CN109276814A - Multi-channel stimulation system and method for transcranial magnetic stimulation - Google Patents
Multi-channel stimulation system and method for transcranial magnetic stimulation Download PDFInfo
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- CN109276814A CN109276814A CN201811290177.4A CN201811290177A CN109276814A CN 109276814 A CN109276814 A CN 109276814A CN 201811290177 A CN201811290177 A CN 201811290177A CN 109276814 A CN109276814 A CN 109276814A
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- 238000000034 method Methods 0.000 title claims abstract description 20
- 238000011491 transcranial magnetic stimulation Methods 0.000 title claims abstract description 19
- 230000000638 stimulation Effects 0.000 title abstract description 24
- 230000004936 stimulating effect Effects 0.000 claims abstract description 107
- 239000003990 capacitor Substances 0.000 claims abstract description 46
- 238000001816 cooling Methods 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 4
- 210000001178 neural stem cell Anatomy 0.000 claims description 4
- 238000012546 transfer Methods 0.000 claims description 4
- 238000012360 testing method Methods 0.000 claims description 3
- 238000004146 energy storage Methods 0.000 abstract description 4
- 238000012544 monitoring process Methods 0.000 abstract description 2
- 238000007599 discharging Methods 0.000 abstract 3
- 210000004556 brain Anatomy 0.000 description 4
- 210000005036 nerve Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000005674 electromagnetic induction Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 238000005424 photoluminescence Methods 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS], computer integrated manufacturing [CIM]
- G05B19/4183—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS], computer integrated manufacturing [CIM] characterised by data acquisition, e.g. workpiece identification
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS], computer integrated manufacturing [CIM]
- G05B19/41845—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS], computer integrated manufacturing [CIM] characterised by system universality, reconfigurability, modularity
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS], computer integrated manufacturing [CIM]
- G05B19/4185—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS], computer integrated manufacturing [CIM] characterised by the network communication
Abstract
The invention discloses a multi-channel stimulation system and a multi-channel stimulation method for transcranial magnetic stimulation. And the upper computer module is used for controlling the stimulation module and displaying system state information. The stimulation module mainly comprises: the device comprises a main control module, a boosting and PFC module, an energy storage capacitor, a discharging loop, a discharging switch and a stimulating coil. The main control module is used for controlling the boosting and PFC module and the discharging switch; collecting and monitoring the temperature of the stimulating coil; the coil type is identified. The multi-channel stimulation module can be connected to a TCP/IP network through the TCP/IP module so as to be interconnected with the upper computer module. The upper computer module sends an instruction to the main control module, controls the boosting and PFC module to charge the energy storage capacitor, and controls the discharge switch to enable the capacitor to discharge to the stimulating coil, so that a time-varying magnetic field of transcranial magnetic stimulation is generated in the coil. The invention can realize millisecond synchronization of multi-channel stimulation and can simultaneously use a plurality of stimulation modes to stimulate a plurality of positions.
Description
Technical field
The present invention relates to electro photoluminescence field more particularly to a kind of multichannel stimulating system for transcranial magnetic stimulation and stimulation sides
Method.
Background technique
High-intensitive magnetic field impulse stimulation is widely used in medical domain, using quite especially in terms of cerebral nerve field
It is more.TMS (Transcranial Magnetic Stimulation) transcranial magnetic stimulation is relatively effective at present for neural class
The safe treatment method that disease treatment, a kind of painless and noninvasive, lossless, non-intruding is controlled.It mainly utilizes electromagnetic induction former
It manages, when the charge in the capacitor of transcranial magnetic stimulation discharges rapidly, is placed in the coil of above-head and is passed through pulse current, into
And pulsed magnetic field is generated around coil, the magnetic line of force penetrates skull stimulation cortex with lesser resistance hurtless measure, in cortex
Conductible induced current is generated, Induced Electric Field can cause bioelectricity to conduct in the tissue, make nerve fibre, neuron and flesh
Meat depolarizes and provides nerve impulse, to influence the functional status of tissue or nervous system, changes big intracerebral nerve cell
Electrical activity.The stimulation of brains is not limited in practical application, peripheral nerve muscle can equally stimulate.The method has safety
Reliably, the features such as non-intrusion type.
