CN106139405A - A kind of vagus nerve magnetic stimulating device - Google Patents
A kind of vagus nerve magnetic stimulating device Download PDFInfo
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- CN106139405A CN106139405A CN201610620894.3A CN201610620894A CN106139405A CN 106139405 A CN106139405 A CN 106139405A CN 201610620894 A CN201610620894 A CN 201610620894A CN 106139405 A CN106139405 A CN 106139405A
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- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
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- A—HUMAN NECESSITIES
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/0245—Detecting, measuring or recording pulse rate or heart rate by using sensing means generating electric signals, i.e. ECG signals
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- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
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- A—HUMAN NECESSITIES
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Abstract
A kind of vagus nerve magnetic stimulating device, including stimulating coil (101), the first respiratory rate detecting electrode (102a), the second respiratory rate detecting electrode (102b), the first ECG detecting electrode (103a), the second ECG detecting electrode (103b), the 3rd ECG detecting electrode (103c), stimulation pulse generator (104), respiratory rate monitoring modular (105), cardioelectric monitor module (106), control module (107) and display module (108).Stimulating coil (101) is attached to patient's skin of neck surface, utilizes applying pulse magnetic field to produce induction field on vagus nerve, thus stimulates vagus nerve so that it is excited.Respiratory rate monitoring modular (105), cardioelectric monitor module (106) monitor respiratory rate and the heart rate of patient (109) in real time, and patient (109) occurs being automatically stopped stimulation when heartbeat and adnormal respiration.
Description
Technical field
The present invention relates to a kind of Medical Devices for suppressing epilepsy, particularly to a kind of noninvasive vagus nerve Neural stem cell
Device.
Background technology
" epilepsy " or " epilepsy " that epilepsy is i.e. commonly called as, during morbidity, the electric discharge of cerebral neuron paroxysmal abnormality, causes short
Temporary cerebral disorder, is that the chronic functional of the serious threat human physical and mental health of a kind of common, recurrent exerbation is neural
Disease, with repeated relapsing tic as principal character, reduces with cognitive and Neuropsychological Dysfunction and quality of life.I
State there are about 10,000,000 epileptics, and wherein about 30% is the treatment of intractable epilepsy that cannot be suppressed by medicine or operation.Fan walks
Nerve stimulation art is the new way of medicine intractable epilepsy.At present, the mechanism of studies of epileptic treatment with vagus nerve stimulation still without
Final conclusion, it may be possible to vagal stimulation adds inhibitory neurotransmitter and decrease excitatory neurotransmitter, as increase γ-
The release of aminobutyric acid and the release of reduction glutamate formiminotransferase, thus improve the outbreak threshold of epilepsy, play anti-insane
Epilepsy effect.Vagal nerve stimulation obtained European Union's approval and is applied to clinical treatment epilepsy in 1994, within 1997, obtained U.S.'s food
Product and Drug Administration's certification, China also has been incorporated into the treatment method of studies of epileptic treatment with vagus nerve stimulation for many years.Fan
Walk neural stimulation system aspect, although be mainly Cyberonics company of the U.S. and China's product in the market and speed medical company
Vagus nerve stimulator.
The effect of epilepsy therapy generally uses " 50% response rate " to characterize, and it refers to that treatment group compares energy with control group
" significantly " reduces the seizure frequency of epilepsy, makes epileptic attack reduce more than 50%.The 50% of studies of epileptic treatment with vagus nerve stimulation should
Rate of answering is about 35%, it means that the minimizing of the patient of about 65% epileptic attack number of times after stimulator for implantation is simultaneously failed to understand
Aobvious, there is small number of patients that the improvement of symptom does not occur after implanting vagus nerve stimulator, also having sub-fraction patient because surveying
Examination occurring, heart arrest eliminates implantation plan.This means that vagus nerve stimulator does not only carry to this some patients
Carry out the improvement of quality of life, also introduce implantation risk, it is not necessary to operation and nurse fees use.Cause this vagal stimulation
Treat that 50% response rate is not high and the reason that part serious side effects essentially consist in the preoperative evaluation that vagus nerve stimulator is implanted
Work is abundant not, and at present in the case that other treatment method is invalid, treatment of intractable epilepsy all can accept vagus nerve
The treatment of stimulation, does not consider whether stimulator can play one's part to the full after implanting.Therefore at vagus nerve stimulator
Before implantation, need evaluation measures before a kind of effective Vagal nerve stimulation, improve the response rate after implanting and reduce serious secondary
The generation of effect.Before Vagal nerve stimulation, the effective premise of appraisal procedure is that it can produce the effect similar with vagal stimulation
Really and it is necessary to be noninvasive.
