UA93043C2 - ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ ПОЛУЧЕНИЯ ТРАНС-5-ХЛОР-2-МЕТИЛ-2,3,3А,12В-ТЕТРАГИДРО-1Н-ДИБЕНЗ[2,3:6,7]ОКСЕПИНО[4,5-с]ПИРОЛА - Google Patents
ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ ПОЛУЧЕНИЯ ТРАНС-5-ХЛОР-2-МЕТИЛ-2,3,3А,12В-ТЕТРАГИДРО-1Н-ДИБЕНЗ[2,3:6,7]ОКСЕПИНО[4,5-с]ПИРОЛАInfo
- Publication number
- UA93043C2 UA93043C2 UAA200711019A UAA200711019A UA93043C2 UA 93043 C2 UA93043 C2 UA 93043C2 UA A200711019 A UAA200711019 A UA A200711019A UA A200711019 A UAA200711019 A UA A200711019A UA 93043 C2 UA93043 C2 UA 93043C2
- Authority
- UA
- Ukraine
- Prior art keywords
- preparation
- oxepino
- dibenz
- pyrrole
- tetrahydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/14—[b,f]-condensed
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05102742 | 2005-04-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA93043C2 true UA93043C2 (ru) | 2011-01-10 |
Family
ID=35511130
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200711020A UA93044C2 (en) | 2005-04-07 | 2006-04-06 | urn:schemas-microsoft-com:office:smarttagsCRYSTALFORM OF ASENAPINE MALEATE |
UAA200711019A UA93043C2 (ru) | 2005-04-07 | 2006-04-06 | ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ ПОЛУЧЕНИЯ ТРАНС-5-ХЛОР-2-МЕТИЛ-2,3,3А,12В-ТЕТРАГИДРО-1Н-ДИБЕНЗ[2,3:6,7]ОКСЕПИНО[4,5-с]ПИРОЛА |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200711020A UA93044C2 (en) | 2005-04-07 | 2006-04-06 | urn:schemas-microsoft-com:office:smarttagsCRYSTALFORM OF ASENAPINE MALEATE |
Country Status (28)
Country | Link |
---|---|
EP (2) | EP1710241B1 (ru) |
JP (1) | JP2008534657A (ru) |
KR (1) | KR20070116973A (ru) |
CN (2) | CN101175741B (ru) |
AR (1) | AR063188A1 (ru) |
AT (1) | ATE447564T1 (ru) |
AU (1) | AU2006231281B2 (ru) |
BR (1) | BRPI0610677A2 (ru) |
CA (1) | CA2603181A1 (ru) |
CY (1) | CY1109722T1 (ru) |
DE (1) | DE602006010132D1 (ru) |
DK (1) | DK1710241T3 (ru) |
ES (1) | ES2333980T3 (ru) |
HK (1) | HK1094800A1 (ru) |
HR (1) | HRP20100031T1 (ru) |
IL (1) | IL186354A0 (ru) |
MX (1) | MX2007012446A (ru) |
NO (1) | NO20075152L (ru) |
NZ (1) | NZ562125A (ru) |
PL (1) | PL1710241T3 (ru) |
PT (1) | PT1710241E (ru) |
RS (1) | RS51341B (ru) |
RU (1) | RU2397164C2 (ru) |
SI (1) | SI1710241T1 (ru) |
TW (1) | TW200716589A (ru) |
UA (2) | UA93044C2 (ru) |
WO (1) | WO2006106136A1 (ru) |
ZA (2) | ZA200708490B (ru) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5027477B2 (ja) * | 2005-10-21 | 2012-09-19 | 住友化学株式会社 | ジベンゾオキセピノピロール化合物およびその中間体の製造方法ならびに新規中間体 |
TW200817414A (en) * | 2006-07-05 | 2008-04-16 | Organon Nv | Process for the preparation of asenapine and intermediate products used in said process |