But during magnetic stimulation treatment, it is often necessary to stimulated simultaneously human body brain multiple regions, either
It is stimulated using the multiple-channel output of an equipment, while to different patients.It thus needs stimulation apparatus to have two-way to be
To the ability of multiple-channel output.There is a multiple output function therefore, it is necessary to a kind of and multiple equipment can be uniformly controlled
Easy to operate system.
Summary of the invention
In order to solve the above problem, the present invention provides a kind of multichannel stimulating systems for transcranial magnetic stimulation, comprising: upper
Machine module, multiple TCP/IP modules and multiple stimulating modules, wherein the upper computer module passes through single TCP/IP module and list
A stimulating module is connected;
The upper computer module receives the multiple TCP/ for sending control signals to the multiple TCP/IP module
IP module send system status information and display;
The TCP/IP module be used for receive upper computer module sending control signal, then send control signals to and its
The stimulating module being connected, and the status information for the system that the stimulating module issues is transferred to upper computer module;
The stimulating module is used to receive the control signal that coupled TCP/IP module is sent, and will test
The status information of system is sent to the TCP/IP module.
Preferably, the stimulating module includes: main control module, boosting and PFC module, storage capacitor, discharge loop, electric discharge
Switch and stimulating coil;Wherein, main control module is connected with boosting and PFC module and discharge switch respectively, storage capacitor
It is connected respectively with boosting and PFC module, discharge switch and discharge loop, discharge switch is connected with stimulating coil;
The main control module is used to receive the control signal of TCP/IP module transfer, exports charging signals to boost module,
Discharge signal is exported to discharge switch, the status information of acquisition system is simultaneously sent to TCP/IP module;
The boosting and PFC module are used to receive the charging signals that the main control module is sent, and charge to storage capacitor;
The storage capacitor is for storing electric energy;
The discharge loop is used to discharge the dump energy in storage capacitor;
The discharge switch is used to receive the discharge signal that the main control module is sent, and the electric energy in storage capacitor is discharged
Into stimulating coil, to stimulating coil instantaneous discharge;
The stimulating coil is used to receive the instantaneous electric energy by discharge switch, generates Neural stem cell pulse.
Preferably, the main control module is for monitoring the system mode of system, the state of temperature of stimulating coil, storage capacitor
Charged state, and the system mode, the state of temperature and the charged state are shown by LED light.
Preferably, the stimulating coil includes annulus stimulating coil, 8-shaped stimulating coil and/or double 8-shaped stimulation line
Circle.
Preferably, the type of cooling of the stimulating coil includes that liquid circulation is cooling and/or circulated air is cooling.
A kind of multichannel stimulating method for transcranial magnetic stimulation, uses above-mentioned system, this method comprises the following steps:
Upper computer module sends control signals to each TCP/IP module;
The control signal received is sent to coupled stimulating module by each TCP/IP module;
Stimulating module described in multichannel starts to execute control instruction after receiving control signal;
The status information of the system monitored is sent to coupled each TCP/IP mould by stimulating module described in multichannel
Block;
The status information of the system received is sent to upper computer module by each TCP/IP module;
Upper computer module shows the status information of the system received.
Preferably, stimulating module described in multichannel starts to execute control instruction to further include walking as follows after receiving control signal
It is rapid:
Charging control signal is sent to boosting and PFC module by main control module;
The storage capacitor being connected with PFC module for it that boosts charges;
Discharge control signal is sent to discharge switch by the main control module;
Discharge switch control storage capacitor discharges to stimulating coil;
Discharge loop discharges to storage capacitor after system cut-off.
The present invention has the advantages that this system can control multiple-channel output module simultaneously, and reach Millisecond and synchronize, it is convenient
Brain multiple regions are stimulated simultaneously, or different patients is stimulated simultaneously;Discharge loop stops in system cut-off
It starts to work when only working, the energy storage in capacitor can be discharged in moment, improve the security reliability of equipment;This system has
Three kinds of stimulating coils it is optional and can automatic identification coil type, enrich range of choice when stimulation.