In noninvasive vagal stimulation field, European Union has had been approved by percutaneous nervus auricularis vagi to stimulate for epilepsy therapy,
But existing document report treatment of intractable epilepsy is after accepting percutaneous nervus auricularis vagi stimulation therapy 24 weeks, and epileptic attack number of times subtracts
Low less than 50%, i.e. 50% response rate is zero, it is clear that it can not reach to produce the requirement of effect similar with vagal stimulation.Its
Reason is that stimulating electrode is fixed on patient skin surface, is actually reached that vagal electric current is less and focusing difference, shadow
Ring effect of stimulation.If increase stimulus intensity, the sense of discomfort such as pain that can cause again patient.United States Patent (USP), US2011/
0190569A1 discloses another kind of noninvasive vagal stimulation technology, and this patent uses the principle of electromagnetic induction, by an electromagnetism
Coil produces magnetic field, is excited induction field to stimulate vagus nerve by magnetic field in patient tissue and conducting medium, this
Technology needs to add conducting medium between patient skin and stimulating coil, relies on conducting medium conduction induced-current.This skill
Art does not still have the report of clinical testing.
Content of the invention
It is an object of the invention to overcome the shortcoming of prior art, propose a kind of noninvasive vagal stimulation based on Neural stem cell
Device.The present invention is for simulating the therapeutic modality after vagus nerve stimulator is implanted, respiratory rate and the electrocardio to patient simultaneously
It is monitored, stop stimulating immediately when breathing abnormal with heart rate, reach safety, the purpose of non-invasive therapy epilepsy.
Vagus innervates is breathed, is digested most organ of two systems and the sensation of heart, motion and gland
The secretion of body, heart and respiratory activity can be impacted by vagal stimulation, including paralysis vocal cord, face is unable, mistake aroused in interest
Relaxing heartbeat to stop, there is heart arrest in the test after vagus nerve stimulator implantation in some patients.Vagal stimulation
While need in real time monitoring respiratory rate and heart rate, it is to avoid the serious side effects that vagal stimulation causes.Neural stem cell is one
Plant noninvasive stimulating method, the induced-current simulation vagal stimulation parameter producing with Neural stem cell, can sting with vagus nerve
Swash the effect playing treatment epilepsy equally.Compared with implantation type electric stimulation, Neural stem cell is a kind of noninvasive stimulating method, utilizes
Mutual transforming relationship between electricity, magnetic realizes vagal noninvasive stimulation.Although the method power consumption of Neural stem cell is high, volume is big,
Not readily portable, also cannot accomplish to replace completely vagal stimulation, but can be by Neural stem cell and respiratory rate, rhythm of the heart phase
In conjunction with for assessment before Vagal nerve stimulation, vagus nerve thorn being carried out to the patient that Neural stem cell function well, side effect are less
Swashing operation, thus improving the normal process of Vagus Nerve Stimulation treatment intractable epilepsy, improving 50% after implanting further should
Answer rate, it is to avoid unnecessary operation and nurse fees are used.
Vagus nerve magnetic stimulating device of the present invention includes stimulating coil, two respiratory rate detecting electrodes, three electrocardio inspections
Survey electrode, stimulation pulse generator, respiratory rate monitoring modular, cardioelectric monitor module, control module and display module.Stimulate line
Circle is attached to patient's skin of neck surface, and stimulating coil is connected with the output of stimulation pulse generator.Stimulation pulse generator
Input is connected with the first output of control module.Two respiratory rate detecting electrodes are simultaneously as current injection electrode and electricity
Pressure detecting electrode, the first respiratory rate detecting electrode is arranged in patient's right subclavian, and the second respiratory rate detecting electrode is arranged in
The left belly of patient, two respiratory rate detecting electrodes are connected with the first output of respiratory rate monitoring modular, breathe frequency for two
Rate detecting electrode is connected with the first input end of respiratory rate monitoring modular, the second input of respiratory rate monitoring modular and control
Second output of molding block connects, and the second output of respiratory rate monitoring modular connects with the first input end of control module
Connect.Three ECG detecting electrodes are arranged in patient's right hand, left hand and right leg skin surface, three ECG detecting electrodes and the heart
The first input end of pyroelectric monitor module connects, and the second input of cardioelectric monitor module connects with the 3rd output of control module
Connecing, the output of cardioelectric monitor module is connected with the second input of control module.3rd input of control module and display
The output of module connects, and the 4th output of control module is connected with the input of display module.
