CN110161264A

CN110161264A - A kind of device for collecting liquid sample

Info

Publication number: CN110161264A
Application number: CN201810714355.5A
Authority: CN
Inventors: 吴志强; 洪亮; 朱杨煜; 科恩·罗玲; 吴淑江
Original assignee: Hangzhou Biotest Biotech Co Ltd
Current assignee: Hangzhou Biotest Biotech Co Ltd
Priority date: 2018-02-13
Filing date: 2018-06-29
Publication date: 2019-08-23
Also published as: CN209014587U; CN209656722U; CN110161266B; CN110161268A; CN209559909U; CN209656723U; CN110161267A; CN110161266A; CN208721694U; CN209014585U; CN110161265A; CN209014584U; CN209148707U; CN209559910U; CN209014586U; CN208953548U

Abstract

The present invention provides the device of a kind of collection and detection liquid sample, which includes the first chamber and the second chamber, and the first chamber is used to collect liquid sample and carries out initial detecting, and the second chamber is used to collect liquid sample in case secondary-confirmation detection is used.The first chamber and the second chamber of the device are detachable combination.When needing to carry out secondary-confirmation detection, the second chamber can be separated with the first chamber, be sent to confirmation testing agency and carried out confirmation detection.The pollution that the detection reagent item and liquid sample that can avoid conventional apparatus may generate sample when contacting；Space needed for effectively reducing storage liquid sample, greatly reduces the risk of transportational process liquid sample leakage.

Description

A kind of device for collecting liquid sample

This application claims Chinese earlier applications, application number 201810150485.0, and applying date 2018-02-13's is preferential Power.

Technical field

The present invention relates to a kind of device for collecting liquid sample, the especially collections in quick diagnosis field and detection liquid The device of analyte in body sample, such as urine collecting and detection device.

Background technique

Currently, for detect in sample whether the detection device containing analyte, be largely used to hospital or family In, these detection devices for being applied to quick diagnosis include one or more detection reagent items, for example early pregnancy detects, and drugs are indiscriminate With detection etc..The detection device of this quick diagnosis is very convenient, can at one minute, or at most ten minutes or so Testing result is obtained on detection reagent item.

Illicit drugs inspection is widely used, and is usually used in prohibition of drug department, public security bureau, narcotic house, medical center, country's conscription physical examination Chu Deng mechanism.Illicit drugs inspection wide variety, number is frequent, can be automatically separated the illicit drugs inspection of remaining sample Yu detected sample Urine cup has the huge market demand, and illicit drugs inspection urine cup currently on the market is after detection is completed, and the sample in urine cup is just Will receive the pollution of detection reagent and cannot continue on for second of confirmation detection, such as United States Patent (USP) 7300633 describe that Sample.

Although detected sample in the conventional technology, can be allowed to be isolated with the sample of collection, cost Height, and do not allow easy to operate.Such as United States Patent (USP), the piston urine cup that the patent No. 7,300,633 describes, when promotion piston advances During, it allows liquid sample in collecting chamber, such as urine, is transferred to test chamber from collecting chamber, there is detection in test chamber The testing element of analyte in sample matter, and the liquid sample of collecting chamber is kept apart by piston, thus two local samples Product will not be obscured, and detect so as to be used to later confirmation.Although can isolate out the sample of detection and the sample of collection in this way This, but the urine cup of this piston is at high cost, and operation is not easy, and pushes piston to need bigger strength after all, this is Because piston needs to reach transfer sample, it is necessarily required to play the effect of hydraulic seal with the wall of piston, achievees the effect that sealing It needs that piston and plunger shaft is allowed closely to combine, in addition, when carrying out secondary detection, it is necessary to which whole device is transplanted on inspection Test mechanism progress.

For another example United States Patent (USP) 8,992,855 describes a kind of device for collecting liquid sample, which includes and lid The piston structure that son is linked together and moves together with lid separates although can detecte sample and the sample of collection, works as It after detection sample enters test chamber, needs to overcome very big pressure just to can enter, and needs sophisticated design lid and rim of a cup Size, the piston being linked together in this way with lid can accurately be just inserted into disengagement chamber.

In addition, carrying out confirmation inspection if necessary to subsequent after the completion of the preliminary tests such as these traditional collections and detection device It surveys, needing an entire collection and detection device to be transported to, the progress of confirmation testing agency is further to confirm detection, this just brings Many problems, at least have a problem in that first, and major part liquid is collected at present and detection device is provided only with Preliminary detection Chamber.When if necessary to subsequent confirmation detection, the whole device containing urine and detection reagent item can only be sent to confirmation detection machine Structure is detected.In this way, the sample in urine cup is possible to the pollution by detection reagent.Second, whole device is sent to really When recognizing testing agency, since rim of a cup is larger, liquid has the risk of leakage during transportation, this is just needed more at original Allow device that there is better seal effect, to reduce the risk of leakage to the greatest extent；Third, confirmation testing agency need huge low Entire detection device is stored in warm warehouse, prevents liquid sample rotten, possible further confirms that standard is done in detection in order to subsequent It is standby, cause confirmation testing agency (being properly termed as secondary detection mechanism) cost to be sharply increased in this way.

It for above-mentioned some technical problems, therefore needs to make improvements, other approach is provided and solves existing traditional skill The deficiency of art.

Summary of the invention

For above situation, to overcome the shortcomings of existing technologies, can be separated initially the purpose of the present invention is to provide a kind of The detection device of sample and confirmation detection sample (secondary detection) is detected, which is carrying out after having collected liquid sample Before detection or after detection, initial detecting sample and confirmation detection sample can be allowed to enter in two cavitys, such as the first chamber Intracavitary with second, then after the completion of initial detecting or before completing, the second chamber can be carried out with initial collection chamber (the first chamber) Separation, to realize the detachable separation of the chamber of the second chamber and initial collection sample.Second separated with initial collection chamber Cavity can be used to carry out subsequent second of detection or subsequent confirmation detection.Initial detecting sample is collected to reach And subsequent possible confirmation detection sample (second of detection) is efficiently separated, final once to collect, at least two detections Witness.

It can also be expected that when collection device includes two cavitys, the two cavitys receive simultaneously or with sequencing Same liquid sample, such as urine, one of cavity, such as the first chamber are used to collection part liquid sample, in addition Cavity, such as the second chamber are used to collect the liquid sample of other part.After gathering or while collection, the first chamber Liquid can be used to contact completion first time test with testing element, and the second chamber can be separated with the first chamber, for carrying out two Secondary detection.

The first aspect of the present invention, the present invention provide a kind of for collecting the device of liquid sample, which includes: use To collect the first chamber of liquid sample；Be used to collect for confirm detect liquid sample the second chamber；Wherein, the first chamber and Second cavity removably combines, and combines or connects.

In some preferred modes, before the second chamber is not separated with the first chamber, the first chamber and the second chamber are in liquid company Logical state；Alternatively, the first chamber and the second chamber are in liquid communication state when the first chamber and the second chamber are combined. In this way, no matter the first chamber or the second chamber are collected or receptive liquid sample, liquid can be allowed to flow in two cavitys, Flowing is the flowing of active or passively flows in this way.

In some preferred modes, the flowing of active is exactly that liquid can not be by external force naturally from the first chamber stream The first chamber is flow to the second chamber or from the second chamber.In some preferred modes, passively flowing is to allow liquid by external force Body from the second chamber is flowed to from the first chamber or flow to the first chamber from the second chamber.Here external force can refer to negative pressure, pressure, Liquid is oppressed, so that liquid be allowed to be flowed.

In some preferred modes, after the second chamber is separated with the first chamber or before will be to be separated, the first chamber and the second chamber It is not at fluid connection, in this way, liquid is allowed not flow between two cavitys.In some preferred modes, the second chamber and Before the separation of one chamber or before will be to be separated, the first chamber and the second chamber be not at fluid connection.Alternatively, some preferred In mode, while the second chamber is separated with the first chamber, the first chamber and the second chamber are not at fluid connection.In some preferred sides In formula, after the second chamber is separated with the first chamber, the liquid sample in the first chamber is stored in the second chamber.Some preferred In mode, when the first chamber collects liquid sample or after having collected, the second chamber, which is also collected, to be had in the first chamber Liquid sample.In some preferred modes, while the first chamber collects liquid sample, the second chamber, which is also collected, to be had from the Liquid sample in one cavity.

In some other embodiments, the first chamber and the second chamber, which are removably combined, can pass through combination Position is combined together, is separated by combining position.Here combination be two cavitys be before use it is separated, Combination is assembled together when use, after the completion of use, it is allowed to be separated.Alternatively, the first chamber and the second chamber can be direct It combines, can also be combined indirectly by a certain structure.Combination position can be the first chamber and the second chamber physics The place of contact.So in another aspect of the invention, the first chamber and the second chamber are assembled together at the beginning, collect After good liquid sample, the second chamber is allowed to separate with the first chamber.First chamber can be used to carry out first time detection, the second chamber be used into Row secondary detection or confirmation detection.In optional mode, the first chamber is to separate not being assembled together at the beginning with the second chamber , after gathering liquid sample, the second chamber is allowed to combine with the first chamber, to allow partially liq between the first chamber and the second chamber It is exchanged or is flowed, when needing secondary detection, two cavitys is allowed to separate.First chamber can be used to carry out first Secondary detection, the second chamber are used to carry out secondary detection or confirmation detection.

The second aspect of the present invention, the present invention provide a kind of for collecting the device of liquid sample, which includes: use To collect the first chamber of liquid sample；Be used to collect for confirm detect liquid sample the second chamber；Wherein, the first chamber and Second cavity by combination position, perhaps combine or link together indirectly by direct dismountable combine.

In some preferred modes, the second chamber and the first chamber pass through an interface channel and are in fluid connection.Some In preferred mode, before the second chamber is not separated with the first chamber, the first chamber and the second chamber are in liquid by the interface channel and connect It is logical.In some preferred modes, while after the second chamber is separated with the first chamber or separation, the first chamber and the second chamber are not located In fluid connection, while the channel is sealed.In some preferred modes, after the second chamber is separated with the first chamber, in the second chamber Store the liquid sample in the first chamber.In some preferred modes, the first chamber collect liquid sample when or After person has collected, the second chamber has the liquid sample in the first chamber also by interface channel collection.Some preferred In mode, while the first chamber collects liquid sample, the second chamber has in the first cavity also by interface channel collection Liquid sample.

In one of one of aforementioned all modes embodiment, the first chamber includes for collecting liquid sample Opening, liquid sample are entered in the first chamber by the opening.In some preferred modes, interface channel fluid connection One chamber and the second chamber, liquid sample can carry out fluid exchange by interface channel between the first chamber and the second chamber.Some In preferred mode, liquid sample can be flowed in the second chamber by the interface channel from the first chamber.In some preferred modes In, interface channel has the first opening and the second opening, wherein first opening and the first chamber fluid connection, second opens Mouth and the second chamber fluid connection.In some preferred modes, interface channel is located on the first chamber or first is intracavitary.Second Chamber is removably connect by interface channel with the first chamber, in conjunction with or combine.So interface channel can allow the first chamber and Second chamber is in indirectly detachable combination, in conjunction with or link together.

In some preferred modes, interface channel include connect the structure of the first chamber and the second chamber and allow the first chamber and The structure that second chamber separates, wherein the structure of the first and second chambers of connection is exactly space or the pipeline for forming channel.Another In outer some preferred modes, alternatively, the interface channel has two states of sealing or non-tight, when in non- The state of sealing, liquid can flow to the second chamber from the first chamber.Preferably, when interface channel is in the state of sealing, the first chamber Liquid cannot to flow to second from interface channel intracavitary.So the sealing or blow-by of interface channel come limit the first chamber and The state of fluid exchange between second chamber can work as connection between two cavitys if interface channel blow-by with fluid exchange When channel seals, there is no the exchange of liquid between two cavitys.

The third aspect of the present invention, the present invention provide a kind of sealing element, which can be tightly connected channel, Interface channel is allowed to be in the shape body of sealing.In a preferred manner, interface channel is connected with the first chamber and the second chamber, thus logical The sealing for crossing sealing element allows the second chamber and the first chamber to be in the state that liquid does not circulate.It, should in some preferred modes Device further includes the sealing element for being tightly connected channel.In some preferred modes, sealing element is when sealed passage Perhaps while sealing or after sealing, the liquid sample of the second inside cavity point is excluded.Preferably, the liquid-like of exclusion This is into the first chamber.Alternatively, sealing element is while being tightly connected channel, partially liq sample in interface channel (if Have) it is just rejected in the place except interface channel, such as the first chamber or other places.In some preferred modes, It is that the sealing element can also be contacted by sealing element with the inner wall of interface channel including elastic seal ring, the sealing ring, To allow sealing element more to seal.In the preferred mode of other, sealing element is for interface channel, more Add flexibility, so that deformation or extruding has occurred in any one by contact between the two, to allow sealing element and company The inner wall for connecting road closely contacts, to play the effect of sealing.For example, sealing element be it is elastic, interface channel is rigid Property, in this way when external force forces sealing element to enter connection circulation passage, elastic element is extruded and deformation, thus It is tightly connected channel.

In other modes, sealing element and connection are sealed by way of screw thread.Such as sealing element has External screw thread, interface channel have internal screw thread, and sealing element is tightly connected channel by way of relative rotation.At other In preferred mode, sealing element is the structure of a similar lid, has internal screw thread, and the first of interface channel the opening is outer Along having external screw thread, such sealing element and interface channel can play the role of sealing.

The fourth aspect of the present invention, the device of the invention can also include draining element, and sealing element is tightly connected channel First opening before, part draining element enters in the second chamber.In some preferred modes, sealing element sealing connects It connects after the opening in road, part draining element enters in the second chamber.Alternatively, sealing element is tightly connected the first of channel Before opening, part draining element is entered in the second chamber by interface channel.

So the fourth aspect of the present invention, assembly of the invention provides a kind of draining element, the element is for excluding the Outside partially liq to the second chamber in two chambers.Preferably, sealing element is tightly connected before first opening in channel, and part is arranged Liquid element enters in the second chamber.In some preferred modes, sealing element is tightly connected after the opening in channel, part Draining element enters in the second chamber.Optionally, draining element is entered in the second chamber by interface channel, thus exclusion portion Outside liquid separation body to the second chamber.In some preferred modes, draining element and sealing element are linked together structure.In some sides In formula, draining element enters fluidic connection channels prior to sealing element.Preferably, the second chamber passes through fluidic connection channels Second opening and the detachable combination of the first chamber, combine or link together.Or it is optional, draining element is prior to close Seal first opening of the element close to interface channel, wherein first, which is opened on the first chamber, is in fluid connection.Some preferred In mode, sealing element and draining element are linked together structure and perhaps removably combines or in some modes, seal Element can serve as two functions, and sealing and drain carry out simultaneously, and optionally, draining element can also play two function Can, sealing link channel while drain.Here the difference of title is only the difference of function, and certain two functions can lead to An element is crossed to realize.

The fifth aspect of the present invention, the device of the invention can also include lyophoby channel, by draining element or sealing member The liquid that part excludes is rejected to except interface channel and/or the second chamber by lyophoby channel.It include first except so-called In chamber or other places, such as in accommodating chamber.It include fluid storage chamber in sealing element in some preferred modes Body, it is described from the second chamber exclude liquid sample sealing element is entered by lyophoby channel receiving cavity in.Here " accommodating chamber " refers to the surplus liquid collected and excluded by draining element or sealing element, so, accommodating chamber can be first Chamber, can also be with other places, such as the space in sealing element or draining element.In this way, the liquid excluded is by dredging Liquid channel enters accommodating chamber.In some preferred modes, lyophoby channel has one or more inlet, allows liquid It is entered in accommodating chamber by inlet.In some preferred modes, what the inlet was located at interface channel first is opened The downstream of mouth.Alternatively, lyophoby channel has one or more inlet, which is located on sealing element, wherein allows The inlet enters in interface channel prior to sealing element.In some preferred modes, sealing element is tightly connected channel Afterwards, lyophoby channel inlet opening is located in the second chamber.In some preferred modes, the accommodating chamber is located at In sealing element.In some preferred modes, the inlet in the lyophoby channel is located on the wall of sealing element.One In a little preferred modes, the inlet in the lyophoby channel is located at the end of sealing element.

In some preferred modes, sealing element and draining element are linked together structure, wherein draining element prior to Sealing element enters in interface channel.In some preferred modes, part draining element is entered in the second chamber, sealing Component seal interface channel, it is preferred that sealing element is located in interface channel.In some modes, the feed liquor in lyophoby channel Mouth is between sealing element and draining element, alternatively, being located under sealing element, or is located on draining element.Some In mode, the end of draining element is arranged in the inlet in lyophoby channel, or enters interface channel prior to draining element In, or enter in the second chamber prior to draining element.

The sixth aspect of the present invention, the present invention provide a kind of opening for covering the collection liquid sample for closing the first chamber One lid, wherein the sealing element for being tightly connected channel is connect with lid, alternatively, sealing element and lid are combined into one Body structure.In this way, sealing element also enters interface channel, close during the opening that the first cover cap closes the first chamber Seal interface channel.In some preferred modes, first lid includes sealing element.In some preferred modes, The sealing element connected while the first cover cap closes the first chamber opening with the first lid is tightly connected the first of channel and opens Mouthful.The first opening that first cover cap closes the process of the opening of the first chamber and sealing element is tightly connected channel is almost substantive same Step carries out.Alternatively, being provided with sealing element when sealing element and draining element are linked together or on the first lid And draining element, three components can be linked together the dismountable combination being also possible to.In this way, cover cap closes the first chamber Opening closes the process completed to lid conjunction from lid and sealing element is tightly connected the opening in channel, and draining element excludes second The liquid of partially liq (if there is) in chamber, extra exclusion is entered in accommodating chamber by lyophoby channel.

In some preferred modes, the central axes of the sealing element on lid and the central axes essence of interface channel exist On the same line, when allowing the first cover cap to close the first chamber opening in this way, sealing element can be allowed also to be tightly connected channel. In some preferred modes, the sealing element is removably connect with lid.It is described in some modes Sealing element connect by way of screw thread with lid.In some modes, sealing element is connected by connecting rod and lid It connects, allows the first chamber that there is certain depth in this way, when cover cap closes the first chamber opening, sealing element is located at or close The opening of interface channel, when closing the first chamber with cover cap, the sealing element of connecting rod connection is from close to interface channel First opening enter in interface channel, to be tightly connected channel.

It is understood that sealing element is connected to one end of connecting rod, and the other end of connecting rod is connect with lid, The movement band moving sealing element of lid moves synchronously, for example, lid rotation of the rotation with moving sealing element or lid from upper Movement under, the also movement with moving sealing element from top to bottom.More it is understood that understanding, when sealing element passes through work Plug can be tightly connected channel to move synchronously when being tightly connected channel.Certainly, if sealing element and For interface channel by way of screw thread, synchronous rotary can also allow sealing element to be tightly connected channel.

In some modes, the present invention mentions a kind of the first lid of opening for covering the collection liquid sample for closing the first chamber, Wherein, first lid includes sealing element and draining element or the sealing element and draining element and lid Connection, or structure is linked together with lid.In some preferred modes, when the first cover cap closes the same of the first chamber opening When the sealing element that is connected with the first lid be tightly connected first opening in channel, draining element enters in the second chamber.It can To understand, the movement band moving sealing element and draining element of the first lid move together.

