ES8703881A1 - Procedimiento para la fabricacion de derivados del acido &- (oxo-2 hexahidro-2,4,5,6,7,7a tieno (3,2-c)piridil-5) fenil acetico - Google Patents

Procedimiento para la fabricacion de derivados del acido &- (oxo-2 hexahidro-2,4,5,6,7,7a tieno (3,2-c)piridil-5) fenil acetico

Info

Publication number
ES8703881A1
ES8703881A1 ES550448A ES550448A ES8703881A1 ES 8703881 A1 ES8703881 A1 ES 8703881A1 ES 550448 A ES550448 A ES 550448A ES 550448 A ES550448 A ES 550448A ES 8703881 A1 ES8703881 A1 ES 8703881A1
Authority
ES
Spain
Prior art keywords
pyridyl
oxo
alpha
preparation
thieno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550448A
Other languages
English (en)
Other versions
ES550448A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES550448A0 publication Critical patent/ES550448A0/es
Publication of ES8703881A1 publication Critical patent/ES8703881A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE FORMULA (I), DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES Y DE SUS ISOMEROS. COMPRENDE LA FIJACION DE UN GRUPO TRITILO SOBRE LA FUNCION NITROGENADA DE LA TETRAHIDRO-4,5,6,7-TIENO-(3,2-C)PIRIDINA, PARA OBTENER EL COMPUESTO DE FORMULA (II), SOBRE EL QUE SE FIJA UN DERIVADO BORONICO; OXIDACION E HIDROLISIS DE ESTE E HIDROLISIS ACIDA PARA FORMAR LA TETRAHIDRO-5,6,7,7A-4H-TIENO(3,2-C)PIRIDONA; Y ESTA SE CONDENSA CON UN ACIDO A-HALOGENADO-FENILACETICO DE FORMULA (III), PARA OBTENER EL COMPUESTO DE FORMULA (I), EN LA QUE X E Y PUEDEN SER VARIOS RADICALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD INHIBIDORA DE LA AGREGACION PLAQUETARIA Y ANTITROMBOTICA.
ES550448A 1985-01-31 1985-12-27 Procedimiento para la fabricacion de derivados del acido &- (oxo-2 hexahidro-2,4,5,6,7,7a tieno (3,2-c)piridil-5) fenil acetico Expired ES8703881A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8501908A FR2576901B1 (fr) 1985-01-31 1985-01-31 Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique

Publications (2)

Publication Number Publication Date
ES550448A0 ES550448A0 (es) 1987-03-01
ES8703881A1 true ES8703881A1 (es) 1987-03-01

Family

ID=9316132

Family Applications (1)

Application Number Title Priority Date Filing Date
ES550448A Expired ES8703881A1 (es) 1985-01-31 1985-12-27 Procedimiento para la fabricacion de derivados del acido &- (oxo-2 hexahidro-2,4,5,6,7,7a tieno (3,2-c)piridil-5) fenil acetico

Country Status (24)

Country Link
US (1) US4740510A (es)
EP (1) EP0192535A1 (es)
JP (1) JPS61246186A (es)
AU (1) AU581487B2 (es)
CA (1) CA1265517A (es)
CS (1) CS253741B2 (es)
DD (1) DD242229A5 (es)
DK (1) DK157553C (es)
ES (1) ES8703881A1 (es)
FI (1) FI860473A (es)
FR (1) FR2576901B1 (es)
GR (1) GR860287B (es)
HU (1) HU193625B (es)
IL (1) IL77598A (es)
MA (1) MA20619A1 (es)
NO (1) NO162965C (es)
NZ (1) NZ214982A (es)
OA (1) OA08196A (es)
PL (1) PL145159B1 (es)
PT (1) PT81946B (es)
SU (1) SU1389679A3 (es)
TN (1) TNSN86012A1 (es)
YU (1) YU11986A (es)
ZA (1) ZA86407B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2652579B1 (fr) * 1989-10-02 1992-01-24 Sanofi Sa Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique.
FI101150B (fi) * 1991-09-09 1998-04-30 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
US5874581A (en) * 1994-10-07 1999-02-23 Ube Industries, Ltd. 2-silyloxy-tetrahydrothienopyridine, salt thereof and process for preparing the same
NZ334389A (en) * 1996-08-28 2001-05-25 Ube Industries Cyclic amine derivatives
ID25589A (id) 1998-02-27 2000-10-19 Sankyo Company Ltd Cs Senyawa-senyawa amino siklik
PT1728794E (pt) 2000-07-06 2008-07-15 Ube Industries Sal de adição maleato de derivados de hidropiridina
PL206138B1 (pl) * 2000-12-25 2010-07-30 Daiichi Sankyo Company Limiteddaiichi Sankyo Company Limited Kompozycja farmaceutyczna zawierająca aspirynę oraz zestaw i zastosowanie składników kompozycji
GB0125708D0 (en) * 2001-10-26 2001-12-19 Generics Uk Ltd Novel compounds and processes
CZ302135B6 (cs) * 2007-07-09 2010-11-10 Zentiva, A. S. Zpusob výroby 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu)
US20100261908A1 (en) * 2007-11-09 2010-10-14 Dr. Reddy's Laboratories Ltd. Processes for the preparation of prasugrel , and its salts and polymorphs
WO2009066326A2 (en) * 2007-11-19 2009-05-28 Msn Laboratories Limited Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts
CN101289454B (zh) * 2008-06-10 2011-02-16 上海医药工业研究院 2-氧-2,4,5,6,7,7α-六氢噻吩并[3,2-c]吡啶的制备方法
DE102008046630A1 (de) * 2008-09-10 2010-03-11 Emitec Gesellschaft Für Emissionstechnologie Mbh Modulares Tanksystem für ein flüssiges Reduktionsmittel mit einem Sumpfelement
CN101402643B (zh) * 2008-11-11 2012-11-28 上海现代制药股份有限公司 一种适于工业生产的普拉格雷的制备方法
CN101402642B (zh) * 2008-11-11 2013-01-09 上海现代制药股份有限公司 一种新型环保制备普拉格雷的方法
CN101402593A (zh) * 2008-11-11 2009-04-08 上海现代制药股份有限公司 用于制备普拉格雷的中间体及其制备方法
CZ2008748A3 (cs) 2008-11-26 2010-06-02 Zentiva, A. S Zpusob výroby vysoce cistého 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c] pyridin-2-yl acetátu, prasugrelu
WO2011042918A2 (en) * 2009-10-07 2011-04-14 Msn Laboratories Limited Novel and improved processes for the preparation of prasugrel, its intermediates and pharmaceutically acceptable salts
HU229031B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel and its intermediate
HU229035B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel
CN102863457B (zh) * 2010-02-02 2013-10-09 江苏威凯尔医药科技有限公司 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途
WO2011110219A1 (en) 2010-03-09 2011-09-15 Synthon Bv A process for making prasugrel
CN102212069A (zh) * 2010-04-06 2011-10-12 刘桂坤 环烷衍生物及其制备方法和在心脑血管病药物上的应用
CN101845052B (zh) * 2010-06-11 2012-01-11 天津药物研究院 一类含氮杂环的噻吩并吡啶酮衍生物、其制备方法和用途
NZ606903A (en) * 2010-08-26 2015-05-29 Ipca Lab Ltd Methods for the treatment or prophylaxis of thrombosis or embolism
CN101948479B (zh) * 2010-09-29 2013-01-30 横店集团家园化工有限公司 普拉格雷中间体及其制备方法
CN102002056B (zh) * 2010-11-02 2012-04-25 北京赛科药业有限责任公司 一种普拉格雷中间体的制备方法
CN101985451B (zh) * 2010-11-02 2012-04-25 北京赛科药业有限责任公司 普拉格雷中间体的制备方法
CN102276623A (zh) * 2011-06-13 2011-12-14 安徽省虹升生物科技有限公司 一种利用有机硅保护剂进行制备普拉格雷的新方法
EP2675813A4 (en) * 2011-06-27 2014-04-30 Ipca Lab Ltd ANTI THROMBOSIS CONNECTIONS
CN104341433B (zh) * 2013-08-02 2017-12-15 鲁南制药集团股份有限公司 一种普拉格雷中间体的制备方法
CN104447867B (zh) * 2013-09-17 2017-12-26 江苏天士力帝益药业有限公司 一种噻吩并哌啶衍生物、制备方法及其应用
CN107698620A (zh) 2015-06-23 2018-02-16 江苏天士力帝益药业有限公司 一种氘代噻吩并哌啶衍生物、制备方法及其应用
CN108570060A (zh) * 2018-05-13 2018-09-25 日照市普达医药科技有限公司 一种4,5,6,7-四氢噻吩并[3,2-c]吡啶类衍生物对血栓的治疗作用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2495157A1 (fr) * 1980-11-28 1982-06-04 Sanofi Sa Procede nouveau de preparation des tetrahydro-5, 6, 7, 7a 4h-thieno (3, 2-c) pyridinones-2
FR2495156A1 (fr) * 1980-11-28 1982-06-04 Sanofi Sa Derives de la thieno-pyridinone, leur procede de preparation et leur application therapeutique
FR2528848A1 (fr) * 1982-06-16 1983-12-23 Sanofi Sa Nouveau derive de thieno-pyridone, son procede de preparation et son application therapeutique
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung

Also Published As

Publication number Publication date
AU581487B2 (en) 1989-02-23
NZ214982A (en) 1988-04-29
ES550448A0 (es) 1987-03-01
IL77598A (en) 1988-12-30
JPS61246186A (ja) 1986-11-01
NO860332L (no) 1986-08-01
FI860473A (fi) 1986-08-01
PL257691A1 (en) 1986-11-04
CA1265517A (fr) 1990-02-06
DK47186D0 (da) 1986-01-30
DK157553B (da) 1990-01-22
HU193625B (en) 1987-11-30
PT81946B (pt) 1987-12-30
CS253741B2 (en) 1987-12-17
MA20619A1 (fr) 1986-10-01
DD242229A5 (de) 1987-01-21
NO162965B (no) 1989-12-04
TNSN86012A1 (fr) 1990-01-01
YU11986A (en) 1987-08-31
PT81946A (fr) 1986-02-01
FR2576901B1 (fr) 1987-03-20
ZA86407B (en) 1986-09-24
DK157553C (da) 1990-06-11
OA08196A (fr) 1987-10-30
SU1389679A3 (ru) 1988-04-15
DK47186A (da) 1986-08-01
GR860287B (en) 1986-06-02
AU5242486A (en) 1986-08-07
EP0192535A1 (fr) 1986-08-27
US4740510A (en) 1988-04-26
FR2576901A1 (fr) 1986-08-08
PL145159B1 (en) 1988-08-31
NO162965C (no) 1990-03-14
HUT40440A (en) 1986-12-28
FI860473A0 (fi) 1986-01-31

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