Detailed description of the invention
By reading the following detailed description of the preferred embodiment, various other advantages and benefits are common for this field
Technical staff will become clear.Attached drawing is only used for showing the purpose of preferred implementations, and is not considered as to the present invention
Limitation.And throughout the drawings, identical component is indicated with same reference symbol.In the accompanying drawings:
Fig. 1 is a kind of structural schematic diagram of multichannel stimulating system for transcranial magnetic stimulation provided by the invention;
Fig. 2 is a kind of circuit diagram of multichannel stimulating system for transcranial magnetic stimulation provided by the invention;
Fig. 3 is a kind of control flow chart of multichannel stimulating method for transcranial magnetic stimulation provided by the invention;
Fig. 4 is a kind of status information flow for displaying of multichannel stimulating method for transcranial magnetic stimulation provided by the invention
Figure;
Fig. 5 is a kind of control flow of the main control module of multichannel stimulating method for transcranial magnetic stimulation provided by the invention
Figure.
Specific embodiment
The illustrative embodiments of the disclosure are more fully described below with reference to accompanying drawings.Although showing this public affairs in attached drawing
The illustrative embodiments opened, it being understood, however, that may be realized in various forms the disclosure without the reality that should be illustrated here
The mode of applying is limited.It is to be able to thoroughly understand the disclosure on the contrary, providing these embodiments, and can be by this public affairs
The range opened is fully disclosed to those skilled in the art.
According to presently filed embodiment, a kind of multichannel stimulating system for transcranial magnetic stimulation is proposed, as shown in Figure 1,
It include: upper computer module, TCP/IP module and stimulating module, wherein the upper computer module passes through each TCP/IP module and more
Stimulating module described in road is connected, while stimulating module described in multichannel being driven to work, and can be realized thorn described in driving multichannel
The Millisecond for swashing module is synchronous.
Upper computer module includes integrated PC machine and upper computer software, for sending control signals to each TCP/IP module,
Receive the status information for the system that each TCP/IP module is sent and display.Upper computer software includes a personal-machine interactive interface, tool
Body is used for: display system state, be set and controlled the stimulation mode of stimulating module described in multichannel, stimulus intensity, frequency of stimulation and
Stimulation time shows coil type and the working method of coil is arranged, monitors and show stimulation progress and coil and its shell
Temperature, display and record patient information, illness description and stimulation protocol.
TCP/IP module is used to receive the control signal of upper computer module sending, then sends control signals to coupled
The stimulating module connect, and the status information for the system that the stimulating module issues is transferred to upper computer module.One TCP/IP
Module connects a stimulating module, and by TCP/IP network, each TCP/IP module can be by coupled each stimulating module
Be connected with upper computer module, upper computer module enable to control stimulating module described in multichannel, thus carry out upper computer module and
The communication of the hardware view of stimulating module described in multichannel, carry out the feedback of information with exchange, also can be more easily by big data, cloud
The involvements such as terminal come in form smart machine.
Stimulating module is used to receive the control signal that coupled TCP/IP module is sent, and the system that will test
Status information be sent to the TCP/IP module.
Stimulating module includes: main control module, boosting and PFC module, storage capacitor, discharge loop, discharge switch and thorn
Swash coil;Wherein, main control module is connected with boosting and PFC module and discharge switch respectively, storage capacitor respectively with boosting
It is connected with PFC module, discharge switch and discharge loop, discharge switch is connected with stimulating coil.Main control module receives
The control signal of TCP/IP module transfer exports charging signals to boost module, exports discharge signal, acquisition system to discharge switch
The status information of system is simultaneously sent to TCP/IP module;Boosting and PFC module receive the charging signals that the main control module is sent, right
Storage capacitor charging;Storage capacitor is for storing electric energy;Discharge loop is used to discharge the dump energy in storage capacitor;Electric discharge is opened
It closes and receives the discharge signal that the main control module is sent, the electric energy in storage capacitor is discharged into stimulating coil, to stimulation line
Enclose instantaneous discharge;Stimulating coil is used to receive the instantaneous electric energy by discharge switch, generates Neural stem cell pulse.
The status information of system includes the charged state of capacitor, the type and temperature of stimulating coil.