The seventh aspect of the present invention, in some preferred modes, the device of the invention can also include being used to seal the Second lid of the opening of two chambers.In some modes, the second lid is arranged on the second lid, when needing to seal second When the opening of chamber, the second lid is removed from the first lid to seal the opening of the second chamber.So in some modes, Second lid is located on the first lid, is arranged on the first lid by modes such as screw thread, piston, bolts.It is excellent at other In the mode of choosing, the second lid is removably located on the first lid, can be easy to remove the second lid from the first lid in this way Body.

In some preferred modes in aforementioned all modes, second chamber, which has, collects opening for liquid sample Mouthful.In some preferred modes, the opening of second chamber and the second opening fluid connection of interface channel.Some In preferred embodiment, the second chamber is removably connect by screw thread with interface channel.It is described in some preferred embodiments The opening of the second chamber there is internal screw thread and external screw thread, wherein the external screw thread of the internal screw thread and interface channel, which cooperates, to be connected It connects.The second lid that the external screw thread and lid of the second chamber opening close the second chamber opening is cooperatively connected.Optionally, the second chamber The second opening with interface channel can not also be by way of screw thread, and the mode that can be clamping is removably attachable to one It rises.

In some preferred modes, the device further includes testing element, at the testing element and the first chamber In fluid connection.In some preferred modes, the device further includes test chamber, and the testing element is located at detection In chamber.

The eighth aspect of the present invention, the present invention provide a kind of method for collecting liquid sample, provide foregoing collection The device of liquid sample, the device include the first chamber for collecting liquid sample；Be used to collect liquid sample be used into Second chamber of row confirmation detection；Wherein, the first chamber and the second cavity removably combine, and combine or connect；Allow liquid sample It is entered in the first chamber by the opening of the first chamber, liquid sample is allowed to enter in the second chamber from the first chamber.

In some preferred modes, which includes allowing the interface channel of the first chamber and the second chamber fluid connection.

In some preferred modes, this method provides a sealing element, after waiting liquid to enter in the second cavity, uses Sealing element is tightly connected channel.

In some preferred modes, after sealing element is tightly connected channel, the second chamber is allowed to separate with the first chamber.

In some preferred modes, after the second chamber is separated with the first chamber, the opening of the second chamber is closed with cover cap.

In some preferred modes, this method includes allowing the first chamber and second after allowing the second chamber to separate with the first chamber Chamber is not at fluid connection.In some preferred modes, after allowing the second chamber to separate with the first chamber, it is used to store in the second chamber There is the liquid sample in the first chamber.In some preferred modes, allow the first chamber collect liquid sample when or receipts After having collected, the second chamber is allowed also to collect the liquid sample having in the first chamber.In some preferred modes, in the first chamber While collecting liquid sample, the second chamber also collects the liquid sample having in the first cavity.

In some preferred modes, this method includes allowing the first chamber and the second chamber to pass through an interface channel to be in liquid Body connection.In some preferred modes, before allowing the second chamber not separate with the first chamber, allow the first chamber and the second chamber by being somebody's turn to do Channel is in fluid connection.In some preferred modes, while after allowing the second chamber to separate with the first chamber or separation, allow First chamber and the second chamber are not at fluid connection, while the interface channel is sealed.In some preferred modes, second is allowed After chamber is separated with the first chamber, allows in the second chamber and store the liquid sample in the first chamber.In some preferred modes, When the first chamber collects liquid sample or after having collected, the second chamber is collected also by the interface channel to be had from the Liquid sample in one chamber.In some preferred modes, the first chamber collect liquid sample while, the second chamber also by Interface channel collection has the liquid sample in the first cavity.

In some preferred modes, the first chamber includes the opening for collecting liquid sample, allows liquid sample by being somebody's turn to do Opening enters in the first chamber.In some preferred modes, interface channel is allowed to be connected to the first chamber and the second chamber, thus, allow liquid Body sample can carry out fluid exchange by interface channel between the first chamber and the second chamber.In some preferred modes, liquid Body sample can be flowed in the second chamber by the fluid passage from the first chamber.In some preferred modes, interface channel has The first opening and the second opening, wherein allow described first to be open and the first chamber fluid connection, allow the second opening and the second chamber Fluid connection.In some preferred modes, allows interface channel to be located on the first chamber or first is intracavitary.The second chamber is allowed to pass through Fluid passage is removably connect with the first chamber, in conjunction with or combination.

In some preferred modes, interface channel have connection the first chamber and the second chamber structure and allow the first chamber and The structure that second chamber separates, wherein the structure of the first and second chambers of connection is exactly to form the space in channel.Alternatively, the company It connects two states that road has sealing or non-tight and when the state for being in non-tight liquid can be flowed to from the first chamber Second chamber；When state of the interface channel in sealing, allow the liquid of the first chamber that cannot flow to second from interface channel intracavitary.

In some preferred modes, this method comprises: the device includes the collection liquid sample for closing the first chamber for covering The first lid of opening, wherein sealing element is connect with lid, in conjunction with.In some preferred modes, first lid Including sealing element.In some preferred modes, when the first cover cap close the first chamber opening while or in the process or Later, the sealing element for allowing the first lid to connect is tightly connected the second chamber opening in channel.In some preferred modes, lid It include the second lid for sealing the opening of the second chamber on body.In some preferred modes, the sealing element and lid Body removably connects.In some modes, the sealing element is connect by way of screw thread with lid.

In some preferred modes, second chamber has the opening for collecting liquid sample.In some preferred sides In formula, the opening of second chamber and the second chamber opening fluid connection of interface channel.In some preferred embodiments, second Chamber is removably connect by screw thread with interface channel.In some preferred embodiments, the opening of second chamber has There are internal screw thread and external screw thread, wherein the external screw thread of the internal screw thread and interface channel is cooperatively connected.Second chamber is opened The external screw thread and lid of mouth close the second lid mating connection of the second chamber opening.

Dismountable connection type of above the first chamber and the second chamber, is the structure by interface channel and the second chamber It designs and is detachably connected to, this dismountable connection is directly to connect.In some preferred modes, second Chamber can be detachably connected to, combined or be combined together with the first chamber with the connection type of channel screw thread, in the second chamber When directly carrying out dismountable mode between chamber and combine, the first chamber and the second chamber are in fluid connection.It is excellent Choosing, the first chamber and the second chamber carry out fluid connection by interface channel.In some preferred modes, the opening of the second chamber Fluid connection is in the second opening of interface channel.In some preferred modes, the second chamber is arranged on a pedestal, The pedestal and the first chamber form dismountable combination.Optionally, the second chamber is also formed with pedestal and is removably combined.In this way, working as When pedestal and the first chamber are directly combined, the interface channel of the opening of the second chamber, which is formed, to be in fluid communication.When pedestal with When first chamber separates, the second chamber on pedestal is separated with the second chamber together in company with pedestal.Preferably, when pedestal with When first chamber separates, the second chamber on pedestal is separated with interface channel together in company with pedestal.Some preferred In mode, after pedestal and the second chamber on pedestal are separated with the first chamber, the second chamber is separated with pedestal.Some In preferred mode, after the second chamber is separated with pedestal, the opening of the second chamber is closed with the second cover cap.

The sixth aspect of the present invention, the present invention also provides the method for collecting liquid sample, this method includes that offer is above-mentioned Collection liquid sample device, which includes the first chamber and the second chamber, wherein the second chamber and the first chamber are dismountable Mode connects, and collects liquid sample with the first chamber, and liquid sample is allowed to be flowed into the second chamber.

In some preferred modes, when waiting the collection of the second cavity to have liquid sample, the second chamber and the first chamber is allowed to divide From to close the opening of the second chamber with the second cover cap.

In some preferred modes, the first chamber and the second chamber is allowed to link together by interface channel, wherein allowing connection First opening in channel and the first chamber fluid connection allow the second of interface channel to be open and the second chamber fluid connection.

In some preferred modes, which further includes sealing element, before the second chamber is separated with the first chamber, is allowed Sealing element is tightly connected channel.

In some preferred modes, which further includes lid, and lid and sealing element are linked together structure, allows lid When body lid closes the first chamber opening, while lid is tightly connected second opening in channel with moving sealing element.

In some preferred modes, lid band moving sealing element is allowed to enter in interface channel.In some preferred sides In formula, after allowing sealing element to be tightly connected channel, the second chamber is allowed to separate with the first chamber.

In some preferred modes, the draining element for excluding partially liq in the second chamber is also set up on lid, Allow lid that draining element is driven to enter in the second chamber.In some preferred modes, sealing element and drain are set on lid Element allows draining element to enter in the second chamber prior to sealing element.

In some preferred modes, which further includes lyophoby channel, and the liquid sample for allowing draining element to be discharged is logical The lyophoby channel is crossed to be rejected to outside the second chamber.In some preferred modes, sealing element is allowed to enter interface channel In, the liquid that sealing element is discharged is rejected to outside interface channel by lyophoby channel.

In some preferred modes, the liquid for allowing sealing element or draining element to exclude is discharged by lyophoby channel Into the first chamber.In some preferred modes, accommodating chamber is set on lid, the accommodating chamber is in lyophoby channel Fluid connection, wherein the liquid for allowing sealing element or draining element to exclude is discharged in accommodating chamber by lyophoby channel.

The ninth aspect of the present invention, the present invention provide a kind of side detected and whether there is analyte in liquid sample Method, the method include the fluid collection device of any one above-mentioned mode, after waiting the collection of the first chamber to have liquid sample, The liquid sample from the first chamber is detected with testing element.After obtaining testing result, the second chamber and the first chamber is allowed to divide From being separated according to above-mentioned arbitrary mode.

In some specific modes, device further includes the test chamber for accommodating testing element, in test chamber and first Chamber is in flow communication, and after the collection of the first chamber has liquid sample, liquid is flowed into test chamber.When test chamber includes to survey When trying element, after waiting testing elements to complete detection, the second chamber is allowed to separate with the first chamber.In some preferred modes, allow Liquid sample from first it is intracavitary be introduced into test chamber, then enter back into the second chamber.Such structure is as being retouched front The structure design stated, so that the liquid for avoiding enter into test chamber also enters the second chamber, thus the liquid-like of the second chamber of pollution This.

In the tenth aspect of the present invention, the present invention provides a lid, and setting is used to be tightly connected channel on the lid Sealing element.In some preferred modes, sealing ring is set on sealing element.In some preferred modes, sealing element It is as being with the material of interface channel or be different.In some preferred modes, sealing element is material flexible Matter, interface channel are the material of rigidity.In some preferred modes, sealing element is linked as by connecting rod and the first lid Integral structure.It further include the opening in lyophoby channel on sealing element in some preferred modes.In some preferred modes In, the opening in lyophoby channel is located under sealing element, alternatively, the opening in lyophoby channel enters connection prior to sealing element In channel.It further include accommodating chamber on lid in some preferred modes, the accommodating chamber and lyophoby channel are in fluid connection. The opening in communication of the accommodating chamber and lyophoby channel.In some preferred modes, accommodating chamber is located in sealing element.

In other preferred modes, draining element is also set up on the first lid, which compares sealing element Further from the first lid.Alternatively, draining element is arranged under sealing element, alternatively, sealing element and draining element are set in this way It sets, draining element is allowed to enter in the second chamber prior to sealing element, alternatively, draining element is allowed to enter company prior to sealing element It connects in road.Alternatively, working as connecting rod is set to connect the first lid and sealing element, while sealing element connection row on lid Liquid element.Alternatively, connecting rod and sealing element and draining element are structure as a whole.

Beneficial effect

Using the above structure, have the characteristics that simple and reasonable, use lower cost for material, function admirable；Convenient for two Secondary detection.Particularly, when needing to carry out subsequent confirmation detection, entire detection device is not needed to be sent to test machine Structure is detected, and is only that the second chamber is removed from device, is sent to detection structure, so not only safety, but also saving Space, save the cost are more environmentally-friendly.

Detailed description of the invention

Fig. 1 is the STRUCTURE DECOMPOSITION structural schematic diagram of the collection device in the specific embodiment of the present invention.

Fig. 2 is the schematic perspective view of the lid in the specific embodiment of the present invention.

Fig. 3 is the vertical section structure schematic diagram of lid shown in Fig. 2 in a specific embodiment of the invention.

Fig. 4 is that the vertical section of the first chamber in a specific embodiment of the invention shows that structure is intended to (without containing detection Chamber).

Fig. 5 is that the vertical section of the second chamber in a specific embodiment of the invention shows that structure is intended to.

Fig. 6 is the schematic perspective view without the first lid in a specific embodiment of the invention.

Fig. 7 is that the vertical section of device shown in fig. 6 in the present invention shows that structure is intended to, wherein the first chamber and the combination of the first chamber Structural schematic diagram together.

Fig. 8 is the part enlarged structure signal of the first chamber and the combination of the second chamber in a specific embodiment of the invention Figure.

Fig. 9 is the schematic perspective view of the first chamber and the combination of the second chamber in a specific embodiment of the invention.

Figure 10 is that the operating process structure that first cover cap closes the first chamber opening in a specific embodiment of the invention is stood Body.

Figure 11 is the stereochemical structure signal that first cover cap closes after the first chamber opening in a specific embodiment of the invention Figure.

Figure 12 is the schematic diagram of the section structure of device shown in Figure 11 in the specific embodiment of the present invention.

Figure 13 is in a specific embodiment of the invention, and the second chamber is detached from the first chamber, and the second lid is detached from the first lid Schematic perspective view.

Figure 14 is the schematic perspective view that second cover cap closes the second chamber in a specific embodiment of the invention.

Figure 15 is the schematic perspective view of the device in another embodiment of the invention.

Figure 16 is the schematic perspective view of the first chamber in the specific embodiment of the present invention.

Figure 17 is the schematic perspective view of the testing element carrier in the specific embodiment of the present invention.

Figure 18 is that the stereochemical structure of the first lid with sealing element in the specific embodiment of the present invention is shown It is intended to.

Figure 19 is the schematic perspective view of the first chamber in a specific embodiment of the invention (without second Chamber).

Figure 20 is the schematic diagram of the section structure (the first chamber in a specific embodiment of the invention and that the second chamber combines The part-structure enlarged diagram detachably combined with the second chamber).

Figure 21 is the three-dimensional knot that first lid starts after lid conjunction the first chamber opening in another embodiment of the present invention Structure schematic diagram (operating process).

Figure 22 is the schematic diagram of the section structure (sealing of device shown in Figure 21 in the specific embodiment of the present invention Element unsealing interface channel starts close to opening).

Figure 23 be the specific embodiment of the present invention in, shown in device the schematic diagram of the section structure (sealing element Into interface channel).

Figure 24 is in a specific embodiment of the invention, and the second chamber is detached from the first chamber, and the second lid is detached from the first lid Schematic perspective view.

Figure 25 is the second chamber and the first chamber in detection or collection device in another embodiment of the invention The schematic perspective view of anabolic process (the second chamber is located in support holder structure).

Figure 26 is the structural schematic diagram in detection of the invention or collection device, after the first chamber and tray combination.

Figure 27 is the schematic diagram of the section structure of structure shown in Figure 26 in detection of the invention or collection device.

Figure 28 is the structural schematic diagram of the second lid the second chamber of sealing in another embodiment of the invention.

Figure 29 is the structural schematic diagram that the second chamber leaves pallet.

Figure 30 is often to have schematic perspective view of the trays of the second chamber to the first chamber.

Figure 31 is the stereochemical structure of the first lid with sealing element in another embodiment of the invention Schematic diagram.

Figure 32 is the first lid with sealing element in another embodiment shown in Figure 31 of the invention The schematic diagram of the section structure.

Figure 33 is to have sealing element schematic perspective view in another embodiment of the invention.

Figure 34 is the schematic diagram of the section structure of structure shown in Figure 33.

Figure 35 A and Figure 35 B be sealing element, sealing element shown in draining element or Figure 33 exchange or it is default its In a component structural schematic diagram.

Figure 36 is that first chamber and the separation of the second chamber and combined theory structure show in other specific embodiments of the invention It is intended to.

Figure 37 is the structural schematic diagram of the first chamber and the combination of the second chamber in another embodiment of the present invention.

Figure 38 A and Figure 38 B are the first chamber shown in 37 and the separation of the second chamber, use the first chamber to detect as secondary-confirmation and use Structural schematic diagram.

The stereochemical structure theory structure of first chamber and the second chamber signal in other specific embodiments of Figure 39 present invention Figure.

First chamber and the separation of the second chamber and combined stereochemical structure principle in other specific embodiments of Figure 40 present invention Structural schematic diagram.

It is described in detail

Structure of the present invention or technical term used in these are described further below, if do not had Spy is standby to be indicated, is understood and is explained according to the general general terms of this field.

Detection

Detection indicates chemical examination or tests a kind of substance or material to whether there is, for example, but it is not limited to this, chemical substance, Organic compound, inorganic compound, metabolism product, drug or drug metabolite, organic organization or organic organization generation Thank object, nucleic acid, protein or polymer.In addition, detection indicates the quantity of test substances or material.Furtherly, table is gone back in chemical examination Show immune detection, chemical detection, enzyme detection etc..

Sample

The sample of detection device or collection of the invention includes biofluid (such as casing fluids or clinical sample Product).Fluid sample or fluid sample can from the sample of solid-state or semisolid, including excreta, biological tissue and Food samples.The sample of solid-state or semisolid can be converted to fluid sample using any method appropriate, such as mix, It smashs to pieces, macerate, being incubated for, dissolving or (such as water, phosphate solution or other buffer solutions) utilize enzymatic hydrolysis in a suitable solution Act on digestion of solid sample." biological sample " includes deriving from animal, plant and food samples, for example including from people or The urine of animal, saliva, blood and its ingredient, spinal fluid, vaginal fluid, sperm, excrement, sweat, secretion, tissue, device Official, tumor, the culture of tissue and organ, cell culture and medium.It is preferred that biological sample is urine.Food samples include food The substance of processing, final products, meat, cheese, wine, milk and reference water.Plant sample includes being derived from any plant, plant group It knits, plant cell cultures and medium." environmental sample " is from environment (for example, from lake or the liquid of other water bodys Sample, sewage sample, soil property sample, underground water, seawater and waste liquid sample).Environmental sample may also include sewage or other are useless Water.

Using the suitable detecting element of the present invention, any analyte can detecte.Saliva is detected preferably by the present invention Drugs small molecule in liquid, urine.Certainly, the sample of any of the above form, nothing can be collected using collection device of the invention By being initially solid or liquid, as long as after these liquid or liquid sample are flowed into the first chamber, these liquid-likes Originally can simultaneously or flow into the second chamber later, since the second chamber can removably be combined with the first chamber, combine or even It connects, when needing to carry out subsequent confirmation detection, the second chamber is allowed to separate with the first chamber, thus, the second chamber can carry out secondary inspection It surveys, and the liquid of the first chamber can carry out primary detection.Optionally, the liquid of the second chamber can carry out primary detection, and first The liquid of chamber can carry out secondary detection.

Alternatively, these liquid samples or processed sample are after liquid is collected into the first chamber, to need It carries out using the second chamber before chemically examining for the first time or after chemical examination to extract the partially liq sample in the first chamber as subsequent confirmationization It tests and only uses.First chamber can be combined with the second chamber at the beginning, be also possible to combine when in use, so It separates again afterwards.

