CN105664357A - Multi-parameter adjustable transcranial current stimulation system - Google Patents
Multi-parameter adjustable transcranial current stimulation system Download PDFInfo
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- CN105664357A CN105664357A CN201610010976.6A CN201610010976A CN105664357A CN 105664357 A CN105664357 A CN 105664357A CN 201610010976 A CN201610010976 A CN 201610010976A CN 105664357 A CN105664357 A CN 105664357A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
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Abstract
The invention provides a multi-parameter adjustable transcranial current stimulation system. The system comprises seven mutually connected parts: namely a main circuit, a conductive electrode, a micro-control unit, an AD module, a WIFI module, a display screen, and a mobile terminal application program. The main circuit comprises a power supply part, a voltage-regulating circuit and a frequency-modulating circuit, wherein the power supply part, the voltage-regulating circuit and the frequency-modulating circuit are connected with one another. According to the technical scheme of the invention, the stimulation system can realize the selection among three current stimulation modes, namely the tDCS mode, the tACS mode and the tRNS mode. In the tDCS current stimulation mode, the current amplitude can be adjusted within the range of 1mA-10mA. In the tACS current stimulation mode, the current amplitude can be adjusted within the range of 1mA-10Ma and the current frequency can be adjusted within the range of 1KHz-2KHz. In the tRNS current stimulation mode, the selection among different noise types, including low frequency, medium frequency, high frequency, white noise and the like, is realized. Meanwhile, users can monitor stimulation parameters and search the stimulation history according to needs by a mobile terminal.
Description
Technical field
The present invention relates to biomedical sector, particularly a kind of adjustable electrical transcranial stimulation system of multiparameter.
Background technology
Neuropsychiatric disease has become as a big killer of harm mankind nowadays Health and Living. The neuropsychiatric disease situation of China causes anxiety, the statistical result showed of 2012, and the number of Chinese all kinds of psychiatric patients alreadys more than 100,000,000, occupies first place in the world. Its economy brought, family, the aspect such as social and medical burden have become as maximum in all Disease Spectrum one. At present, mainly utilizing medicine, operation and three kinds of methods of psychological consultation to carry out the treatment of neuropsychiatric disease, these methods have respective defect: Drug therapy can not radical curing of disease and also have bigger side effect; Operation method risk is high, and human body causes irreversible damage, and with sequela; Psychological consultation is mainly for light-duty disease or complementary therapy alternatively. In addition, also having a kind of invasive therapy is deep brain stimulation (DBS). Treatment dyskinetic neuropsychiatric disease is had good curative effect by it. But it is invasive treatment means, and technical difficulty, medical expense and side effect are all bigger.
For the shortcoming of said method, man invented non-intruding brain stimulation technology, it has the prominent advantages that it stimulates central nervous system in non-invasive mode thus realizing brain function modulation, it is not necessary to operation, without et al. Ke stimulating apparatus. Distinguishing according to stimulus intensity, non-invasive brain stimulation technology is divided into the non-intrusion type that can realize supraliminal stimulus to stimulate and can realize the non-intrusion type stimulation of subthreshold stimulus. Through cranium galvanic stimulation (tDCS), stimulate (tACS) through cranium alternating current and stimulate (tRNS) to broadly fall into the non-intrusion type galvanism of subthreshold stimulus through cranium noise. Relative to supraliminal stimulus, subthreshold stimulus side effect is little, safer. At present, the electrical transcranial stimulation of these patterns has been widely studied and clinical practice, and the treatment for neuropsychiatric disease brings new dawn.
There are some tDCS, tACS and tRNS equipment at present on the market, but equipment all can be only done the galvanism of a kind of pattern mostly, and often lack friendly interactive interface, cause the not convenient of patient's application.
Summary of the invention
For the defect of existing channel-cranium electro-stimulating device, the object of the invention propose a kind of multiparameter can regulating menstruation cranium galvanism system, be beneficial to realize the optional stimulation of tDCS, tACS and tRNS;Realize the adjustment of noise type during adjustment and the tRNS stimulation of current amplitude and power frequency when the closed loop control of electric current when tDCS stimulates, tACS stimulation; Realize mobile terminal to the setting of stimulus parameter and the record stimulating history.
