisk A/S | Novel Insulin Derivatives |
EP2275439A2 (en) | 2003-08-05 | 2011-01-19 | Novo Nordisk A/S | Novel insulin derivatives |
EP2287184A2 (en) | 2003-08-05 | 2011-02-23 | Novo Nordisk A/S | Novel insulin derivatives |
EP2033662A1 (en) | 2004-01-21 | 2009-03-11 | Novo Nordisk Health Care AG | Transglutaminase mediated conjugation of peptides |
EP2368579A1 (en) | 2004-01-21 | 2011-09-28 | Novo Nordisk Health Care AG | Transglutaminase mediated conjugation of peptides |
EP2292653A1 (en) | 2005-02-02 | 2011-03-09 | Novo Nordisk A/S | Novel insulin derivatives |
USRE46170E1 (en) | 2005-02-02 | 2016-10-04 | Novo Nordisk A/S | Insulin derivatives |
US8067362B2 (en) | 2005-02-02 | 2011-11-29 | Novo Nordisk As | Insulin derivatives |
US8476228B2 (en) | 2005-02-02 | 2013-07-02 | Novo Nordisk A/S | Insulin derivatives |
EP2256130A1 (en) | 2005-02-02 | 2010-12-01 | Novo Nordisk A/S | Novel insulin derivatives |
WO2006082204A1 (en) | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
US8859493B2 (en) | 2005-02-02 | 2014-10-14 | Novo Nordisk A/S | Insulin derivatives |
US11167035B2 (en) | 2005-12-28 | 2021-11-09 | Novo Nordisk A/S | Insulin compositions and method of making a composition |
US8710001B2 (en) | 2006-07-31 | 2014-04-29 | Novo Nordisk A/S | PEGylated, extended insulins |
US9018161B2 (en) | 2006-09-22 | 2015-04-28 | Novo Nordisk A/S | Protease resistant insulin analogues |
US9387176B2 (en) | 2007-04-30 | 2016-07-12 | Novo Nordisk A/S | Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein |
US9034818B2 (en) | 2007-06-13 | 2015-05-19 | Novo Nordisk A/S | Pharmaceutical formulations comprising an insulin derivative |
US9260502B2 (en) | 2008-03-14 | 2016-02-16 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
US9688737B2 (en) | 2008-03-18 | 2017-06-27 | Novo Nordisk A/S | Protease stabilized acylated insulin analogues |
US10259856B2 (en) | 2008-03-18 | 2019-04-16 | Novo Nordisk A/S | Protease stabilized acylated insulin analogues |
US9603904B2 (en) | 2008-10-30 | 2017-03-28 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
US10596229B2 (en) | 2010-10-27 | 2020-03-24 | Novo Nordisk A/S | Method of treating diabetes mellitus by administration, at specifically defined intervals, of a derivative of a naturally occurring insulin or insulin analogue, the derivative having a prolonged profile of action |
US9481721B2 (en) | 2012-04-11 | 2016-11-01 | Novo Nordisk A/S | Insulin formulations |
US10137172B2 (en) | 2013-04-30 | 2018-11-27 | Novo Nordisk A/S | Administration regime |
US9896496B2 (en) | 2013-10-07 | 2018-02-20 | Novo Nordisk A/S | Derivative of an insulin analogue |
US10596231B2 (en) | 2016-12-16 | 2020-03-24 | Novo Nordisk A/S | Insulin containing pharmaceutical compositions |
US10265385B2 (en) | 2016-12-16 | 2019-04-23 | Novo Nordisk A/S | Insulin containing pharmaceutical compositions |
US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
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