CN105879219A - Multi-channel high-voltage pulse power generator for transcranial magnetic stimulation - Google Patents
Multi-channel high-voltage pulse power generator for transcranial magnetic stimulation Download PDFInfo
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- CN105879219A CN105879219A CN201510069014.3A CN201510069014A CN105879219A CN 105879219 A CN105879219 A CN 105879219A CN 201510069014 A CN201510069014 A CN 201510069014A CN 105879219 A CN105879219 A CN 105879219A
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Abstract
The invention provides a multi-channel high-voltage pulse power generator for transcranial magnetic stimulation. The multi-channel high-voltage pulse power generator is formed by an AC-DC module, n groups of DC-DC step-up modules (n is larger than or equal to 2), n groups of energy-storage-discharge switch modules (n is larger than or equal to 2), and a master control module. The AC-DC module converts input alternating current voltage into direct current voltage and is connected to the input end of the n groups of DC-DC step-up modules. The n groups of DC-DC step-up modules convert the direct current voltage outputted by the AC-DC module into n paths of direct current high voltage to supply power to the n energy storage capacitors in the n groups of energy-storage-discharge switch modules. Under the control of the master control module, the n groups of energy-storage-discharge switch modules discharge n externally connected stimulation coils. The master control module is connected to a computer through a data collection card interface. Under the control of the computer, the master control module controls the connection and charging voltage of the n groups of DC-DC modules, controls the n group of energy-storage-discharge switch modules to discharge the stimulation coil, and collects the temperature/voltage state of a power supply. The multi-channel high-voltage pulse power generator comprises multiple paths of charging power modules, multiple energy storage capacitors and multiple discharge switches and can be equivalent to multiple transcranial magnetic stimulation high voltage pulse power supply generators, the stimulation of multiple coils at the same time can be realized, and each coil can be stimulated separately.
Description
Technical field
The invention belongs to transcranial magnetic stimulation field, particularly to a kind of high-voltage pulse electric source generator for transcranial magnetic stimulation.
Background technology
Transcranial magnetic stimulation (Transcranial Magnetic Stimulation, TMS) by scholars such as the Barker of Britain in 1985
First founding, the induction field utilizing time-varying pulse electromagnetic field to produce acts on cerebral central nervous system, changes cerebral cortex god
Through the film potential of cell, affect brain intracellular metabolite and neuroelectricity is movable, thus cause a kind of brain god of a series of biochemical reactions
Through art treatments method, there is painless, not damaged, without advantages such as x-ray radiations.Along with the development of computer technology, repeat warp
Cranium Neural stem cell technology (Repeated TMS, rTMS) obtains more at Cognitive Neuroscience, clinical neuropsychiatric disease and rehabilitation field
Carry out the most accreditations.Israel's approval in 2002 enters clinical practice, and within 2008, U.S. Food is ratified with drug administration (FDA)
It is used in antiradiation drug refractory depression.China's traditional Chinese medicines prison tool [2002] 302 approval magnetic stimulator is II class medical electronic apparatus
Equipment.
Transcranial magnetic stimulation equipment is mainly made up of high-voltage pulse electric source generator, stimulating coil and control computer.Its operation principle
For: control computer and high-voltage pulse electric source generator is sent charge/discharge instruction；During charging, high-voltage pulse electric source generator is internal
Portion's storage capacitor charging；During electric discharge, stimulating coil is discharged by storage capacitor, produces pulsed magnetic field, acts on brain, produces sensing
Electric field.
High-voltage pulse electric source generator is the core of transcranial magnetic stimulation equipment, mainly includes high-voltage pulse power source, and storage capacitor can
Control transwitch, backward dioded, its function is the control instruction accepting computer, charges for storage capacitor, and controls energy storage electricity
Discharge capacitor.
Transcranial magnetic stimulation equipment in the market is made up of, such as China a high-voltage pulse electric source generator and a stimulating coil
Patent CN101984548A, the shortcoming of this kind equipment is that an independent equipment can not stimulate multiple position simultaneously.Chinese patent
CN101234231A proposes the magnetic stimulator of a kind of multiple stimulating coil, and one of feature is that an equipment shares a high-tension electricity
Source, a storage capacitor, connect multiple coil；The two of feature are multiple power supply, connect multiple electric capacity, multiple discharge switch and
Multiple coils.This structural system is complicated, and efficiency reduces.
Summary of the invention
The present invention proposes a kind of multichannel high-voltage pulse electric source generator for transcranial magnetic stimulation, from the angle of Power Management Design, each
Individual circuit module is integrated into inside a power source generator, decreases the complexity of TMS system, reduces the cost of TMS system,
Improve the power-efficient of system.
The present invention adopts the following technical scheme that and realizes above-mentioned technical purpose:
For the multichannel high-voltage pulse electric source generator of transcranial magnetic stimulation, by AC-DC module, n group DC-DC boost module (n >=
2), n group energy storage-discharge switch module (n >=2), main control module four part form.Wherein,
The alternating voltage of input is converted into DC voltage by AC-DC module, it is characterised in that a road exchange input, n road direct current is defeated
Go out, be connected in parallel to the input of n group DC-DC boost module；
The dc voltage boost that AC-DC module exports is transformed into n road high direct voltage by n group DC-DC boost module, stores up to n group
N storage capacitor in energy-discharge switch module is powered, it is characterised in that the access of DC-DC boost module is controlled by control mould
Block, the voltage range 0～2000V of output is adjustable, and output voltage values is controlled by the 0 of control panel～the d. c. voltage signal of 10V；
N group energy storage-discharge switch module, is characterized by that each group all includes a storage capacitor, a controllable silicon discharge switch,
One protection diode, master control module controls opens each reverse-blocking tetrode thyristor, to external stimulating coil electric discharge；
Main control module includes data acquisition card interface, optical coupling isolation circuit, gathers and control circuit.It is characterized by capture card interface
It is connected with computer, the control signal that computer sends, through light-coupled isolation, after signals collecting control circuit processes, sends three kinds
Control signal, the temperature/voltage state of power supply is acquired by main control module, and is input to computer by capture card interface and enters
Row processes.
As it has been described above, three kinds of control signals that main control module sends, it is characterized by: the first high/low level signal in n road, control
Whether the access of n group DC-DC module；The second n road 0～10V voltage signal, controls n group DC-DC module charging voltage model
It is trapped among 0～2000V；The third output n road clock pulse signal, the controllable silicon controlled in n group energy storage-discharge switch module is opened
Closing open-minded, discharge frequency could be arranged to 0～100Hz.
In the present invention, the input of n group DC-DC boost module is same AC-DC module, compared to using multiple high-tension electricities
The mode (CN101984548A) in source, improves the whole efficiency of power supply.Count according to the peak power 1.5KVA on every road, this
The power source generator power consumption of invention is in more than 3KVA (n >=2).
Charge power supply between each road of multichannel high-voltage pulse electric source generator of transcranial magnetic stimulation of the present invention, storage capacitor,
Discharge switch and stimulating coil aspect are completely independent, and can meet magnetic stimulation treatment needs in many-side.One of application is n line
Corresponding n the patient of circle, an equipment treats to multiple patients simultaneously.The two of application use n coil simultaneously for same patient
Stimulate n position, extend the application for the treatment of.The three of application act on same coil for n storage capacitor, pass through
Change the electric discharge clock on each road, make frequency of stimulation superposition, add the frequency of stimulation of single coil.
The present invention uses a multichannel high-voltage pulse electric source generator to substitute multiple power supplys, adds stimulation quantity, decreases TMS
The complexity of system, reduces the cost of TMS system, extends kind and the scope for the treatment of.
Accompanying drawing explanation
Fig. 1 is for the multichannel high-voltage pulse power source generator architecture block diagram of transcranial magnetic stimulation；
AC-DC circuit embodiments 1 described in Fig. 2 a Fig. 1；
AC-DC circuit embodiments 2 described in Fig. 2 b Fig. 1；
A kind of DC-DC boost module circuit described in Fig. 3 Fig. 1 implements schematic diagram；
A kind of energy storage described in Fig. 4 Fig. 1-discharge switch module implements schematic diagram；
Main control module described in Fig. 5 Fig. 1 implements theory diagram.
Detailed description of the invention
The present invention is further illustrated below in conjunction with the drawings and the specific embodiments.
Fig. 1 is the multichannel high-voltage pulse power source generator architecture block diagram for transcranial magnetic stimulation.The course of work of the present invention: input
Alternating current be transformed into direct current through AC-DC module, this direct current is divided into n road, after n group DC-DC boost module, gives
Electric capacity charging in n group energy storage-discharge switch module；Whether master control module controls n group DC-DC boost module accesses, and passes through
The charging control signal of main control module controls output voltage, charges to capacitor；Discharge under clock control sending of computer,
Open the controllable silicon in n group energy storage-discharge switch module, control n storage capacitor and n stimulating coil is discharged.