Downstream and upstream

Downstream or upstream are that liquid flow direction is divided, and general liquid flows from upstream to downstream area.Position Receive the liquid from upstream region in downstream area, liquid can also flow to downstream area along upstream region.Here general It is also to be divided according to the direction of liquid flowing, for example, being promoted on some materials of liquid flowing using capillary force, liquid can It is flowed with gravity to the opposite direction of gravity, upstream is divided also according to the flow direction of liquid under this when Trip.For example, in collection device of the invention, in some preferred modes, chamber of first chamber as collection liquid sample, And the second chamber and the first chamber are in fluid connection, the liquid into the first chamber is flowed into the second chamber, and the first chamber can be referred to as Upstream, and the second chamber can be referred to as downstream.Certainly, this flowing is the natural flowing under the gravity of liquid.It is optional , this natural flowing is that liquid is flow in the second chamber from the first chamber.Certainly, liquid can also passively be flowed from upstream It moves to downstream, such as in the case that liquid is reacted power, liquid is forced to flow from upstream to downstream, or from low location stream High position is moved, this row reaction can be the effect of capillary or forcing for ambient pressure, to allow liquid from low level A high position is flowed to, the division of upstream and downstream here, which is not necessarily meant that, centainly needs liquid presence, and referring to has liquid In the presence of, it is to be flowed according to the sequence of flowing.

Gas connection or fluid connection

Gas connection or fluid connection refer to that liquid or gas can flow to another place from a place, During flowing guiding function may be played by the structure of some physics.It is so-called to generally refer to liquid by the structure of physics The space of the inside on surface or these structures of the body by the structure of these physics and it is passive or actively flow to other one A place, passive is usually the flowing received under flowing caused by external force, such as capillarity.Here flowing can also be with It is liquid or gas because of self-acting (gravity or pressure), is also possible to passively flow.Here connection not table Show and centainly needs liquid perhaps gas exists and only shows connection relationship or shape between two objects in some cases State can be from a material flows to another object if there is liquid exists.This refers to the shapes of two objects connection State, on the contrary, if not having fluid connection or gas connection state between two objects, if there is liquid is in an object Perhaps on liquid cannot flow in another object or on, such state be non-interconnected, on-liquid or gas The state of connection.

Dismountable combination

Detachable combination refers to that the connection relationship between two components is in several different states or position Relationship, such as when being two physical significance upper-parts, can be at the beginning it is separated, when in suitable first situation Lower connection is combined, and at suitable second, two components can be allowed to separate, this is separately physics Space in meaning is separated without contacting.It, can when in a suitable case alternatively, two components are combined at the beginning It is separated with the space for allowing two components to be formed in physical significance.Again alternatively, two objects be at the beginning it is separated, need when Time, which is combined, completes certain function, then separates again, or combine again again for certain purpose later. In short, the two combine or both between to separate be readily to carry out, it is this to combine or separate It is that can be repeated as many times to recycle, it is of course also possible to be disposably to combine and separate.Furthermore it is possible to be can between two components The combination of disassembly can also be three or three with dismountable combination two-by-two between upper-part.For example, having first, second And third member, the first component and second component removably combine, second component and third member are also possible to detachably The combination of formula, the first component and third member removably can also be combined or be separated.In addition, combined mode can be Two objects itself detachably, can also indirectly combine by other object.

Testing element

Here so-called " testing element " refers to that can detecte sample or sample is whether containing interested analyzed The element of substance can be referred to as testing element, and this detection is either based on which kind of technical principle, immunology, chemistry, electricity It learns, optics, molecules, nucleic acid, physics etc. are ok.Testing element can select the test strip of lateral flow, it can Detect a variety of analytes.Certainly, other suitable testing elements can also be used in the present invention,

Various testing elements can be grouped together and apply in the present invention.A kind of form is Test paper.For dividing The Test paper of analyte (such as drugs or showing the metabolin of physical condition) in analysis sample can be various forms, such as The form of immunoassays or chemical analysis.Test paper can be using non-competing method or the analytical model of competition law.Test paper Water-absorbent material comprising one with sample application zone, reagent area and test section.Sample-adding passes through capillary originally to sample application zone Effect flows to reagent area.In reagent area, if there is analyte, sample is in conjunction with reagent.Then sample continues to flow to inspection Survey area.Other reagents, such as molecule with analyte specific binding are fixed on detection zone.In these reagents and sample Analyte (if present) react and analyte be incorporated in the area, or in conjunction with some reagent of reagent area. For showing that the marker of detection signal exists and reagent area or isolated mark zone.

Typical non-competing method analytical model is if containing analyte in sample, and signal will generate, if do not wrapped Containing analyte, signal is not just generated.In competition law, if analyte is not present in sample, signal is generated, if There are analytes, then do not generate signal.

Testing element can be Test paper, the material that can be selected water suction or not absorb water.Test paper may include a variety of Material is transmitted for liquid sample.The material of one of Test paper can cover on another material, as filter paper is covered on On nitrocellulose filter.One area of Test paper can select one or more materials, and another area selects other different One or more materials.Test paper can be attached on certain support or hard surface and be affectedly bashful detection examination for improving The intensity of paper.

Analyte is detected by signal generating system, as using specific reaction occurs with this analyte Specific combinating substance is fixed on the method on Test paper using such as aforementioned, by one or more signals by one or more enzymes The composition of generating system is fixed on the analyte detection zone of Test paper.The substance for generating signal can be in sample application zone, reagent On area or detection zone, or entire Test paper, which can be full of on one or more materials of Test paper.It will contain The solution of signal object is added to the surface of test paper or one or more materials of test paper is immersed in the solution of the object containing signal.Make The test paper that the solution of object containing signal is added is dry.

Each area of Test paper can arrange in the following manner: sample application zone, reagent area, detection zone, control zone, determine The whether adulterated area of sample, liquid sample uptake zone.Control zone is located at after detection zone.All areas, which can be arranged at, only to be used On an a kind of test paper of material.It can also be not same district and use different materials.Each area can directly connect with liquid sample The direction arrangement of touching or different areas according to liquid sample flowing, the end in each area is connected and is handed over the front end in another area It is folded.Material used can be the preferable material of water imbibition such as filter paper, glass or nitrocellulose filter etc..Test paper Other forms can be used.

General common reagent strip is nitrocellulose assay strip, i.e. detection zone includes nitrocellulose filter, in nitre Specific binding molecule is fixed on acid cellulose film to show the result of detection；It can also be cellulose acetate film or nylon membrane etc. Deng.Such as the description of the following patent reagent strip or device containing reagent strip: US 4857453；US 5073484；US 5119831；US 5185127；US 5275785；US 5416000；US 5504013；US 5602040；US 5622871；US 5654162；US 5656503； US 5686315；US 5766961；US 5770460；US 5916815；US 5976895；US 6248598； US 6140136；US 6187269；US 6187598；US 6228660；US 6235241；US 6306642； US 6352862；US 6372515；US 6379620；With US 6403383.Test-strips disclosed in patent documents above and Similar device with test-strips can be applied in testing element or detection device of the invention and carry out analyte The detection of matter, for example, in sample analyte detection.

Apply to lateral effluent reagent strip (the Lateral flow that detection reagent item of the invention can be known as Test strip), the specific structure and testing principle of these detection reagent items are this field general technology people in the prior art Technology well known to member.Common detection reagent item, including sample collection region, marked region, detection zone and suction zone, Sample collection region includes sample receiving pad, and marked region includes label pad, and suction zone may include water absorption pad, wherein examining Survey on region includes that can detect whether the necessary chemical substance containing analyte, such as immunoreagent or enzymology are tried Agent.General common detection reagent item is nitrocellulose assay strip, i.e. detection zone includes nitrocellulose filter, in nitre Specific binding molecule is fixed on acid cellulose film to show the result of detection；It can also be cellulose acetate film or nylon membrane etc. Deng, certainly, the downstream of detection zone can also include testing result control area, in general, on control area and detection zone Occur in the form of horizontal line, is detection line or control line.Such detection reagent item is that traditional reagent strip certainly can also It is the other types of reagent strip that other are detected using capillarity.In addition, having dry chemical on general detection reagent item Agent formulations, such as fixed antibody or other reagents, after encountering liquid, liquid is as capillarity is along reagent strip Flowing, with flowing, allows dry agent formulations to be dissolved in liquid, so that the dry reagent to next regional processing in the area is sent out Raw reaction, to carry out necessary detection.Liquid flowing mainly carries out through capillary action.These testing elements are shown in as follows The description and record of file: " regeneration treatment of nitrocellulose filter and its research of adhesion protein ability " of Li Fugang；Ma Hong It is gorgeous, " analysis of membrane material characteristic is chromatographed in colloidal gold diagnosis kit " of Li Qiang etc.；Wang Yong, Wang Luhai's etc. is " a kind of novel Colloidal gold immuno-chromatography test paper strip ".It can be applied in detection device of the invention herein, or be arranged on inspection It surveys in chamber and is contacted with liquid sample, or whether there is for detecting analyte in the liquid sample entered in test chamber Or existing quantity.

Carry out test fluid in addition to above-mentioned test-strips or lateral flow test strip itself are used to contact with the liquid of the first chamber Whether containing outside analyte in body sample.In some preferred modes, testing element can also be arranged on some loads On body, such as 106 on some cards, there are many grooves, in the grooves, entire test card is set testing element on card It sets in test chamber 105, contact liq sample is carried out in the bottom 1051 for allowing the sample applying zone of testing element to be located at test chamber. Such liquid sample may come from the first chamber 103, such as liquid sample passes through between test chamber 105 and the first chamber 1038 phase fluid connection of through-hole (such as shown in Fig. 9 and Fig. 1).It is also possible that the sample application zone of testing element is allowed to be located at the sample of test chamber This collection region carrys out contact liq sample, to complete the detection of analyte.

In other mode, such as shown in Figure 16 and 17, a kind of carrier 206 is provided, has a plurality of one end to seal on carrier 2062, one or more of test-strips, the sample applied area of test-strips is arranged in the channel of another end opening 2063 in the channel Domain is located at one end of opening 2063, has one or more channels for accommodating test-strips, each channel setting in carrier 206 The test member of different analysis substances can be arranged when with multiple channels in one testing element in each channel Part, in this way, can detect multiple analytes using the same sample.This carrier 206 is placed on the first chamber In 203, there are two positive stop strips 2032 and 2033 on the wall of chamber 203, carrier 206 is inserted into or snaps fit onto two limits In slot, allow the one end 2065 in the channel with opening close to the bottom of the first chamber, one end 2064 with sealed passage is close to the The opening 2031 (Figure 16) of one chamber.When liquid sample is flowed into the first chamber by the opening 2031 of the first chamber, liquid sample It is just contacted with the sample applying zone of test-strips, to complete to detect.The United States Patent (USP) that such carrier is applied in the applicant Application, application number 15/644,148 and Chinese Patent Application No. 2016106132817,2016106079834 have specifically Description.Certainly, in addition to the carrier of the above patent disclosure, carrier in addition can also be applied in the present invention as carrying The carrier of test-strips.

For example, the first chamber can first collect liquid sample in some modes, then with individually being carried out with testing element The detection of analyte in liquid sample in first chamber.With test-strips or the card with test-strips or carrier insertion It is detected into the first chamber.Those of ordinary skill in the art are appreciated that documented according to the present invention, these tests Item can be not provided on carrier, but be individually present, and test chamber 105 of the invention is also in some cases can be with Lack, test-strips are also that can lack in some cases.It will do it explanation in elaborating below.

Analyte

It can include some small-molecule substances with the example of the analyte involved in the present invention, these small molecules include Drugs (such as drug abuse)." drug abuse " (DOA) refers to that the work of paralysis nerve (is usually played using drug in non-medical destination With).It abuses these drugs and will lead to body & mind and be damaged, generate dependence, addicted and/or dead.Drug is indiscriminate Example includes cocaine；Amphetamine AMP is (for example, black beauty, white amphetamine tablet, dextroamphetamine, the right side Revolve amphetamine tablet, Beans)；Crystal methamphetamine MET (crank, meth, crystal, speed)；Barbiturates Salt BAR (such as Valium, Roche Pharmaceuticals, Nutley, New Jersey)；Sedative (i.e. sleep adjuvant Product)；Lysergic acid diethylamide (LSD)；Inhibitor (downers, goofballs, barbs, blue devils, yellow Jackets, methaqualone)；The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin)；Two methylenedioxy groups Methylaniline MDMA；Phencyclidine (PCP)；Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc..)；Opiate (i.e. morphine MOP or opium, cocaine COC；, heroin, hydroxyl dihydrocodeinone)；Anxiolytic and hypnotic sedative agent, Anxiolytic is that one kind is mainly used for anxiety reduction, anxiety, fear, is set the mind at rest, and has the drug of hypnosis sedation concurrently, packet Include Benzodiazepines BZO (benzodiazepines), atypia BZ class, fusion phenodiazine NB23C class, benzene nitrogen Zhuo class, BZ receptor Ligand class, open loop BZ class, diphenylmethane derivatives, piperazine carboxylic acid salt, piperidine carboxylic acid salt, Kui oxazoline ketone, thiazine and Thiazole, other heterocyclics, imidazole type calmness/anodyne (such as hydroxyl dihydrocodeinone OXY, methadone MTD), the third two 01 derivatives-carbamates, aliphatic compound, anthracene derivative etc..It can also be used using detection device of the invention Belong to medical usage in detection but be easy the detection of overdose, such as tricyclic antidepressant (imipramine or the like) and Paracetamol etc..These drugs can be metabolized to small-molecule substance after being absorbed by the body, these small-molecule substances are present in blood In the body fluid such as liquid, urine, saliva, sweat or part body fluid there are above-mentioned small-molecule substances.

For example, including but is not limited to creatinine, bilirubin, nitrite, egg with the analyte that the present invention detects White (non-specificity), hormone (for example, human chorionic promotes sex hormone, luteinizing hormone, follicular stimulating hormone etc.), blood, white blood Ball, sugar, heavy metal or toxin, bacterial components (albumen or glucide as being directed to specific bacterial, such as such as Escherichia coli 0157:H7, staphylococcus, salmonella, fusobacterium, Campylobacter, L.monocytogenes, vibrio or cactus bar Bacterium) and urine sample in substance relevant to physiological characteristic, such as pH and specific gravity.Other any Clinical Urinary chemical analyses are all using side Apparatus of the present invention are cooperated to be detected to flow test format.

The flowing of liquid

The flowing of liquid typically refers to flow to another place, under normal circumstances, the liquid of nature from a place The flowing of body is most of to flow to lower from eminence by the effect of gravity, and flowing here is also by external force, i.e., external weight Flowing in the case of power can become the flowing of natural gravity.In addition to gravity, the flowing of liquid can also with customer service gravity, Carry out the movement that eminence is flow to from lower.For example, the extraction of liquid or the compressing of liquid or liquid receive pressure, And go out to flow to eminence the bottom of from, also or the care of pressure and the gravity of client's liquid itself and the flowing that carries out.For example, figure In 9,19,22,27, the first chamber is located on the second chamber, and the second chamber is located under the first chamber, when thering is liquid to enter the second chamber, Liquid relies on the gravity of itself, can naturally rely on gravity flowing into the second chamber from the first chamber, can also be from upstream Naturally it flow to downstream position.

Detection device or collection device

Detection device refer to for detect in sample whether the device containing analyte.Collection device refers to progress The collection and storage of liquid sample.Detection device may include collection device, and collection device also may include detection device, or Person's collection device is separated with detection device, when detection, is combined to collection device and detection device, thus complete At detection.It is also possible to collection device and device that detection device is structure as a whole, after collecting liquid sample, so that it may It is detected at once, obtains test result, while carried out detection sample and collecting the separation of sample, it is secondary so as to carry out It detects (if necessary).Here the meaning of detection device or test chamber can be interchanged, collection device and collection chamber It can be interchanged, only play the role of exchange that is different and carrying out function.For example, when the present invention mentions collection device, it can With do not include test chamber do not include perhaps testing element but collection device may include have testing element or containing test The carrier of element, the collection device containing testing element can also be referred to as detection device.Certainly, collection device may include It for the space of testing element is arranged, but is not necessarily required to containing testing element, testing element can be subsequent any When suitable and collection device is combined and becomes detection device.For example, collection device may include for accommodating test The space of element, such as there is suitable position containing test chamber 105 (Fig. 7), or in the chamber of the collection liquid of collection device It sets testing element is arranged or the carrier (Figure 16) containing testing element, so, the present invention can be used for the purpose of collection liquid Body sample and the device designed are also possible to when collecting, while the detection device detected.

First chamber and the second chamber removably combine, combination or cooperation

First chamber and the second chamber of the invention can form detachable pair of combination, when collecting it needing to carry out liquid Before, the first chamber and the second chamber have been combined, and after the completion of collecting liquid sample, the second chamber can be separated with the first chamber. Alternatively, the first chamber and the second chamber be it is separated, when needing to be collected liquid sample, recombinant together, has been collected Cheng Hou, the first chamber and the second chamber are separated.In some specific embodiments in the present invention, as represented in figures 1 through 14 one In a concrete mode, the present invention provide in a kind of detection liquid sample whether the detection device containing analyte, Huo Zheyong In the collection device for collecting liquid sample comprising the first chamber 103 and the second chamber 104, the first chamber 103 can be used as collecting chamber Use, that is, be used to collect liquid sample, wherein the first chamber and the second chamber be removably combined, connect or Assembling.

Here " combination, connection or assembling " actually indicates the same meaning, and only word used is different, It can indicate to be combined together, this combination is corresponding with " separation ".In conjunction with and separation be all can it is any under the conditions of , it can be with unrestricted choice.In some modes, when the first chamber and the second chamber are combined, the first chamber and the second chamber State in liquid communication.In other modes, when before separating before the first chamber and second or separating, Huo Zhefen From rear, the first chamber and the second chamber are not at the state of liquid communication.

In some preferred modes, which further includes interface channel, and the first chamber removably connects with interface channel Conjunction, combination or assembling.To realize and removably the organizing of the second chamber, combination or assembling.Shown in Fig. 9, the first chamber 103 come as collecting chamber using it has the opening 1031 collected or receive liquid sample, and liquid sample passes through opening stream Enter into the first chamber 103, there is interface channel 109 in the bottom of the first chamber, interface channel has the first opening 1091, another End has the second opening 1092.The opening 1091 of interface channel 109 first and the first chamber 103 are in liquid communication, the liquid of the first chamber Body sample can be flow into interface channel 109 by opening 1091 come then by 1092 stream of the second opening of the other end Out.So the present invention provides a kind of cavity for collecting fluid sample, the cavity includes that an opening 1031 allows fluid sample It include a channel in the bottom of collecting chamber, which has the first opening and the second opening, partially liq into chamber 103 Sample can enter interface channel by the first opening 1091 of interface channel, by 1090 stream of the second opening of interface channel Out.Outflow, which refers to, flows out to 103 outside of the first chamber.Preferably, it is entered 104 in the second chamber from the liquid that interface channel flows out In.So the collection collection device can also include the second chamber, generally, there is the first chamber opening and side wall and bottom to surround One cavity.Interface channel is normally on the bottom of the first chamber.In this specific embodiment, interface channel is located at bottom On the region in portion.But, it is not limited to the position of interface channel can be located on side wall, can also be located at bottom and side wall Intersection.As long as any position of interface channel can be entered into the liquid sample of collecting chamber 103.

The meaning of " interface channel " herein is usually to connect a structure of the first chamber and the second chamber, when needs Wait, the first chamber and the second chamber allowed to connect or be combined together, when in some cases, can allow the second chamber and the first chamber into Row separation.In fact, herein, interface channel plays two functions simultaneously, one is to make the first chamber and the second chamber detachable Mode link together, in addition structure simultaneously play the role of the first cavity and the second cavity fluid connection, can be by this Structure liquid between two cavitys flows mutually, such as pipe, groove or other modes, so, it uses and " connects logical Road " is a preferred embodiment of the invention.It is appreciated that herein, than connecting and having in more preferably scheme The channel of the first chamber and the second chamber fluid connection is allowed to form two different functions for the same structure, such as of the invention Interface channel shown by the structure of tubular shape, Fig. 9 or Fig. 9 and Fig. 4 has connection the second chamber to the first chamber simultaneously On, while also functioning to the structure of the state of fluid connection.It is appreciated that interface channel mechanism can with defect, behind in addition Embodiment in be discussed in detail.Certainly, the understanding of " interface channel " here can also function only as the work of connection With, allow the second chamber and the dismountable mode of the first chamber to be attached or combine, and and do not have allow the second chamber and the first chamber into The function of row fluid connection；Optionally, here " interface channel " is it can be appreciated that function only as allowing the second chamber and the first chamber The function of carrying out fluid connection, without the please function with the second chamber of connection first.Optionally, " interface channel " here It also will be understood that as described above, that is, have connection it is total can, also have the function of allowing fluid connection simultaneously.

In some preferred modes, there is external screw thread in the outside of the second opening of interface channel.Second chamber is provided 104, the second chamber 104 have opening 1042, second opening 1042 and interface channel outer diameter quite or less times greater than even The outer diameter for connecting road has internal screw thread in the opening inner side of the second chamber 104, in this way, passing through the external screw thread and second of interface channel The externally threaded cooperation of chamber can allow the second chamber and the first chamber to be in and be detachably matched, combine or connect.That is, carrying out group When conjunction, directly the second chamber is connect by way of screw thread with interface channel；When needing to dismantle, derotation screw thread Form allows the second chamber 104 to separate with interface channel, to separate with collecting chamber 103.Alternatively, in the second opening of interface channel Internal screw thread is set in 1092, external screw thread, the internal screw thread of access portal and second are set on the outside of the opening 1042 of the second chamber 104 The external screw thread of chamber cooperates, and assembles or connects so that the first chamber and the second chamber be allowed to be in off-loadable mode.When the second chamber is from After the separation of one chamber, the opening 1042 of the second chamber is closed using the second cover cap, thus the second chamber of sealing.

Certainly, optionally, as shown in figure 9, the outer wall of the second opening 1092 of interface channel does not have screw thread, but even A long and narrow space 1098 is arranged in the second 1092 outer walls of opening for connecting road 109, which just can be with the second chamber 104 opening is cooperated, i.e., cooperates with the thickness of the opening of the second chamber.For example, long and narrow space is by interface channel The outer wall 1905 and corresponding wall 110 of second opening 1092 form (such as shown in Fig. 8), and helicitic texture is arranged on wall 110, External screw thread cooperation at the opening 1042 of the helicitic texture and the second chamber 104, so as to allow the external screw thread and wall of the second chamber Being threadedly engaged on 110, to realize the combination of the first chamber and the second chamber, this combination is also to be open by the second chamber The outer wall of one end 1092 of inner wall and interface channel cooperates and completes.Second chamber 104 and the first chamber 103 are in dismountable Cooperation, combination or connection.In order to allow there is better seal matching relationship before the first chamber and second, it can be in the second chamber Opening inner side has the second sealing ring 107, it allows the inner wall of opening of the second chamber and the outer wall of interface channel closer to match It closes, to prevent the liquid sample entered in the second chamber 104 leakage (as shown in FIG. 8 and 9).Those of ordinary skill in the art It should be understood that it is so-called here it is " detachable " refer to two objects when needed and can be grouped together into one it is whole Body structure, when needing that two objects is allowed to separate, they can readily be separated, and this is separately mainly physical significance On space structure on do not contact.

This dismountable mode is other than the connection of the form of screw thread, and there are also other any modes, such as the shape of buckle Formula, the form of piston, the mode of grafting, snap close mode etc. can be with as long as allowing the first chamber and the second chamber when needed Combination links together, to obtain partially liq sample from the first chamber, when both needing to separate, allow the first chamber and The separation of second chamber.For example, the form of screw thread, is exactly to rotate in opposite directions, to isolate from the first chamber；Or with Other way, such as the mode of extraction, the mode of unlock allow the second chamber 104 after obtaining liquid sample in the first chamber, can be with Easily separating from the second chamber can.This mode for obtaining liquid, can allow the first chamber 103 and the second chamber 104 when connection, keeps fluid connection can.

Certainly, in a particular embodiment, and in preferred mode, interface channel 109 and the first chamber 103 are one Secondary property injection molding, and the second chamber 104 be other injection molding, the second chamber by with interface channel it is dismountable combine, Engagement or combination.It should be understood that interface channel 109 and the second chamber 104 are one-time injection molding, and interface channel 109 It is also feasible for removably combining, engage or combine with the first chamber 103 together with the second chamber 104.

So the function itself of can also be so-called " connection " allows an individual structure to complete, have allow the first chamber and Second chamber fluid connection state is completed by another structure.Such mode is also readily comprehensible, such as by connecting machine Structure allows the first chamber and the second chamber removably to link together, and the liquid cannot be existed by the bindiny mechanism itself It is flowed between second chamber and the first chamber, but by other structure, such as channel, allow liquid to flow to the second chamber from the first chamber. So, it will be understood that, in some preferred modes, which further includes connection structure, and the first chamber and the second chamber pass through The connection structure forms dismountable engagement, combination or assembling, when connecting by the connection structure, allows the first chamber Liquid communication state is in the second chamber.Here liquid communication can be by other structure, such as pipe, channel, groove allow Two chambers are in liquid communication state.

Those of ordinary skill in the art are appreciated that interface channel 109 here is dispensed.As long as allowing When one chamber collects liquid sample, it can allow liquid sample for example to can in the second chamber to link together with the first chamber With, when needing the second chamber to separate with the first chamber, be easy to allow the second chamber separated with the first chamber can, it is such Mode can be those of ordinary skill in the art see marrow of the invention it is conceivable that other suitable modes.For example, Shown in Figure 36, the first chamber 903 side wall have a hole 903, the hole be at the beginning the diaphragm seal for being easy to puncture or from The silica gel of sealing, rubber, flexible plastic sealing collect sample with the first chamber 903, collect liquid when needing to collect sample After sample is good, the second chamber 904 (not at the beginning being to link together with the first chamber) is provided, allows the opening portion of the second chamber Position punctures the sealing film (not shown) on the first chamber, thus, allow the liquid of the first chamber to be flowed into the second chamber, then again It is separated with the first cavity, to carry out secondary detection with the liquid of the second chamber.For another example as Figure 37-38 is illustrated, First chamber and the second chamber are also not detachably to be combined by interface channel, but the first chamber and the second chamber pass through it is mutual The helicitic texture progress of cooperation can open the combination unloaded.Such as Figure 25-27 is illustrated again, and being carried out by support holder structure can The combination of detachable, is described in detail below.

Selectable, referring to Fig. 8, the present invention designs interface channel 109, it is allowed to connect the opening 1042 of the second chamber 104, Interface channel 109 can of course not be needed, but allows the opening position 1042 of the second chamber 104 as interface channel, the second chamber Opening 1042 directly connect with the inside of the first chamber, being clamped of this connection, the form of piston type, lock, this when It waits, the bottom of the first chamber has a hole, as long as the opening 1042 of the second chamber is corresponding with hole, allows liquid that can lead to the flowing of the first chamber It can to the second chamber.Preferably, the first chamber and the second chamber are just connected to one before the first chamber is collected sample It rises, when needing that the second chamber and the first chamber point is allowed, facilitates realization separation just feasible.

In other preferred modes, dismountable connection, combination or the combination of the first chamber and the second chamber, not Be the first chamber and the second chamber as shown in figure 33 direct dismountable connection without by other structure, also unlike such as figure 8-9, as shown in 1,22-23, the first chamber and the second chamber carry out indirect detachable connection by interface channel, but Dismountable connection or combination as shown in figs. 25-30.It illustrates in detail below.

So another aspect of the present invention, providing a kind of collection or detection device, the device includes for collecting First chamber of liquid sample；With the second chamber for carrying out confirmation secondary detection, wherein device further includes a support holder structure, The support holder structure removably combines with the first chamber, combination or assembling.In some modes, the second chamber is located on pallet, i.e., Second chamber is between the first chamber in conjunction with dismountable mode or to combine be dismountable mode knot by pallet and the first chamber It closes or combines come what is realized indirectly, is i.e. support holder structure and the second chamber is carried out by way of linkage, and linkage here is usually The movement of pallet drives the movement of the second chamber, thus realize with the separation of the first chamber, then and after linkage, may be implemented with The separation of support holder structure or not.

This when, interface channel can have, and can also not have, so, connectivity structure it is not necessary to.Example Such as, as shown in figs. 25-30, the second cavity is located on a understructure or support holder structure 1004, and the opening of the second chamber is still With interface channel fluid connection (have interface channel), yet it is not desirable to rely on the second cavity and interface channel as described above It is directly connected to reach the conducting of liquid by the structure of itself like that, and in this embodiment, it is thus only necessary to second The opening of chamber and the second outlet of interface channel are bonded together, and the bottom of understructure 1004 and the first chamber 103 is by matching It closes structure to be bonded together (Figure 27), the form of this fit structure such as screw thread.In this way, understructure has screw thread, such as outer Screw thread, and the bottom of the first chamber has internal screw thread, the two is combined by way of screw thread, passes through the binding force of screw thread The second chamber is allowed closely to cooperate with interface channel.Specifically, such as under type: for example, as shown in Figure 25-28, the second chamber 304 In a base tray 1004, and base tray 1004 and the first chamber be removably connect, and the second chamber 304 also with The detachable combination of the base tray 1004.Specifically, support holder structure 1004 has internal screw thread, the internal screw thread and the first chamber The external screw thread 3031 that 303 bottom extends cooperates, to realize the detachable combination of support holder structure 1004 and the first chamber 303.This Sample, if as shown in figure 27, interface channel 309, which still can have, is in liquid flowing with the first chamber there is also interface channel The first opening 3091 and be in the second opening 3092 of liquid flowing with the second chamber, and interface channel is with a Duan Yanshen Section 3098, the extended segment are deep into 3052 the inside of opening of the second chamber, contact with the inner wall of opening 3041, can be connected to one It rises, it may be assumed that the outer diameter of elongated area and the internal diameter matching of opening 3041.Although the second chamber can also be logical by connecting with the first chamber Road 109 as shown in Figure 27 clamping connection, but it is this connection do not need firmly to connect very much, do not need as Fig. 8-9 that Sample closely connects (by modes such as screw threads), this is because support holder structure 1004 passes through screw thread 10041 and the first chamber 103 The external screw thread 3031 of extended segment cooperates, and no matter the second chamber 304 collects how much liquid sample is measured in this way, and it is logical not will cause connection Leakage problem between road 109 and the second chamber opening 1042.So the internal diameter of interface channel 109 can opening less than the second chamber The internal diameter of mouth 1042, can allow interface channel to be inserted into the opening 3042 of the second chamber, the mode of this insertion can be light in this way Insertion (shown in Figure 27).And it only closes in lid of the opening outer setting screw thread of opening 3042 for the second lid (as schemed 27).This when, as long as the connection of the opening of interface channel and the second chamber guarantees not reveal when collecting liquid sample Can, can allow liquid enter the second chamber can, without more structures limit.This connection It can be clamped, the form of piston type, lock is ok.In fact, allow the first chamber removably to combine with the second chamber, in conjunction with or Person's engagement is indirect mode to complete.

After the completion of equal collections, the sealing in channel or the row of the second cavity are attached according to the method described below After liquid function, if necessary to carry out second of confirmation chemical examination, subiculum dish structure 1004 is separated from the first chamber 103, such as pass through Derotation pallet and the first bottom of chamber portion cooperate volume helicitic texture, this when, the second chamber 104 on pallet is also with pallet Structure is separated with the first chamber 103 together, and such as Figure 27, this when takes down the opening 3042. that the second lid 101 lid closes the second chamber Then the second chamber is allowed to separate 1004 (such as Figure 29) with pallet, this is because the bottom of the second chamber and the bottom of pallet have clamping Structure 10042, so, pallet and the second chamber can be separated with the first chamber 103 together.Then subiculum is dismantled from the second chamber 304 After disk 1004, then individually pallet 1004 is connect with the first chamber 103 again, is combined.Still maintain this when The integrality of one chamber, and the chemical examination mechanism that the second chamber can be sent to confirmation carries out secondary-confirmation chemical examination.In order to allow the second chamber 304 It is detached from the first chamber with the movement of pallet, there is clamping ring 10042, the shape of the clamping ring and the second chamber 304 on pallet Cavity geometry adapt to, such as the cavity of the second chamber is U-shaped, and is clamped ring 10042 also for U-shaped, in this way, support holder structure 1004 When rotation, the second chamber 304 is driven also to rotate together, since the second chamber and clamping ring slightly can closely cooperate, from Right second chamber 304 is detached from the first chamber 303 together with support holder structure 1004 together.Certainly in some modes, the second chamber is similar The structure of square is arranged 4 buckle structures in pallet, allows the second chamber and buckle structure to be connected together, to realize pallet Movement drive the second chamber movement, and then realize the second chamber and the first chamber separation.

It during this time, can be in the second chamber in order to guarantee the security property after the second cavity is closed by the second cover cap On stick strip of paper used for sealing, which covers the second lid and the second cavity of part.Guarantee that the sample in second cavity is not replaced maliciously It changes, the liquid in the second cavity is allowed to keep consistent with the original sample in the first chamber.Certainly optional, it can allow pallet 1004 It is packaged transport together with the second cavity, strip of paper used for sealing is allowed to cover the lid of the second cavity and pallet and the second cavity of sealing, thus Overall structure is formed to be transported.Understandable, understructure 1004 and the second cavity 104 are structure as a whole, and are one The structure of secondary property injection molding, in this way, second cavity 104 also together and connects when pedestal 1004 is combined with the first chamber 104 Road 109 is connected to combine.

Optionally, here interface channel and extended segment 3098 can omit, this is because, it is only necessary to first A hole is opened in the bottom of chamber 103, and the size in hole is allowed to be less than or equal to the opening 3042 of the second chamber 304, leads to without connecting Road has extended segment (such as Figure 27), and the opening of interface channel first 3091 can play the part of the function of base apertures, in this way, when passing through support When disk allows the second chamber to be incorporated on the first chamber, bottom opening (the similar figure of the opening 1042 of the second chamber and the first chamber 103 Show 3091 position) place it is corresponding, by the cooperation of pallet 1004 and the first chamber 303, allow the second chamber 304 opening and hole The region of surrounding forms close cooperation, or forms closely contact, so that the second chamber and the first chamber be allowed to form liquid communication State, when the collection of the first chamber has liquid, liquid can also be flowed in the second chamber.Allow the first chamber 103 and second if necessary Chamber separation, seals up the hole (similar Figure 27 shows 3091 position) in the second bottom of chamber portion, to allow pallet 1004 and the first chamber 103 Separation drives the second chamber 103 also to separate together with the first chamber.Also achieve identical function.Optionally, which is at the beginning The sealing material sealing for being easy to puncture after collection has liquid, or after starting detection, punctures the sealing material, allows liquid flow Enter into the second chamber, the mode of sealing element, behind can be specifically described.

Deng the first chamber liquid collect after, the second chamber can be allowed to separate with the first chamber, thus the second chamber can store or Person is shipped for testing agency and carries out secondary-confirmation detection, and the liquid in the first chamber can be used as the first time or primary detection, or Person can allow the second chamber to separate with the first chamber after waiting the first chamber liquid to collect, and after separation, carry out to the liquid of the first chamber Primary detection waits after obtaining testing result, the second chamber of separation can be stored or is routed directly to detection structure progress Second confirmation detection, then alternatively, detect after liquid sample collection to the liquid sample of the first cavity, wait acquisition After primary detection result, the second chamber is being allowed to separate with the first chamber, the second chamber of separation is used for storage or subsequent true for the second time Recognize detection.

Certainly, the liquid in the first chamber can store, and the needs suitable time is waited to carry out primary detection.Some In preferred mode, it is desirable to after the liquid in the first chamber gathers, while carry out corresponding first or detect for the first time, wait inspection After surveying result, for the result of some primary detections, if it is desired, carry out secondary-confirmation detection.Once primary detection Only whether there are also analyte in preliminary detection sample, the sensitivity of detection do not need generally it is very high, sometimes, When the analyte in sample is in critical threshold values, the result of primary detection cannot provide certainly or negate As a result, wishing this when to carry out secondary-confirmation detection to same part sample.

After the first chamber and the separation of the second chamber, if it is used to confirm secondary detection with the second chamber or the first chamber, such as It can be used to carry out secondary detection with the first chamber, and the liquid sample of the second chamber carries out primary detection, is possible to. So the first chamber and the second chamber can only have the second chamber just there is no restriction and can be carried out confirmation detection.In some modes, such as Shown in Figure 37 and 38, the present invention provides a kind of the first chamber 603 for collecting liquid sample and for carrying out primary detection Two chambers 604, the second chamber have test chamber 605, and test chamber and the second chamber have fluid connection through-hole 6038.First chamber, which has, to be opened Mouth 6031 has interface channel 609 in the bottom of chamber, which there is the first opening 6091 and the first chamber liquid to connect It is logical, there is the second opening 6092, wherein the first opening is sealed by sealing element, which is the sealing element that shell punctures, Such as the sealing such as film, double-sided adhesive, aluminium foil.In this way, when using the first chamber to collect liquid sample, liquid will not one Start the first opening outflow just by interface channel.After the collection of the first chamber has liquid sample, combined with the second chamber, such as It is combined using the external screw thread 6031 of the first chamber and the internal screw thread of the second chamber, alternatively, the first chamber and the second chamber pass through at the beginning The mode of screw thread has been combined, and directly collects liquid sample with the first chamber 603.After the completion of receipts, with sealing 6028 and puncturing elements 6029 puncture the sealing element for being tightly connected channel first and being open, release liquid is to the second chamber 604 Primary detection is carried out, which enters test chamber 605 and carry out chemically examining detection for the first time, when needs carry out second of confirmation detection When, dismantle lower first chamber from the second chamber, the opening of the first chamber sealed with lid, thus the liquid sample of the first chamber into The secondary confirmation detection of row.Optional mode is, including the sealing element 6028 on the lid for sealing the first chamber With puncturing elements 6029, the channels with an extension corresponding with the first opening 6091 of interface channel 609 in the first chamber 610, the channel is to the first intracavitary extension, in this way, when cover cap closes the first chamber, lid and sealing element 6028 and thorn Broken element 6029 forms the relationship of linkage, moves together with moving sealing element and puncturing elements in this way, when puncturing elements puncture it is close When sealing the opening of connecting cavity first 6091, the liquid in sealing element promotion channel 610 is flowed into the second chamber to be changed for the first time It tests, this when of lid seals the opening of the first chamber.As shown in the figure of the upper surface of Figure 38.It is chemically examined when carrying out confirmation second When, it is detached from the first chamber 603 from the second chamber 604, second opening in channel, such as spiral shell are then tightly connected with the second lid Then first chamber 603 is sent to testing agency and carries out secondary-confirmation detection, as shown in the figure under Figure 38 by the mode of line.

Certainly, puncturing elements can also have the function of excluding the second cavity segment liquid, this when, on puncturing elements Also lyophoby channel and inlet and accommodating chamber be can have.It is open after 7091 in this way, puncturing and being tightly connected the first of channel, Puncturing elements direct part is inserted into the second chamber, in order to which liquid can exclude outside, liquid can be allowed to pass through lyophoby channel Inlet is flowed into accommodating chamber, such as accommodating chamber is located in puncturing elements, this combines subsequent detailed description that can understand Understanding and combination.

In some optional modes, when as detection device, the collection device also packet testing element can be with The sample of collection is tested.Such as collection device includes test chamber, wherein test chamber and the first collecting chamber are in liquid flow It is logical, i.e., it can be flowed in test chamber positioned at the liquid sample of the first chamber.Certainly, detection device here include test chamber only It is preferred embodiment, when as collection device, test chamber can be lacked or the detection device includes detection Chamber, but and without testing element, wait when need to detect, detecting element be inserted into test chamber.Some specific In embodiment, test chamber 105 is set outside the side wall of the first chamber, and the first chamber 103 and test chamber 105 are in fluid connection (such as Fig. 9), if there is liquid sample in the first chamber 103, liquid can pass through the through-hole of test chamber 105 and the setting of collecting chamber 103 1038 carry out fluid connections, hence into carrying out necessary first chemical examination or detection into test chamber.

Generally, the sensitivity (for the first time or primary detection) of the detection of the liquid sample in the first chamber 103 is not secondary Confirm the high sensitivity of detection, either for the first time or the specificity of the primary detection specificity that does not have secondary-confirmation to detect is accurate. Carry out secondary detection in this way can be confirmed whether primary detection is just very accurate substantially.For example, primary detection is by immune, change Method carries out, and secondary-confirmation detection is generally adopted by mass spectrum (GS), gas phase or liquid chromatographic detection.This two Secondary detection is generally carried out with the liquid sample in the second chamber separated with the first chamber, this is because the first chamber and the second chamber are all It is directed to a sample, their property is only to be divided into different parts all, and second of detection can To play the role of confirmation to primary detection.

In some preferred modes, wait the first chamber 103 collect liquid sample while or collect after it is very short In time, the liquid in the first chamber is detected at once.So in a preferred mode of the invention, the first chamber 103 It is in fluid connection with test chamber 105, includes testing element in test chamber.In some preferred modes, these testing elements It is arranged on carrier.In a preferred manner, test chamber includes test carrier 106, and testing on carrier has many card slots 1061, testing element is provided in each card slot.For example, as shown in figure 9, when the first 103 inner collection liquid sample of chamber It waits, liquid sample a part is flowed into test chamber 105 by through-hole 1038, the liquid sample being flowed into test chamber and survey Element contact is tried, to complete the detection of analyte；The liquid sample of another part passes through the opening of interface channel 109 1091 are flowed into the second chamber 104.After the testing element being located in test chamber terminates detection, first test result is carried out It reads, after reading, when feeling it is necessary to carry out confirmation secondary detection, the second chamber 104 is separated from the first chamber 103, Then the opening 1042 that the second chamber 104 is sealed with the second lid 101, stores the second chamber 104 or be routed directly to confirm The chemical examination structure of test carries out further confirmation chemical examination.And in the first chamber 103 and test chamber 105 detected for the first time Liquid can be abandoned or be handled.

By the way of detection for the first time and secondary-confirmation detection separation, some of conventional detection devices are thus overcome Drawback.In conventional detection devices, after the completion of test, secondary chemical examination is carried out if necessary, is required entire detection device (as the cavity for collecting liquid and/or test chamber being had with the first chamber, alternatively, the testing element in test chamber) saves Get up, either entire detection device packed and transported (automobile land, sea-freight or air transportion) is confirmed to secondary chemical examination mechanism Chemical examination, this just needs to guarantee or ensure any structure of entire detection device, cannot Anywhere there is leak liquid sample, Because once causing the leakage of sample to will result in extraneous pollution, and sample also can mutually pollute, confirmation or secondary is given Detection detection brings uncertain result.This structure that certainly will just may cause leakage to each is sealed encapsulation, this gives It manufactures this detection device and increases a large amount of cost and design difficulty, because these primary detection devices are usually plastics system Product, and be it is disposable, the leakage that will cause liquid to reach this device in no instance is that comparison is tired It is difficult, even if can guarantee not reveal, but manufacturing cost really need it is very high.Ideally, it on the one hand drops as far as possible Low cost, meanwhile, and need to guarantee that liquid sample is not revealed, biggish challenge is brought to producer.For example, this is just needed Complicated design is carried out to the first lid 102 of the opening 1031 of the first cavity of sealing, it is ensured that liquid cannot pass through opening 1031 It leaks out.If device further includes testing element, this just needs to carry out more the cavity (if there is) for accommodating testing element Accurate processing or design, it is ensured that liquid sample cannot be leaked out by test chamber, and particularly, these devices generally need Air transportion is carried out, is not revealed in the case where negative pressure or high pressure, brings bigger challenge to manufacture and design.Tradition In, it avoids leakage from always using sealing ring or changes component of the silicagel pad as sealing, but device storage time once compares Long, these silica gel or plastics have oxidation or aging, cause the leakage of liquid when in use.Second, if necessary The sample of primary detection result is saved, it is also desirable to which more storage spaces accommodate the detection device of large volume；This Also more spaces are necessarily increased, special standby for profession chemically examines mechanism, the sample size of detection is very huge, this is just Need enough spaces to store these samples Jing Guo primary detection, these samples Jing Guo primary detection are accommodated in ratio In biggish detection device, bigger area or volume are required storage space.Third completes these primary detections Device significantly increases transportation cost since volume is big, and transportation and packing are caused with the raising of cost, after all traditional detection dress It sets bulky, and is all independent packaging and transport.4th, if detection device has testing element at the beginning, transported Cheng Zhong, what the liquid of collection always contacted with testing element, and contain chemical substance on testing element, these chemistry Substance is not to allow liquid sample to contact with testing element for a long time, cause to liquid sample in liquid sample existing for itself Pollution, may cause negative impact to subsequent secondary detection.In short, whatsoever reason, traditional detection device or Person's collection device has one or several defects described above.

And the device of the invention is used, volume of the volume of the second chamber generally than the first chamber is small, or even only tradition inspection Survey chamber 1/10th are either part.Second chamber generally only needs 1-50 milliliters of sample with regard to carrying out secondaryization enough It tests, such as needs 0.1 milliliter, 0.2 milliliter, 0.3 milliliter, 0.4 milliliter, 0.5 milliliter, 0.6 milliliter, 0.7 milliliter, 0.8 milliliter, 0.9 milliliter, 1 milliliter, or it is only necessary to 1.2 milliliters, 1.4 milliliters, 1.6 milliliters, 1.8 milliliters, 2 milliliters, or it is only necessary to 3 milliliters, 4 milliliters, 5 milliliters, 6 milliliters are sufficient, and 7 milliliters, 8 milliliters, 9 milliliters, 10 milliliters, 11 milliliters, 12 milliliters, 15 millis It rises, 25 milliliters, 30 milliliters.The volume of first chamber is usually 5-500 milliliters of volume, for example, 8 milliliters, 10 milliliters, 12 milliliters, 14 milliliters, 16 milliliters, 18 milliliters, 20 milliliters, 22 milliliters, 24 milliliters, 26 milliliters, 28 milliliters, 30 milliliters, 32 milliliters, 34 millis It rises, 36 milliliters, 38 milliliters, 40 milliliters, 42 milliliters, 44 milliliters, 46 milliliters, 48 milliliters, 50 milliliters, 60 milliliters, 70 milliliters, 80 Milliliter, 100 milliliters, 150 milliliters, 200 milliliters, 250 milliliters, 500 milliliters.Moreover, general, only one opening of the second chamber 1042, it is not leaked as long as 1042 confirmatory sample of the second opening is sealed.On the one hand, the second chamber small in size, weight Gently, such transportation and packing cost significantly reduces, storage space very little.On the other hand, it does not need to the first chamber and/or containing inspection The component for surveying chamber has seal request high as conventional apparatus, such as the opening 1031 of the first chamber is sealed to the first lid Seal request with regard to much lower, and it is also more much lower than traditional for the seal request of the test chamber of testing element setting, very Can not extremely consider the first lid whether to the sealing effect of the opening of the first chamber 103, it is also different to consider test chambers itself Sealing effect, this is because after completing primary detection, the first chamber 103 and the first chamber with test chamber 105, very Discard processing can be carried out to the first lid 102.Disposable detection device as tradition relatively, has saved a large amount of cost, And it is safer reliable.In addition, the property due to the liquid in the second chamber is consistent with the property of the first cavity, to guarantee The efficacy characteristics of secondary detection.Third, it is small in size due to the second chamber, it does not need special appendix and considers storage space, the ground of very little Side can store a large amount of second cavity, reduce the pressure in confirmation chemical examination laboratory, decrease transportation cost, simultaneously It can guarantee the safety of transport.Because not needing the risk for worrying very much liquid leakage.

In some preferred modes, when need to the first chamber 103 collect liquid sample detected and collected it is secondary It is when completion under the same time in confirmatory sample to the second chamber 104, it is desirable to be flowed into test chamber (if having detection When chamber) sample the liquid sample that enter the second chamber 104 will not be caused potentially to pollute, allow interface channel 109 Opening 1091 position be higher than through-hole 1038 height (such as shown in Fig. 7 and Fig. 6, shown in Fig. 9), in this way, flow into test chamber Liquid would not or can hardly enter in the second cavity, thus ensure that liquid in the second chamber 104 and without and survey The liquid sample essence for trying element contact is the same.It after all may be containing on testing element with the liquid sample of testing element contact It, may if perhaps the such reagent of other ingredients or ingredient enter in the second cavity processed some chemical reagent Second of test result is had adverse effect on.It is appreciated that the opening 1091 with interface channel is higher than through-hole 1038, Or as the method previously described, flow into the second chamber liquid pass through opening be higher than flow into test chamber through-hole position (such as The base apertures of previous embodiment, do not have to connect this when), it can be to avoid the liquid sample contacted with test-strips It enters in the second chamber, when testing element is included in device and contacts with liquid sample.

In some preferred modes, the first cavity contains the collection region 1035 or 1036 for collecting liquid, these remittances Collection region is located at the bottom of the first chamber 103, and around interface channel 109 or interface channel first is open for 1091 week It encloses.In some preferred modes, the position of these collection regions is lower than the position of interface channel opening 1091, in this way, working as liquid Body enters in the first chamber, first collect in collection region, then by through-hole 1038 enter in test chamber with testing element Contact.So the sequence reached according to liquid, collection region first has reaching for liquid, is then flowed into through-hole 1038 and enters inspection Chamber (if present) is surveyed, the position of the first opening 1091 of interface channel is then just reached.

In some preferred modes, for example, Figure 12, shown in 4,5, has protrusion in the bottom middle position of the first chamber Region, the main structure of the second cavity of accommodating portion 104 is carried out in the formed space of the elevated regions.It is set on the region of protrusion Interface channel or hole are set, raised region also forms collection region u (shown in Figure 4 and 5) from (example in terms of the bottom of the first cavity Such as Fig. 4), bottom is just used to the opening of the second cavity of accommodating portion 104 to 103 sunken inside of the first chamber, the region of this recess Partial region including 1042 will not additionally increase the material of detection device, will not seem prominent in this way, seeing on the whole It is towering, as described in Fig. 7-11, the opening portion of the second chamber is set under the bottom of the first chamber 103, is seen on the whole, is still and passes The detection device difference of system is only.In some preferred modes, the position of collection region 1036 and 1035 is lower than through-hole 1038 Position allows the liquid sample collected to pass through through-hole 1038 first and enters in test chamber (if present) 105, in this way as long as filling After full test chamber or liquid closing through-hole 1038, extra liquid will pass through the first opening 1091 of interface channel 109 It enters in the second chamber 104.It thus avoids to be flowed into the liquid of test chamber and come out from test chamber as far as possible and enters the In two chambers.Alternatively, according to liquid flowing sequence for, liquid usually first reach collection region collected, wait and be pooled to After certain altitude, be flowed into test chamber by through-hole 1038 and carry out test assay, etc. after test chambers collect liquid sample, Through-hole 1038 can be by hydraulic seal, with increasing for liquid, and liquid level can reach the position of interface channel opening 1091, thus into Enter into the second chamber, fills full second chamber or partially liq sample enters in the second chamber as subsequent progress secondary-confirmation inspection It surveys.

In other mode, detection device does not individually contain test chamber (as illustrated in Figure 1), such as such as Figure 15-17 includes a region on the side wall in the first chamber 203 like that, for example, as shown in Figure 16, packet in the first chamber 203 Two vertical strips 2032 and 2033 are included, two strips limit such a region, carrier as shown in figure 17 is allowed to be inserted into Into the region, the structure with test function is formed.For example, carrier structure as described in Figure 17, it is arranged on the carrier multiple The channel 2063 of testing element is accommodated, the one end of the channel 2062 closing, another end opening 2061, each channel is according in this way Compatible direction be arranged on carrier, the detection zone and suction zone on testing element are located in channel, and testing element On sample applying zone be located at one end of access portal 2063, the testing element in each channel in this way, this The sample applying zone of sample, the testing element in each channel is all located at the end 2065 of carrier, corresponding, testing element Detection zone is all located at close to one end of channel sealing, positioned at the top of carrier 2064.Carrier assembly is being combined to the first chamber It in 103, allows the end 2065 of carrier close to the bottom of the first chamber 2034, and allows the opening close to the first chamber of top 2064 of carrier Mouth 2031.In this way, the part sample of the liquid sample entered from the opening of the first chamber 203 is just and close to the bottom of the first chamber 203 2034 near testing element the contact of sample applying zone, to complete test to analyte in liquid sample Chemical examination.In other some preferred modes, such as shown in Figure 25-30, the second chamber 304 and the first chamber 303 it is dismountable The combined form of mode can be with previously described such as his Fig. 1, and the mode of 6-13 is realized or aforementioned any mode It carries out, also includes subsequent any mode to be sealed or separate.

In some preferred modes, the bottom 2034 of the first chamber has 2035 structure of groove, and groove structure 2035 can be with Liquid template is allowed to collect this in the first chamber, as depicted in figures 22 and 23.In some preferred modes, the of interface channel 209 The height of one opening 2091 is higher than the height of groove, the i.e. opening 2091 of interface channel 2091 upstream that is in groove 2035, this What sample can prevent from contacting with testing element, the liquid sample near groove passes through the opening of interface channel 209 first 2091 It is flowed into the second chamber 204.Equally, when the testing element in the carrier being located in the first chamber is completed to test for the first time or for the first time Afterwards, it is believed that when it is necessary to carry out the detection of subsequent secondary-confirmation, the second chamber can be directly separated from the first chamber, after separation, It is individually stored with the opening 2041 that the second lid 201 seals the second chamber 204, or individually packaging is transported to second Confirmation detection structure carries out confirmation detection.It is corresponding, it completes the carrier 206 of primary detection and suffers a chamber 203 with carrier And 2,031 first lid 202 of opening with the first chamber 203 of sealing is abandoned or is handled together.The volume of first chamber Will be generally above the volume of the second chamber, the difference that they are also possible to volume as elucidated before is designed, certainly, first The volume of chamber can also be equal with the volume of the second chamber, and optionally, the volume of the first cavity might be less that the body of the second chamber Product.

In some modes, the shape of shape and the second chamber for the first chamber is not particularly limited, for example, in general, The shape of first cavity is cylinder, and the shape of the second chamber is cylinder, and certainly, the shape of the first chamber can be cuboid, Square, ellipsoid or cone, correspondingly, the shape of the second chamber can be cuboid, square, ellipsoid or cone.

Front teaches dismountable mode of the first chamber and second, general second cavity be located at the first inside cavity or Person bottom, alternatively, at the beginning, the first chamber and the first chamber are just combined, generally after collecting liquid, carry out the first chamber and The separation of second chamber.Certainly, it is not intended to limit the specific location of the second cavity, the second cavity can also be otherwise.

Sealing element

In some preferred modes, after the first chamber is separated with the second cavity or before will separating or by stages before, Allow original the first chamber in liquid communication state and the second chamber to be not at liquid flowing, thus prevent liquid in the first chamber and It circulates between second chamber.Alternatively, whether liquid, which is connected to, between the first chamber and the second chamber has following several states: first State is that liquid is not connected to, and the second state is fluid connection,；Alternatively, first state is fluid connection, the second state is liquid It is not connected to.It is in fluid connection as the different conditions of the second chamber and the second chamber in different purposes or operating process Still it is not connected to, it can arbitrarily devised and selection.For example, when the first chamber collects fluid sample or liquid sample, the One chamber and second is at liquid communication state；When need separate before or separation when, allow the second chamber not with the first chamber be in Liquid communication state.Alternatively, the first chamber and second is not just located when the first chamber collects fluid sample or liquid sample In liquid communication state；When need separate before or separation when, allow the second chamber not with the first chamber be in liquid communication state, To allow the second chamber to collect the liquid from the first chamber, the first chamber and second is then allowed just to be not at liquid communication state again, from And it separates the second chamber and is detached from the first chamber.

So a sealing element is provided in some modes, if the first chamber 103 passes through interface channel 109 and second When chamber 104 removably combines, which is tightly connected channel, and the liquid of the first chamber cannot be allowed to enter back into the Two chambers, or the liquid of the first chamber cannot be allowed to flow out in the channel by the liquid for entering the second chamber.The so-called liquid that do not allow It is flowed out by interface channel, is exactly tightly connected the place of the first chamber of sealing and the second chamber connection of channel either essence, This connection can be indirectly connected with by interface channel, can not also be connected by interface channel, anyway, in these realities It applies in mode, while allowing the second chamber perhaps to separate after separating with the first chamber or before point separation, the first chamber and the second chamber connect The place connect is in hydraulic seal, thus after not allowing liquid in entering the second chamber or the separation of the second cavity, liquid-like Originally it will not be leaked to by junction in the outside environment of the first chamber.In some preferred modes, liquid cannot pass through connection Place is leaked in the external environment of the first chamber containing test chamber, alternatively, liquid cannot be leaked to containing test by junction In the external environment of first chamber of element.It is readily understood that connection and liquid communication are not preferred modes through the invention When " interface channel " is realized, but connected by connection structure with two independent structures of circulation passage, once the first chamber After being separated with the second chamber by connection structure, as long as being achieved that the flowing of liquid with sealing element sealing circulation passage.Institute With the function of sealing element is exactly the state for allowing the first chamber and the second chamber to be not at liquid communication, and the state flowed from liquid becomes Change to the immobilising state of liquid.