Described stimulation pulse generator produces pulse current, and pulse current sends pulsed magnetic field, arteries and veins by stimulating coil
Rush magnetic field in patient's vagus nerve, produce induced-current, make vagal excitation.Respiratory rate monitoring modular is exhaled by two
Inhale the respiratory rate of frequency detecting electrode measurement patient, respiratory rate is sent to control module, and shows on the display device.
Cardioelectric monitor module passes through three ECG detecting electrode measurement patient's electrocardios, calculates heart rate, heart rate is sent to control module, and
Show on the display device.In stimulating course, if patient occurs that heart rate and respiratory rate are abnormal, control module can be automatic
Stop stimulation pulse generator work, it is to avoid further bad reaction.
Described stimulating coil is plane disc type coil or " 8 "-shaped coil, and excitation coil is by enamel covered wire coiling
Becoming, outside is cased with insulation crust.Flat disc coil turn is that a few circle is less than 10 centimetres to tens circles, coil diameter, line
Circle axial width is less than 1 centimetre." 8 "-shaped coil is made up of the contrary circular planar disk-like coil of two direction of windings, is formed
The shape of numeral " 8 ".The inductance of stimulating coil is in the magnitude of several microhenrys to tens microhenrys.Stimulating coil is in the effect of pulse current
Under in its vicinity space produce pulsed magnetic field, pulse width is hundreds of microsecond.Patient's vagus nerve and surrounding tissue are in pulse
Producing induced-current under the effect in magnetic field, the induced-current peak value in vagus nerve is more than or equal to 1mA, causes vagus nerve emerging
Put forth energy, provide action potential.
Described stimulation pulse generator includes storage capacitor, high speed thyristor, fly-wheel diode, diode, current limliting electricity
Resistance and high-voltage DC power supply.In discharge loop, the first pin of storage capacitor is connected with the anode of high speed thyristor, energy storage electricity
The second pin holding is connected with one end of stimulating coil, and the negative electrode of high speed thyristor is connected with the other end of stimulating coil, quickly
The gate pole of IGCT is connected with the first output of control module.The negative electrode of fly-wheel diode connects with the anode of high speed thyristor
Connecing, the anode of fly-wheel diode is connected with the negative electrode of high speed thyristor.In charge circuit, the first pin of storage capacitor and two
The negative electrode of pole pipe connects, and the anode of diode and one end of current-limiting resistance connect, the other end of current-limiting resistance and high voltage direct current
The positive output end in source connects, and the negative output terminal of high-voltage DC power supply is connected with the second pin of storage capacitor.High-voltage DC power supply
Input be connected with control module.During stimulation pulse generator work, first control module is set charging voltage, charged electrical
The parameters such as stream, frequency of stimulation, then storage capacitor is charged by high-voltage DC power supply, reaches to stop charging during setting voltage.
During stimulation, control module sends trigger by the first output to the gate pole of high speed thyristor, and high speed thyristor turns on, storage
Stimulating coil can be discharged electric capacity, complete once to stimulate.Repeating this process and can realizing repetitive stimulation, repetition rate is tens hertz
Hereby.
Two described respiratory rate detecting electrodes are post-chip electrode, simultaneously as current injection electrode and voltage detecting electricity
Pole.It is a few KHz to the ac signal of hundreds of KHz that described respiratory rate monitoring modular can produce frequency, and passes through
First output is applied to two respiratory rate detecting electrodes, and electric current is less than 5mA.Respiratory rate monitoring modular can lead to simultaneously
Cross the voltage between first input port two respiratory rate detecting electrodes of detection, can divided by input current with the magnitude of voltage recording
Obtain the impedance of patient chest.During human body respiration, chest impedance is cyclically-varying, and respiratory rate monitoring modular is hindered by chest
The computation of Period respiratory rate of resistance, and by the first output port of frequency monitoring module, respiratory rate data are sent extremely
Control module.
Three described ECG detecting electrodes are post-chip electrode or electrocardioelectrode folder, described cardioelectric monitor module and three
The computation of Period heart rate that ECG detecting electrode operation detection together is changed to the electrocardio of patient, cardioelectric monitor module by electrocardio,
And sent heart rate data to control module by the first output of cardioelectric monitor module.
Described display device completes whole monitor device display function and provides human-computer interaction interface.On the one hand, device
Operating personnel can pass through display device input stimulus parameter, such as stimulus intensity, frequency of stimulation, stimulation time etc., then can click on
" starting to stimulate " button on screen, starts stimulation pulse generator by control module, carries out vagus nerve Neural stem cell.Another
Aspect, after display device receives respiratory rate and heart rate information, real time patient respiratory rate, heart rate number on screen
According to, and chest impedance variation diagram and electrocardiogram, the feedback information of vagus nerve Neural stem cell is provided to device operator.