Preferably, discharge loop and main control module are located on same circuit printing plate, are specifically used for after system cut-off
Or power-off suddenly, when stopping working, the electric energy in storage capacitor is discharged, improves the security reliability of equipment.
As shown in Fig. 2, main control module is specifically used for the first boosting of control respectively and PFC module, the second boosting and PFC mould
Block controls the first storage capacitor being connected respectively with the first boosting and PFC module, the second boosting and PFC module, the second energy storage
Capacitor charges;By controlling the first discharge switch and the second discharge switch respectively, control respectively with the first discharge switch and
The first storage capacitor that second discharge switch is connected, the second storage capacitor are to corresponding first stimulating coil, the second stimulation line
Circle electric discharge.
Main control module monitors the state of system, the state of temperature of stimulating coil, the charged state of storage capacitor, and passes through
LED light shows corresponding each section state.
Preferably, stimulating coil includes: annulus stimulating coil, 8-shaped stimulating coil and/or double 8-shaped stimulating coils;Energy
It is enough to be replaced as needed.Main control module can identify the type of stimulating coil, according to the difference of coil, the work side of coil
Formula also can be different.For annulus stimulating coil without focus, intensity is high;8-shaped stimulating coil and double 8-shaped stimulating coils, which have, to be focused
Type has specific most strong stimulation point.
Preferably, the stimulating coil type of cooling includes that liquid circulation is cooling and/or circulated air is cooling, can be selected as needed
It selects.Described two types of cooling are that design has liquid circulation cooling two kinds cooling with circulated air in the outer enclosure of stimulating coil
Structure.When coil temperature is excessively high, and cooling device is unable to reach desired effects, whole system can be automatically stopped work, and
And upper computer software can not be operated again, to protect the safety of equipment and user.
As shown in figure 3, being a kind of control flow chart of multichannel stimulating method provided by the invention, when using above system control
When stimulating module processed works, the multichannel stimulating method includes the following steps: that upper computer module is sent control signals to respectively
TCP/IP module;The control signal received is sent to coupled stimulating module by each TCP/IP module;Described in multichannel
Stimulating module starts to execute control instruction after receiving control signal.
As shown in figure 4, being a kind of status information flow for displaying figure of multichannel stimulating method provided by the invention, when using upper
When stating system display system status information, include the following steps: that stimulating module described in multichannel believes the state of the system monitored
Breath is sent to coupled each TCP/IP module;The status information of the system received is sent to by each TCP/IP module
Position machine module;Upper computer module shows the status information of the system received.
As shown in figure 5, being a kind of control flow chart of the main control module of multichannel stimulating method provided by the invention, master control mould
The control flow of block includes the following steps: that charging control signal is sent to boosting and PFC module by main control module;Boosting and PFC
The storage capacitor that module is connected for it charges;Discharge control signal is sent to discharge switch by the main control module;
Discharge switch control storage capacitor discharges to stimulating coil;Discharge loop puts storage capacitor after system cut-off
Electricity.
In system of the invention, upper computer module issues control signal and arrives through TCP/IP network and each TCP/IP module transfer
In stimulating module described in multichannel connected to it, each main control module in stimulating module described in multichannel receives control signal, output
Two-way charge control and discharge control signal, charging control signal arrive separately at the first boosting and PFC module and the second boosting and
PFC module charges to the first storage capacitor and the second storage capacitor, after capacitor is charged, the first discharge switch and
Two discharge switches are started to work, and are opened thyristor to the first stimulating coil and the second stimulating coil instantaneous discharge, are generated Neural stem cell
Pulse., it can be achieved that the Millisecond of multichannel stimulating module is synchronous in the course of work.After system cut-off, discharge loop is started to open,
It discharges the remaining capacity of storage capacitor, makes not charged its security reliability of raising of capacitor.The system can control simultaneously
Multiple stimulating module work, it is easy to operate, brain multiple regions can not only be stimulated simultaneously, additionally it is possible to while to difference
Patient stimulate.For different needs, additionally it is possible to different stimulating coils and the different types of cooling are used, it is practical
Property is strong.Coil when the temperature is excessively high, system can be automatically stopped operation, and introduce discharge loop, make this system have very
High safety.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
In the technical scope disclosed by the present invention, any changes or substitutions that can be easily thought of by anyone skilled in the art,
It should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention should be with the protection model of the claim
Subject to enclosing.
