HUP9802586A2 - A (-)-[2-(2-tienil)-etilamino]-(2-halogénfenil)-acetamidok racemizálási eljárása - Google Patents

A (-)-[2-(2-tienil)-etilamino]-(2-halogénfenil)-acetamidok racemizálási eljárása

Info

Publication number
HUP9802586A2
HUP9802586A2 HU9802586A HUP9802586A HUP9802586A2 HU P9802586 A2 HUP9802586 A2 HU P9802586A2 HU 9802586 A HU9802586 A HU 9802586A HU P9802586 A HUP9802586 A HU P9802586A HU P9802586 A2 HUP9802586 A2 HU P9802586A2
Authority
HU
Hungary
Prior art keywords
acetamides
halophenyl
ethylamino
thienyl
racemizing
Prior art date
Application number
HU9802586A
Other languages
English (en)
Inventor
Mária Bakonyi
Katalin Gáspár
Zsolt Dombrády
Attila Supic
Tiborné Bai
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Priority to HU9802586A priority Critical patent/HU226421B1/hu
Publication of HU9802586D0 publication Critical patent/HU9802586D0/hu
Priority to AU12896/00A priority patent/AU1289600A/en
Priority to US09/830,930 priority patent/US6670486B1/en
Priority to DE69927044T priority patent/DE69927044T2/de
Priority to AT99956254T priority patent/ATE303377T1/de
Priority to BR9914883-8A priority patent/BR9914883A/pt
Priority to DK99956254T priority patent/DK1129087T3/da
Priority to ES99956254T priority patent/ES2249038T3/es
Priority to EP99956254A priority patent/EP1129087B1/en
Priority to PCT/HU1999/000076 priority patent/WO2000027840A1/en
Priority to JP2000581018A priority patent/JP4598276B2/ja
Priority to CA002347853A priority patent/CA2347853C/en
Publication of HUP9802586A2 publication Critical patent/HUP9802586A2/hu
Publication of HUP9802586A3 publication Critical patent/HUP9802586A3/hu
Priority to US10/718,925 priority patent/US7109356B2/en
Publication of HU226421B1 publication Critical patent/HU226421B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Abstract

A találmány tárgya a (VII) általános képletű optikailag aktív[2-(2-tienil)-etilamino]-(2-halogénfenil)-acetamidok racemizálási eljárása,mely során bázikus vegyületeket alkalmaznak. A kapott (VII) általánosképletű racémvegyületek így visszaforgathatók a (VI) általános képletűgyógyhatású vegyületek szintézisébe. Ó
HU9802586A 1998-11-09 1998-11-09 Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides HU226421B1 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
HU9802586A HU226421B1 (en) 1998-11-09 1998-11-09 Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides
CA002347853A CA2347853C (en) 1998-11-09 1999-11-05 Process for racemization of [2-(2-thienyl)ethylamino] (2-halogenophenyl)acetamides
DK99956254T DK1129087T3 (da) 1998-11-09 1999-11-05 Fremgangsmåde til racemisering
EP99956254A EP1129087B1 (en) 1998-11-09 1999-11-05 Process for racemization
DE69927044T DE69927044T2 (de) 1998-11-09 1999-11-05 Verfahren zur racemizierung
AT99956254T ATE303377T1 (de) 1998-11-09 1999-11-05 Verfahren zur racemizierung
BR9914883-8A BR9914883A (pt) 1998-11-09 1999-11-05 Processo para a racemização
AU12896/00A AU1289600A (en) 1998-11-09 1999-11-05 Process for racemization
ES99956254T ES2249038T3 (es) 1998-11-09 1999-11-05 Procedimiento de racemizacion.
US09/830,930 US6670486B1 (en) 1998-11-09 1999-11-05 Process for racemization
PCT/HU1999/000076 WO2000027840A1 (en) 1998-11-09 1999-11-05 Process for racemization
JP2000581018A JP4598276B2 (ja) 1998-11-09 1999-11-05 ラセミ化方法
US10/718,925 US7109356B2 (en) 1998-11-09 2003-11-21 Process for racemization

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9802586A HU226421B1 (en) 1998-11-09 1998-11-09 Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides

Publications (4)

