ATE303377T1 - Verfahren zur racemizierung - Google Patents

Verfahren zur racemizierung

Info

Publication number
ATE303377T1
ATE303377T1 AT99956254T AT99956254T ATE303377T1 AT E303377 T1 ATE303377 T1 AT E303377T1 AT 99956254 T AT99956254 T AT 99956254T AT 99956254 T AT99956254 T AT 99956254T AT E303377 T1 ATE303377 T1 AT E303377T1
Authority
AT
Austria
Prior art keywords
general formula
vii
compounds
racemization method
racemization
Prior art date
Application number
AT99956254T
Other languages
English (en)
Inventor
Maria Bakonyi
Tiborne Bai
Zsolt Dombrady
Katalin Gaspar
Attila Supic
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Application granted granted Critical
Publication of ATE303377T1 publication Critical patent/ATE303377T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
AT99956254T 1998-11-09 1999-11-05 Verfahren zur racemizierung ATE303377T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9802586A HU226421B1 (en) 1998-11-09 1998-11-09 Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides
PCT/HU1999/000076 WO2000027840A1 (en) 1998-11-09 1999-11-05 Process for racemization

Publications (1)

Publication Number Publication Date
ATE303377T1 true ATE303377T1 (de) 2005-09-15

Family

ID=89997319

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99956254T ATE303377T1 (de) 1998-11-09 1999-11-05 Verfahren zur racemizierung

Country Status (12)

Country Link
US (2) US6670486B1 (de)
EP (1) EP1129087B1 (de)
JP (1) JP4598276B2 (de)
AT (1) ATE303377T1 (de)
AU (1) AU1289600A (de)
BR (1) BR9914883A (de)
CA (1) CA2347853C (de)
DE (1) DE69927044T2 (de)
DK (1) DK1129087T3 (de)
ES (1) ES2249038T3 (de)
HU (1) HU226421B1 (de)
WO (1) WO2000027840A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
US6800759B2 (en) 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
EP1606231A1 (de) * 2003-02-03 2005-12-21 Nadkarni, Sunil Sadanand Verfahren zur herstellung von clopidogrel, seine salze und pharmazeutische zusammensetzungen
WO2004108665A2 (en) * 2003-04-24 2004-12-16 Sun Pharmaceutical Industries Limited A process for preparation of clopidogrel
US20090247569A1 (en) * 2006-08-03 2009-10-01 Claude Singer Process for Preparing Clopidogrel Bisulphate
FR2916441B1 (fr) * 2007-05-22 2009-08-28 Clariant Specialty Fine Chem Procede de racemisation d'alpha-aminoacetals optiquement actifs.
EP2319926B1 (de) 2007-07-05 2016-08-31 Arrowhead Research Corporation DSRNA zur Behandlung viraler Infektionen
FR2927900B1 (fr) * 2008-02-27 2010-09-17 Clariant Specialty Fine Chem Procede de preparation d'alpha-aminoacetals optiquement actifs.
EP2346879A1 (de) * 2008-10-24 2011-07-27 Sandoz AG Verfahren zur herstellung von s-clopidogrel
CN110627808B (zh) * 2018-06-21 2022-04-01 江苏同禾药业有限公司 一种硫酸氢氯吡格雷拆分母液的回收处理工艺

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632646A (en) * 1967-05-25 1972-01-04 Uniroyal Inc Succinamides
HU178455B (en) * 1979-07-17 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 1-substituted-3-cycloalkyl-sulfonyl-pyrrolidine-2,5-dione derivatives
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
NL8501093A (nl) * 1985-04-12 1986-11-03 Stamicarbon Werkwijze voor het racemiseren van een optisch aktief n- benzylideenaminozuuramide.
JPS62252751A (ja) * 1986-04-25 1987-11-04 Nitto Chem Ind Co Ltd α−アミノ酸アミドのラセミ化法
JPH0780823B2 (ja) * 1986-08-26 1995-08-30 東ソー株式会社 光学活性フェニルアラニンのラセミ化方法
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
HU225504B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
HU222283B1 (hu) 1997-05-13 2003-05-28 Sanofi-Synthelabo Eljárás tieno[3,2-c]piridin-származékok előállítására
HU225503B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them