Described control module completes whole monitor device control function, including three below aspect:
(1), after receiving the beginning stimulus signal that display device sends, control module is according to the stimulus intensity setting, stimulation
The parameter such as frequency, stimulation time starts stimulation pulse generator, starts vagus nerve Neural stem cell；
(2) receive the respiratory rate information from respiratory rate monitoring modular, if respiratory rate is too fast or it is slow to cross, stop
Only stimulate；
(3) receive the heart rate information from cardioelectric monitor module, if heart rate is too fast or crosses slow value, stop stimulating.
The operating process of device of the present invention is as follows:
Stimulating coil is arranged in patient's neck by the first step, respiratory rate detecting electrode is pasted on right subclavian side and
Cardioelectric monitor electrode is arranged in the right hand, left hand and right leg by left belly；
Second step, sets the stimulation pulse generator ginsengs such as stimulus intensity, frequency of stimulation, stimulation time on the display device
Number, and the normal cardiac rate scope of the normal respiratory rate scope of respiratory rate monitoring modular and cardioelectric monitor module；
3rd step, clicks on " starting to stimulate " button in display device screen, and apparatus of the present invention start simultaneously at following three
Work:
(1) stimulation pulse generator provides pulse current according to setup parameter to stimulating coil, and near stimulating coil
Form pulsed magnetic field, vagus nerve is stimulated；
(2) respiratory rate monitoring modular exports alternating currents by the first output to two respiratory rate detecting electrodes,
Detect the voltage between two respiratory rate detecting electrodes simultaneously, calculate patient chest impedance's period of change, then by breathing frequency
Second output of rate monitoring modular sends respiratory rate to control module；
(3) cardioelectric monitor module detects patient's electrocardiosignal by first input port, calculates Heart Rate, then by the heart
Pyroelectric monitor module the first output port sends heart rate to control module；
4th step, the respiratory rate data receiving and heart rate data are compared by control module with the normal range (NR) of setting
Relatively, it is judged that in stimulating course, patient has or not respiratory rate or the situation of heart rate exception, if " having " device is automatically stopped stimulation, enters
Enter the 5th step, if "None" carries out the 6th step；
5th step, device waits medical personnel to decide whether again to stimulate, if "Yes", returns to second step, if "No"
Carry out the 6th step；
6th step, stimulation terminates, shutoff device, removes stimulating coil from patient's neck, takes off respiratory rate detection electricity
Pole and ECG detecting electrode.
The advantage of apparatus of the present invention is the following aspects:
First, compared with apparatus of the present invention use implanted vagus nerve stimulator with prior art, it is not necessary to implant patient, easily
In being accepted by patients.
Secondly, compared with apparatus of the present invention use percutaneous nervus auricularis vagi stimulator with prior art, result for the treatment of is more preferable.This
Invent described device and simulate the parameter of implanted vagus nerve stimulator completely, implanted vagus nerve stimulator can be reached
Result for the treatment of, 50% response rate of implanted vagus nerve stimulator treatment epilepsy is about 35%, and percutaneous nervus auricularis vagi
50% response rate of stimulator treatment epilepsy is 0.
3rd, apparatus of the present invention contain breathing and cardioelectric monitor system, can send out in breathing or anomalous ecg situation
Stop immediately when raw stimulating, it is ensured that the security of vagal stimulation.
Brief description
Fig. 1 is vagus nerve magnetic stimulating device schematic diagram of the present invention；
Fig. 2 is device stimulation pulse generator schematic diagram of the present invention；
Fig. 3 is device stimulating coil schematic shapes of the present invention；
Fig. 4 is the device stimulating coil location drawing of the present invention；
Fig. 5 is the location drawing in neck cross section for the device stimulating coil of the present invention.
Detailed description of the invention
Further illustrate the present invention below in conjunction with the drawings and specific embodiments.