Fig. 2 a is AC-DC circuit embodiments 1, exchanges specified input 220V, uses EMI circuit and rectifier bridge, is transformed into
Nominal value is the direct current of 300V, and is divided into n road, by switch K1, K2 ..., Kn, to DC-DC boost module
Input stage is powered.Its breaker in middle K1, K2 ..., opening of Kn is controlled by main control module.The feature of this circuit is output
DC voltage relatively big, between 200V～310V, to rear class DC-DC boost module circuit voltage with load change fluctuation
Adjustment adds difficulty.
Fig. 2 b is AC-DC circuit embodiments 2, exchange input 90～260V, uses EMI circuit, rectifier bridge and PFC electricity
Road, is transformed into the direct current that nominal value is 400V, and is divided into n road, by switch K1, K2 ..., Kn, to DC-DC
Boost module input stage is powered.AC-DC circuit embodiments 2 has wide alternating voltage input range, adapts in world wide
The grid ac voltage of major country.The direct current fluctuation range of 400V output is little, reduces rear class DC-DC boost module
The difficulty that circuit voltage adjusts.
Fig. 3 is a kind of DC-DC boost module circuit embodiments schematic diagram described in Fig. 1.The present invention is by n group circuit realiration
The output of n road high pressure.Come for therein, the DC voltage of input through full bridge inverter and high frequency transformation,
And high-frequency rectification circuit, become high direct voltage, charge to storage capacitor.By the direct current signal of 0～10V, by regulation
The dutycycle of full bridge inverter pwm signal, it is achieved corresponding 0～the pressure regulation of 2000V.DC-DC boost module
It is practiced without limitation to full-bridge inverting, it is also possible to half-bridge or other DC-DC topological structure.
Fig. 4 is that a kind of energy storage described in Fig. 1-discharge switch module implements schematic diagram.The present invention is n by n group circuit realiration
Road energy storage-discharge switch module.Come for therein, all include that a storage capacitor Cs, a controllable silicon electric discharge open
Closing SCR, a protection diode Dp, each reverse-blocking tetrode thyristor is sent clock pulse signal by main control module and controls to open, clock
Pulse signal 0～100Hz is adjustable.
Fig. 5 is that the main control module described in Fig. 1 implements theory diagram.Main control module includes data acquisition card interface, light-coupled isolation
Circuit, gathers and control circuit.Main control module passes through capture card interface computer control signal, uploads voltage and temperature
Gather signal；Optical coupling isolation circuit realizes the signal isolation of Computer signal and power supply；Gather and computer is sent by control circuit
The conditioning of three kinds of control signals after give different functional modules.Three kinds of control signals include: the high/low level signal in n road, control
Whether the access of n group DC-DC module；N road 0～10V voltage signal, control n group DC-DC module charge voltage range 0～
2000V；N road clock pulse signal, controls the reverse-blocking tetrode thyristor in n group energy storage-discharge switch module open-minded.Gather and control
Circuit also by voltage and temperature signal regulation with after pass to computer interface through optocoupler.
Claims (3)
1. for the multichannel high-voltage pulse electric source generator of transcranial magnetic stimulation, by AC-DC module, n group DC-DC boost module (n
>=2), n group energy storage-discharge switch module (n >=2), main control module four part form.
2. according to the multichannel high-voltage pulse electric source generator for transcranial magnetic stimulation described in claim 1, its spy of AC-DC module
Levying and be, a road exchange input, n road direct current exports, is connected in parallel to the input of n group DC-DC boost module；N group DC-DC
Boost module, it is characterised in that the access of DC-DC boost module is controlled by control module, the voltage range 0～2000V of output
Adjustable, output voltage values is controlled by the 0 of control panel～the d. c. voltage signal of 10V；N group energy storage-discharge switch module, it is special
Levy and all include a storage capacitor, a controllable silicon discharge switch, a protection diode, each reverse-blocking tetrode thyristor for each group
Sent clock pulse signal by main control module to control to open；Main control module includes data acquisition card interface, optical coupling isolation circuit, adopts
Collection and control circuit, is characterized by send three kinds of control signals, and be acquired the temperature/voltage state of power supply.
