AR052866A1 - Fenil-metanonas monociclicas sustituidas - Google Patents
Fenil-metanonas monociclicas sustituidasInfo
- Publication number
- AR052866A1 AR052866A1 ARP060100050A ARP060100050A AR052866A1 AR 052866 A1 AR052866 A1 AR 052866A1 AR P060100050 A ARP060100050 A AR P060100050A AR P060100050 A ARP060100050 A AR P060100050A AR 052866 A1 AR052866 A1 AR 052866A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- phenyl
- substituted
- halogen
- monociclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
Se refiere a compuestos de la formula general (1), en la que: R1 es -OR1', -SR1' o es un grupo heterocicloalquilo; R1' es alquilo inferior, alquilo inferior sustituido por halogeno o es -(CH2)n-cicloalquilo; R2 es -S(O)2-alquilo inferior, -S(O)2NH- alquilo inferior, NO2 o CN; X1 es CR3 o N; X2 es CR3' o N; R3/R3' con independencia entre si son hidrogeno, halogeno, alquilo inferior, CN, NO2, -S(O)2)- fenilo, -S(O)2-alquilo inferior, -S(O)2-piridin-2-, -3- o -4-ilo, fenilo, opcionalmente sustituido por uno o dos sustituyentes elegidos entre el grupo formado por NO2 o halogeno, o es alquilo inferior sustituido por halogeno o es -C(O)-alquilo inferior; n es 0, 1 o 2; y a sales de adicion de ácido farmacéuticamente aceptable de los mismos. Se ha encontrado que los compuestos de la formula (1) son buenos inhibidores del transportador de glicina 1 (GlyT-1). Pueden utilizarse para el tratamiento de la esquizofrenia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05100077 | 2005-01-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR052866A1 true AR052866A1 (es) | 2007-04-11 |
Family
ID=35998949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060100050A AR052866A1 (es) | 2005-01-07 | 2006-01-06 | Fenil-metanonas monociclicas sustituidas |
Country Status (19)
Country | Link |
---|---|
US (1) | US7220744B2 (es) |
EP (1) | EP1838308B1 (es) |
JP (1) | JP5006799B2 (es) |
KR (1) | KR100895752B1 (es) |
CN (1) | CN101137363B (es) |
AR (1) | AR052866A1 (es) |
AT (1) | ATE472327T1 (es) |
AU (1) | AU2005324024B2 (es) |
BR (1) | BRPI0519794A2 (es) |
CA (1) | CA2593463C (es) |
DE (1) | DE602005022113D1 (es) |
ES (1) | ES2346335T3 (es) |
IL (1) | IL184353A (es) |
MX (1) | MX2007008189A (es) |
NO (1) | NO20073667L (es) |
RU (1) | RU2396270C2 (es) |
TW (1) | TWI313174B (es) |
WO (1) | WO2006072436A1 (es) |
ZA (1) | ZA200705472B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
CA2580781A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coa-desaturase (scd) |
BRPI0515489A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e sua utilização como inibidores de estearoil-coa desaturase |
US7919496B2 (en) * | 2004-09-20 | 2011-04-05 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes |
JP5094398B2 (ja) * | 2004-09-20 | 2012-12-12 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環式誘導体およびステアロイル−CoAデサチュラーゼのメディエータとしてのそれらの使用 |
CA2580857A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
WO2007130075A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
ATE532516T1 (de) * | 2007-03-05 | 2011-11-15 | Hoffmann La Roche | Verfahren zur synthese von glyt-1-hemmern |
KR20110063862A (ko) | 2008-10-09 | 2011-06-14 | 에프. 호프만-라 로슈 아게 | 피롤리딘 n-벤질 유도체 |
