CN101876661A - Device for analyzing analyte in liquid sample - Google Patents
Device for analyzing analyte in liquid sample Download PDFInfo
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- CN101876661A CN101876661A CN2009101390102A CN200910139010A CN101876661A CN 101876661 A CN101876661 A CN 101876661A CN 2009101390102 A CN2009101390102 A CN 2009101390102A CN 200910139010 A CN200910139010 A CN 200910139010A CN 101876661 A CN101876661 A CN 101876661A
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Abstract
The invention relates to a device for analyzing an analyte in a liquid sample. The device can be used for acquiring the liquid sample and simultaneously detecting whether the analyte exists in the sample or not. The device comprises a collection chamber for storing the liquid sample, a detection chamber for accommodating a detection element and a liquid sample transfer chamber, wherein the transfer chamber is connected with the detection chamber and the collection chamber, and the detection chamber is not in direct liquid communication with the liquid sample collection chamber; the transfer chamber is provided with a first position and a second position; when the transfer chamber is positioned in the first position, the transfer chamber is opened to the collection chamber and closed to the detection chamber and can receive a part of liquid sample in the collection chamber to the transfer chamber; and when the transfer chamber is positioned in the second position, the transfer chamber is closed to the collection chamber and opened to the detection chamber and can release the liquid sample in the transfer chamber to the detection chamber. The liquid sample is transferred to the detection chamber from the collection chamber through the transfer chamber so as to carry out detection or test, therefore, the pollution to the liquid sample in the collection chamber from the detection element in the detection chamber is avoided.
Description
Technical field
The invention belongs to the liquid sample assembling sphere, belong to the field of collecting liquid sample and detecting analyte in the sample especially, especially detect the metabolin that whether contains the drug abuse material in the sample or the quick diagnosis of women's gestation aspect and detect.
Background technology
In recent years, pick-up unit is made the body fluid that is used for detecting the people in a large number, urine for example, the analyte in saliva or the blood, for example indicator substance of drug abuse or disease.Traditional like this pick-up unit need be collected in liquid sample to a container usually, inserts testing element in the liquid then and then takes out and read test result on (with the naked eye see or read with machine) testing element.Might allow the operator by sample contamination like this.Use this pick-up unit except being used by professional testing staff, do not had the people of professional experiences to use by some gradually, for example use in the family, this just need provide a kind of operation simpler, and testing result is pick-up unit more accurately.
Summary of the invention
The present invention relates to the device of analyte in a kind of analytic liquid sample body, this device can be collected liquid sample and whether have analyte in the test sample simultaneously.In a concrete embodiment, this device comprises collecting chamber that is used for the liquid sample storage and the test chamber that is used to accommodate detecting element; And a liquid sample transfer chamber, this transfer chamber connects described test chamber and collecting chamber, test chamber not with the direct fluid connection of liquid sample collecting chamber.Preferably, this transfer chamber has the primary importance and the second place; When transfer chamber was positioned at primary importance, this transfer chamber was to the collecting chamber opening and to the test chamber sealing, and the partially liq sample in the reception collecting chamber is in transfer chamber; When transfer chamber was positioned at the second place, this transfer chamber was to the collecting chamber sealing and to the test chamber opening, and the liquid sample in the release transfer chamber is in test chamber.By transfer chamber liquid sample is transferred to from collecting chamber and to be detected the test chamber or chemically examine, thereby avoid detecting element in the test chamber to pollute liquid sample in the collecting chamber.More preferred, this device also comprises a lid that the transfer chamber position is changed.Specifically, lid has the primary importance and the second place, and when lid was positioned at primary importance, transfer chamber was positioned at primary importance, and when lid was positioned at the second place, transfer chamber was positioned at the second place.More concrete, lid has the primary importance and the second place, and when lid and transfer chamber were positioned at primary importance, this transfer chamber was to the collecting chamber opening and to the test chamber sealing, receives partially liq sample in the collecting chamber in transfer chamber; When lid and transfer chamber were positioned at the second place, this transfer chamber was to the collecting chamber sealing and to the test chamber opening, discharged liquid sample in the transfer chamber in test chamber.In a more concrete embodiment, this lid can cooperate the collecting chamber sealing.When collecting chamber was positioned at unlimited state, lid was positioned at primary importance, and transfer chamber also is positioned at primary importance, and at this moment, liquid sample can flow into transfer chamber from collecting chamber, but can not flow into test chamber; When collecting chamber is positioned at closed state, lid is positioned at the second place, transfer chamber also is positioned at the second place, at this moment, liquid sample can not flow into transfer chamber from collecting chamber again, but flow into test chamber, thereby whether contain analyte in the analytic liquid sample body and draw result directly perceived from transfer chamber.
In some embodiments, pick-up unit also comprises a piston and the plunger shaft of accommodating piston.This piston and plunger shaft can help the transfer of the liquid sample in the transfer chamber.Preferably, this transfer chamber of the inner wall limit of the outer wall of this piston and plunger shaft.
For example, in some concrete embodiments, piston is arranged in plunger shaft and has the described primary importance and the second place; The plunger shaft both ends open; When piston was positioned at primary importance, piston was opened end opening receiving unit sample from the liquid sample collecting chamber of plunger shaft, and another opening of piston closes plunger shaft stops liquid sample to enter in the test chamber simultaneously; When piston was positioned at the second place, an end opening of piston closes plunger shaft stoped the liquid sample in the collecting chamber to enter in the plunger shaft, and piston is opened another opening of plunger shaft simultaneously, allows liquid sample enter in the test chamber.Can set in advance owing to hold the volume of liquid sample in the piston, like this,, can realize the detection of quantitative liquid sample according to parameters such as the diameter of piston and length.
In other embodiments, piston has primary importance and position, the ends two in plunger shaft; Plunger shaft one end opening, end sealing; When piston is positioned at primary importance, an end of plunger shaft opening receiving unit sample from the liquid sample collecting chamber, an end that is closed still is closed; When piston was positioned at the second place, an end of plunger shaft opening was closed, and stoped the liquid sample in the collecting chamber to enter in the plunger shaft, and an end that is closed simultaneously is opened, and allows liquid sample enter the test chamber from transfer chamber.
In other specific embodiment, transfer chamber is arranged in a cavity.Transfer chamber one end opening, the material seal that the other end is punctured easily, transfer chamber has the primary importance and the second place in cavity.When transfer chamber was positioned at primary importance, a termination of opening was received from the partially liq sample in the collecting chamber, and an end that is closed still is in the state of sealing; When the transfer chamber position was positioned at the second place, an end of opening was closed, and stop the liquid in the collecting chamber to enter in the transfer chamber, and a sealed end was opened, and discharges liquid sample in test chamber again.
In the concrete embodiment of other, " sealing " can adopt the material that is punctured easily to come an end of closed piston chamber or transfer chamber, opening by an end of " sealing " to adopt brokenly element to puncture encapsulant, this element that punctures can be included on the piston, also can be set at bottom of accommodating piston or transfer chamber etc.
Beneficial effect
The present invention settles the detection sample at one go, and can not pollute environment, and simple operation can realize that quick diagnosis detects family and uses.In addition, this device can detection by quantitative, can improve the accuracy and the sensitivity of detection.
Description of drawings
Fig. 1 is the structure exploded perspective view of specific embodiment of device of the present invention;
Fig. 2 is the profile synoptic diagram of device shown in Figure 1, and the expression piston is at the structural representation of primary importance;
Fig. 3 is the enlarged diagram of A part among Fig. 2;
Fig. 4 is the profile synoptic diagram of device shown in Figure 1, and the expression piston is at the structural representation of the second place;
Fig. 5 is the enlarged diagram of B part among Fig. 4;
Fig. 6 is the structure exploded perspective view of another specific embodiment of device of the present invention;
Fig. 7 is the profile synoptic diagram of device shown in Figure 6, and the expression piston is at the structural representation of primary importance;
Fig. 8 is the enlarged diagram of C part among Fig. 7;
Fig. 9 is the profile synoptic diagram of device shown in Figure 6, and the expression piston is at the structural representation of the second place;
Figure 10 is the enlarged diagram of D part among Fig. 9;
Figure 11 is the structure exploded perspective view of the 3rd specific embodiment of device of the present invention;
Figure 12 is the profile synoptic diagram of device shown in Figure 11, and the expression transfer chamber is at the structural representation of primary importance;
Figure 13 is the enlarged diagram of E part among Figure 12;
Figure 14 is the profile synoptic diagram of device shown in Figure 11, and the expression transfer chamber is at the structural representation of the second place;
Figure 15 is the enlarged diagram of F part among Figure 14;
Figure 16 is the structure exploded perspective view of the 4th specific embodiment of device of the present invention;
Figure 17 is the profile synoptic diagram of device shown in Figure 16, and the expression piston is at the structural representation of primary importance;
Figure 18 is the enlarged diagram of G part among Figure 17;
Figure 19 is the profile synoptic diagram of device shown in Figure 16, and the expression piston is at the structural representation of the second place;
Figure 20 is the enlarged diagram of H part among Figure 19.
Description of reference numerals:
Pick-up unit 100,200,300,400; Detect box 14,24,34,44; Detecting element 142,242,342,442; Lid 13,23,33,43; Cup 11,21,31,41; Base 12,22,32,42; Piston 15,25,35,45; Piston outer wall 155,156,157,255,256,257,355,356,357,455,456,457; Test chamber 18,28,38,48; Transfer chamber 17,27,37,47; Collecting chamber 111,211,311,411; Collecting chamber opening 114,214,314,414; Cup sidewall 115,215,315,415; Push rod 152,252,352,452; Plunger shaft 16,26,36,46; Plunger shaft inwall 164,165,167,264,265,266,364,365,366,464,465,466; O-ring seal 19,191,192,193,29,291,292,293,39,391,392,393,49,491,492,493.
Embodiment
In the following detailed description, the explanation of accompanying drawing and corresponding character only is the mode that illustrates that by way of example the present invention can actable specific concrete scheme.We do not get rid of the present invention can also be in any other embodiment in claim scope of the present invention.
" sample " refer to need chemical examination whether to exist and (or) analyze any material of analyte concentration, maybe need to determine whether one or more samples exist and (or) material of the analyte of quantity, maybe need to carry out the material of qualitative evaluation.Sample can be liquid sample, for example liquid sample.Liquid sample comprises body fluid, such as blood, serum, blood plasma, saliva, urine, tears, seminal fluid and marrow; Sample can be a water sample, such as seawater, river, river etc., perhaps from domestic water, municipal water use or service water resource, runoff water or sewage; Sample can be a food sample, such as milk and wine.Mucus, semisolid or solid sample can be used for making liquid, eluate, suspending liquid or leachate equal samples.For example, throat or genitals sample may be dipped in and make sample in the liquid.Sample can comprise potpourri or any relevant potpourri of liquid, solid and gas, such as the cell suspending liquid in dilution or the solution.Sample comprises biological substance, such as cell, microorganism, organelle and biochemical complexes.Liquid sample can be from producing such as solid, semisolid or high-viscosity materials such as soil, ight soil, tissue, organ, biological fluid or other occurring in nature non-liquid samples.For example, these solids or semi-solid samples can be mixed with the suitable solution of dilution one class.Sample can be macerated, freezing and thaw, perhaps other extracting method form liquid samples.Remaining particulate material can use traditional method such as filtration or precipitation to remove.