CN101563312A (zh) * | 2006-12-22 | 2009-10-21 | 住友化学株式会社 | 阿塞那平合成中间体的制备方法 |
US7875729B2 (en) * | 2007-01-05 | 2011-01-25 | Synthon Bv | Process for making asenapine |
JP5245428B2 (ja) | 2007-07-06 | 2013-07-24 | 住友化学株式会社 | トランス−ジベンゾオキセノピロール化合物の製造方法およびその中間体 |
JP2011508751A (ja) * | 2008-01-04 | 2011-03-17 | ナームローゼ・フエンノートチヤツプ・オルガノン | アセナピンの調製方法および前記方法において使用される中間生成物 |
AU2010264670A1 (en) | 2009-06-24 | 2012-01-19 | Merck Sharp & Dohme B.V. | Injectable formulations containing asenapine and method of treatment using same |
CN101851242B (zh) * | 2010-05-25 | 2013-07-24 | 上海皓元生物医药科技有限公司 | 阿塞那平中间体的制备方法 |
ES2466767T3 (es) * | 2010-07-29 | 2014-06-11 | Laboratorios Lesvi, S.L. | Nuevo proceso para la preparación de asenapina |
WO2012038975A2 (en) * | 2010-09-22 | 2012-03-29 | Msn Laboratories Limited | Process for the preparation of (3ars,12brs)-5-chloro-2-methyl-2,3,3a12b-tetrahydro-1hdibenzo[2,3:6,7] oxepino [4,5-c]pyrrole maleate and it's pharmaceutical composition thereof |
ES2575544T3 (es) | 2010-12-24 | 2016-06-29 | Medichem, S.A. | Procedimientos para la preparación de 5-cloro-2-metil-2,3,3a,12b-tetrahidro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pirrol |
ITMI20110734A1 (it) * | 2011-05-02 | 2012-11-03 | Olon Spa | Sali cristallini di asenapina |
WO2013024492A2 (en) * | 2011-07-01 | 2013-02-21 | Megafine Pharma (P) Ltd. | A process for the preparation of asenapine and novel salts thereof |
CN102952144A (zh) * | 2011-08-29 | 2013-03-06 | 上海华拓医药科技发展股份有限公司 | 阿森纳平马来酸盐的晶型、制备方法及其药物组合物 |
WO2013080069A1 (en) * | 2011-11-28 | 2013-06-06 | Ranbaxy Laboratories Limited | Process for the preparation of asenapine intermediate |
CN102746209A (zh) * | 2012-06-20 | 2012-10-24 | 盛世泰科生物医药技术(苏州)有限公司 | 一种3-(2-(4-氯苯氧基)苯基)-1-甲基-2,4-二酮的合成方法 |
CN103965206A (zh) * | 2013-01-29 | 2014-08-06 | 北京京卫燕康药物研究所有限公司 | 一种阿色纳品马来酸盐的新晶型及制备方法 |
CN103113379A (zh) * | 2013-03-12 | 2013-05-22 | 盛世泰科生物医药技术(苏州)有限公司 | 阿塞那平马来酸盐的合成工艺 |
CN103254202A (zh) * | 2013-05-19 | 2013-08-21 | 甘肃皓天化学科技有限公司 | 阿塞纳平的制备方法 |
CN103342707B (zh) * | 2013-06-28 | 2015-09-02 | 甘肃皓天化学科技有限公司 | 用于制备阿塞纳平中间体的制备方法 |
CN104447771A (zh) * | 2013-09-12 | 2015-03-25 | 天津市汉康医药生物技术有限公司 | 一种稳定的马来酸阿塞那平化合物 |
CN103864802B (zh) * | 2014-03-31 | 2016-08-17 | 四川科伦药业股份有限公司 | 马来酸阿塞那平的制备方法 |
CN105693735A (zh) * | 2016-01-15 | 2016-06-22 | 万特制药(海南)有限公司 | 马来酸阿塞那平一种制备方法 |
MX2019007391A (es) | 2016-12-20 | 2019-08-16 | Lts Lohmann Therapie Systeme Ag | Sistema terapeutico transdermico que contiene asenapina. |
CN110087641B (zh) | 2016-12-20 | 2024-03-12 | 罗曼治疗系统股份公司 | 含有阿塞那平和聚硅氧烷或聚异丁烯的透皮治疗系统 |
CN110799180A (zh) | 2017-06-26 | 2020-02-14 | 罗曼治疗系统股份公司 | 含阿塞那平和硅氧烷丙烯酸杂化聚合物的经皮治疗系统 |
CN109200025A (zh) * | 2017-06-29 | 2019-01-15 | 哈尔滨莱博通药业有限公司 | 一种阿森纳平马来酸盐舌下片 |