Fig. 1 is the schematic diagram of apparatus of the present invention.Vagus nerve magnetic stimulating device of the present invention includes stimulating coil the 101st, first
Respiratory rate detecting electrode 102a, the second respiratory rate detecting electrode 102b, the first ECG detecting electrode 103a, the second electrocardio inspection
Survey electrode 103b, the 3rd ECG detecting electrode 103c, stimulation pulse generator the 104th, respiratory rate monitoring modular the 105th, electrocardio prison
Survey module the 106th, control module 107 and display module 108.Stimulating coil 101 is attached to patient 109 skin of neck surface, stimulates line
Circle 101 is connected with the output of stimulation pulse generator 104.The input of stimulation pulse generator 104 and control module 107
First output connects.Two respiratory rate detecting electrodes are simultaneously as current injection electrode and voltage detecting electrode, and first exhales
Inhaling frequency detecting electrode 102a and being arranged in patient 109 right subclavian, the second respiratory rate detecting electrode is arranged in the left abdomen of patient 109
Portion, two respiratory rate detecting electrodes are connected with the first output and the first input end of respiratory rate monitoring modular 105 simultaneously,
Second input of respiratory rate monitoring modular 105 is connected with the second output of control module 107, respiratory rate monitoring modular
Second output of 105 is connected with the first input end of control module 107.First ECG detecting electrode 103a, the second electrocardio inspection
Survey electrode 103b, the 3rd ECG detecting electrode 103c is arranged in patient's right hand, left hand and right leg skin surface, three electrocardios
Detecting electrode is connected with the first input end of cardioelectric monitor module 106, the second input of cardioelectric monitor module 106 and control mould
3rd output of block 107 connects, and the output of cardioelectric monitor module 106 is connected with the second input of control module 107.Control
3rd input of molding block 107 is connected with the output of display module 108, the 4th output of control module 107 and display
The input of module 108 connects.
In vagus nerve magnetic stimulating device of the present invention, stimulation pulse generator 104 can produce pulse current, and pulse current leads to
Stimulation oversaturation coil 101 sends pulsed magnetic field, and pulsed magnetic field produces induced-current in patient's vagus nerve, makes vagus nerve emerging
Put forth energy.Respiratory rate monitoring modular 105 can be by the breathing of first, second respiratory rate detecting electrode 102a, 102b measurement patient
Respiratory rate is sent to control module 107, and shows on the display device 108 by frequency.Cardioelectric monitor module 106 can be passed through
Heart rate is sent to by first, second, third ECG detecting electrode 103a, 103b, 103c measurement patient's electrocardio, calculating heart rate
Control module 107, and show on the display device 108.In stimulating course, if patient occurs that heart rate and respiratory rate are different
Often, control module 107 can be automatically stopped stimulation pulse generator 104 and works, it is to avoid further bad reaction.
The operating process of apparatus of the present invention is as follows:
Stimulating coil cloth 101 is placed in patient 109 neck by the first step, pastes respiratory rate detecting electrode 102a, 102b
In right subclavian side and left belly, cardioelectric monitor electrode 103a, 103b, 103c are arranged in the right hand, left hand and right leg；
Second step, sets the stimulation pulse generators such as stimulus intensity, frequency of stimulation, stimulation time on the display device 108
104 parameters, and the normal cardiac rate of the normal respiratory rate scope of respiratory rate monitoring modular 105 and cardioelectric monitor module 106
Scope；
3rd step, clicks on " starting to stimulate " button on display device 108 screen, and apparatus of the present invention start simultaneously at following three
Item work:
(1) stimulation pulse generator 104 provides pulse current according to setup parameter to stimulating coil 101, and is stimulating line
Circle 101 is formed about pulsed magnetic field, stimulates vagus nerve；
(2) respiratory rate monitoring modular 105 is defeated to two respiratory rates detecting electrode 102a, 102b by the first output
Go out alternating current, simultaneously voltage between two respiratory rates detecting electrode 102a, 102b for the detection, calculate the resistance of patient 109 chest
Anti-period of change, is then sent respiratory rate by the second output of respiratory rate monitoring modular 105 to control module 107；
(3) cardioelectric monitor module 106 detects patient 109 electrocardiosignal by first input port, calculates patient 109 heart
Rate, is then sent heart rate by cardioelectric monitor module 106 first output port to control module 107；
4th step, the respiratory rate data receiving and heart rate data are entered by control module 107 with the normal range (NR) of setting
Row compares, it is judged that in stimulating course, patient 109 has or not respiratory rate or the situation of heart rate exception, if " having " device is automatically stopped
Stimulate, enter the 5th step, if "None" carries out the 6th step；
5th step, device waits medical personnel to decide whether again to stimulate, if "Yes", returns to second step, if "No"
Carry out the 6th step；
6th step, stimulation terminates, shutoff device, removes stimulating coil 101 from patient 109 neck, takes off respiratory rate
Detecting electrode 102a, 102b and ECG detecting electrode 103a～103c.
