EA200401234A1 - Способ приготовления клопидогрела - Google Patents

Способ приготовления клопидогрела

Info

Publication number
EA200401234A1
EA200401234A1 EA200401234A EA200401234A EA200401234A1 EA 200401234 A1 EA200401234 A1 EA 200401234A1 EA 200401234 A EA200401234 A EA 200401234A EA 200401234 A EA200401234 A EA 200401234A EA 200401234 A1 EA200401234 A1 EA 200401234A1
Authority
EA
Eurasian Patent Office
Prior art keywords
claps
preparing
thienopyridylmethane
clopidogrel
tetrahydro
Prior art date
Application number
EA200401234A
Other languages
English (en)
Other versions
EA007907B1 (ru
Inventor
Грациано Кастальди
Джузеппе Баррека
Альберто Болонья
Original Assignee
ДИФАРМА С. п. А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ДИФАРМА С. п. А. filed Critical ДИФАРМА С. п. А.
Publication of EA200401234A1 publication Critical patent/EA200401234A1/ru
Publication of EA007907B1 publication Critical patent/EA007907B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Способ приготовления клопидогрела (1) по реакции N,N'-бис-4,5,6,7-тетрагидро-[3,2-c]-тиенопиридилметана (12) с производными (R)-2-хлорфенилуксусной кислоты, имеющими формулу (13), в которых X и R имеют обозначения, указанные в описании.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401234A 2002-05-03 2003-04-22 Способ приготовления клопидогрела EA007907B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002MI000933A ITMI20020933A1 (it) 2002-05-03 2002-05-03 Procedimento per la sintesi di clopidogrel
PCT/EP2003/004179 WO2003093276A1 (en) 2002-05-03 2003-04-22 A process for the preparation of clopidogrel

Publications (2)

Publication Number Publication Date
EA200401234A1 true EA200401234A1 (ru) 2005-06-30
EA007907B1 EA007907B1 (ru) 2007-02-27

Family

ID=11449820

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401234A EA007907B1 (ru) 2002-05-03 2003-04-22 Способ приготовления клопидогрела

Country Status (19)

Country Link
US (1) US7329751B2 (ru)
EP (1) EP1501838B1 (ru)
JP (1) JP2005530757A (ru)
KR (1) KR20040106449A (ru)
CN (1) CN1293080C (ru)
AT (1) ATE359287T1 (ru)
AU (1) AU2003224115A1 (ru)
CA (1) CA2485070A1 (ru)
DE (1) DE60313157T2 (ru)
DK (1) DK1501838T3 (ru)
EA (1) EA007907B1 (ru)
ES (1) ES2285116T3 (ru)
HR (1) HRP20041017B1 (ru)
IL (1) IL164978A0 (ru)
IT (1) ITMI20020933A1 (ru)
MX (1) MXPA04010765A (ru)
PL (1) PL375213A1 (ru)
PT (1) PT1501838E (ru)
WO (1) WO2003093276A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100406568C (zh) * 2005-02-18 2008-07-30 淮北市辉克药业有限公司 氯吡格雷新生产工艺
KR100681512B1 (ko) * 2005-03-08 2007-02-09 주식회사 한서켐 클로피도그렐의 신규한 제조 중간체 및 이를 이용한 클로피도그렐의 제조방법
CN100390180C (zh) * 2005-12-15 2008-05-28 上海应用技术学院 氯吡格雷及其盐的制备方法
CN100396687C (zh) * 2006-05-26 2008-06-25 浙江海翔药业股份有限公司 (+)-(s-)-氯吡格雷硫酸氢盐(i型)的制备方法
US20090247569A1 (en) * 2006-08-03 2009-10-01 Claude Singer Process for Preparing Clopidogrel Bisulphate
KR20160033792A (ko) 2007-04-27 2016-03-28 사이덱스 파마슈티칼스, 인크. 클로피도그렐 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 및 사용 방법
KR100848936B1 (ko) 2007-05-17 2008-07-29 주식회사 대희화학 클로피도그렐 이성질체의 제조방법 및 이의 제조에사용되는 신규 중간체 화합물
US8236782B2 (en) 2009-05-13 2012-08-07 Cydex Pharmaceuticals, Inc. Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
CN110527722A (zh) * 2019-09-11 2019-12-03 上海交通大学 一种利用rs2644592和rs11264580检测氯吡格雷药效试剂盒

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
HU222283B1 (hu) * 1997-05-13 2003-05-28 Sanofi-Synthelabo Eljárás tieno[3,2-c]piridin-származékok előállítására
FR2769313B1 (fr) * 1997-10-06 2000-04-21 Sanofi Sa Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese

Also Published As

Publication number Publication date
CN1649877A (zh) 2005-08-03
US20050143414A1 (en) 2005-06-30
MXPA04010765A (es) 2005-07-05
DK1501838T3 (da) 2007-08-20
PT1501838E (pt) 2007-06-28
US7329751B2 (en) 2008-02-12
PL375213A1 (en) 2005-11-28
JP2005530757A (ja) 2005-10-13
HRP20041017B1 (en) 2007-08-31
EP1501838A1 (en) 2005-02-02
CA2485070A1 (en) 2003-11-13
CN1293080C (zh) 2007-01-03
WO2003093276A1 (en) 2003-11-13
ITMI20020933A1 (it) 2003-11-03
AU2003224115A1 (en) 2003-11-17
ES2285116T3 (es) 2007-11-16
EP1501838B1 (en) 2007-04-11
DE60313157T2 (de) 2007-12-20
EA007907B1 (ru) 2007-02-27
HRP20041017A2 (en) 2004-12-31
DE60313157D1 (de) 2007-05-24
ITMI20020933A0 (it) 2002-05-03
ATE359287T1 (de) 2007-05-15
IL164978A0 (en) 2005-12-18
KR20040106449A (ko) 2004-12-17

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM