CY1120477T1 - Ενεργοποιητης του υποδοχεα που ενεργοποιειται απο πολλαπλασιαστες των υπεροξεισωματων - Google Patents

Ενεργοποιητης του υποδοχεα που ενεργοποιειται απο πολλαπλασιαστες των υπεροξεισωματων

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Publication number
CY1120477T1
CY1120477T1 CY20181100803T CY181100803T CY1120477T1 CY 1120477 T1 CY1120477 T1 CY 1120477T1 CY 20181100803 T CY20181100803 T CY 20181100803T CY 181100803 T CY181100803 T CY 181100803T CY 1120477 T1 CY1120477 T1 CY 1120477T1
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CY
Cyprus
Prior art keywords
actuator
multipliers
receiver
sub
actuated
Prior art date
Application number
CY20181100803T
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English (en)
Inventor
Shogo Sakuma
Rie Takahashi
Hideki Nakamura
Original Assignee
Nippon Chemiphar Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co., Ltd. filed Critical Nippon Chemiphar Co., Ltd.
Publication of CY1120477T1 publication Critical patent/CY1120477T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Μία ένωση που αναπαριστάται από τον τύπο (I) ή ένα φαρμακολογικά αποδεκτό άλας αυτής χρησιμοποιείται ως ενεργοποιητής του PPAR. Όπου έκαστο από τα R1 και R2 είναι υδρογόνο, αλκύλιο με C1-8, αλκύλιο με C1-8 υποκατεστημένο με αλογόνο, ή παρόμοιο· έκαστο από τα R3, R4, R5, και R6 είναι υδρογόνο, αλκύλιο με C1-8, ή παρόμοιο· το Χ είναι θείο ή παρόμοιο· το Υ είναι οξυγόνο, ένας δεσμός, ή παρόμοιο· το p είναι 0 ή 1· το Α είναι οξυγόνο, CH2, Ν-ΝΗ2, ή παρόμοιο· όταν το p είναι 1, το Β είναι φαινύλιο, το οποίο μπορεί να έχει έναν υποκατάστατη· όταν το p είναι 0, το Β είναι συμπυκνωμένος δακτύλιος όπως βενζισοξαζόλιο, ο οποίος μπορεί να έχει έναν υποκατάστατη· το m είναι ένας ακέραιος από 1 έως 4· και το n είναι ένας ακέραιος από 0 έως 5.
CY20181100803T 2008-04-15 2018-08-01 Ενεργοποιητης του υποδοχεα που ενεργοποιειται απο πολλαπλασιαστες των υπεροξεισωματων CY1120477T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008105899 2008-04-15
PCT/JP2009/057946 WO2009128558A1 (ja) 2008-04-15 2009-04-15 ペルオキシソーム増殖剤活性化受容体の活性化剤

Publications (1)

Publication Number Publication Date
CY1120477T1 true CY1120477T1 (el) 2019-07-10

Family

ID=41199240

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20181100803T CY1120477T1 (el) 2008-04-15 2018-08-01 Ενεργοποιητης του υποδοχεα που ενεργοποιειται απο πολλαπλασιαστες των υπεροξεισωματων

Country Status (24)

Country Link
US (1) US8648208B2 (el)
EP (2) EP3424917A1 (el)
JP (1) JP5474769B2 (el)
KR (2) KR101710340B1 (el)
CN (2) CN102083810B (el)
AU (1) AU2009236877B2 (el)
BR (1) BRPI0911197A2 (el)
CA (1) CA2721339C (el)
CY (1) CY1120477T1 (el)
DK (1) DK2277874T3 (el)
ES (1) ES2683012T3 (el)
HR (1) HRP20181168T1 (el)
HU (1) HUE039145T2 (el)
IL (1) IL208754A (el)
LT (1) LT2277874T (el)
MX (1) MX2010011252A (el)
NZ (1) NZ588612A (el)
PL (1) PL2277874T3 (el)
PT (1) PT2277874T (el)
RU (1) RU2501794C2 (el)
SI (1) SI2277874T1 (el)
TW (1) TWI440633B (el)
WO (1) WO2009128558A1 (el)
ZA (1) ZA201007392B (el)

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WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013068486A1 (en) 2011-11-08 2013-05-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of male infertility
US20170101209A1 (en) * 2015-10-08 2017-04-13 Cash J Viedt Growler
WO2019105234A1 (zh) * 2017-11-30 2019-06-06 四川科伦博泰生物医药股份有限公司 芳香族化合物及其药物组合物和用途
CN111393405B (zh) * 2019-01-02 2022-11-25 中国科学院上海药物研究所 一类含氟取代的苯并噻吩类化合物及其药物组合物及应用
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Also Published As

Publication number Publication date
RU2501794C2 (ru) 2013-12-20
US20110098480A1 (en) 2011-04-28
MX2010011252A (es) 2010-11-30
DK2277874T3 (en) 2018-08-06
CN104672220B (zh) 2017-09-22
TWI440633B (zh) 2014-06-11
EP2277874A1 (en) 2011-01-26
ZA201007392B (en) 2012-01-25
HRP20181168T1 (hr) 2018-11-02
PT2277874T (pt) 2018-08-10
CA2721339C (en) 2017-01-24
KR20100132070A (ko) 2010-12-16
HUE039145T2 (hu) 2018-12-28
CA2721339A1 (en) 2009-10-22
EP2277874A4 (en) 2011-10-12
CN102083810B (zh) 2014-10-29
US8648208B2 (en) 2014-02-11
NZ588612A (en) 2012-08-31
KR101871665B1 (ko) 2018-06-27
CN102083810A (zh) 2011-06-01
ES2683012T3 (es) 2018-09-24
CN104672220A (zh) 2015-06-03
RU2010146166A (ru) 2012-05-20
IL208754A0 (en) 2010-12-30
IL208754A (en) 2016-04-21
TW200946514A (en) 2009-11-16
AU2009236877B2 (en) 2014-01-23
EP3424917A1 (en) 2019-01-09
JP5474769B2 (ja) 2014-04-16
EP2277874B1 (en) 2018-06-27
WO2009128558A1 (ja) 2009-10-22
JPWO2009128558A1 (ja) 2011-08-04
BRPI0911197A2 (pt) 2015-10-13
KR101710340B1 (ko) 2017-02-27
PL2277874T3 (pl) 2018-11-30
AU2009236877A1 (en) 2009-10-22
LT2277874T (lt) 2018-10-10
KR20170021918A (ko) 2017-02-28
SI2277874T1 (sl) 2019-01-31

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