Analyte can be " drug abuse " (DOA) or other have interested material in the sample." drug abuse " (DOA) is meant that the non-medical destination uses medicine (playing the paralysis nerve usually).Abuse these medicines and can cause body ﹠ mind to suffer damage, produce dependence, habit-forming and/or dead.The example of drug abuse comprises cocaine; Amphetamine (for example, black beauty, white amphetamine tablet, dextroamphetamine, dexie, Beans); Crystal methamphetamine (crank, meth, crystal, speed); Barbiturate (as Valium, Roche Pharmaceuticals, Nutley, New Jersey); Sedative (paramedicines of promptly sleeping); Lysergic acid diethylamide (LSD); Inhibitor (downers, goofballs, barbs, blue devils, yellow jackets, methaqualone); The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin); Hog (PCP); Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); Opiate (being morphine, opium, codeine, heroin, the hydroxyl dihydrocodeinone); Anxiolytic and hypnotic sedative agent, anxiolytic is that a class is mainly used in anxiety reduction, nervous, frightened, set the mind at rest, have the medicine of hypnosis sedation concurrently, comprise Benzodiazepines (benzodiazepines, BZ), atypia BZ class, merge phenodiazine NB23C class, the tall and erect class of benzene nitrogen, the part class of BZ acceptor, open loop BZ class, diphenylmethane derivatives, the piperazine carboxylic acid salt, the piperidine carboxylic acid salt, Kui azoles quinoline ketone, thiazine and thiazole, other heterocyclic, imidazole type calmness/anodyne, propanediol derivative-carbamates, fatty compound, anthracene derivative etc.Use this device also can be used to detect and belong to medical usage but the detection of overdose easily, as tricyclic antidepressant (imipramine or analog) and Paracetamol etc.Can resolve into different small-molecule substances after these medicines are absorbed by the body, these small-molecule substances are present in the body fluid such as blood, urine, saliva, sweat or there is above-mentioned small-molecule substance in part body fluid.
The invention provides the device of analyte in a kind of tracer liquid sample.This device 100 can detect chemical examination to the liquid sample of quantitative volume and not pollute other remaining liquid samples.And this detection is to finish in a step, does not need the complicated operations step.This device 100 comprises: be used for the collecting chamber that liquid sample stores, 111,211,311 and 411; Be used to accommodate the test chamber of detecting element, 18,28,38 and 48; Test chamber 18 not with liquid sample collecting chamber 111 direct fluid connections; With a liquid sample transfer chamber, 17,27,37 and 47, this transfer chamber 17 connects described test chamber 18 and collecting chamber 111.Preferably, this transfer chamber 17 is between test chamber 18 and the collecting chamber 111 and connect liquid flow between these two chambeies; Wherein, this transfer chamber 17 has the primary importance and the second place; When transfer chamber 17 was positioned at primary importance, 17 pairs of liquid sample collecting chamber 111 openings of this transfer chamber and to test chamber 18 sealing received partially liq sample in the collecting chamber 111 in transfer chamber 17; When transfer chamber 17 was positioned at the second place, 17 pairs of liquid sample collecting chambers of this transfer chamber 111 sealed and to test chamber 18 openings, the liquid sample in the release transfer chamber 17 is in test chamber 18.In the present invention, the position of transfer chamber 17 when primary importance can be defined as liquid sample and do not enter test chamber 18, and the position of the second place can be a liquid sample when entering test chamber 18 transfer chamber 17.In the specific embodiment mode, the primary importance of transfer chamber 17 and the second place are to form according to the position change of transfer chamber 17.Specifically, the primary importance of transfer chamber 17 can be the position change on the vertical direction to the variation of the second place, also can be the position change on the horizontal direction.As, transfer chamber 17 can move from top to bottom, just primary importance moving to the second place.Preferably, this position change can also can itself reach by mobile transfer chamber 17 by realizing by other structures.The mode of mobile transfer chamber 17 pushes away, and presses, and presses, and commentaries on classics or other modes commonly used can directly allow operator's hand carry out this a series of actions.More preferred, moving of transfer chamber 17 can be finished by certain structure of installing on 100.In a concrete embodiment, device 100 also comprises a lid 13 that transfer chamber 17 positions are changed.In particular, lid 13 also has the primary importance and the second place, and when lid 13 was positioned at primary importance, transfer chamber 17 was positioned at primary importance, and when lid 13 was positioned at the second place, transfer chamber 17 was positioned at the second place.Preferably, lid 13 can seal collecting chamber 111, and the collecting chamber 111 that has sealed even adorning liquid sample, can not make liquid sample flow out contaminated environment for 111 mouthfuls from collecting chamber yet, thus the transportation of being convenient to the secondary checking or detecting.