Also Published As

Publication number Publication date
DE69927044D1 (de) 2005-10-06
DE69927044T2 (de) 2006-06-22
US20040106824A1 (en) 2004-06-03
US7109356B2 (en) 2006-09-19
AU1289600A (en) 2000-05-29
JP4598276B2 (ja) 2010-12-15
HU9802586D0 (en) 1999-01-28
ES2249038T3 (es) 2006-03-16
CA2347853A1 (en) 2000-05-18
HUP9802586A3 (en) 2001-05-28
HU226421B1 (en) 2008-12-29
EP1129087B1 (de) 2005-08-31
JP2002529462A (ja) 2002-09-10
CA2347853C (en) 2009-08-18
BR9914883A (pt) 2001-07-17
EP1129087A1 (de) 2001-09-05
WO2000027840A1 (en) 2000-05-18
HUP9802586A2 (hu) 2001-04-28
US6670486B1 (en) 2003-12-30
DK1129087T3 (da) 2006-01-16

Similar Documents

Publication Publication Date Title
ATE303377T1 (de) Verfahren zur racemizierung
DE60012268D1 (de) Verfahren zum Herstellen von Acrylsäure
DE60110497D1 (de) Verfahren zur Herstellung von Acrylsäure
DE60128429D1 (de) Verfahren zur kontiuierlichen Herstellung von optischen Gegenständen
DE60005870D1 (de) Verfahren zur Herstellung von Acrylsäure
DE69903698T2 (de) Verfahren zur Herstellung von Acrylsäure
DE60038560D1 (de) Verfahren zur fermentativen Herstellung von L-Arginin
DE60005682D1 (de) Verfahren zur herstellung von naproxennitroxyalkylestern
DE60228724D1 (de) Verfahren zur herstellung von beraprost und dessen salzen
EA200300520A1 (ru) Способ получения кристаллического моногидрата n-формимидоилтиенамицина (моногидрата имипенема)
ATE281434T1 (de) Verfahren zur herstellung von benzoperhydroisoindolen
ITMI20002187A0 (it) Processo per la produzione dell'acido r(+) -lipico
DK0690133T3 (da) Fremgangsmåde til enzymatisk spaltning af 2-amino-4-methylphosphinobutansyreamid-derivater
ITMI20002186A0 (it) Processo per la produzione dell'acido tiottico racemo
DE60133395D1 (de) Verfahren zur herstellung von alpha'-chlorketonen
DE60012802D1 (de) Verfahren zur Herstellung von optisch aktiven Cyanhydrinen
ATE282594T1 (de) Verfahren zur herstellung von (+)-trans-4-p- fluorophenyl-3-hydroxymethyl-1-methylpiperidin
ATE282589T1 (de) Verfahren zur herstellung eines chiralen-beta- aminosäureesters
DE59909775D1 (de) Verfahren zur Herstellung von Sechsring-Carbocyclen
ATE253548T1 (de) Verfahren zur verbesserung der optischen reinheit von 2r-(1-hydroxy-1-trifluormethyl-3- cyclopropylpropyn-2-yl)-4-chloranilin
DE69833365D1 (de) Verfahren zur herstellung optisch aktiver amine
ATE256099T1 (de) Verfahren zur herstellung einer kristallsuspensionhenonen
DE59700707D1 (de) Verfahren zur Racemisierung optisch aktiver Amine
DE69906876T2 (de) Verfahren zur Reinigung von Carbazol-ester Vorstufen von 6-Chlor-alpha-methyl-carbazole-2-essigsäure
DE69917240D1 (de) Verfahren zur Herstellung von gereinigter Sorbinsäure

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1129087

Country of ref document: EP