TW201127806A (en) * | 2009-09-02 | 2011-08-16 | Du Pont | Process for the synthesis of fluorinated ethers of aromatic acids |
TW201127805A (en) * | 2009-09-02 | 2011-08-16 | Du Pont | Process for the synthesis of fluorinated ethers of aromatic acids |
CN101885708B (zh) * | 2010-07-07 | 2013-03-06 | 中国科学院上海有机化学研究所 | 5-多氟烷基取代的2-氨基噻唑类化合物、合成方法及其应用 |
WO2011082660A1 (zh) * | 2010-01-08 | 2011-07-14 | 中国科学院上海有机化学研究所 | 5-多氟烷基取代的2-氨基噻唑类化合物、合成方法及其应用 |
CA2801074A1 (en) * | 2010-06-04 | 2011-12-08 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
US9012489B2 (en) * | 2011-08-03 | 2015-04-21 | Boehringer Ingelheim International Gmbh | Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament |
US9266838B2 (en) | 2011-08-15 | 2016-02-23 | University Of Utah Research Foundation | Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors |
CA2841037C (en) | 2011-08-17 | 2020-03-31 | Remynd Nv | Piperazine thiazole derivatives useful in the treatment of tauopathies such as alzheimer's disease |
CN104119343A (zh) * | 2013-04-25 | 2014-10-29 | 苏州科捷生物医药有限公司 | 2-三氟甲基噻二唑类化合物及其用途 |
ES2739814T3 (es) * | 2013-06-19 | 2020-02-04 | Univ Utah Res Found | Compuestos de (3-(5-cloro-2-hidroxifenil)-1-benzoil-1H-pirazol sustituidos como inhibidores de histona desmetilasa |
EP3134406A1 (en) | 2014-04-24 | 2017-03-01 | Dart Neuroscience (Cayman) Ltd | Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2h-pyrazolo [4,3-c]pyridine compounds as glyt1 inhibitors |
EP3215500A1 (en) | 2014-11-05 | 2017-09-13 | Dart NeuroScience (Cayman) Ltd. | Substituted azetidinyl compounds as glyt1 inhibitors |
CN105712952B (zh) * | 2014-12-22 | 2021-03-26 | 上海翰森生物医药科技有限公司 | 2-取代氧基-5-甲砜基苯基哌嗪酰胺类似物及其制备方法和用途 |
CN105712945B (zh) * | 2014-12-22 | 2020-12-01 | 上海翰森生物医药科技有限公司 | 2-取代氧基-5-甲砜基芳基哌嗪酰胺类似物及其制备方法和用途 |
MA46589A (fr) * | 2016-10-24 | 2019-08-28 | Yumanity Therapeutics Inc | Composés et utilisations de ces derniers |
CA3083000A1 (en) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
TW202108574A (zh) | 2019-05-10 | 2021-03-01 | 美商迪賽孚爾製藥有限公司 | 雜芳基胺基嘧啶醯胺自噬抑制劑及其使用方法 |
WO2020257180A1 (en) | 2019-06-17 | 2020-12-24 | Deciphera Pharmaceuticals, Llc | Aminopyrimidine amide autophagy inhibitors and methods of use thereof |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB867273A (en) * | 1959-02-20 | 1961-05-03 | Wallace & Tiernan Inc | Piperazine derivatives |
DE2423847A1 (de) | 1973-05-28 | 1975-01-02 | Ciba Geigy Ag | Neue sulfamoylbenzoesaeureamide |
DE2611705A1 (de) | 1976-03-18 | 1977-09-22 | Josef Dipl Chem Dr Rer N Klosa | N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel |
IT1176613B (it) * | 1984-08-14 | 1987-08-18 | Ravizza Spa | Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione |
RU2124511C1 (ru) | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
TR200002570T2 (tr) | 1998-03-06 | 2000-12-21 | Janssen Pharmaceutica N.V. | Glisin naklini önleyiciler |
EP1059922A2 (en) * | 1998-03-06 | 2000-12-20 | Janssen Pharmaceutica N.V. | Glycine transport inhibitors |
GB0021419D0 (en) | 2000-08-31 | 2000-10-18 | Oxford Glycosciences Uk Ltd | Compounds |
AR032653A1 (es) * | 2001-02-09 | 2003-11-19 | Telik Inc | Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos. |
