DK1129087T3 - Fremgangsmåde til racemisering - Google Patents
Fremgangsmåde til racemiseringInfo
- Publication number
- DK1129087T3 DK1129087T3 DK99956254T DK99956254T DK1129087T3 DK 1129087 T3 DK1129087 T3 DK 1129087T3 DK 99956254 T DK99956254 T DK 99956254T DK 99956254 T DK99956254 T DK 99956254T DK 1129087 T3 DK1129087 T3 DK 1129087T3
- Authority
- DK
- Denmark
- Prior art keywords
- general formula
- vii
- compounds
- racialization
- halogenophenyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003869 acetamides Chemical class 0.000 abstract 1
- 150000007514 bases Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 abstract 1
- 230000006340 racemization Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Glass Compositions (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Processing Of Stones Or Stones Resemblance Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9802586A HU226421B1 (en) | 1998-11-09 | 1998-11-09 | Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1129087T3 true DK1129087T3 (da) | 2006-01-16 |
Family
ID=89997319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99956254T DK1129087T3 (da) | 1998-11-09 | 1999-11-05 | Fremgangsmåde til racemisering |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6670486B1 (hu) |
| EP (1) | EP1129087B1 (hu) |
| JP (1) | JP4598276B2 (hu) |
| AT (1) | ATE303377T1 (hu) |
| AU (1) | AU1289600A (hu) |
| BR (1) | BR9914883A (hu) |
| CA (1) | CA2347853C (hu) |
| DE (1) | DE69927044T2 (hu) |
| DK (1) | DK1129087T3 (hu) |
| ES (1) | ES2249038T3 (hu) |
| HU (1) | HU226421B1 (hu) |
| WO (1) | WO2000027840A1 (hu) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6767913B2 (en) | 2001-12-18 | 2004-07-27 | Teva Pharmaceutical Industries Ltd. | Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms |
| US7074928B2 (en) | 2002-01-11 | 2006-07-11 | Teva Pharmaceutical Industries, Ltd. | Polymorphs of clopidogrel hydrogensulfate |
| HUP0200438A3 (en) * | 2002-02-06 | 2003-10-28 | Egis Gyogyszergyar Nyilvanosan | Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them |
| US6800759B2 (en) | 2002-08-02 | 2004-10-05 | Teva Pharmaceutical Industries Ltd. | Racemization and enantiomer separation of clopidogrel |
| IL166593A0 (en) | 2002-08-02 | 2006-01-15 | Racemization and enantiomer separation of clopidogrel | |
| EP1606231A1 (en) * | 2003-02-03 | 2005-12-21 | Nadkarni, Sunil Sadanand | Process for preparation of clopidogrel, its salts and pharmaceutical compositions |
| WO2004108665A2 (en) * | 2003-04-24 | 2004-12-16 | Sun Pharmaceutical Industries Limited | A process for preparation of clopidogrel |
| US20090247569A1 (en) * | 2006-08-03 | 2009-10-01 | Claude Singer | Process for Preparing Clopidogrel Bisulphate |
| FR2916441B1 (fr) * | 2007-05-22 | 2009-08-28 | Clariant Specialty Fine Chem | Procede de racemisation d'alpha-aminoacetals optiquement actifs. |
| EP2319926B1 (en) | 2007-07-05 | 2016-08-31 | Arrowhead Research Corporation | DSRNA for treating viral infection |
| FR2927900B1 (fr) * | 2008-02-27 | 2010-09-17 | Clariant Specialty Fine Chem | Procede de preparation d'alpha-aminoacetals optiquement actifs. |