WO2019243452A1 (en) | 2018-06-20 | 2019-12-26 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
CN110183457A (zh) * | 2019-06-27 | 2019-08-30 | 浙江天顺药业有限公司 | 一种阿塞那平及其制备方法 |
CN112194665A (zh) * | 2020-10-20 | 2021-01-08 | 连云港杰瑞药业有限公司 | 一种合成阿塞那平中间体的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7605526A (nl) * | 1976-05-24 | 1977-11-28 | Akzo Nv | Nieuwe tetracyclische derivaten. |
CZ284633B6 (cs) | 1994-03-02 | 1999-01-13 | Akzo Nobel N. V. | Farmaceutický prostředek a použití trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrolu pro výrobu farmaceutického prostředku |
AU2418499A (en) | 1997-12-19 | 1999-07-12 | Akzo Nobel N.V. | Org-5222 in the treatment of depression |
-
2006
- 2006-04-06 RS RSP-2010/0014A patent/RS51341B/en unknown
- 2006-04-06 DE DE602006010132T patent/DE602006010132D1/de active Active
- 2006-04-06 JP JP2008504777A patent/JP2008534657A/ja not_active Withdrawn
- 2006-04-06 EP EP06112333A patent/EP1710241B1/en active Active
- 2006-04-06 SI SI200630526T patent/SI1710241T1/sl unknown
- 2006-04-06 BR BRPI0610677-3A patent/BRPI0610677A2/pt not_active IP Right Cessation
- 2006-04-06 UA UAA200711020A patent/UA93044C2/ru unknown
- 2006-04-06 DK DK06112333.7T patent/DK1710241T3/da active
- 2006-04-06 EP EP09174540A patent/EP2154134B1/en active Active
- 2006-04-06 UA UAA200711019A patent/UA93043C2/ru unknown
- 2006-04-06 PL PL06112333T patent/PL1710241T3/pl unknown
- 2006-04-06 MX MX2007012446A patent/MX2007012446A/es active IP Right Grant
- 2006-04-06 CN CN2006800167535A patent/CN101175741B/zh not_active Expired - Fee Related
- 2006-04-06 PT PT06112333T patent/PT1710241E/pt unknown
- 2006-04-06 NZ NZ562125A patent/NZ562125A/en not_active IP Right Cessation
- 2006-04-06 AR ARP060101357A patent/AR063188A1/es unknown
- 2006-04-06 TW TW095112190A patent/TW200716589A/zh unknown
- 2006-04-06 ES ES06112333T patent/ES2333980T3/es active Active
- 2006-04-06 AU AU2006231281A patent/AU2006231281B2/en not_active Ceased
- 2006-04-06 RU RU2007141161/04A patent/RU2397164C2/ru not_active IP Right Cessation
- 2006-04-06 KR KR1020077025399A patent/KR20070116973A/ko not_active Application Discontinuation
- 2006-04-06 CN CN2006100916992A patent/CN1861604B/zh active Active
- 2006-04-06 WO PCT/EP2006/061409 patent/WO2006106136A1/en not_active Application Discontinuation
- 2006-04-06 AT AT06112333T patent/ATE447564T1/de not_active IP Right Cessation
- 2006-04-06 CA CA002603181A patent/CA2603181A1/en not_active Abandoned
-
2007
- 2007-02-26 HK HK07102138.2A patent/HK1094800A1/xx not_active IP Right Cessation
- 2007-10-04 ZA ZA200708490A patent/ZA200708490B/xx unknown
- 2007-10-04 ZA ZA200708493A patent/ZA200708493B/xx unknown