Claims (7)
1. a kind of multichannel stimulating system for transcranial magnetic stimulation characterized by comprising upper computer module, multiple TCP/IP
Module and multiple stimulating modules, wherein the upper computer module is connected by single TCP/IP module with single stimulating module;
The upper computer module receives the multiple TCP/IP mould for sending control signals to the multiple TCP/IP module
Block send system status information and display;
The TCP/IP module is used to receive the control signal of upper computer module sending, then sends control signals to coupled
The stimulating module connect, and the status information for the system that the stimulating module issues is transferred to upper computer module;
The stimulating module is used to receive the control signal that coupled TCP/IP module is sent, and the system that will test
Status information be sent to the TCP/IP module.
2. multichannel stimulating system as described in claim 1, which is characterized in that the stimulating module includes: main control module, boosting
And PFC module, storage capacitor, discharge loop, discharge switch and stimulating coil;Wherein, main control module respectively with boosting and PFC
Module and discharge switch are connected, and storage capacitor is connected with boosting and PFC module, discharge switch and discharge loop respectively
It connects, discharge switch is connected with stimulating coil;
The main control module is used to receive the control signal of TCP/IP module transfer, exports charging signals, Xiang Fang to boost module
Electric switch exports discharge signal, and the status information of acquisition system is simultaneously sent to TCP/IP module;
The boosting and PFC module are used to receive the charging signals that the main control module is sent, and charge to storage capacitor;
The storage capacitor is for storing electric energy;
The discharge loop is used to discharge the dump energy in storage capacitor;
The discharge switch is used to receive the discharge signal that the main control module is sent, and the electric energy in storage capacitor is discharged into thorn
Swash in coil, to stimulating coil instantaneous discharge;
The stimulating coil is used to receive the instantaneous electric energy by discharge switch, generates Neural stem cell pulse.
3. multichannel stimulating system as claimed in claim 2, which is characterized in that the system that the main control module is used to monitor system
The charged state of state, the state of temperature of stimulating coil, storage capacitor, and the system mode, institute are shown by LED light
State state of temperature and the charged state.
4. multichannel stimulating system as claimed in claim 2, which is characterized in that the stimulating coil includes annulus stimulating coil, 8
Font stimulating coil and/or double 8-shaped stimulating coils.
5. multichannel stimulating system as claimed in claim 2, which is characterized in that the type of cooling of the stimulating coil includes liquid
Circulating cooling and/or circulated air are cooling.
6. a kind of operation method of the multichannel stimulating system as claimed in claims 1-5 for transcranial magnetic stimulation, feature exist
In this method comprises the following steps:
Upper computer module sends control signals to each TCP/IP module;
The control signal received is sent to coupled stimulating module by each TCP/IP module;
Stimulating module described in multichannel starts to execute control instruction after receiving control signal;
The status information of the system monitored is sent to coupled each TCP/IP module by stimulating module described in multichannel;
The status information of the system received is sent to upper computer module by each TCP/IP module;
Upper computer module shows the status information of the system received.
7. method as claimed in claim 6, which is characterized in that stimulating module described in multichannel starts to hold after receiving control signal
Row control instruction further includes following steps:
Charging control signal is sent to boosting and PFC module by main control module;
The storage capacitor being connected with PFC module for it that boosts charges;
Discharge control signal is sent to discharge switch by the main control module;
Discharge switch control storage capacitor discharges to stimulating coil;
Discharge loop discharges to storage capacitor after system cut-off.
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Cited By (3)
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CN110193143A (en) * | 2019-04-19 | 2019-09-03 | 北京大学(天津滨海)新一代信息技术研究院 | A kind of transcranial magnetic stimulation system and method |
CN112755395A (en) * | 2021-01-21 | 2021-05-07 | 武汉依瑞德医疗设备新技术有限公司 | True and false pulse magnetic stimulation therapeutic instrument |
CN112891748A (en) * | 2021-01-21 | 2021-06-04 | 武汉依瑞德医疗设备新技术有限公司 | Magnetic shock therapeutic instrument |
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