Fig. 2 is the stimulation pulse generator schematic diagram of apparatus of the present invention.Described stimulation pulse generator includes charging back
Road and two parts of discharge loop.Discharge loop includes storage capacitor the 201st, high speed thyristor the 202nd, fly-wheel diode 203 and thorn
Swash coil 204.Charge circuit includes storage capacitor the 201st, diode the 205th, current-limiting resistance 206 and high-voltage DC power supply 207.Putting
In electricity loop, the first pin of storage capacitor 201 is connected with the anode of high speed thyristor 202, the second pin of storage capacitor 201
Being connected with one end of stimulating coil 204, the negative electrode of high speed thyristor 202 is connected with the other end of stimulating coil 204, quick brilliant lock
The gate pole of pipe 204 is connected with the first output of control module in Fig. 1 107.The negative electrode of fly-wheel diode 203 and high speed thyristor
The anode of 204 connects, and the anode of fly-wheel diode 203 is connected with the negative electrode of high speed thyristor 204.In charge circuit, energy storage
The negative electrode of the first pin of electric capacity 201 and diode 205 connects, and the anode of diode 205 and one end of current-limiting resistance 206 are even
Connecing, the other end of current-limiting resistance 206 is connected with the positive output end of high-voltage DC power supply 207, the negative output of high-voltage DC power supply 207
End is connected with the second pin of storage capacitor 207.The input 207 of high-voltage DC power supply and first of control module 107 in Fig. 1
Output connects.During stimulation pulse generator work, first control module 107 is set charging voltage, charging current, stimulation frequency
The parameters such as rate, then storage capacitor 201 is charged by high-voltage DC power supply 207, reaches to stop charging during setting voltage.Due to
The existence of diode 205, can not discharge to high-voltage DC power supply 207 one end after storage capacitor 201 is fully charged.Stimulate time control molding
Block sends trigger by the first output to the gate pole of high speed thyristor 202, and high speed thyristor 202 turns on, storage capacitor
201 pairs of stimulating coils 204 discharge, and electric current is flowed out by the first pin of storage capacitor 201, through high speed thyristor 202 and stimulation
Coil 204 is back to the second pin of storage capacitor 201；When the current drops to zero, the backward voltage on storage capacitor 201 reaches
Maximum, electric current is flowed out by the second pin of storage capacitor 201, is back to energy storage through stimulating coil 204 and fly-wheel diode 203
First pin of electric capacity 201；When the current drops to zero, the voltage regulation secondary on storage capacitor 201 is reverse, high speed thyristor 202
Having been switched off, stimulation terminates.Repeating this process and can realizing repetitive stimulation, the capacitance of the present embodiment storage capacitor 201 is 150 μ
F, pressure 3000V, charging voltage is 1500V, and stimulating coil 204 inductance value is 18 μ H, and resistance value is 50m Ω.From calculating,
In stimulating coil 304, current maxima is about 4000A, pulsewidth 330 μ s.The resistance of current-limiting resistance 206 is more than 10 ohm, it is ensured that fill
Electricity loop resistance is much larger than discharge loop resistance.
Fig. 3 is device figure of eight stimulating coil schematic shapes of the present invention.Figure of eight stimulating coil is led by one
Line coiling forms, and wire is the enamel covered wire of the square-section of long 4mm width 1mm or a diameter of 2mm circular cross-section.Left and right two halves
Part planar disc coil at grade, and has identical external diameter, internal diameter and the number of turn.The coil winding of left-half
Direction is counterclockwise, and the coil winding direction of right half part is clockwise, forms figure of eight shape.In figure, arrow indication is electric current
Direction, in " 8 " word center, the sense of current of left and right two parts coil is consistent, and left and right two produce at " 8 " word center
Induction field superposition.This " 8 " wordline circle is compared circular coil and is had bigger induction field and more preferable focusing.
Fig. 4 is the device stimulating coil location drawing of the present invention.401 is patient's atlas bone, and 402 is patient the 5th neck
Vertebra, 403 is patient's sixth cervical vertebra bone, and 404 is patient's C7 bone.The position of stimulating coil 405 is between 401～407
It is close to skin.
Fig. 5 is device stimulating coil neck cross-sectional location figure of the present invention.In conjunction with Fig. 5, stimulating coil arrangement side is described
Method, vagus nerve 507 and arteria carotis communis the 506th, jugular vein 505 are co-located in carotid sheath 504.Arrange stimulating coil 501
When, it is necessary first to patient's rotary head to the right, expose nutator 503 on the left of neck, in nutator 503 leading edge deep, can
Touch and significantly beat, it is simply that arteria carotis communis 506.The center of figure of eight stimulating coil 501 is directed at this position, is close to skin
502 place, and stimulate vagus nerve 507, carry out the position of stimulating coil 501 according to patient perceptions near this position
Fine setting, determines final stimulating coil position.