Specific embodiments more of the present invention have been showed as Fig. 1-5.In a scheme, the invention provides a kind of device 100 and comprise liquid sample collecting chamber 111, be used to hold the test chamber 18 of detecting element, plunger shaft 16 and piston 15.Preferably, the outer wall 155 of the inwall 164 of plunger shaft 16 and piston 15 limits liquid sample transfer chamber 17.Specifically, piston 15 is arranged in plunger shaft 16 and has primary importance and the second place.When piston 15 was positioned at primary importance, an end opening 168 in an end 152 closed piston chambeies 16 of piston 15 stoped the liquid in the transfer chamber 17 to enter in the test chamber 18.The opening 163 of the other end of plunger shaft 16 is in the position of opening owing to piston 15 and opens to liquid sample collecting chamber 111, partially liq in the collecting chamber 111 just enters in the transfer chamber 17 like this, during this time a part of cavity of piston 15 and collecting chamber 111 constitutes transfer chamber 17, as Fig. 2 and 3.When piston 15 is positioned at the second place, the opening 163 of piston 15 closed piston chambeies 16 and liquid sample collecting chamber 111, open the opening 168 of transfer chamber 17 and test chamber 18, allow liquid sample enter in the test chamber 18, thereby and the detecting element 142 in the test chamber 18 carries out contact reaction, shown in Fig. 4-5, the both ends open 163 and 168 of plunger shaft 16 has formed two openings 171 and 172 of transfer chamber 17.
In another preferred mode, connect a push rod 152 on the piston 15, this push rod 152 extends upward with the lid 13 of pick-up unit and contacts.When lid 13 is covered on the opening of collecting chamber 114, along with the rotation of lid 13, allow push rod 152 move to the second place from primary importance, can allow piston 15 move to the second place like this, thereby finish the transfer of liquid sample from primary importance.This transfer only needs to finish once going on foot operation, does not allow simultaneously the sample in the sample contamination collecting chamber in the test chamber, the size that can change plunger shaft 16 and piston 15 in addition arbitrarily limit to need the sample volume that shifts, and reaches the purpose of quantitative sampling.
In order to prevent to cause in the process that piston 15 moves the leakage of liquid in plunger shaft 16, the shape seal element is installed on the two ends 153 and 152 in piston 15, " 0 " shape O-ring seal for example, seal element is made of resilient material, as rubber, silica gel or the like.Because elastic reaction, allow the two ends of piston 15 contact closely with the inwall 164 of plunger shaft 16, in case an end opening 163 of transfer chamber 17 or 171 sealed after, the liquid in the collection well 111 is in can not entering plunger shaft 16.
In a preferred embodiment, the profile of plunger shaft 16 and piston 15 is funnel-form or " Y " shape, the inwall 164 of plunger shaft 16 and the outer wall of piston 15 155 limit a transfer chamber 17 that is funnel-form or " Y " shape, as Fig. 1-5, or the diameter D1 of piston 15 1 ends 153 is greater than the diameter D2 of the other end 154, simultaneously, the interior diameter of the opening 171 of an end opening 163 of the part or all of plunger shaft 16 corresponding with piston 15 or transfer chamber is greater than the interior diameter of plunger shaft 16 another openings 172.When piston 15 when primary importance is moved down into the second place, two outer walls 156 of piston 15 contact with 165 with two inwalls 166 of plunger shaft respectively with 157, this structure is done further moving after having stoped piston 15 to arrive the second place, and the structure with similar functions is called " barrier element "; Because piston 15 moves up and down along the longitudinal axis of plunger shaft 16, promptly can allow the liquid sample in the transfer chamber 17 enter in the test chamber 18 fully in addition, make sampling more accurate; And this structure operation is more prone to, and do not need too big strength just can finish.In addition, in design, make the diameter of littler than the plunger shaft 16 a little end of the diameter D1 of the little end of piston 15 diameters little, like this when the O-ring seal 191 of piston 15 breaks away from the plunger shaft inwall, between piston and plunger shaft, form a slit 173, along with piston further moves, the liquid in the transfer chamber 17 enters in the test chamber by slit 173.
The other specific embodiments of having showed device of the present invention as Fig. 6-10.In concrete side's embodiment, compare with Fig. 1-5 device of being showed, device 200 piston 25 and the plunger shaft 26 corresponding with piston 25 are about isodiametric right cylinder, on piston 25, comprise an opening 251, the diameter of opening part is littler than the interior diameter of plunger shaft 26, the inner wall limit transfer chamber 27 of this opening 251 and plunger shaft 26 allows liquid sample transfer to the test chamber 28 from collecting chamber 211.The both ends open 263 and 268 of plunger shaft 26 has formed two openings 271 and 272 of transfer chamber 27.In addition, in mode more preferably, can also comprise a projection 256 on the piston 25 and on plunger shaft 26, comprise a bayonet socket that cooperates with projection 265, this projection 256 and bayonet socket 265 form barrier element, when piston 25 when primary importance moves to the second place, projection 256 is stuck on the bayonet socket 265, moves thereby stop piston 25 to be done further.Except concrete mode described above, can be used for forming outside " barrier element " of identical or similar functions, also have other design or structure, snap close for example, latch or the like.Except these differences, the principle of work of the pick-up unit in these specific embodiment shown in Fig. 6-10 is identical with Fig. 1-5 principle of work of being showed, the parts of other constituent apparatus and position also and Fig. 1-5 showed similar, corresponding Reference numeral has added 10 or 100 on the Reference numeral of Fig. 1-5.