For achieving the above object, the technical solution used in the present invention be to provide a kind of multiparameter can regulating menstruation cranium galvanism system energy, wherein: this system includes interconnective seven parts: main circuit, conductive electrode, micro-control unit, A/D module, WiFi module, display screen, application program for mobile terminal; Described main circuit includes interconnective power pack, regulating circuit, FM circuit.
Described micro-control unit is a control chip based on ARM kernel, this chip regulates timer internal according to set information and exports five road pulse width modulating signals, one road signal input carries out voltage-regulation to the regulating circuit of main circuit, and then realizing the adjustment of stimulating current amplitude, another four road signals inputs to the FM circuit of main circuit carries out the frequency of stimulating current and regulates.
Set information is sent to micro-control unit by WiFi module by described application program for mobile terminal, and micro-control unit adjusts five tunnel control signals according to set information and the voltage and current information of main circuit that receives via A/D module.
The voltage and current information of described main circuit is sent to micro-control unit by A/D module, these information are transferred to display screen and display by micro-control unit, and these information are displayed and record to application program for mobile terminal by display screen by micro-control unit by WiFi module transmission simultaneously.
Effect of the present invention is the selection that this stimulating system can realize the galvanism of tDCS, tACS and tRNS Three models, can realize under tDCS stimulation, the adjustment of current amplitude (1mA 10mA), under tACS stimulates, current amplitude (1mA 10mA), power frequency (1 2KHz) adjustment, can realize under tRNS stimulation, the selection of the different noise type such as low frequency, intermediate frequency, high frequency, white noise, it may be achieved user passes through mobile terminal to the monitoring of stimulus parameter and the inquiry stimulating history according to oneself demand.
Accompanying drawing explanation
The structural representation of electrical transcranial stimulation system that Fig. 1, multiparameter are adjustable;
The application program for mobile terminal interface schematic diagram of electrical transcranial stimulation system that Fig. 2, multiparameter are adjustable.
In figure:
1, main circuit 2, conductive electrode 3, micro-control unit 4, A/D module
5, WiFi module 6, display screen 7, application program for mobile terminal 8, power pack
9, regulating circuit 10, FM circuit 11, rechargeable battery 12, switch
13, voltage sensor 14, field effect transistor 15, regulate resistance
16, milliampere current sensor 17, main interface 18, model selection interface
19, parameter setting interface 20, information display interface 21, stimulate history interface
Detailed description of the invention
In conjunction with accompanying drawing, the adjustable electrical transcranial stimulation system structure of multiparameter of the present invention is illustrated.
As shown in Figure 1, 2, the adjustable electrical transcranial stimulation system structure of multiparameter of the present invention is that this system includes interconnective seven parts: main circuit 1, conductive electrode 2, micro-control unit 3, A/D module 4, WiFi module 5, display screen 6, application program for mobile terminal 7; Described main circuit 1 includes interconnective power pack 8, regulating circuit 9, FM circuit 10.
Described micro-control unit 3 is a control chip based on ARM kernel, this chip regulates timer internal according to set information and exports five road pulse width modulating signals, one road signal input carries out voltage-regulation to the regulating circuit 9 of main circuit 1, and then realizing the adjustment of stimulating current amplitude, another four road signals inputs to the FM circuit 10 of main circuit 1 carries out the frequency of stimulating current and regulates.
Set information is sent to micro-control unit 3 by WiFi module by described application program for mobile terminal 7, and micro-control unit 3 adjusts five tunnel control signals according to set information and the voltage and current information of main circuit 1 that receives via A/D module 4.
The voltage and current information of described main circuit 1 is sent to micro-control unit 3 by A/D module 4, these information are transferred to display screen 6 and display by micro-control unit 3, and simultaneously these information is transmitted to application program for mobile terminal 7 by WiFi module 5 and displayed and record by display screen 6 by micro-control unit 3.