In some preferred modes, when the second chamber is removably connect by interface channel with the first chamber, when the second chamber Before separating with the first chamber, while later or separation, the interface channel is sealed by sealing element.The sealing Element can be tightly connected first opening 1091 in channel, as described in Figure 12.Herein, sealing element is as a plug, The opening 1091 of interface channel is blocked, so that liquid be prevented to enter in the second chamber, or does not allow liquid from interface channel One opening 1091 flows out to except the first cavity.Here sealing element can be the shape phase with the opening of interface channel Match or be adapted, to be tightly connected channel.Here adaptable refers to that sealing element and interface channel pass through suitable ruler One of very little, suitable material, suitable shape or combination cooperate and play the role of liquid sealing.For example, interface channel The first opening be it is round, sealing element is also circular, alternatively, interface channel is plastics, sealing element is also plastics , it is sealed by the mechanical elasticity of material having in itself, alternatively, sealing element is rigid, interface channel is elasticity , then alternatively, sealing element is rigid, the rigidity of interface channel, these modes can achieve the effect that sealing, from And realize the function of foregoing description.For example, sealing element is elastically-deformable, and interface channel is rigid, sealing element quilt Interface channel is filled in, to seal the opening of interface channel.This sealing means are can be optional.Sealing element It can individually be used to be tightly connected channel or seal the place of the first chamber and the second chamber liquid communication, allow the first chamber and the Two chamber fluid connections.

It include the sealing element for being tightly connected channel in some preferred modes, on the first lid 102, While first cover cap closes the opening of the first chamber, the sealing element is tightly connected the opening in channel.In fact, sealing Element and lid form joint-action mechanism, and the movement of lid is with the movement of moving sealing element.The movement of first lid seals The opening of one chamber, if the first lid move, can also allow sealing element simultaneously be tightly connected channel, in this way operation On it is more convenient.It will be appreciated, of course, that it is not connection that the first cover cap, which closes the first cavity and sealing element sealed connection channel, Dynamic, two steps can be divided into complete to be also to belong to the scope of the present invention.Preferably, sealing element is tightly connected channel First opening.It is also possible that say, the movement of the first lid and allow the first chamber and the second chamber fluid connection state change It links and completes together.For example, the movement of the first lid, in the process of movement, allow the first chamber in fluid connection and Second chamber changes into the first chamber and the second chamber is not at the state of fluid connection.Alternatively, the movement of the first lid, the first chamber is allowed The state for being not at fluid connection with the second chamber becomes the first chamber and the second chamber is in fluid connection state, with movement, again The first chamber and the second chamber is allowed to be not at the state of fluid connection.

Here lid closes the lid that can refer to the first lid and the cooperation of the first cavity and cover the opening 1031 of the first chamber Body, it is of course also possible to be the opening 1031 that lid seals the first chamber 103, sealing here can be only general sealing, Alternatively, being also possible to the state of blow-by, spill in the first chamber simply against liquid sample and, for example, in mobile first chamber When, avoid liquid from overflowing to come from the opening 1031 of the first cavity.As set forth above, the first lid and the first cavity Opening lid close there is no need to the sealing effects as conventional detection devices because not needing to entire detection device Carry out transport or transportational process under some extreme conditions.Sealing element waits the first cavity to collect sufficient amount on lid Liquid when, generally require cover cap close the first chamber opening, cover cap close the first chamber opening 1031 while, The sealing element that is connected on lid while the opening or interface channel for being tightly connected channel, to not allow liquid to enter In second chamber, after the second cavity is separated with the first chamber, liquid cannot be leaked in the external world by interface channel.It allows in this way It operates more convenient, easily and quickly, two functions is completed while operating a step.Here sealing element, which seals, to be connected The sealing effect for connecting road, which only can be, does not temporarily allow liquid to be leaked to the external world by interface channel, without such as traditional Sealing effect as detection device guarantees under extreme traffic condition to reveal under (such as high pressure or vacuum).This It is because the sample of the second chamber carries out secondary-confirmation detection as transport agent, and the liquid in the first chamber need not be transported Or storage, subsequent discard processing can be carried out.So here to the opening 1031 and interface channel of the first chamber or company The sealing for connecing access portal 1091 is only general sealing, without being needed as conventional apparatus in negative pressure, vacuum state Under sealing state.Be primarily due to the first chamber of fluid connection in the first chamber is not needed to be transported to profession laboratory or Person chemically examines mechanism and carries out secondary chemical examination.

For convenience and production cost it is cheap, the first chamber and the second chamber are all plastic materials, these all be injection molding once Property is molding, and sealing element and the first lid are also injection molding, can be reached by the physical property between plastic material Sealing element is allowed to seal the junction of the first chamber and the second chamber, it is preferred that the connection for being tightly connected the first chamber and the second chamber is logical Road.In order to reach better seal effect, elastic seal ring 108, such as " O " type sealing ring can be set on sealing element, Such as silica gel sealing ring, the material relative to sealing element of these sealing rings can have flexibility, thus, work as sealing element When being tightly connected first opening 1091 in channel, increase its sealing effect.It is appreciated that when needing lid and sealing member Part link when, the opening of usual first lid and the first chamber is joined together by screw thread, first this be rotation The opening of the first chamber of mode lid, and sealing element is also the mode of rotation to enter interface channel or be tightly connected channel Opening, or the hole (if interface channel omit in the case where) of the first chamber of sealing and the second chamber fluid connection.

It is appreciated that " O " type sealing ring and sealing element are used cooperatively, then " O " type sealing ring, which can individually produce, to be filled It is fitted on sealing element, has Packed function in this way, certainly, the structure of " O " type sealing ring can be sealed with installation " O " type The position of circle is but disposably to be completed by injection molding with the same material, in this way, facilitate production and processing technology.When So, in other cases, " O " type sealing ring be also can be default, only rely on interface channel and sealing element material It is different and can realize sealing.

It, can be by once at injection molding when sealing element and the connection of the first lid in some preferred modes Molding, can also be connect by dismountable mode with lid.Such as shown in Figures 2 and 3, sealing is connected on the first lid Sealing ring 108 is arranged on sealing element for element 1028, and sealing element is structure as a whole with lid 102.In order to better A groove structure is arranged in fixed seal ring on sealing element, allows sealing element is elastic to be fixed on groove.General One chamber needs to accommodate the liquid sample of certain volume, so there is certain volume, so, 1031 distance of opening of the first chamber First opening 1091 of the interface channel of the bottom of the first chamber has one section of distance, so, sealing element passes through connection structure 1023 and lid 102 link together, become one structure.As shown in figure 12, it when lid is in such a way that lid closes, such as revolves It is also rotated together when the mode lid turned is closed to opening 1031 of the first chamber with sealing element 1028 that lid is linked together It enters in interface channel 109, the lid of lid closes process therewith, and sealing element enters in interface channel, thus sealing element 1028 are tightly connected an opening 1091 in channel, to prevent liquid sample to enter the first chamber, when the second chamber and the first chamber When separation, positioned at the liquid sample of the first chamber will not be leaked to by interface channel it is extraneous come.

For example, as shown in figure 22, connection structure 2023 is connected on the first lid 202, connection structure 2023 extends one Duan Zuowei sealing element 2028 is tightly connected channel；State shown by Figure 22, sealing element 2028 (is exactly band at this time There is the place of sealing ring 208) there are no when close opening 2091, the first chamber and the second chamber are in liquid flowing state.With The seat variation of lid, sealing element is close to the position of opening 2091, and with movement, sealing element seals up opening 2091, reach sealing effect at this time, the liquid in the first chamber would not flow in the second chamber.

Using lid and sealing element linkage by the way of carry out being preferred mode, allow in this way the first chamber and the second chamber not In fluid connection state.No doubt, lid and sealing element can disposably be molded completion, can also be assemblied in Multi-step injection molding Together.For example, lid is that disposable injection molding is completed, connecting rod 2023 and sealing element 2028 are that disposable injection molding is completed；Then It is combined by any optional grafting, screw thread or other way, the movement band moving sealing element of lid is allowed to transport together It is dynamic, referred to as " link ".In other mode, sealing element, connecting rod and lid are molded respectively, are then fitted together It is also possible.

So sealing element is also that dismountable mode is connect with lid in some preferred modes.For example, as schemed Shown in 31-35, lid 402 includes sealing element 4028, the shape matching of the shape of the sealing element and interface channel or and First opening, 1091,3091 matching, such as the shape of piston.This mode, a part of connection structure 4023 is as sealing member Part 4028 uses, and this when does not have sealing ring.But material can be different, the material of general sealing element is general More high resilience, even if in this way, flexible sealing element is easier to be tightly connected channel, or sealing without sealing ring First opening of interface channel.For example, sealing element can be latex, silica gel or other flexible materials, alternatively, Sealing element is made of two parts, and inside is the material composition for comparing hard, and one layer of covering is rich on the material surface of hard The materials such as silica gel, rubber, latex of elasticity come enhance sealing element and interface channel or be open 1091 opening sealing Effect.Meanwhile first lid of lid 402 when close the opening of the first chamber 103,203, spend smaller strength that can allow sealing Element 4028 is tightly connected channel or opening, such as allows sealing element to enter in interface channel and be tightly connected channel.Or Person, sealing element 5029 (when the structure using 5029 is as sealing element) with connecting rod 5023 are connected by screw thread It is connected together, such as Figure 33-34, in this embodiment example, external screw thread is arranged in one end 5030 of sealing element 5029, even Internal screw thread is arranged in one end on binding structure 5023, and sealing element is linked together structure by thread forms and lid, in this way, close Different materials can be had with lid and from connection structure by sealing element, and sealing element has more design forms and side Formula meets different sealing needs,.

Here sealing may be an individual component or be arranged on the ground connected in the second chamber and the first chamber Side can obstruct the liquid flowing before the second chamber and the first chamber.Here flowing is usually the flowing of active.In fact, working as When liquid passively flow to the first chamber from the second chamber, sealing element it is not necessary to.

In addition, as being talked about above in conjunction with Figure 27, when the structure for being not provided with interface channel in the first chamber and the second chamber When, only actually has a hole, such as 3091 similar holes, and lacks the part 3098 of interface channel extension, this When a, sealing element it is only necessary to sealed openings 3091 can, it is not necessary to allow sealing element to enter in interface channel Come.Such as sealing element such as a rubbery stopper, the rubbery stopper are arranged in the connecting rod 3023 of lid, the linkage of lid It drives plug to clog opening 3091, realizes the change of the liquid communication state between the first chamber and the second chamber.

In addition, sealing element can seal the first opening of interface channel at the very start, when the first chamber 103 has collected After liquid sample, alternatively, utilizing puncturing elements before or after carrying out the first chamber liquid sample progress primary detection It punctures the sealing element or cancels sealing element, liquid sample is allowed to be flowed into interface channel, enter the by the second opening In two chambers 104, moreover, the second chamber is removably to combine with the first chamber, to allow the second chamber to separate with the first chamber, after progress Continue possible confirmation chemical examination test.So sealing element here can be that can be punctured when puncturing sealing element Structure, for example, this sealing element can be adhesive sticker, double-sided adhesive, plastic sheet etc..Generally, which opens Beginning will not allow liquid to enter in interface channel, but just enter after being punctured.The mode being punctured has many kinds, For example, sharp thing punctures.In some modes, puncturing elements can be arranged on the first lid 102, Gai Lilian Dynamic puncture structure, when the first cover cap closes the opening of the first chamber 103, puncturing elements sealing element, to allow liquid The second chamber that body is flowed to from the first chamber.It allows the first chamber and the second chamber to separate if necessary, before separation, makes another sealing first Part sealing punctures place, to realize the change of the liquid communication state between the first cavity and the second chamber.

For example, the figure anticipated as shown in figs. 39-40, the first chamber 702 includes the opening 7031 of receptive liquid sample, first There is hole in chamber, which is the first opening 7091 of interface channel, sealing element which can be punctured seals 70281, and The test chamber 705 of first chamber fluid connection carries out fluid connection by channel 7038.It is not both with shown by Figure 37-38, the Chamber of one chamber as the collection liquid sample of primary detection, and it is detachable at the second opening 7092 of interface channel It is connected with the second chamber 704.When collection has liquid sample, the liquid portion of the first chamber is flowed into test chamber and carries out for the first time Chemical examination detection, the opening of the first chamber is then closed with the first cover cap, with the second lid on lid, is arranged on the first lid There are sealing element 7028 and puncturing elements 7029.Lid and sealing element 7028 and puncturing elements 7029 form gear in this way System, when such first cover cap closes the first chamber, band moving sealing element and puncturing elements link, and puncturing elements are existing It punctures and is tightly connected the sealing element that channel first is open, then discharge liquid into the second chamber, then seal up the with sealing element The opening of two chambers.Certainly, puncturing elements can also have the function of excluding the second cavity segment liquid, this when, puncturing elements On also can have lyophoby channel and inlet and accommodating chamber.In this way, puncturing the first opening 7091 for being tightly connected channel Afterwards, puncturing elements direct part is inserted into the second chamber, in order to which liquid can exclude outside, liquid can be allowed logical by lyophoby The inlet in road is flowed into accommodating chamber, such as accommodating chamber is located in puncturing elements, this combines subsequent detailed description can be with It is clearly understood from and combines.Such as shown in Figure 40 draw above.When needing to carry out secondary-confirmation detection, from the first chamber On remove the second chamber, for example rotation screw thread is removed, and the opening 7041 of the second chamber 704 is then sealed with the second lid, and progress is subsequent Secondary-confirmation detection.

To sum up see, allow liquid from the first chamber flow to the second chamber can be allow liquid to enter the first chamber when, also together When can flow to the second chamber, liquid simultaneously or is not immediately entered to the after perhaps allowing liquid sample to flow into the second chamber Two chambers, this be should be the second chamber and the first chamber be not in fluid connection, but it is subsequent whenever, allow the second chamber Fluid connection is in the first chamber.It is not at fluid connection and the mode in fluid connection is exactly the control to sealing element Opportunity problem, such as puncturing the sealing element being tightly connected in the opening of channel first 1091 or the second opening 1092 is exactly to allow The mode of two chambers connection.Certainly, in order to allow the second chamber to separate it is unlikely to that the first chamber liquid is allowed to proceed to the second chamber, simultaneously It also needs to seal after puncturing.

So in some modes, the second chamber and first when collecting liquid sample, are not allowed with the first chamber 104 Chamber is in fluid connection, waits when collecting liquid or after collecting liquid sample, the second chamber is allowed to be not at the first chamber Fluid connection.Certainly, optionally, when collecting liquid sample, do not allowed with the first chamber 104 second chamber and the first chamber not In fluid connection, waits when collecting liquid or after collecting liquid sample, the second chamber and the first chamber is allowed to be in liquid Connection, when allowing liquid sample to enter in the second chamber or later, before needing that the first chamber and the second chamber is allowed to separate, The second chamber and the first chamber is allowed to be not at fluid connection again.In the above mode, sealing element is played the part of with the different time Different functions.When seal, when blow-by, can be selected according to suitable opportunity.

In the example for needing sealing element above, liquid sample always be free to flow to second from the first chamber 103 Chamber (such as under the action of gravity, liquid always flow to low level from a high position) continues to flow after avoiding two cavitys of separation, Just use sealing element；It is close but in fact, when liquid sample passively overcomes gravity to flow to a high position from low level Envelope element is not necessary.Such as the example in design 3, do not need individual sealing element.

Lyophoby channel

Described " lyophoby channel " is exactly the channel of similar drain herein, liquid dredge by the channel or Person's discharge, it is also assumed that being the channel for allowing liquid to flow to another place from a place by the channel.Except this it Outside, " lyophoby channel " here can also exclude extra gas, thus the effect relieved stress；By the channel gas It is dredged or is discharged, it is also assumed that being that gas is allowed to flow to the logical of another place from a place by the channel Road.So " lyophoby channel " here can exclude extra liquid, extra gaseous state or gas and liquid can also be excluded The mixed state of state.So-called " channel " ordinary meaning is, such as the shape of pipe, such as all round closure, and opens including two Mouthful, an opening can be used as inlet, another opening can be used as liquid outlet；Alternatively, an opening can be used as air inlet Mouthful, another opening can be used as gas outlet；Alternatively, an opening can be used as into liquid and gaseous mixed state mouth, it is another A opening can be used as the mouth for excluding liquid and gaseous mixed state.Here a import and an outlet is only one Kind embodiment, it is of course possible to contain one or more import, also may include one or more outlet.Here right The length in channel itself does not have any limitation, can be long, can also be shorter, this general technology for this field Personnel come, and can all be easy to realize according to the actual situation.

In some more preferably modes, if only the hole between the first chamber of sealing and the second chamber can four realities It now seals, still, if it is desired to which the sealing for reaching more preferable effect connects the first chamber and the second chamber for example, by using interface channel When, interface channel generally has extended segment 3094, which extends into Figure 27 in the opening of the second chamber, certainly, It can also be at interface channel 3091 to first intracavitary extension one end distance or length.In order to preferably reach sealing effect, The same sealing element of plug, which generally requires, to be inserted partially into interface channel to be tightly connected channel, generally, is being tightly connected Before channel, liquid sample, the liquid sample also filled in the second chamber are contained in interface channel.This is because the liquid collected Sample will meet secondary-confirmation detection and the primary detection for testing element, liquid sample still need enough volumes.Institute With in some preferred modes, the height of the liquid level of the liquid sample in the first chamber is higher than the first opening of interface channel Position, i.e. the first opening of interface channel is located under liquid level, in such interface channel and has been filled with liquid in the second chamber Body.In this case, it to allow sealing element part to enter in interface channel and reach better seal effect, this liquid Liquid sample will not be unlikely to liquid and be leaked to the external world in the first chamber after subsequent second chamber is separated with the first chamber again for sealing. In this case, sealing element enters interface channel with certain difficulty, although because sealing element and connection are logical The size in road is suitable, inevitable when being tightly connected channel 109, needs to overcome the certain liquid acted on sealing element The reaction force of body.This is because in order to reach preferable sealing effect needing that sealing element is allowed to enter interface channel one In part, to obtain better seal.In order to obtain better seal, in the presence of interface channel, seal process It is a dynamic process, it is complete to sealing element close to the first opening (first state) of interface channel since sealing element Portion blocks the first opening (the second state, this when are possible, and can play the role of sealing) of interface channel, then Enter interface channel (third state, it is exactly to obtain better seal effect that this, which reaches the third state) to sealing element, this In the process, when need become the third state from the second state when, actually need to overcome in interface channel with sealing The reaction force of the liquid sample of element contact, especially sealing element enters in interface channel, and it is logical to need to oppress connection Liquid in road if liquid cannot be excluded is difficult that sealing element is allowed to become the third state from the second state.From sealing First opening of interface channel can be 0.1-10 millimeters or farther distance to the distance for entering interface channel, to protect Demonstrate,prove preferable sealing effect, such as it is 0.1 millimeter that sealing element, which enters the distance of interface channel, 0.2 millimeter, 0.3 millimeter, 0.4 Millimeter, 0.5 millimeter, 0.6 millimeter, 0.7 millimeter, 0.8 millimeter, 0.9 millimeter, 1 millimeter, 2 millimeters, 3 millimeters, 4 millimeters, 5 millimeters, 6 Millimeter or 7-10 millimeters.In order to mitigate the reaction force of this liquid, this reaction force is exactly that liquid is applied to sealing member The pressure of part needs the liquid volume for allowing sealing element to exclude smoothly to be rejected to other place, could mitigate sealing in this way The counteractive pressure that element is born, enters in interface channel so that sealing element be allowed to be relatively easy to.So just needing Will when sealing element enters interface channel, exclude interface channel in partially liq volume, allow sealing element smoothly into Enter in interface channel, to smoothly be tightly connected the opening of channel or interface channel.This is just similar with the plug plug with bottle The reason of the opening of bottle inlet is the same, if filling water in bottle, plug be difficult to fill in it is the same, need to allow bottle water or Person's liquid outwells a part, and such plug can just fill in bottleneck to the opening of closed bottle.However, when the second chamber is full of Liquid is also filled with liquid in interface channel, and sometimes the first opening of interface channel is located under the liquid level of the first chamber, needs Sealing element entrance or sealing element are tightly connected the opening in channel in the form of piston, and it is logical that this just needs to exclude connection Partially liq in road conveniently allows sealing element to enter in interface channel to other place, best mode entrance when It waits, exclusive segment liquid, the entrance of sealing element is to receive forcing for external force and enter in interface channel.