In addition, in all embodiments of Fig. 1-10 device of being showed, plunger shaft 16 or 26 can be positioned at the bottom 113 and the shared bottom of collecting chamber of collecting chamber.Plunger shaft 16 or 26 can be fixed on the bottom 113 or 213 of collecting chamber 111 or 211, allows piston 15 or 25 move to the second place from primary importance in plunger shaft 16 or 26. Lid 13 or 23 can cooperate with the mode with screw thread of cup 11 or 21, when lid 13 or 23 being rotated on the opening 114 or 214 of collecting chamber, lid 13 or 23 promotes push rod 15 or 25 and moves to the second place from primary importance, move on the second place from primary importance in plunger shaft 16 or 26 thereby drive piston 15 or 25, finished the quantitative sampling and the transfer of liquid sample.
The other specific embodiments of having showed device of the present invention as Figure 11-15.Device 300 comprises the collecting chamber 311 of stored samples and is arranged in the sample transfer chamber 37 of collecting chamber that sample transfer chamber 37 comprises an end 371 of opening and the other end 372 of sealing.A push rod 331 is set on lid 33, and these push rod 331 1 ends link to each other with lid 33, and the other end is used for sealing the opening 371 of transfer chamber 37.When transfer chamber 37 was positioned at primary importance, opening 371 and collecting chamber 311 communicated, and the partially liq sample in the collecting chamber 311 is full of transfer chamber 37; When lid 33 being covered on the opening 314 of collecting chamber 311, one end 333 of push rod 331 has sealed the opening 371 of transfer chamber 37, when continuing rotation lid 33, push rod is shifted transfer chamber 37 onto the second place from primary importance, in the process that promotes transfer chamber 37, opening 371 is sealed by push rod 331 all the time, has stoped the liquid in the collecting chamber 311 to enter in the transfer chamber 37; In addition, an end 372 of transfer chamber 37 sealing is punctured, and discharges liquid in the transfer chamber 37 and detects in the test chamber 38 or chemically examine, as Figure 14 and 15.In a preferred mode, transfer chamber 37 is arranged in the another one chamber 36 of accommodating transfer chamber, an element that punctures that is used for puncturing end sealing 372 is set on the bottom in chamber 36, thisly punctures nail 366 or the structure other points or sharp that element can be a projection.Simultaneously, the material that is punctured easily that is used for sealing transfer chamber 37 other ends has a lot, for example double sticky tape, adhesive membrane or other any materials or the like.In order to prevent to cause when transfer chamber from moving the leakage of liquid in chamber 36, between transfer chamber 37 and chamber 36, seal element can also be set, for example " 0 " shape O- ring seal 391 or 392 stops liquid to be revealed by the fine gap that transfer chamber 37 outer wall surface and cavity inner wall surface may form.In addition, can also have a hole 367, can enter in the test chamber 38 by hole 367 from the liquid of transfer chamber in the bottom of cavity 36.Also have, when an end 333 promotion transfer chamber 37 of push rod move, for the inside surface of anti-throw-out lever 331 outside surfaces and cavity 36 cooperates closely and may cause that the liquid in the collecting chamber 311 enters in the transfer chamber 37, can also be at an end 333 of push rod 331 seal element, for example " 0 " shape O-ring seal 393 be set in appearance.
The other specific embodiments of having showed device of the present invention as Figure 16-20.Device 400 comprises chamber 411 of collecting sample and the sample transfer chamber 47 that is arranged in collecting chamber, and sample transfer chamber 47 comprises an end 471 of opening and the other end 472 of sealing.A push rod 431 is set on lid 43, and these push rod 431 1 ends link to each other with lid 43, and the other end and piston 45 are connected as one.Transfer chamber 47 is fixed on the bottom of collecting chamber 411, and piston 45 can directly move to the second place from primary importance in transfer chamber 47, thereby causes transfer chamber 47 moving indirectly with respect to piston 45.When piston 45 was positioned at primary importance, opening 471 and collecting chamber 411 communicated, and the partially liq sample in the collecting chamber 411 is full of transfer chamber 47; This moment, the end that is closed of transfer chamber 47 still sealed, thereby liquid that can not enters in the test chamber 48 and goes, as Figure 17 and 18.When lid 44 being covered on the opening 414 of collecting chamber 411, one end 433 of push rod 331 has sealed the opening 471 of transfer chamber 47, and when continuing rotation lid 47, the top 454 of piston 45 punctures the blind end 472 of transfer chamber, release liquid sample wherein is in test chamber, as Figure 19 and 20.In this process, opening 471 is sealed by piston 45 all the time, has stoped the liquid in the collecting chamber 411 to enter in the transfer chamber 47.In a preferred mode, one end 453 of the piston 45 that links to each other with push rod 452 and the end opening coupling of transfer chamber 47, can come sealed open 471, and the other end 454 of piston 45 is configured to point or sharp structure, a this end 472 that can puncture transfer chamber 47 sealings easily, for example " T " font or other shapes.This " T " the quantitative volume of the common qualification of the inside surface of font and transfer chamber.Correspondingly, the material that is punctured easily that is used for sealing transfer chamber 47 other ends 472 has a lot, for example double sticky tape, adhesive membrane or other any materials or the like.In order to prevent that piston 45 from may cause the leakage of liquid when move in chamber 47, outside surface at an end 453 of piston 45 can also be provided with seal element, " 0 " shape O-ring seal 491 for example stops inner wall surface and the outer wall surface of piston 45 fine gap that may form of liquid by transfer chamber 47 to be revealed.
