PT1206457E - Derivados de diaril-oxa(tia)zol e seu uso como moduladores dos ppars - Google Patents

Derivados de diaril-oxa(tia)zol e seu uso como moduladores dos ppars

Info

Publication number
PT1206457E
PT1206457E PT00959401T PT00959401T PT1206457E PT 1206457 E PT1206457 E PT 1206457E PT 00959401 T PT00959401 T PT 00959401T PT 00959401 T PT00959401 T PT 00959401T PT 1206457 E PT1206457 E PT 1206457E
Authority
PT
Portugal
Prior art keywords
diaril
ppars
zol
tia
oxa
Prior art date
Application number
PT00959401T
Other languages
English (en)
Inventor
Donald P Matthews
Alan M Warshawsky
Dawn A Brooks
Christopher J Rito
Anthony J Shuker
Samuel J Dominianni
Lynn S Gossett
David A Hay
Robert J Ardecky
Pierre-Yves Michellys
John S Tyhonas
Original Assignee
Lilly Co Eli
Ligand Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Ligand Pharm Inc filed Critical Lilly Co Eli
Publication of PT1206457E publication Critical patent/PT1206457E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
PT00959401T 1999-08-27 2000-08-23 Derivados de diaril-oxa(tia)zol e seu uso como moduladores dos ppars PT1206457E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15116299P 1999-08-27 1999-08-27

Publications (1)

Publication Number Publication Date
PT1206457E true PT1206457E (pt) 2004-03-31

Family

ID=22537578

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00959401T PT1206457E (pt) 1999-08-27 2000-08-23 Derivados de diaril-oxa(tia)zol e seu uso como moduladores dos ppars

Country Status (13)

Country Link
US (3) US6417212B1 (pt)
EP (1) EP1206457B1 (pt)
JP (1) JP2003508389A (pt)
AR (1) AR025386A1 (pt)
AT (1) ATE252091T1 (pt)
AU (1) AU7073400A (pt)
CA (1) CA2382966A1 (pt)
DE (1) DE60005973T2 (pt)
DK (1) DK1206457T3 (pt)
ES (1) ES2204684T3 (pt)
PE (1) PE20010529A1 (pt)
PT (1) PT1206457E (pt)
WO (1) WO2001016120A1 (pt)

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EP1206457B1 (en) 2003-10-15
AU7073400A (en) 2001-03-26
AR025386A1 (es) 2002-11-27
US20030045558A1 (en) 2003-03-06
US6417212B1 (en) 2002-07-09
CA2382966A1 (en) 2001-03-08
ATE252091T1 (de) 2003-11-15
ES2204684T3 (es) 2004-05-01
US20040019090A1 (en) 2004-01-29
PE20010529A1 (es) 2001-05-18
DE60005973D1 (de) 2003-11-20
WO2001016120A1 (en) 2001-03-08
US6610696B2 (en) 2003-08-26
DK1206457T3 (da) 2004-02-16
WO2001016120A9 (en) 2002-07-11
US6825222B2 (en) 2004-11-30
JP2003508389A (ja) 2003-03-04
EP1206457A1 (en) 2002-05-22
DE60005973T2 (de) 2004-05-13

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