So the device further includes lyophoby channel in some preferred modes, it can be close by the lyophoby channel Seal element enter interface channel generate extruding fluid removal to interface channel except, thus allow sealing element successfully Into interface channel.For example, the inlet in lyophoby channel is located on sealing element, with sealing in some preferred modes Element enters interface channel, and extra liquid is entered in lyophoby channel by inlet, to be rejected to interface channel Outside.It generally can be not except lyophoby channel mentioned here and include interface channel and be detachably connected with interface channel Perhaps in test chamber or other places in place except including second chamber, such as accommodating chamber, such as the first chamber.Institute With the present apparatus further includes accommodating chamber, and the accommodating chamber is for receiving liquid or gas in lyophoby channel.Generally, it seals Component seal interface channel or the first chamber of barrier and the second chamber carry out liquid flowing or flowing, are generally divided into two states, First, before being tightly connected channel, the first chamber and the second chamber communicate sealing element, this when, liquid can be two A chamber swaps, and liquid can usually be allowed naturally to flow in the second chamber from the first chamber.Second, when sealing element starts When being tightly connected channel, such as the opening of interface channel, the first chamber and the second chamber be not communicated with, due to sealing element after Continue and enter interface channel, the pressure of interface channel and the second cavity will increase, due to the effect of pressure, interface channel and second The liquid of cavity will be entered by the inlet in lyophoby channel to reduce the former pressure in accommodating chamber, to allow sealing element Smoothly it is tightly connected channel.Certainly, lyophoby channel here can be arbitrarily arranged, and general lyophoby channel and accommodating chamber are in liquid Body connection.In this way, if the liquid that sealing element goes successively to be discharged in interface channel enters receiving by lyophoby channel In chamber.

In some modes, such as shown in Fig. 3 and 2, sealing element 1028 is used to be tightly connected the opening in channel 109 1091, and accommodating chamber can be located in sealing element, such as sealing element is hollow structure, the liquid excluded in this way can be with Enter in accommodating chamber, hollow structure 1029 can be used as accommodating chamber come using.For example, as shown in figure 3, sealing element It further include an accommodating chamber 1029 on 1028, when sealing element enters interface channel, extra liquid passes through lyophoby Channel 1025 enters in accommodating chamber 1029, to alleviate pressure, lyophoby channel 1025 certainly here is very short, this be because For sealing element be thin-wall construction or sealing element is hollow structure.It will of course be readily appreciated that accommodating chamber might not position In on sealing element, when connection rod structure 1023 is hollow structure 1030, hollow structure 1030 and accommodating chamber 1029 communicate group As soon as accommodating the liquid volume of sealing element exclusion at big accommodating chamber, or hollow structure 1030 is used as accommodating chamber It uses, has the effect of equivalent.In some preferred modes, such as such as Fig. 2-3, shown in 12, the sealing of sealing element 1028 The opening of interface channel 1091 simultaneously enters in interface channel 109, and extra liquid enters receipts by lyophoby channel 1025 In cavity 1029.In such an embodiment, the liquid flow in (inlet) open at one end Yu interface channel in lyophoby channel It is logical, and the liquid of another end opening (liquid outlet) and accommodating chamber fluid connection, to can just liquid be allowed to enter accommodating chamber In, herein, it is arranged on hollow sealing element due to lyophoby channel, so, lyophoby channel is very short, and it is no matter how short, always have Liquid-inlet and liquid outlet.In fact, when accommodating chamber is located in sealing element or in subsequent draining element, inlet With liquid outlet not stringent division in fact, only arrive lyophoby channel it is long when, just have inlet and liquid outlet position The division set, this is because sealing element or draining element are hollow structures, and wall be also it is very thin, actually As soon as opening hole on wall, which plays the effect for allowing liquid to enter accommodating chamber, for inlet or goes out this when Inevitable position does not divide liquid mouth, which can also be referred to as inlet, can also be referred to as liquid outlet, in short, position is drawn Dividing is not clearly.

In some preferred modes, as shown in figure 12, the inlet in lyophoby channel is located at below sealing element.? In some preferred modes, the inlet in lyophoby channel is located on sealing element, and it is logical to enter connection earlier than sealing element In road, thus could be outside extra fluid removal to interface channel, to reduce the anti-work for the liquid level that sealing element is born Use resistance.Lyophoby channel is exactly that can refer to the through-hole on accommodating chamber 1029 herein.Such lyophoby channel can be one Or it is multiple.

In one preferred embodiment, the inlet in lyophoby channel enters in interface channel prior to sealing element. So in some modes, if lyophoby channel is long, and when the first chamber is used as accommodating chamber, lyophoby channel Inlet is located on sealing element, but enters in interface channel earlier than sealing element, in this way, as sealing element enters During interface channel, the liquid of exclusion enters lyophoby channel by the inlet in lyophoby channel, then logical by lyophoby The liquid outlet in road is into the first chamber, or enters in accommodating chamber.Here, the first chamber is a specific mode of accommodating chamber, First chamber can also become a cavity with the total energy of accommodating chamber.So accommodating chamber is not necessarily located on sealing element, Best mode is located on sealing element or in the connecting rod for allowing sealing element to connect with lid.In this way, with close Envelope element enters in interface channel, and extra liquid is rejected to except interface channel by the inlet in lyophoby channel.This Kind excludes to be to enter interface channel due to sealing element and the pressure to liquid level generated and the liquid for being forced to exclude.Certainly, it receives The size of cavity and the liquid of exclusion are related.As long as suitable volume capacity is arranged to accommodate the liquid of exclusion.

The positional relationship of " inlet in lyophoby channel " can oppress if sealing element needs to enter in interface channel Liquid sample in interface channel, in this case, the position of inlet should be located at below sealing element, so-called " under For face " is only relative position, it is not necessarily located on sealing element.For example, can be located on the wall of interface channel, when When sealing element enters interface channel, being located relatively at below sealing element into liquid port on interface channel wall at this time Position forces partially liq to enter inlet and is excluded, thus smoothly as sealing element continues into interface channel Allow sealing element to enter.In one case, sealing element can go successively to interface channel until sealing element and connection Inlet overlapping on the wall in channel, liquid cannot just be entered in lyophoby channel by inlet, so that it is logical to be rejected to connection Outside road.So inlet is located under sealing element, such as shown in Fig. 2-3, sealing element in some preferred modes Inlet 1032, the inlet in the inlet lyophoby channel 1025 are set under 1028 position.

For another example Figure 15, illustrated in 18,22,23,27.Such as shown in Figure 15-24, sealing element 2024 It is structure as a whole with connection structure 2023, the extension of the connection structure entire connection structure and is prolonged as sealing element Stretching structure is hollow structure 2030,2029, the hollow structure accommodating chamber big as one use, and lyophoby channel enters Liquid mouth 2025 is the opening positioned at extended structure side wall, which is the inlet in lyophoby channel, also is located under sealing element 's.For another example as shown in figure 23, during waiting sealing elements 2028 to enter interface channel, dredging under sealing element The entrance 2025 in liquid channel extra fluid removal to outer, to reduce the resistance of sealing element entrance.Some preferred Mode in, the difference is that, lack the sealing element 3028 of sealing ring 208 with structure shown in Figure 31, it be connection knot A part of structure 3024 as sealing element, meanwhile, the top of connection structure extended structure have opening 3025, the opening 3025 are connected to the hollow accommodating chamber 2039 in sealing element, more when sealing element enters interface channel Remaining liquid sample is entered in accommodating chamber by lyophoby feeder connection 3025, such as shown in Figure 33-35B, although sealing element 4029 removably combine with connecting rod 4024, and inlet 4038 is arranged on the top of sealing element, it is extra can to play exclusion The function of liquid.It is appreciated that sealing element is for better seal interface channel, shape or size preferably with connection Channel matching, such as interface channel is circular hollow structure, sealing element is also circular structure, conveniently between the two Sealing cooperation.

With continued reference to Figure 33-35, connecting rod 5023 is set on the first lid 502, there is sealing element in the connecting rod 5028, which can be used to be tightly connected channel, if logical to be tightly connected with sealing element 4028 described above When road, the inlet 4038 in lyophoby channel is set in the place on its top 4029, and in sealing element 5028 includes receiving Chamber 5030 enters the liquid that interface channel excludes to collect sealing element.It is of course also possible to be set below sealing element 5028 Inlet 5025 is set, sealing element 5028 enters interface channel come when being tightly connected channel, extra liquid passes through feed liquor Mouth 5025 enters in accommodating chamber, i.e., hollow structure is as accommodating chamber 5030.This when, component 4029 are not to play The effect of sealing, but the effect of drain, and the effect sealed is the place of the extending end 4028 of connecting rod 4024.

Certainly, if the part-structure 5028 for not having to connecting rod 5022 is used as sealing element, but knot shown in 5035 Sealing element 5029 is set on structure, and as shown in Figure 33-35, which can removably connect with connecting rod, example As the mode of grafting, screw thread or clamping links together.Such as element 5035 includes having externally threaded one end 5030, it should End and the internal screw thread 5027 of connecting rod cooperate.And the cooperation of the inner wall of sealing element 5029 and interface channel is tightly connected channel.And The top 5038 of element 5035 is then arranged in the inlet in lyophoby channel, more when sealing element 5029 enters in interface channel Remaining liquid head is entered in the accommodating chamber 4029 in sealing element by inlet 4038, this when, inlet 5025 could To lack or omit.

In some preferred modes, in order to facilitate liquid exclusion also easily and effectively allow feed liquor body to enter inlet, The perpendicular position of the position of the inlet in lyophoby channel will change sentence lower than the vertical position in the outermost face of sealing element It talks about, the floor projection region of the position of the inlet in lyophoby channel is not completely the same with the floor projection region of sealing element, Preferably, the region of the floor projection of the position of the inlet in lyophoby channel is located within the floor projection region of sealing element. Understand from the other meaning, is exactly the inner wall contact of sealing element needs and interface channel, and the position of the inlet in lyophoby channel It sets and is not contacted with the inner wall of interface channel preferably, because contact can seal inlet；Liquid is facilitated to enter lyophoby channel in this way Inlet to exclude except.Such as Fig. 2 and 3 is as can be seen that the diameter of position of the sealing element with sealing ring 108 is big The inner wall of diameter in the position where inlet 1025, the position and interface channel that thus are avoided that 1025 place of inlet connects It touches and influencing liquid can smoothly enter into lyophoby channel, to reach in accommodating chamber.In Fig. 2, the region 1055 of dotted line For the region A-A ' of sealing element projection, and view field's point of inlet 1025 or region are removed in B, view field position Between A-A '.So according to such principle, in some schemes, sealing element can one inverted circular cone of band knot Structure (can also illustrate the function of the structure, that is, have the function of drain) below, and the inlet 1025 in lyophoby channel is located at circular cone Surface facilitate the liquid of exclusion to enter in this way, the inlet in lyophoby channel will not be contacted with the inner surface of interface channel The inlet in lyophoby channel and be excluded.For Figure 18 it is also to be understood that the position of sealing element 2028 is since there are sealing rings 208, so the projection for being located at the inlet 2025 of sealing element 2028 is within the projection of sealing ring.Similar Figure 27 Also it is readily understood that having an inverted cone shape, the inlet in lyophoby channel is set on the surface of circular cone, is easy Liquid is allowed to enter in lyophoby channel, to exclude extra liquid sample.In such as Figure 31-32, the feed liquor in lyophoby channel The case where position on top is arranged in mouth, does not take into account that the inlet in interface channel side wall sealing lyophoby channel, but Ren Ranman The projection of sufficient inlet position is the principle positioned at the floor projection region of sealing element.Figure 33-34 is seen again, when no matter adopting It uses the extending end 5028 of connecting rod 5023 as sealing element, or is partially used as sealing element shown in use 5029 It is good, and the inlet 5025 in lyophoby channel or 5027 projection are still located within the floor projection of sealing element, this be because For, in recess setting inlet 5025, perhaps 5027 inlets will not be connected the side wall sealing in channel or stop up, The inner wall of general interface channel be it is flat and smooth, easy in this way to be sealed, such structure facilitates the exclusion of liquid.

In short, preferred mode is exactly that sealing element is allowed to enter connection when sealing element is tightly connected channel Channel, and the pressure of sealing element entrance is alleviated, it needs to be arranged lyophoby channel, sealing element is entered interface channel row The liquid removed is discharged to other place.Concrete mode as described above is sealing the inlet setting in lyophoby channel Under element, one end inlet ratio sealing element in the lyophoby channel will enter in interface channel in advance, thus could allow it is extra Liquid enters lyophoby channel.Also as described above, in sealing element or it is located at other positions when accommodating chamber, Another outlet (liquid outlet) in lyophoby channel is connected to accommodating chamber, to accommodate the extra liquid in interface channel.

In other some optional schemes, the first chamber can also be used as accommodating chamber come using, allow sealing element even The liquid sample that road excludes is connected to be discharged in the first chamber by lyophoby channel.In above embodiment, the entrance in lyophoby channel It is linked together in the connection structure of structure or under sealing element on sealing element or positioned at lid.Certainly may be used Choosing, lyophoby channel is not on sealing element, can be located on interface channel, for example, lyophoby channel is located at interface channel Side wall on, the entrance (inlet) in lyophoby channel is located on the side wall of interface channel, and liquid outlet is connected with the first chamber, When sealing element enters interface channel, the extra liquid being discharged because of the entrance of sealing element is logical by lyophoby The inlet in road enters in the first chamber, until the inlet port in sealing element sealing lyophoby channel.The general skill of this field Art personnel read embodiments of the present invention, it is envisaged that obtain, no matter how lyophoby channel is arranged, for example, inlet and The setting of liquid outlet position, as long as can exclude because sealing element enters the liquid sample of the exclusion of interface channel, thus Reduce sealing element liquid to the resistance of sealing element can, for example, the inlet in lyophoby channel is located at sealing element On or other positions be all possible.

In other mode, the size of inlet can carry out it is arbitrarily devised, for example, liquid can enter, still Liquid cannot be flowed out freely from inlet.Because it is often the pressure because of liquid that liquid, which enters lyophoby channel by inlet, Compel and enter in lyophoby channel, after liquid enters lyophoby channel, liquid because inlet surface tension without from Inlet outflow.Such benefit is exactly, because inlet is normally at sealing element in the following, when the second chamber and interface channel Mouth is separated, inlet is exposed to outside, if the liquid of accommodating chamber can be flowed out by inlet, also results in liquid The risk of sample contamination environment, therefore, it is desirable to which inlet can only be that liquid is allowed to enter and liquid cannot be allowed to flow out.Generally, it is arranged The size of inlet, such as 0.1-1-2 millimeters, the liquid in accommodating chamber is since surface tension from inlet without flowing out.

It in some modes, after sealing element is tightly connected channel, can be separated with the first lid, if sealing Element is arranged when on lid.In a mode, sealing element is linked together or combines with lid, Channel is connected and sealed as the first cover cap closes the opening of the first chamber in sealing element.After the completion of sealing, if necessary Open the first lid, thus the first lid of reverse rotation and expose the opening of the first chamber, this when, allow sealing element still Rest on and be tightly connected channel in interface channel, and remove the first lid can from first it is intracavitary take away partially liq sample into Row other detection or chemical examination.For example, sealing element 5029 is removable by connecting rod 5023 with lid as shown in Figure 33-35 That unloads combines, this when, and sealing element 5029 is located on element 5035.And the connecting rod of element 5035 and lid 5023 removably combine, this dismountable mode not instead of helicitic texture as shown in Figure 33-35, grafting Mode, i.e. one end 5030 of element 5035 is inserted into one end of connecting rod.When the first lid 502 is with moving sealing element 5029 are tightly connected after channel, the second chamber can be allowed to separate with the first chamber this when, so that the second chamber of sealing is opened Mouthful, for example, with the second lid seal the second chamber opening, using the sample in the second chamber as the second time test come.This When, the first lid 502, which has covered, has got togather the first chamber, such as the opening 1031 of the first chamber 103 shown in Fig. 9；If this It also needs when a from the first intracavitary taking-up liquid sample, inverts the first lid this when, when reversion, this when, Sealing element closely cooperation compared with interface channel has, and element 5035 is only the mode of grafting with connecting rod, first Lid can be separated with first chamber 103 again, and element 5035 is allowed to rest in interface channel.The advantage designed in this way It is that sample seals interface channel after gathering sample if the first chamber is only used for collection, has carried out liquid sample Separation processing, the first lid can be opened this when, from the first chamber take out part sample as chemical examination, if chemical examination knot Fruit needs to further confirm that detection, the second chamber can be removed from the first chamber, carry out secondary chemical examination.In fact, from the first chamber The interior sample that can repeatedly take out carries out the detection or chemical examination that do not have to index repeatedly.

The liquid for needing to exclude above is usually interface channel and when the second chamber all fills liquid sample.It can manage Solution, when the liquid sample of the second chamber is not filled up with the second chamber, will not generally contain liquid sample in interface channel, If sealing element enters interface channel sealed connection channel, this when of lyophoby channel can play exclusion quilt Outside the portion gas of compressing to the second chamber, the resistance that sealing element enters interface channel, the resistance of this when can also be mitigated Power is that the reaction force for hindering sealing element to enter is generated because of gas urges.

So in both cases, when interface channel has liquid, lyophoby is logical in some preferred modes Play the role of being exactly the effect for excluding liquid in road；When the second chamber is not liquid filled, in order to preferably allow sealing Component seal interface channel, the lyophoby channel of this when play the role of being exactly the effect being vented.So lyophoby channel exists Functionally play the role of two kinds or any of them effect simultaneously, so, it can also claim lyophoby channel that can be called discharge The channel of fluid, fluid here refers to the mixing of liquid or gas or the two, corresponding, the liquid inlet in lyophoby channel It can also be referred to as air intake, liquid outlet can also be referred to as gas outlet, or be referred to as mouth and fluid out into fluid Mouthful.It is appreciated that when if necessary to exclude the gas being oppressed, it may not be necessary to exhaust passage, Ke Yili specially be arranged Exhaust is realized with lyophoby channel, can also not have to it is special design such channel because sealing element have liquid when It waits, as long as reaching the degree of liquid sealing, if there is gas, actually also only reaching liquid sealing can.Institute With when needing to exclude gas, the function of excluding gas be may be selected between sealing element and interface channel element Small gap can, these small gaps can be the error between mechanical structure, can also be the knot being deliberately designed Structure, these small gaps can allow gas by that liquid cannot be allowed to pass through, and thus have the function that exclude gas.Certainly, this In exhaust passage or the structure of exhaust nor is it necessary that because sealing element is tightly connected channel it is desirable that liquid is close Envelope effect, rather than hermetic seal effect.In contrast, not necessarily reach hermetic seal when reaching liquid sealing, but reach When hermetic seal, the effect of hydraulic seal also reaches.