In all examples of implementation that Fig. 1-2 0 is showed, collecting chamber 111,211,311 and 411 can be included in the cup 11,21,31 and 41.Collecting chamber comprises opening 114,214,314 and 414 and bottom 113,213,313 and 413 and the cup sidewall of connection opening and bottom enclose 115,215,315 and 415.These cups can also comprise a base 12,22,32 and 42, and base 12 and cup 11 can be linked as one or be soldered on the cup 11.On base, comprise passage 121,221,321 and 421 and test chamber bottom 122,222,322,422.Bottom 122 outer walls of passage 121 and collecting chamber are common forms a fluid path, allows liquid flow to test chamber 18,28 through this path, in 38 and 48.In addition, can also comprise a test chamber 18,28,38 and 48 on the cup 11, it can comprise the test chamber bottom of taking at the end 113 by test chamber 18.In test chamber 18, can also comprise testing element 142, testing element 142 can be immunoreagent bar or horizontal effluent reagent strip, one end of the reception sample on the reagent strip 142 is near the bottom 122 of test chamber, so directly the liquid in the absorption detecting chamber 18 detects or chemically examines, shown in Fig. 4,12,17." testing element " can be any assembly that testing result is provided.In specific embodiment, testing element 142 is test-strips.In a concrete example, be fixed with specific bond molecule and immunological assay reagents on the test-strips, in other concrete example, test-strips contains chemical reagent, also can be to contain the suitable test of promising realization to produce the necessary reagent of signal.In specific embodiment, testing element contains the reagent of testing drug abuse.Testing element can also be included in the cassette box, also comprises the equipment of testing result on the read test element in box, for example shows testing result with digitized form.Also comprise a window 141 on box, window can be transparent, by the direct test result on the interpretation testing element with the naked eye of window, also can be the result that lcd screen shows detection.
In addition, from all embodiments that Fig. 1-2 0 is showed, transfer chamber is arranged in collecting chamber; In the other embodiment, transfer chamber also can be positioned at outside the collecting chamber, and for example transfer chamber is positioned at the side of collecting chamber etc.The material of constituent apparatus is generally plastics, and preferred mode is transparent plastics.
It is not unique constant being used for the term and the expression way of tracing device or method herein, and we use these terms and expression way to get rid of without any intention and describe method of the present invention, the expression way of any same meaning of device or feature, the various expression way of our approvals in the scope of the present invention's statement.Therefore, although we think the present invention in this article with various concrete schemes and arbitrarily feature description clearly display, but the expression way that changes the design that discloses herein also will be sought help from those experienced professional technique personages, and these changes are consistent with the statement that the present invention attaches.
Article, patent, patent application and the content of all other documents and the useful digitized information of mentioning herein and quote as proof combine, must come reference as a complete content, delivering wherein, any one part all will specialize this point.The applicant has and these any and whole articles, patent, patent is used or the information of other document and material are integrated with the right of the part that this application book discloses as patent specification.
Below in conjunction with concrete accompanying drawing embodiments of the invention is described in detail.These specific embodiment only are limited the enumerating under spirit of the present invention, do not get rid of one of ordinary skill in the art prior art and the present invention in conjunction with and other specific embodiments of producing.
Showed embodiment 1 as Fig. 1-5.Pick-up unit 100 comprises cup 11 and bowl cover 13, and cup 11 comprises liquid sample collecting chamber 111 and plunger shaft 16 and piston 15.On the lid 13 screw thread is arranged, the screw thread that cooperates is arranged on the cup 11 with it, the sealing of can working in coordination of lid 13 and cup 11.A test chamber 18 that is used to hold detecting element 14 is arranged on the sidewall 115 of cup 11.Comprise two O-ring seals 19 between piston 15 and the plunger shaft 16, the profile of plunger shaft 16 and piston 15 is a funnel-form, and the inwall 164,165,166 of plunger shaft and the outer wall 155,156 of piston limit transfer chamber 17 between 157.The both ends open 163 and 168 of plunger shaft 16 has formed two openings 171 and 172 of transfer chamber 17.One end diameter of piston 15 is big, and other end diameter is little, and is corresponding, plunger shaft 16 to hold piston 15 large diameter ends big, an end that holds piston 15 minor diameters is little, and in addition, the diameter of the end that the diameter D1 of the end that piston 15 diameters are little is littler than plunger shaft 16 a little is little.Like this when lid 13 is rotated down, can push up the top of piston 15, make piston 15 be moved down into the second place from primary importance, when the O-ring seal 19 of piston 15 breaks away from plunger shaft 16 inwalls, between piston 15 and plunger shaft 16, form a slit 173, along with piston 15 further moves, the liquid in the transfer chamber 17 enters in the test chamber 18 by slit 173.When moving downward, lid 13 make piston 15 when being issued to the second place, " 0 " shape rubber seal 19 on the two ends 153 and 152 in the piston 15, allow the two ends of piston 15 contact closely with the inwall 164 of plunger shaft, in case an end opening 163 of transfer chamber 17 or 171 sealed after, the liquid in the collection well 111 is in can not entering plunger shaft 16.Two outer walls 156 of piston 15 contact with 165 with two inwalls 166 of plunger shaft respectively with 157, and this structure is done further moving after having stoped piston 15 to arrive the second place; Because piston 15 moves up and down along the longitudinal axis of plunger shaft 16, promptly can allow the liquid sample in the transfer chamber 17 enter in the test chamber 18 fully in addition, make sampling more accurate; And this structure operation is more prone to, and do not need too big strength just can finish.This liquid shifts only to be needed finish once going on foot operation, and the while does not allow the sample in the sample contamination collecting chamber in the test chamber 18.