Claims (5)
1. a vagus nerve magnetic stimulating device, is characterized in that: described device includes stimulating coil (101), the first breathing frequency
Rate detecting electrode (102a), the second respiratory rate detecting electrode (102b), the first ECG detecting electrode (103a), the second electrocardio inspection
Survey electrode (103b), the 3rd ECG detecting electrode (103c), stimulation pulse generator (104), respiratory rate monitoring modular
(105), cardioelectric monitor module (106), control module (107) and display module (108)；Stimulating coil (101) is attached to patient
(109) skin of neck surface, stimulating coil (101) is connected with the output of stimulation pulse generator (104)；Boost pulse occurs
The input of device (104) is connected with the first output of control module (107)；Two respiratory rate detecting electrodes (102a,
102b) simultaneously as current injection electrode and voltage detecting electrode；First respiratory rate detecting electrode (102a) is arranged in patient
(109) right subclavian, the second respiratory rate detecting electrode (102b) is arranged in the left belly of patient (109), two respiratory rate inspections
Survey electrode (102a, 102b) to be connected with the first output of respiratory rate monitoring modular (105), two respiratory rate detecting electrodes
(102a, 102b) is connected with the first input end of respiratory rate monitoring modular (105), the of respiratory rate monitoring modular (105)
Two inputs are connected with the second output of control module (107), the second output of respiratory rate monitoring modular (105) and control
The first input end of molding block (107) connects；First ECG detecting electrode (103a), the second ECG detecting electrode (103b),
Three ECG detecting electrodes (103c) are arranged in patient's right hand, left hand and right leg skin surface, three ECG detecting electrodes
(103a, 103b, 103c) is connected with the first input end of cardioelectric monitor module (106), and the second of cardioelectric monitor module (106) is defeated
Enter end to be connected with the 3rd output of control module (107), the output of cardioelectric monitor module (106) and control module (107)
Second input connect；3rd input of control module (107) is connected with the output of display module (108), controls mould
4th output of block (107) is connected with the input of display module (108).
2. according to the vagus nerve magnetic stimulating device described in claim 1, it is characterized in that: described stimulation pulse generator includes
Charge circuit and discharge loop；Described discharge loop includes storage capacitor (201), high speed thyristor (202), fly-wheel diode
And stimulating coil (204) (203)；Described charge circuit includes storage capacitor (201), diode (205), current-limiting resistance
And high-voltage DC power supply (207) (206)；In discharge loop, the first pin of storage capacitor (201) and high speed thyristor
(202) anode connects, and the second pin of storage capacitor (201) is connected with one end of stimulating coil (204), high speed thyristor
(202) negative electrode is connected with the other end of stimulating coil (204), the gate pole of high speed thyristor (202) and control module (107)
First output connects；The negative electrode of fly-wheel diode (203) is connected with the anode of high speed thyristor (204), fly-wheel diode
(203) anode is connected with the negative electrode of high speed thyristor (204)；In charge circuit, the first pin of storage capacitor (201) and
The negative electrode of diode (205) connects, and the anode of diode (205) and one end of current-limiting resistance (206) connect, current-limiting resistance
(206) the other end is connected with the positive output end of high-voltage DC power supply (207), the negative output terminal of high-voltage DC power supply (207) with
Second pin of storage capacitor (207) connects；The input (207) of high-voltage DC power supply is defeated with the first of control module (107)
Go out end to connect；
During stimulation pulse generator (104) work, first control module (107) is set charging voltage, charging current, stimulation frequency
Rate, then storage capacitor (201) is charged by high-voltage DC power supply (207), reaches to stop charging during setting voltage；Control during stimulation
Module (107) sends trigger by the first output to the gate pole of high speed thyristor (202), and high speed thyristor (202) is led
Logical, stimulating coil (204) is discharged by storage capacitor (201), completes once to stimulate；Repeat this process and be capable of repetitive stimulation,
Repetition rate is tens hertz.