| EP2346879A1 (en) * | 2008-10-24 | 2011-07-27 | Sandoz AG | A process for the preparation of s-clopidogrel |
| CN110627808B (zh) * | 2018-06-21 | 2022-04-01 | 江苏同禾药业有限公司 | 一种硫酸氢氯吡格雷拆分母液的回收处理工艺 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3632646A (en) * | 1967-05-25 | 1972-01-04 | Uniroyal Inc | Succinamides |
| HU178455B (en) * | 1979-07-17 | 1982-05-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing new 1-substituted-3-cycloalkyl-sulfonyl-pyrrolidine-2,5-dione derivatives |
| FR2530247B1 (fr) * | 1982-07-13 | 1986-05-16 | Sanofi Sa | Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique |
| NL8501093A (nl) * | 1985-04-12 | 1986-11-03 | Stamicarbon | Werkwijze voor het racemiseren van een optisch aktief n- benzylideenaminozuuramide. |
| JPS62252751A (ja) * | 1986-04-25 | 1987-11-04 | Nitto Chem Ind Co Ltd | α−アミノ酸アミドのラセミ化法 |
| JPH0780823B2 (ja) * | 1986-08-26 | 1995-08-30 | 東ソー株式会社 | 光学活性フェニルアラニンのラセミ化方法 |
| FR2664596B1 (fr) * | 1990-07-10 | 1994-06-10 | Sanofi Sa | Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese. |
| HU225504B1 (en) * | 1997-05-13 | 2007-01-29 | Sanofi Aventis | Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them |
| HU222283B1 (hu) | 1997-05-13 | 2003-05-28 | Sanofi-Synthelabo | Eljárás tieno[3,2-c]piridin-származékok előállítására |
| HU225503B1 (en) * | 1997-05-13 | 2007-01-29 | Sanofi Aventis | Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them |
-
1998
- 1998-11-09 HU HU9802586A patent/HU226421B1/hu unknown
-
1999
- 1999-11-05 ES ES99956254T patent/ES2249038T3/es not_active Expired - Lifetime
- 1999-11-05 DK DK99956254T patent/DK1129087T3/da active
- 1999-11-05 AT AT99956254T patent/ATE303377T1/de active
- 1999-11-05 BR BR9914883-8A patent/BR9914883A/pt not_active Application Discontinuation
- 1999-11-05 WO PCT/HU1999/000076 patent/WO2000027840A1/en active IP Right Grant
- 1999-11-05 DE DE69927044T patent/DE69927044T2/de not_active Expired - Lifetime
- 1999-11-05 EP EP99956254A patent/EP1129087B1/en not_active Expired - Lifetime
- 1999-11-05 CA CA002347853A patent/CA2347853C/en not_active Expired - Lifetime
- 1999-11-05 JP JP2000581018A patent/JP4598276B2/ja not_active Expired - Lifetime
- 1999-11-05 AU AU12896/00A patent/AU1289600A/en not_active Abandoned
- 1999-11-05 US US09/830,930 patent/US6670486B1/en not_active Expired - Lifetime
-
2003
- 2003-11-21 US US10/718,925 patent/US7109356B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69927044D1 (de) | 2005-10-06 |
| DE69927044T2 (de) | 2006-06-22 |
| US20040106824A1 (en) | 2004-06-03 |
| US7109356B2 (en) | 2006-09-19 |
| AU1289600A (en) | 2000-05-29 |
| JP4598276B2 (ja) | 2010-12-15 |
| HU9802586D0 (en) | 1999-01-28 |
| ES2249038T3 (es) | 2006-03-16 |
| CA2347853A1 (en) | 2000-05-18 |
| HUP9802586A3 (en) | 2001-05-28 |
| HU226421B1 (en) | 2008-12-29 |
| EP1129087B1 (en) | 2005-08-31 |
| JP2002529462A (ja) | 2002-09-10 |
| CA2347853C (en) | 2009-08-18 |
| ATE303377T1 (de) | 2005-09-15 |
| BR9914883A (pt) | 2001-07-17 |
| EP1129087A1 (en) | 2001-09-05 |
| WO2000027840A1 (en) | 2000-05-18 |
| HUP9802586A2 (hu) | 2001-04-28 |
| US6670486B1 (en) | 2003-12-30 |
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