Embodiment 2
As different from Example 1, connect a push rod 252 on the lid 23, the other end of push rod 252 is connecting piston 25.Device 200 piston 25 and with the corresponding plunger shaft 26 of piston be the right cylinder of about equal diameter, on piston 25, comprise an opening 251, the diameter at opening 251 places is littler than the interior diameter of plunger shaft 26, the inwall 264 of this opening 251 and plunger shaft 26 limits transfer chamber 27, allows liquid sample transfer to the test chamber 28 from collecting chamber 211.The both ends open 263 and 268 of piston 25 has formed two openings 271 and 272 of transfer chamber 27.Also comprise a projection 256 on the piston 25 and on plunger shaft, comprise a bayonet socket that cooperates with projection 265.This projection 256 and bayonet socket 265 forms barrier elements, when piston 25 when primary importance moves to the second place, projection is stuck on the bayonet socket 265, moves thereby stop piston 25 to be done further.
-15 descriptions of present embodiment such as Figure 11, pick-up unit 300 comprises cup 31 and lid 33, cup 31 comprises liquid sample collecting chamber 311 and plunger shaft 36 and piston 35.On the lid 33 screw thread is arranged, the screw thread that cooperates is arranged on the cup 31 with it, the sealing of can working in coordination of lid 33 and cup 31.A push rod 331 is set on lid 33, and these push rod 331 1 ends link to each other with lid 33, and the other end is used for sealing the opening 371 of transfer chamber 37.In collecting chamber 311 bottoms, be mounted with one and puncture element 366, can puncture the blind end of transfer chamber.A test chamber 18 that is used to hold detecting element 14 is arranged on the sidewall 315 of cup 11.In addition, also have a hole 367, can enter in the test chamber 38 by hole 367 from the liquid of transfer chamber 37 in the bottom of collecting chamber 36.Comprise two O-ring seals 39 between piston 35 and the plunger shaft 36, the inwall 364,365,366 of plunger shaft and the outer wall 355,356 of piston limit transfer chamber 17 between 357.The both ends open 163 and 168 of plunger shaft 36 has formed two openings 171 and 172 of transfer chamber 17.When an end 333 promotion transfer chamber 37 of push rod 331 move, for the inside surface of anti-throw-out lever 331 outside surfaces and cavity 36 cooperates closely and may cause that the liquid in the collecting chamber 311 enters in the transfer chamber 37, can also be at an end 333 of push rod 331 establish reset shape O-ring seal 391 in appearance, 392,393.When transfer chamber 37 was positioned at primary importance, opening 371 and collecting chamber 311 communicated, and the partially liq sample in the collecting chamber 311 is full of transfer chamber 37; When lid 33 being covered on the opening 314 of collecting chamber 311, one end 333 of push rod 331 has sealed the opening 371 of transfer chamber, when continuing rotation lid 33, push rod 331 is shifted transfer chamber 37 onto the second place from primary importance, in the process that promotes transfer chamber 37, opening 371 is sealed by push rod 331 all the time, has stoped the liquid in the collecting chamber 311 to enter in the transfer chamber 37; In addition, an end 372 of transfer chamber 37 sealing is punctured, and discharges liquid in the transfer chamber 37 and detects in the test chamber 38 or chemically examine, as Figure 14 and 15.
Embodiment 4
Embodiments of the invention 4 have been showed as Figure 16-20.Pick-up unit 400 comprises chamber 411 of collecting sample and the sample transfer chamber 47 that is arranged in collecting chamber, and sample transfer chamber 47 comprises an end 471 of opening and the other end 472 of sealing.A push rod 431 is set on lid 43, and these push rod 431 1 ends link to each other with lid 43, and the other end and piston 45 are connected as one.Transfer chamber 47 is fixed on the bottom 42 of collecting chamber, and piston 45 can directly move to the second place from primary importance in transfer chamber 47, thereby causes transfer chamber 47 moving indirectly with respect to piston 45.One end 453 of the piston 45 that push rod 452 links to each other and the end opening coupling of transfer chamber 47 can come sealed open 471, and the other end 454 of piston 345 are raised structures, and this raised structures 454 punctures an end 472 of transfer chamber 47 sealings easily.This raised structures 454 and the quantitative volume of the common qualification of the inside surface of transfer chamber 47.Correspondingly, be used for sealing transfer chamber 47 other ends 472 by adhesive membrane as material.In order to prevent that piston 45 from may cause the leakage of liquid when move in chamber 47, outside surface at an end 453 of piston 45 is also established reset shape O-ring seal 491,492,493, stop inner wall surface and outer wall 455 surfaces of piston 45 fine gap that may form of liquid by transfer chamber 47 to be revealed.When piston 45 was positioned at primary importance, opening 471 and collecting chamber 411 communicated, and the partially liq sample in the collecting chamber 411 is full of transfer chamber 47; This moment, the end that is closed of transfer chamber 47 still sealed, thereby liquid that can not enters in the test chamber 48 and goes, as Figure 17 and 18.When lid 43 being covered on the opening 414 of collecting chamber 411, one end 433 of push rod 331 has sealed the opening 471 of transfer chamber 47, and when continuing rotation lid 43, the top 454 of piston 45 punctures the blind end 472 of transfer chamber 47, release liquid sample wherein is in test chamber 48, as Figure 19 and 20.In this process, opening 471 is sealed by piston 45 all the time, has stoped the liquid in the collecting chamber 411 to enter in the transfer chamber 47.