Publication Number Publication Date
HU9802586D0 HU9802586D0 (en) 1999-01-28
HUP9802586A2 true HUP9802586A2 (hu) 2001-04-28
HUP9802586A3 HUP9802586A3 (en) 2001-05-28
HU226421B1 HU226421B1 (en) 2008-12-29

Family

ID=89997319

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802586A HU226421B1 (en) 1998-11-09 1998-11-09 Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides

Country Status (12)

Country Link
US (2) US6670486B1 (hu)
EP (1) EP1129087B1 (hu)
JP (1) JP4598276B2 (hu)
AT (1) ATE303377T1 (hu)
AU (1) AU1289600A (hu)
BR (1) BR9914883A (hu)
CA (1) CA2347853C (hu)
DE (1) DE69927044T2 (hu)
DK (1) DK1129087T3 (hu)
ES (1) ES2249038T3 (hu)
HU (1) HU226421B1 (hu)
WO (1) WO2000027840A1 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
US6800759B2 (en) 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
EP1606231A1 (en) * 2003-02-03 2005-12-21 Nadkarni, Sunil Sadanand Process for preparation of clopidogrel, its salts and pharmaceutical compositions
WO2004108665A2 (en) * 2003-04-24 2004-12-16 Sun Pharmaceutical Industries Limited A process for preparation of clopidogrel
US20090247569A1 (en) * 2006-08-03 2009-10-01 Claude Singer Process for Preparing Clopidogrel Bisulphate
FR2916441B1 (fr) * 2007-05-22 2009-08-28 Clariant Specialty Fine Chem Procede de racemisation d'alpha-aminoacetals optiquement actifs.
EP2319926B1 (en) 2007-07-05 2016-08-31 Arrowhead Research Corporation DSRNA for treating viral infection
FR2927900B1 (fr) * 2008-02-27 2010-09-17 Clariant Specialty Fine Chem Procede de preparation d'alpha-aminoacetals optiquement actifs.
EP2346879A1 (en) * 2008-10-24 2011-07-27 Sandoz AG A process for the preparation of s-clopidogrel
CN110627808B (zh) * 2018-06-21 2022-04-01 江苏同禾药业有限公司 一种硫酸氢氯吡格雷拆分母液的回收处理工艺

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632646A (en) * 1967-05-25 1972-01-04 Uniroyal Inc Succinamides
HU178455B (en) * 1979-07-17 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 1-substituted-3-cycloalkyl-sulfonyl-pyrrolidine-2,5-dione derivatives
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
NL8501093A (nl) * 1985-04-12 1986-11-03 Stamicarbon Werkwijze voor het racemiseren van een optisch aktief n- benzylideenaminozuuramide.
JPS62252751A (ja) * 1986-04-25 1987-11-04 Nitto Chem Ind Co Ltd α−アミノ酸アミドのラセミ化法
JPH0780823B2 (ja) * 1986-08-26 1995-08-30 東ソー株式会社 光学活性フェニルアラニンのラセミ化方法
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
HU225504B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
HU222283B1 (hu) 1997-05-13 2003-05-28 Sanofi-Synthelabo Eljárás tieno[3,2-c]piridin-származékok előállítására
HU225503B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them

Also Published As

Publication number Publication date
DE69927044D1 (de) 2005-10-06
DE69927044T2 (de) 2006-06-22
US20040106824A1 (en) 2004-06-03
US7109356B2 (en) 2006-09-19
AU1289600A (en) 2000-05-29
JP4598276B2 (ja) 2010-12-15
HU9802586D0 (en) 1999-01-28
ES2249038T3 (es) 2006-03-16
CA2347853A1 (en) 2000-05-18
HUP9802586A3 (en) 2001-05-28
HU226421B1 (en) 2008-12-29
EP1129087B1 (en) 2005-08-31
JP2002529462A (ja) 2002-09-10
CA2347853C (en) 2009-08-18
ATE303377T1 (de) 2005-09-15
BR9914883A (pt) 2001-07-17
EP1129087A1 (en) 2001-09-05
WO2000027840A1 (en) 2000-05-18
US6670486B1 (en) 2003-12-30
DK1129087T3 (da) 2006-01-16

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