Described application program for mobile terminal 7 includes five interactive interfaces: main interface 17, model selection interface 18, parameter setting interface 19, information display interface 20 and stimulation history interface 21; Described model selection interface 18 provides tDCS, tACS and the selection of multiple noise type tRNS; Described parameter setting interface 19 provides the setting of stimulating current, stimulus frequency, stimulation time; Described information display interface 20 provides the display of stimulus modelity, stimulus frequency, stimulation time, stimulating current; Described stimulation history interface 21 provides the display of three kinds of stimulus modelities stimulation history and synchronizes storage.
TDCS stimulus settings information is sent to micro-control unit 3 by WiFi module 5 by described application program for mobile terminal 7, first micro-control unit 3 regulates the four tunnel control signals inputted to FM circuit 10 according to demand and makes its frequency be 0 i.e. direct current output, then micro-control unit 3 combines the current information of the main circuit 1 received via A/D module 4, it is achieved the closed loop of the current amplitude of tDCS is regulated; TACS stimulus settings information is sent to micro-control unit 3 by WiFi module 5 by described application program for mobile terminal 7, micro-control unit 3 adjusted in concert according to demand inputs the five tunnel control signals to main circuit 1, it is achieved the adjustment to the tACS current amplitude stimulated and frequency; TRNS stimulus settings information is sent to micro-control unit 3 by WiFi module 5 by described application program for mobile terminal 7, and micro-control unit 3 is according to the noise type adjusted in concert five tunnel control signal set, it is achieved the tRNS of different noise types stimulates.
The adjustable electrical transcranial stimulation systemic-function of multiparameter of the present invention is achieved in that
As it is shown in figure 1, the multiparameter of the present invention adjustable electrical transcranial stimulation system includes interconnective main circuit 1, conductive electrode 2, micro-control unit 3, A/D module 4, WiFi module 5, display screen 6, application program for mobile terminal 7. Main circuit 1 includes interconnective power pack 8, regulating circuit 9, FM circuit 10. Power pack 8 includes rechargeable battery 11, switch 12 and voltage sensor 13, regulating circuit 9 is the chopper circuit driven by a field effect transistor 14, FM circuit 10 is the inverter circuit driven by four field effect transistor 14, additionally, it also comprises adjustment resistance 15, milliampere current sensor 16.
The adjustable electrical transcranial stimulation system of multiparameter of the present invention can realize three kinds of galvanism patterns. Micro-control unit 3 is a control chip based on ARM kernel, and it regulates timer internal according to set information and exports five road pulse width modulating signals. One road signal input realizes pressure regulation to a field effect transistor 14 of regulating circuit 9, and another four road signal inputs realize frequency modulation to four field effect transistor 14 of FM circuit 10. Realize tDCS stimulus modelity when the frequency of FM circuit is 0, the current signal that now milliampere current sensor 16 records inputs to micro-control unit 3 via A/D module 4.The micro-control unit 3 current signal according to set current amplitude and acquisition, regulate input to regulating circuit 9 control signal so that realize stimulating current closed loop regulate. The tACS that micro-control unit 3 can realize different frequency amplitude by adjusted in concert five tunnel control signal stimulates, tRNS can be realized according to certain types of noise signal stimulate when control signal changes: when realizing high-frequency noise, control signal is the irregular pulse signal of high frequency, when realizing low-frequency noise, control signal is the irregular pulse signal of low frequency, when realizing the stimulation of similar white noise, input the control signal change Tong Bu with the control signal of input to FM circuit 10 to regulating circuit 9 so that the current power of different frequency section is identical.
The multiparameter adjustable electrical transcranial stimulation system of the present invention has good interface alternation function, and stimulus parameter can be set by user by application program for mobile terminal 7. Application program for mobile terminal 7 realizes mutual with the information of micro-control unit 3 by WiFi module 5. Its interface as in figure 2 it is shown, be made up of five interfaces, main interface 17, model selection interface 18, parameter setting interface 19, information display interface 20, stimulate history interface 21. Model selection interface 18 provides the selection (tRNS that tDCS, tACS and multiple noise select) of three kinds of stimulus modelities. Parameter setting interface 19 provides the setting of stimulating current, stimulus frequency, stimulation time. Information display interface 20 provide stimulus modelity, stimulus frequency, stimulation time numerical value show and the waveform of stimulating current shows. Stimulate history interface 21 provide to Three models stimulate history display and to stimulate history Network Synchronization storage, and also provide with other wearable devices realize information mutual link entrance. Meanwhile, user's facility information such as can pass through that display screen 6 checks that the stimulus informations such as stimulus modelity, stimulating current and voltage and battery electric quantity, WiFi are connected.