Claims (21)
1. the device of analyte in the analytic liquid sample body, comprise: the collecting chamber and the test chamber that is used to accommodate detecting element that are used for the storaging liquid sample, and liquid sample transfer chamber, this transfer chamber connects described test chamber and collecting chamber, test chamber not with the direct fluid connection of liquid sample collecting chamber, it is characterized in that this transfer chamber has the primary importance and the second place; When transfer chamber was positioned at primary importance, this transfer chamber was to the collecting chamber opening and to the test chamber sealing, and the partially liq sample in the reception collecting chamber is in transfer chamber; When transfer chamber was positioned at the second place, this transfer chamber was to the collecting chamber sealing and to the test chamber opening, and the liquid sample in the release transfer chamber is in test chamber.
2. device as claimed in claim 1 is characterized in that, described device also comprises a lid that the transfer chamber position is changed.
3. device as claimed in claim 2 is characterized in that described lid has the primary importance and the second place, and when lid was positioned at primary importance, transfer chamber was positioned at primary importance, and when lid was positioned at the second place, transfer chamber was positioned at the second place.
4. device as claimed in claim 3 is characterized in that, described device also comprises a cavity of accommodating transfer chamber.
5. device as claimed in claim 4 is characterized in that, described transfer chamber one end opening, the material seal that the other end is punctured easily.
6. device as claimed in claim 4 is characterized in that described transfer chamber has the primary importance and the second place, and when transfer chamber was positioned at primary importance, a termination of opening was received from the partially liq sample in the collecting chamber; When transfer chamber was positioned at the second place, a sealed end was punctured element and punctures.
7. device as claimed in claim 6 is characterized in that, describedly punctures that element is positioned at the bottom of collecting chamber and to upper process.
8. device as claimed in claim 2 is characterized in that, described device also comprises a piston and accommodates plunger shaft, the outer wall of this piston and the described transfer chamber of the inner wall limit of plunger shaft of piston.
9. device as claimed in claim 8 is characterized in that, described piston is arranged in plunger shaft and has the described primary importance and the second place; The plunger shaft both ends open; When piston was positioned at primary importance, piston was opened end opening receiving unit liquid sample from collecting chamber of plunger shaft, and another opening of piston closes plunger shaft stops liquid sample to enter in the test chamber; When piston was positioned at the second place, an end opening of piston closes plunger shaft stoped the liquid sample in the collecting chamber to enter in the plunger shaft, and piston is opened another opening of plunger shaft simultaneously, allows liquid sample enter in the test chamber.
10. the described device of claim 9 is characterized in that, the diameter of an end opening of described plunger shaft is greater than the diameter of other end opening, and the diameter of an end of the piston corresponding with plunger shaft is greater than the diameter of the other end.
11. pick-up unit as claimed in claim 10 is characterized in that: also establish the reset V-shaped ring between the outer wall of described piston and the inwall of plunger shaft.
12. the described device of claim 8 is characterized in that, described piston is arranged in plunger shaft and has the described primary importance and the second place; Plunger shaft one end opening, the seal element sealing that the other end is punctured easily; When piston is positioned at primary importance, an end opening of plunger shaft receiving unit sample from collecting chamber; When piston was positioned at the second place, an end opening of piston closes plunger shaft stoped the liquid sample in the collecting chamber to enter in the plunger shaft, and piston punctures the seal element of the other end of plunger shaft simultaneously, allows liquid sample enter in the test chamber.
13. as claim 9 or 11 described pick-up units, it is characterized in that: also comprise a barrier element that stops that piston moves on described piston, when piston was positioned at the second place, this barrier element stopped that the piston work further moves.
14. device as claimed in claim 2 is characterized in that, described transfer chamber is arranged in collecting chamber, and moves along the longitudinal axis of collecting chamber.
15. device as claimed in claim 2 is characterized in that, comprises a push rod between the lid of this device and the transfer chamber, when the lid tegmentum was on described device, lid promoted push rod and moves to the second place by transfer chamber from primary importance.
16. device as claimed in claim 15 is characterized in that, when transfer chamber was positioned at the second place, described push rod one end sealing transfer chamber stoped the liquid sample in the collecting chamber to enter in the transfer chamber.
17. device as claimed in claim 15 is characterized in that, described push rod one end is connected with lid.
18. the pick-up unit as claim 8 is stated is characterized in that, a push rod is set between the lid of this device and the piston, when the lid tegmentum was on described device, lid promoted push rod and moves to the second place by piston from primary importance.
19. the pick-up unit that claim 18 is stated is characterized in that, described push rod and piston are connected as a single entity.
20. the described device of claim 1 is characterized in that, comprises detecting element in the described test chamber.
21. the described device of claim 20 is characterized in that, comprises the device that reads testing result on the detecting element in the described test chamber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101390102A CN101876661A (en) | 2009-05-08 | 2009-05-08 | Device for analyzing analyte in liquid sample |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101390102A CN101876661A (en) | 2009-05-08 | 2009-05-08 | Device for analyzing analyte in liquid sample |
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| CN101876661A true CN101876661A (en) | 2010-11-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2009101390102A Pending CN101876661A (en) | 2009-05-08 | 2009-05-08 | Device for analyzing analyte in liquid sample |
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| CN (1) | CN101876661A (en) |
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Open date: 20101103 |