3. according to the vagus nerve magnetic stimulating device described in claim 1, it is characterized in that: described stimulating coil is the figure of eight,
Formed by the enamel covered wire coiling that single line footpath is millimetre-sized square-section or circular cross-section；The stimulating coil number of turn is that a few circle arrives
Tens circles, coil diameter is less than 10 centimetres；The left and right two halves part of stimulating coil is circular planar disk-like coil, stimulating coil
The external diameter of left and right two halves part, internal diameter identical with the number of turn, in the same plane, the coil winding direction of left-half is
Counterclockwise, the coil winding direction of right half part is clockwise, forms figure of eight shape；In " 8 " word center, left and right two
The sense of current of sub-coil is identical, the induction field superposition that left and right two parts coil produces at " 8 " word center.
4. according to the vagus nerve magnetic stimulating device described in claim 1, it is characterized in that: two described respiratory rate detection electricity
Pole (102a, 102b) is post-chip electrode；Three described ECG detecting electrodes (103a, 103b, 103c) are post-chip electrode or the heart
Electricity electrode holder.
5. according to the vagus nerve magnetic stimulating device described in claim 1, it is characterized in that: described stimulation pulse generator
(104) producing pulse current, pulse current sends pulsed magnetic field by stimulating coil (101), and pulsed magnetic field is confused patient (109)
Walk generation induced-current in nerve, make vagal excitation；Respiratory rate monitoring modular (104) is by two respiratory rate detections
Respiratory rate is sent to control module (107) by the respiratory rate of electrode (102a, 102b) measurement patient (109), and in display
The upper display of equipment (108)；Cardioelectric monitor module (106) is by three ECG detecting electrode (103a～103c) measurement patient's hearts
Electricity, the computation of Period heart rate that cardioelectric monitor module (106) is changed by electrocardio, and by the first of cardioelectric monitor module (106)
Output port sends heart rate data to control module (107), and in the upper display of display device (108)；
Described respiratory rate monitoring modular (105) applies the electric current to two less than 5mA by the first output and breathes frequency
Rate detecting electrode (102a, 102b), respiratory rate monitoring modular (105) detects two by first input port and breathes frequency simultaneously
Voltage between rate detecting electrode (102a, 102b), obtains the impedance of patient chest with the magnitude of voltage recording divided by input current；
The computation of Period patient respiratory frequency that respiratory rate monitoring modular (105) is changed by chest impedance, and supervised by respiratory rate
Survey the first output port of module (105), send respiratory rate data to control module (107)；
After described control module (107) receives the beginning stimulus signal that display device (108) sends, control module (107)
Start stimulation pulse generator (104) according to the stimulus intensity setting, frequency of stimulation, stimulation time, start vagus nerve magnetic thorn
Swash；Control module (107) receives the respiratory rate information from respiratory rate monitoring modular (105), if respiratory rate is too fast
Or cross slow then stopping stimulation；Control module (107) receives the heart rate information from cardioelectric monitor module (106), if heart rate mistake
Fast or cross slow value and then stop stimulating.
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| CN201610620894.3A CN106139405A (en) | 2016-08-01 | 2016-08-01 | A kind of vagus nerve magnetic stimulating device |
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| CN109567778A (en) * | 2017-09-29 | 2019-04-05 | 脸谱科技有限责任公司 | Heart rate monitor apparatus |
| CN109641127A (en) * | 2017-09-06 | 2019-04-16 | 大冢科技株式会社 | Urination disorder therapeutic equipment |
| CN110392593A (en) * | 2018-02-23 | 2019-10-29 | 奥默有限公司 | Utilize the vagal stimulation method and device of pulsed magnetic field |
| CN110496309A (en) * | 2019-08-22 | 2019-11-26 | 西安八水健康科技有限公司 | A kind of respiration gate control vagal stimulation system and device |
| CN113082529A (en) * | 2021-04-30 | 2021-07-09 | 黄开文 | Magnetic stimulation device and method for respiratory rehabilitation |
| CN114522072A (en) * | 2022-01-27 | 2022-05-24 | 南京鼓楼医院 | Peak locking pulse interaction vagus nerve stimulation device for arrhythmia patients |
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| CN109641127A (en) * | 2017-09-06 | 2019-04-16 | 大冢科技株式会社 | Urination disorder therapeutic equipment |
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| CN113082529A (en) * | 2021-04-30 | 2021-07-09 | 黄开文 | Magnetic stimulation device and method for respiratory rehabilitation |
| CN114522072A (en) * | 2022-01-27 | 2022-05-24 | 南京鼓楼医院 | Peak locking pulse interaction vagus nerve stimulation device for arrhythmia patients |
| CN114522072B (en) * | 2022-01-27 | 2022-10-21 | 南京鼓楼医院 | Peak locked pulse interactive vagus nerve stimulation device for arrhythmia patient |
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Application publication date: 20161123 |