Claims (3)
1. the adjustable electrical transcranial stimulation system of multiparameter, is characterized in that: this system includes interconnective seven parts: main circuit (1), conductive electrode (2), micro-control unit (3), A/D module (4), WiFi module (5), display screen (6), application program for mobile terminal (7); Described main circuit (1) includes interconnective power pack (8), regulating circuit (9), FM circuit (10);
Described micro-control unit (3) is a control chip based on ARM kernel, this chip regulates timer internal according to set information and exports five road pulse width modulating signals, one road signal input carries out voltage-regulation to the regulating circuit (9) of main circuit (1), and then realizing the adjustment of stimulating current amplitude, another four road signals inputs to the FM circuit (10) of main circuit (1) carries out the frequency of stimulating current and regulates;
Set information is sent to micro-control unit (3) by WiFi module by described application program for mobile terminal (7), and micro-control unit (3) adjusts five tunnel control signals according to set information and the voltage and current information of main circuit (1) that receives via A/D module (4);
The voltage and current information of described main circuit (1) is sent to micro-control unit (3) by A/D module (4), these information are transferred to display screen (6) and display by micro-control unit (3), and these information is displayed and record to application program for mobile terminal (7) by display screen (6) by micro-control unit (3) by WiFi module (5) transmission simultaneously.
2. the adjustable electrical transcranial stimulation system of multiparameter according to claim 1, is characterized in that: described application program for mobile terminal (7) includes five interactive interfaces: main interface (17), model selection interface (18), parameter setting interface (19), information display interface (20) and stimulation history interface (21);Described model selection interface (18) provides the selection of tDCS, tACS and multiple noise type tRNS; Described parameter setting interface (19) provides the setting of stimulating current, stimulus frequency, stimulation time; Described information display interface (20) provides the display of stimulus modelity, stimulus frequency, stimulation time, stimulating current; Described stimulation history interface (21) provides the display of three kinds of stimulus modelities stimulation history and synchronizes storage.
3. the adjustable electrical transcranial stimulation system of multiparameter according to claim 1, it is characterized in that: tDCS stimulus settings information is sent to micro-control unit (3) by WiFi module (5) by described application program for mobile terminal (7), micro-control unit (3) first regulates the four tunnel control signals inputted to FM circuit (10) according to demand and makes its frequency be 0 i.e. direct current output, then micro-control unit (3) combines the current information of the main circuit (1) received via A/D module (4), it is achieved the closed loop of the current amplitude of tDCS is regulated; TACS stimulus settings information is sent to micro-control unit (3) by WiFi module (5) by described application program for mobile terminal (7), micro-control unit (3) adjusted in concert according to demand inputs the five tunnel control signals to main circuit (1), it is achieved the adjustment to the tACS current amplitude stimulated and frequency; TRNS stimulus settings information is sent to micro-control unit (3) by WiFi module (5) by described application program for mobile terminal (7), micro-control unit (3) is according to the noise type adjusted in concert five tunnel control signal set, it is achieved the tRNS of different noise types stimulates.