DE60234453D1 (de) | 2001-07-02 | 2009-12-31 | High Point Pharmaceuticals Llc | Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren |
WO2003035602A1 (fr) | 2001-10-25 | 2003-05-01 | Sankyo Company, Limited | Modulateurs lipidiques |
DE10217006A1 (de) * | 2002-04-16 | 2003-11-06 | Merck Patent Gmbh | Substituierte Indole |
US20060052597A1 (en) | 2002-10-22 | 2006-03-09 | Best Desmond J | Aryloxyalkylamine derivatives as h3 receptor ligands |
ME00116B (me) | 2003-08-11 | 2010-10-10 | Hoffmann La Roche | Piperazin sa ili supstituisanom fenil grupom i njihova upotreba kao inhibitora glyt1 |
JP4563386B2 (ja) * | 2003-09-09 | 2010-10-13 | エフ.ホフマン−ラ ロシュ アーゲー | 精神病の処置のためのグリシン取り込み阻害剤としての1−(2−アミノ−ベンゾール)−ピペラジン誘導体 |
KR100774621B1 (ko) * | 2003-09-09 | 2007-11-14 | 에프. 호프만-라 로슈 아게 | 정신병 치료용의 글라이신 섭취 억제제로서의1-벤조일-피페라진 유도체 |
-
2005
- 2005-12-28 WO PCT/EP2005/014082 patent/WO2006072436A1/en active Application Filing
- 2005-12-28 KR KR1020077018037A patent/KR100895752B1/ko not_active IP Right Cessation
- 2005-12-28 DE DE602005022113T patent/DE602005022113D1/de active Active
- 2005-12-28 CA CA2593463A patent/CA2593463C/en not_active Expired - Fee Related
- 2005-12-28 ES ES05824313T patent/ES2346335T3/es active Active
- 2005-12-28 CN CN2005800490086A patent/CN101137363B/zh not_active Expired - Fee Related
- 2005-12-28 JP JP2007549824A patent/JP5006799B2/ja not_active Expired - Fee Related
- 2005-12-28 BR BRPI0519794-5A patent/BRPI0519794A2/pt not_active IP Right Cessation
- 2005-12-28 AU AU2005324024A patent/AU2005324024B2/en not_active Ceased
- 2005-12-28 EP EP05824313A patent/EP1838308B1/en not_active Not-in-force
- 2005-12-28 MX MX2007008189A patent/MX2007008189A/es active IP Right Grant
- 2005-12-28 AT AT05824313T patent/ATE472327T1/de active
- 2005-12-28 RU RU2007124545/04A patent/RU2396270C2/ru not_active IP Right Cessation
-
2006
- 2006-01-03 US US11/324,990 patent/US7220744B2/en not_active Expired - Fee Related
- 2006-01-06 TW TW095100678A patent/TWI313174B/zh active
- 2006-01-06 AR ARP060100050A patent/AR052866A1/es unknown
-
2007
- 2007-07-02 IL IL184353A patent/IL184353A/en not_active IP Right Cessation
- 2007-07-04 ZA ZA200705472A patent/ZA200705472B/xx unknown
- 2007-07-17 NO NO20073667A patent/NO20073667L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN101137363B (zh) | 2010-09-15 |
CA2593463A1 (en) | 2006-07-13 |
RU2007124545A (ru) | 2009-02-20 |
DE602005022113D1 (de) | 2010-08-12 |
MX2007008189A (es) | 2007-08-07 |
AU2005324024A1 (en) | 2006-07-13 |
RU2396270C2 (ru) | 2010-08-10 |
IL184353A0 (en) | 2007-10-31 |
TWI313174B (en) | 2009-08-11 |
IL184353A (en) | 2012-06-28 |
NO20073667L (no) | 2007-07-24 |
JP2008526796A (ja) | 2008-07-24 |
TW200635585A (en) | 2006-10-16 |
EP1838308B1 (en) | 2010-06-30 |
AU2005324024B2 (en) | 2011-02-17 |
ZA200705472B (en) | 2008-09-25 |
JP5006799B2 (ja) | 2012-08-22 |
KR20070092759A (ko) | 2007-09-13 |
US7220744B2 (en) | 2007-05-22 |
ATE472327T1 (de) | 2010-07-15 |
KR100895752B1 (ko) | 2009-04-30 |
CN101137363A (zh) | 2008-03-05 |
EP1838308A1 (en) | 2007-10-03 |
ES2346335T3 (es) | 2010-10-14 |
WO2006072436A1 (en) | 2006-07-13 |
BRPI0519794A2 (pt) | 2009-03-17 |
US20060167009A1 (en) | 2006-07-27 |
CA2593463C (en) | 2013-10-08 |
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