- 2007-10-07 IL IL186354A patent/IL186354A0/en not_active IP Right Cessation
- 2007-10-10 NO NO20075152A patent/NO20075152L/no not_active Application Discontinuation
-
2010
- 2010-01-08 CY CY20101100023T patent/CY1109722T1/el unknown
- 2010-01-18 HR HR20100031T patent/HRP20100031T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA93043C2 (ru) | ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ ПОЛУЧЕНИЯ ТРАНС-5-ХЛОР-2-МЕТИЛ-2,3,3А,12В-ТЕТРАГИДРО-1Н-ДИБЕНЗ[2,3:6,7]ОКСЕПИНО[4,5-с]ПИРОЛА | |
MX2007006397A (es) | Derivados de tetrahidropirano. | |
WO2007015017A3 (fr) | Nouveaux derives de polyquinoleines et leur utilisation therapeutique | |
IL185611A0 (en) | Novel imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same | |
TW200722428A (en) | Crystal form of asenapine maleate | |
TNSN08059A1 (en) | Novel crystalline form of a pyridazino [4,5-b] indole derivative | |
GEP20135780B (en) | Novel pyrazolo [3,4-d] pyrimidine derivatives as anti-cancer agents | |
HK1125358A1 (en) | Substituted cyclohexylmethyl derivatives | |
TW200500339A (en) | Pyrrolidine derivatives, and process for the preparation | |
TW200800969A (en) | Compounds | |
TW200626600A (en) | Octahydropyrrolo[3, 4-c]pyrrole derivatives | |
WO2005040171A8 (en) | Pyrazolo and imidazo-pyrimidine derivatives | |
TW200745102A (en) | Pyrido[2,3-d]pyrimidine derivatives, preparation thereof, therapeutic use thereof | |
NO20070550L (no) | Fremgangsmate for fremstilling av pyrrolotriazinforbindelser | |
GEP20105095B (en) | Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents | |
RS51912B (en) | 1,2,3,4-TETRAHYDROPYROLO (1,2-a) PYRAZINE-6-CARBOXAMIDE AND 2,3,4,5-TETRAHYDROPYROLO (1,2-a) (1,4) -DIAZEPIN-7-CARBOXAMIDE DERIVATIVES THEIR OBTAINING AND THERAPEUTIC APPLICATION | |
WO2006029210A3 (en) | Acyclic 1,3-diamines and uses therefor | |
ZA200900165B (en) | 4-amino-3-arylamino-6-arylpyrazolo[3,4-D]pyrimidine derivatives, methods for their preparation and their use as antiviral agents | |
SG152296A1 (en) | Novel process for the preparation of 5-amino-3h-thiazolo[4,5-d]pyrimidin-2- one | |
IL187441A0 (en) | Derivatives of 6,7-dihydro-5h-imidazo[1,2-a] imidazole-3-sulfonic acid | |
IL164978A0 (en) | A process for the preparation of clopidogrel | |
DE602005026035D1 (en) | Festphasenpeptidsynthese | |
IS8034A (is) | Imídasó[4,5-B]kínólínafleiður og notkun þeirra sem NO-myndunarhemla | |
GB2434795A (en) | Pyrrolo [2, 1-C] [1, 4] benzodiazepine-anthraquinone conjugates useful as antitumour agents | |
TW200731989A (en) | Use of a compound comprising a camptothecin derivative for preparing pharmaceutical formulations useful in the treatment of melanoma |