3. the three kinds of control signals sent according to the main control module described in claim 2, is characterized by: the first n road is high/low
Level signal, whether the access of control n group DC-DC module；The second n road 0～10V voltage signal, controls n group DC-DC
Module charge voltage range is 0～2000V；The third output n road clock pulse signal, controls n group energy storage-discharge switch mould
Reverse-blocking tetrode thyristor in block is open-minded.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510069014.3A CN105879219A (en) | 2015-02-10 | 2015-02-10 | Multi-channel high-voltage pulse power generator for transcranial magnetic stimulation |
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| CN201510069014.3A CN105879219A (en) | 2015-02-10 | 2015-02-10 | Multi-channel high-voltage pulse power generator for transcranial magnetic stimulation |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108055023A (en) * | 2017-12-19 | 2018-05-18 | 乐普医学电子仪器股份有限公司 | A kind of boost pulse for Implantable Pulse Generator generates and control circuit |
| CN108134517A (en) * | 2018-01-31 | 2018-06-08 | 南京溯远基因科技有限公司 | High voltage power supply and DNA sequencer |
| CN108187231A (en) * | 2018-02-02 | 2018-06-22 | 河南正痛医疗服务有限公司 | A kind of pulsed magnetic field analgesia instrument |
| CN109276814A (en) * | 2018-10-31 | 2019-01-29 | 北京大学（天津滨海）新代信息技术研究院 | Multi-channel stimulation system and method for transcranial magnetic stimulation |
| CN109471393A (en) * | 2018-11-22 | 2019-03-15 | 广州龙之杰科技有限公司 | A kind of device and method in security control magnetic field |
| CN111744116A (en) * | 2020-06-15 | 2020-10-09 | 王继珍 | Multi-dimensional variable-frequency resonance infrared physiotherapy system and control method thereof |
| WO2021082156A1 (en) * | 2018-12-26 | 2021-05-06 | 苏州景昱医疗器械有限公司 | Voltage regulator module and implantable nerve stimulation system |
| CN112755395A (en) * | 2021-01-21 | 2021-05-07 | 武汉依瑞德医疗设备新技术有限公司 | True and false pulse magnetic stimulation therapeutic instrument |
| CN112891748A (en) * | 2021-01-21 | 2021-06-04 | 武汉依瑞德医疗设备新技术有限公司 | Magnetic shock therapeutic instrument |
| CN112996558A (en) * | 2018-09-27 | 2021-06-18 | 约纳·佩莱德 | Method and apparatus for multi-channel simultaneous high power magnetic coil driver |
| CN113101519A (en) * | 2021-03-31 | 2021-07-13 | 深圳市倍轻松科技股份有限公司 | Massager control circuit and massager |
| CN115282488A (en) * | 2022-06-21 | 2022-11-04 | 中国科学院自动化研究所 | Magnetic stimulation instrument |
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- 2015-02-10 CN CN201510069014.3A patent/CN105879219A/en active Pending
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108055023A (en) * | 2017-12-19 | 2018-05-18 | 乐普医学电子仪器股份有限公司 | A kind of boost pulse for Implantable Pulse Generator generates and control circuit |
| CN108134517A (en) * | 2018-01-31 | 2018-06-08 | 南京溯远基因科技有限公司 | High voltage power supply and DNA sequencer |
| CN108187231A (en) * | 2018-02-02 | 2018-06-22 | 河南正痛医疗服务有限公司 | A kind of pulsed magnetic field analgesia instrument |
| CN112996558A (en) * | 2018-09-27 | 2021-06-18 | 约纳·佩莱德 | Method and apparatus for multi-channel simultaneous high power magnetic coil driver |
| CN109276814A (en) * | 2018-10-31 | 2019-01-29 | 北京大学（天津滨海）新代信息技术研究院 | Multi-channel stimulation system and method for transcranial magnetic stimulation |
| CN109471393A (en) * | 2018-11-22 | 2019-03-15 | 广州龙之杰科技有限公司 | A kind of device and method in security control magnetic field |
| WO2021082156A1 (en) * | 2018-12-26 | 2021-05-06 | 苏州景昱医疗器械有限公司 | Voltage regulator module and implantable nerve stimulation system |
| CN111744116A (en) * | 2020-06-15 | 2020-10-09 | 王继珍 | Multi-dimensional variable-frequency resonance infrared physiotherapy system and control method thereof |
| CN112755395A (en) * | 2021-01-21 | 2021-05-07 | 武汉依瑞德医疗设备新技术有限公司 | True and false pulse magnetic stimulation therapeutic instrument |
| CN112891748A (en) * | 2021-01-21 | 2021-06-04 | 武汉依瑞德医疗设备新技术有限公司 | Magnetic shock therapeutic instrument |
| CN113101519A (en) * | 2021-03-31 | 2021-07-13 | 深圳市倍轻松科技股份有限公司 | Massager control circuit and massager |
| CN115282488A (en) * | 2022-06-21 | 2022-11-04 | 中国科学院自动化研究所 | Magnetic stimulation instrument |
| CN115282488B (en) * | 2022-06-21 | 2023-09-12 | 中国科学院自动化研究所 | Magnetic stimulation instrument |
| WO2023245928A1 (en) * | 2022-06-21 | 2023-12-28 | 中国科学院自动化研究所 | Magnetic stimulator |
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Application publication date: 20160824 |