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| CN201610010976.6A CN105664357A (en) | 2016-01-04 | 2016-01-04 | Multi-parameter adjustable transcranial current stimulation system |
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| CN201610010976.6A CN105664357A (en) | 2016-01-04 | 2016-01-04 | Multi-parameter adjustable transcranial current stimulation system |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581854A (en) * | 2016-11-16 | 2017-04-26 | 西安交通大学 | Transcranial direct current stimulation device and work method thereof |
| RU176302U1 (en) * | 2017-03-13 | 2018-01-16 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Амурская государственная медицинская академия" Министерства здравоохранения Российской Федерации | Device for transcranial stimulation of the brain by direct current |
| CN107875512A (en) * | 2017-12-01 | 2018-04-06 | 中国人民解放军第三〇七医院 | System and method occurs for a kind of neuron electronic impulse |
| CN108671389A (en) * | 2018-04-25 | 2018-10-19 | 中国人民解放军军事科学院军事医学研究院 | Multi-mode is wearable through cranium electric current stimulating apparatus |
| CN108853723A (en) * | 2017-05-13 | 2018-11-23 | 陕西诺奕生物医药科技有限公司 | A kind of application method of transcutaneous electrical stimulation physics headache therapeutic equipment |
| CN109908476A (en) * | 2019-03-20 | 2019-06-21 | 华南理工大学 | A kind of wearable multi-mode radio neural stimulation system |
| CN110262336A (en) * | 2019-06-18 | 2019-09-20 | 中国科学院自动化研究所 | Current output circuit and channel-cranium electro-stimulating device including it |
| EP3698844A1 (en) * | 2019-02-25 | 2020-08-26 | Neuro Device Group Spolka Akcyjna | Brain stimulation system, device, arrangement and corresponding method for treating aphasia |
| CN112023263A (en) * | 2020-09-15 | 2020-12-04 | 天津大学 | Remote monitoring household high-precision transcranial current stimulation system |
| CN116931738A (en) * | 2023-09-13 | 2023-10-24 | 杭州般意科技有限公司 | Intervention stimulation method for dynamically adjusting current intensity based on brain waves |
| CN117095808A (en) * | 2023-10-18 | 2023-11-21 | 杭州般意科技有限公司 | Mode recommendation method and device based on terminal operation, terminal and storage medium |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106581854A (en) * | 2016-11-16 | 2017-04-26 | 西安交通大学 | Transcranial direct current stimulation device and work method thereof |
| RU176302U1 (en) * | 2017-03-13 | 2018-01-16 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Амурская государственная медицинская академия" Министерства здравоохранения Российской Федерации | Device for transcranial stimulation of the brain by direct current |
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| CN108671389A (en) * | 2018-04-25 | 2018-10-19 | 中国人民解放军军事科学院军事医学研究院 | Multi-mode is wearable through cranium electric current stimulating apparatus |
| WO2020173916A1 (en) * | 2019-02-25 | 2020-09-03 | Neuro Device Group S.A. | Brain stimulation system, device, arrangement and corresponding method for treating aphasia |
| EP3698844A1 (en) * | 2019-02-25 | 2020-08-26 | Neuro Device Group Spolka Akcyjna | Brain stimulation system, device, arrangement and corresponding method for treating aphasia |
| CN109908476A (en) * | 2019-03-20 | 2019-06-21 | 华南理工大学 | A kind of wearable multi-mode radio neural stimulation system |
| CN109908476B (en) * | 2019-03-20 | 2020-12-22 | 华南理工大学 | Wearable multi-mode wireless nerve stimulation system |
| CN110262336A (en) * | 2019-06-18 | 2019-09-20 | 中国科学院自动化研究所 | Current output circuit and channel-cranium electro-stimulating device including it |
| CN110262336B (en) * | 2019-06-18 | 2021-02-02 | 中国科学院自动化研究所 | Current output circuit and transcranial electrical stimulation device comprising same |
| CN112023263A (en) * | 2020-09-15 | 2020-12-04 | 天津大学 | Remote monitoring household high-precision transcranial current stimulation system |
| CN116931738A (en) * | 2023-09-13 | 2023-10-24 | 杭州般意科技有限公司 | Intervention stimulation method for dynamically adjusting current intensity based on brain waves |
| CN116931738B (en) * | 2023-09-13 | 2023-12-12 | 杭州般意科技有限公司 | Intervention stimulation method for dynamically adjusting current intensity based on brain waves |
| CN117095808A (en) * | 2023-10-18 | 2023-11-21 | 杭州般意科技有限公司 | Mode recommendation method and device based on terminal operation, terminal and storage medium |
| CN117095808B (en) * | 2023-10-18 | 2024-02-20 | 杭州般意科技有限公司 | Mode recommendation method and device based on terminal operation, terminal and storage medium |
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Application publication date: 20160615 |