" lyophoby channel " is also a preferred mode of the invention, is because the connection of sealing element better seal is logical Road allows portion sealing element to enter interface channel and preferably reach sealing effect.If it is other way, sealing element It is only tightly connected first opening in channel, needs to enter interface channel one end distance without sealed opening, and Feasible, this when, lyophoby channel can be default.If second is intracavitary also other, it is not filled by liquid Full, lyophoby channel is also can be default, is not important because the effect of sealed opening or interface channel just seems, because For the leakage for not having liquid.

In addition, in other situations, it is also not necessary to which the structure in similar lyophoby channel is arranged, such as schemed institute Show (design 2 does not need lyophoby channel when being tightly connected the opening in channel with lid)

Draining element

In some preferred modes, the device of the invention can also include draining element, for excluding the second chamber inner part Divide liquid sample.Here so-called " draining element " is when an object enters in liquid sample, since the object has one Fixed volume, the volume can occupy the certain space of liquid, to exclude the liquid of certain volume, object enters the body of liquid Product is exactly to exclude the volume of liquid, which can be referred to as draining element.It is to be understood that for similar wheel Ship in water, due to steamer weight reasons and need to exclude the water of certain volume, steamer can occupy sky occupied by original water Between.Certainly, as being said above, if do not contain liquid in space, and contain gas, draining element enters Behind space containing gas, exclusion is exactly gas and on-liquid.

In other mode, for example, when the second chamber fills liquid sample, even if sealing element seals company Road is connected, still, the liquid of the second chamber is that complete complete essence fills out and is filled with liquid sample, when needing that the second chamber is torn open from the first chamber When unloading down, due to being all mechanically actuated, the liquid in the second chamber filled with can be overflowed due to mechanically actuated to be come, and is made At the unfriendly property of operation, the pollution to extraneous or operator also will cause.Even if in addition, carefully filling with liquid Second chamber of sample is taken off or is disassembled from the first chamber, and the opening that the second chamber is sealed with the second lid is also not allow Easy, such second chamber, which fills liquid during transportation, can also cause the risk of some leakages.So more more It in preferred mode, needs while sealing element is tightly connected channel perhaps later or before, it is also desirable to exclude the Outside partially liq sample to the second chamber in two chambers.To allow the liquid of the second chamber to be not that filling is full, thus, from the first chamber On liquid sample in the second chamber for separating do not overflow, increase the safety and friendly of operation, while also reducing The subsequent disclosure risk carried out in secondary detection transportational process also increases the close friend of the operation of subsequent second of detection Property and safety.

When the second chamber is disassembled from device, such as shown in Figure 13, there is certain space in the second chamber It reserves and, liquid is not just to fill with the second chamber, and in this way when disassembly, liquid sample would not overflow from the second chamber Out, the extraneous risk of pollution is reduced.

In some preferred modes, device further includes that the liquid sample of the second chamber of exclusion is first to the drain outside the second chamber Part.It is appreciated that draining element can be any structure or method for reducing by the second chamber liquid sample.Some preferred In mode, draining element is the extension of sealing element and is formed or draining element is located on sealing element.For example, In Fig. 2-3, Figure 18, the structure of meaning shown in 23,27,31,33.Such as in Fig. 2-3, sealing element 1028 and draining element 1027 are structure as a whole, and drainage structure 1017 and 1028 shape of sealing element are about the same, and only longitudinal size is less times greater than close Element is sealed, the size of sealing element is laterally less than.This when, the floor projection for being also possible to draining element are located at sealing member Alternatively, the floor projection of partial draining element is located within the floor projection of sealing element within the floor projection of part.This When, it is that draining element 1027 enters in interface channel first when sealing element enters interface channel, due to row The diameter of liquid element 1027 is smaller than the diameter of interface channel 109, owns, the surface that extra liquid sample passes through draining element Space or gap 809 between the surface of interface channel 109 are rejected to outside the second chamber 104 or 109 outside interface channel The first chamber 103 in, it is this when, close with entering further into the second chamber (such as Figure 22,12) for draining element 1027 Envelope element just starts the opening 1091 for being tightly connected channel 109, so that as described above, it is logical carry out hydraulic seal connection The sealing in road.Since draining element 1027 enters in the second chamber, the partially liq sample in the second chamber is eliminated.It is sealing Element 1028 is tightly connected the opening 1091 in channel at the beginning, at this point, being located at the liquid sample under interface channel opening 1091 It cannot be excluded by the space between the surface of draining element 1027 and the surface of interface channel 109, at this time if sealing Element also needs to move downward, this when, and draining element continues the liquid sample excluded and sealing element itself excludes The entrance that liquid sample just passes through lyophoby channel enters in lyophoby channel, hence into accommodating chamber.So some preferred Mode in, the entrance in lyophoby channel is located on draining element.More preferably, accommodating chamber is located in draining element.It can hold Readily understood, sealing element and draining element can be with one-time injection moldings.When injection molding, it is molded into hollow structure, from And accommodating chamber is formed to accommodate the liquid of discharge.

As front is said, it is discharged to outside in order to smoothly allow liquid to enter the entrance in lyophoby channel, drain member The trans D of part is less than the interior diameter of interface channel.For example, draining element can be the shape of back taper, and such as Figure 18 Draining element, i.e. pyramidal structure where the entrance 3025 in lyophoby channel.Such as the draining element 3027 in Figure 27 is back taper Structure.Pyramidal structure 4027 under sealing element 4029 shown in shown in Figure 31 and 32, the drain as shown in Figure 33-35 Structure 435 is formed by pyramidal structure.In fact, drainage structure does not need individual structure, if sealing element is enough Long, sealing element can be deep into the second chamber, this when, sealing element can play dual effect, that is, realize the The change of liquid communication state between two chambers and the first chamber, while also eliminating the second intracavitary partially liq.So row Liquid element is only restriction functionally, and non-individual needs other structure to realize.In fact, these pyramidal structures It can be used as draining element use, this is discussed in detail subsequent.

In other modes, for example, Figure 15,18,22-23, shown in 27, draining element 2027,3027 and sealing element 2028,3028 connection and sealing element extension and formed.Sealing ring 208 is set outside sealing element 2024, in this way, sealing Circle 208 is arranged on the surface of sealing element, slightly above the outer surface of sealing element 2014.Even if in this way, draining element 2017 diameter is as the diameter 2024 of sealing element, (example when draining element 2027 enters interface channel 209 Such as such as Figure 22), this when, sealing element and draining element enter in interface channel together, since draining element is located at end End, and sealing element is located at the upper surface of draining element, so, draining element is first into interface channel, if connection is logical There is liquid in road, draining element enters interface channel and the liquid that is discharged just passes through surface and the interface channel of draining element Gap 809 before inner surface enters in the first chamber 103.With the further movement of sealing element and draining element, Draining element 2027 enters in the first chamber, this when, sealing ring may be tightly connected the opening in channel 209 not yet 2091, as draining element 2027 further enters in the second chamber 204, liquid still can be excluded by gap 809 Into the first chamber 203.When the sealing ring 2023 on sealing element 2024 is tightly connected opening 2091 in channel 209, liquid Body cannot be rejected in the first chamber by gap 900.This when, sealing element and sealing ring are needed in interface channel Continue to move, reaches stable sealing effect.Continue movement to need to continue to exclude liquid sample, this when is extra to be arranged Liquid except liquid sample just pass through lyophoby channel inlet 2025 be rejected to interface channel and the second chamber in addition to.Such as pass through The import 2025 in lyophoby channel enters in lyophoby channel, then enters accommodating chamber 2029 by the liquid outlet in lyophoby channel In or the first chamber in.It allows the second chamber 204 and device to separate this when, such as Figure 24, shown in 28, is carried out with interface channel Separation, since draining element 2027 is located in the second chamber, eliminates the partially liq sample in the second chamber.When the second chamber from When disassembling in device, such as shown in Figure 28, in the second chamber there is certain space to be preserved to come out, liquid is not just The second chamber is filled with, in this way when disassembly, liquid sample would not be overflowed from the second chamber to be come, and it is extraneous to reduce pollution Risk.

It is appreciated that draining element, as the size of sealing element, sealing element is tightly connected before channel, connection Liquid in channel can not be excluded from gap, but be rejected to outside two interface channels by the liquid inlet in lyophoby channel Or second outside chamber.

In other some modes, sealing element and draining element are not divided significantly, such as such as Figure 31-32 institute Show there is no sealing ring, the extended segment of 5028 connection structures 5023 of draining element 5027 and sealing element on sealing element 5028 On, 5023 one end of connection structure is connect with the first lid 502, the other end and the connection of sealing element 5028 either connection structure End.Sealing element 5028 is connected with draining element 5027 again.And the feed liquor body 5025 in lyophoby channel is located at draining element On end, accommodating chamber, which is located in draining element, to be perhaps located in sealing element or is located in connection structure.Work as connection structure, When sealing element and draining element are hollow structure, the liquid outlet in lyophoby channel is communicated with accommodating chamber.It is retouched with reference to above It states, when such draining element 5027 is entered in interface channel, the liquid of exclusion is by being located at draining element end Inlet 5038 enter in lyophoby channel, then entered in accommodating chamber by the liquid outlet in lyophoby channel.Inlet can Such size is arranged, liquid is allowed to pass through, but is into the liquid of accommodating chamber due to the liquid at the place of inlet Body surface tension from inlet without leaking.This is because draining element once passes through the opening 2091 of interface channel, 1091 enter in interface channel 109,209, and the surface of draining element 5027 forms also close with the inner surface of interface channel 209 Envelope, this when, draining element and sealing structure are exactly the same structure, draining element play simultaneously be tightly connected channel with Exclude the double action of liquid.With movement of the draining element in interface channel, there can be one to the liquid in interface channel Pressure, the pressure reaction is to draining element, to increase the difficulty that draining element 4027 enters interface channel.In order to The reaction force for reducing liquid, allows extra liquid to enter the inlet 4025 in lyophoby channel, hence into positioned at drain 4029 in accommodating chamber in solution structure 4027.

After allowing the second chamber to separate with device, since draining element 1027 is located in the second chamber, eliminate in the second chamber Partially liq sample.Have when the second chamber is disassembled from device, such as shown in Figure 13, in the second chamber certain Space to be preserved come out, liquid is not just to fill with the second chamber, in this way disassembly when, liquid sample would not be from second It overflows to come in chamber, reduces the extraneous risk of pollution.In addition, being located in accommodating chamber due to the surface tension at inlet 3025 Liquid sample will not be leaked by inlet 3025.

In some modes, such as shown in Figure 33-35, it can use and seal using original part 5035 as draining element Element 5028 is located in connecting rod 5024, this when, the connection of draining element and sealing element for detachable, draining element 5035 whole lateral dimension is less than the size of sealing element 5028, such as the diameter of draining element is less than sealing element 5028 size (as shown in figure 33), the connection of draining element and sealing element are the connections of the mode of screw thread, such as schemed Shown in 35A and 35B, sealing element 5028 is hollow structure, and internal screw thread is arranged in inner surface, and draining element 5035 has one End upwardly extends section 5030, and external screw thread is arranged on extended segment, passes through the cooperation of internal and external threads in this way, so that it may make drain first Part links together with sealing element 5028.When allowing sealing element and draining element to enter in interface channel 209, Since the size of draining element is less than the size of interface channel, so, draining element is easily accessible interface channel, extra Liquid entered in the first chamber by the gap between draining element and interface channel.Lead to as sealing element is tightly connected After the opening 2091 in road 209, liquid cannot be entered in the first chamber by gap, as the connection that enters of sealing element is led to Road, the inlet 4025 that extra liquid just passes through lyophoby channel are entered in accommodating chamber or are entered in the first chamber.

In some preferred modes, referring again to Figure 33 and 35, the size of draining element 5035 and sealing element 5028 Diameter is suitable or the size of draining element is less than the diameter of sealing element, and just setting is extending the inlet 5025 in lyophoby channel In section 5030, by Figure 34 as can be seen that the diameter in the place with inlet 5025 is less than the straight of sealing element 5028 Diameter forms a sunk area again smaller than the diameter of draining element 5029 at inlet 5025.In this way, working as draining element 5035 when enter interface channel 209, and the liquid for being excluded structure 5029 exclusion just passes through the lyophoby channel of recess Inlet 4025 is excluded.Same reason finally enters with the interface channel that enters further into of draining element Come to the space of the second chamber, sealing element is tightly connected the opening 2091 in channel, finally enters in interface channel, the two One of or both the liquid that excludes can be excluded by the inlet 5025 in lyophoby channel, such as be rejected to receiving In chamber or the first chamber.It is appreciated that draining element is also preferred mode herein, be not complete it is of the invention necessary Mode.

The movement of sealing element or draining element

It talks about in front, sealing element is tightly connected channel, and draining element can also enter interface channel or enter In second chamber.These are all the processes of a movement, and the movement for starting these sealing elements and draining element is needed by certain External force or allow sealing element and/or draining element to be moved by other mechanical structure.So sealing element It is carried out with the mode that draining element can link, such as the movement for moving drive draining element of sealing element；For example, row Movement of the movement of liquid element with moving sealing element.

Here so-called " linkage " refers to that the movement an of object can directly or indirectly drive the fortune of another object Dynamic, in general, the motion mode of two objects is consistent, such as an object rotary motion, the object driven is also rotation Movement；Such as a plug-type movement of object, another object of drive are also plug-type movement.For another example, an object Body moves to the position of end from initial position, in this motion process, another substance is driven also to move to from initial position End position.Rotary motion can play the movement that end position is moved to from initial seat, and certainly, rotation and insertion can be with It is used in mixed way or is used alone.Here it moves and movement means the understanding that can be interchanged.

First lid is moved by the way of linkage with sealing element or draining element, i.e. the movement band of the first lid The movement of moving sealing element, to drive the movement of draining element.Alternatively, the first lid and person's draining element are using linkage Mode moves, i.e. the movement of the first lid drives the movement of draining element, thus the movement with moving sealing element.Some excellent In the mode of choosing, sealing element is located on the first lid, and when lid, which carries out lid, closes the opening of the first chamber, lid is driven Sealing element is attached the sealing in channel, forms sealing state.As noted-above, sealing element is to interface channel Sealing be generally divided into three states, first state is that sealing element will not be contacted with the opening of interface channel.For example, Shown in Figure 22, sealing element 2028 is had on the first lid 202, when lid, which carries out lid, closes the first chamber 203 opening 2031 It waits, band moving sealing element 2028 enters in the first chamber, and sealing element does not connect first opening 2091 in channel at this time (Figure 22), interface channel connects the first chamber and the second chamber at this time, meanwhile, the first chamber and the second chamber pass through channel progress liquid company It is logical.As cover cap is closed onto the opening 2031 of the first chamber, lid moves from the top down along the y direction of the first chamber, band Moving sealing element moves closer to the opening 2091 of interface channel.At this point, as the first lid further covers conjunction, sealing element 2028 contact with the first opening 2091 of interface channel 209, to seal the opening (Figure 23).It may be considered sealing at this time Interface channel 209.But, in order to guarantee more stable sealed connection channel, it is desirable to which sealing element enters interface channel 209 a distances, thus more stable sealed connection channel, at this point, there is still a need for the conjunctions of the lid of lid, to push sealing Element 2028 enters in interface channel.Similar process, the process shown in such as Figure 27.Either what type or It is a preferred mode that the sealing element of person's form, these sealing elements and lid carry out movement simultaneously.Certainly, lid Movement and the movement of sealing element can also be separated movement, such as the first lid is used to cover the opening for closing the first chamber, thus complete The process closed at lid.Sealing element but the sealing that interface channel is completed additionally by individual movement are not and the The collaboration of one lid is completed.

As for draining element, effect is exactly the partially liq excluded in the second chamber, as front is said, when second When hydraulically full in chamber, need draining element carry out liquid exclusion, still, if do not have in the second chamber it is hydraulically full, This when may there is no need to draining elements.So draining element is a preferred mode of the invention, being not must The mode of palpus.When needing draining element, draining element and lid can be allowed to be connected as one, in this way, lid Movement drives the movement of draining element, to be inserted into the exclusion for carrying out liquid in the second chamber.Certainly, as front is said, Sealing element and draining element are two different elements, moreover, draining element enters in the second chamber prior to sealing element. In preferred mode, draining element enters in interface channel prior to sealing element, hence into the second chamber.For this The design of sample, draining element is located at the end of sealing element, further from the first lid, to reach such Functional Design.

So the present invention provides a lid, and setting is used to close on the lid in some preferred modes of the present invention Seal the sealing element of interface channel.In some preferred modes, sealing ring is set on sealing element.In some preferred sides In formula, sealing element with the material of interface channel be as or be different.In some preferred modes, sealing member Part is material flexible, and interface channel is the material of rigidity.In some preferred modes, sealing element by connecting rod and First lid is linked together structure.It further include the opening in lyophoby channel on sealing element in some preferred modes.One In a little preferred modes, the opening in lyophoby channel is located under sealing element, alternatively, the opening in lyophoby channel is prior to sealing member Part enters in interface channel.It further include accommodating chamber on lid in some preferred modes, the accommodating chamber and lyophoby channel In fluid connection.The accommodating chamber is connected with the liquid outlet in lyophoby channel.In some preferred modes, accommodating chamber is located at close It seals in element.

In other preferred modes, draining element is also set up on the first lid, which compares sealing element Further from the first lid.Alternatively, draining element is arranged under sealing element, alternatively, sealing element and drain in this way, It allows draining element to enter in the second chamber prior to sealing element, leads to alternatively, draining element is allowed to enter connection prior to sealing element In road.Alternatively, working as connecting rod is set to connect the first lid and sealing element, while sealing element connected drainage member on lid Part.Alternatively, connecting rod and sealing element and draining element are structure as a whole.

In other mode, if the first chamber and the second chamber be not at the beginning for liquid communication state, but After the collection of first chamber has liquid sample, need that the first chamber and the second chamber is allowed to be in liquid flowing state, this when, lid can With with allowing the first chamber and the second chamber to be in the first element of flow regime and the first chamber and the second chamber allowed to be not at flow-like The second element of state.For example, it is to have sealing that the first chamber and the second chamber are not for the realization of liquid communication state at the beginning Element sealed at the very start interface channel first opening 1091, if lid moon first element and second linkage Words, allow first element to contact with sealing element first, such as when sealing element is the structure for being easy to puncture, first element is Sharp puncture structure, after puncturing, the liquid of the first chamber is advanced in the second chamber.Then, second element is allowed to seal first again Opening, to realize the change of liquid flowing state.It is thus possible to which the second chamber is allowed to separate with the first chamber.Those skilled in the art can To understand, it also may include draining element that second element, which can be the alternative of any sealing element described above, It can also be with the setting etc. in lyophoby channel.Such as in specific embodiment shown in prior figures 37-40.

First lid and the second lid

First lid is the lid for covering the first chamber of conjunction herein, and the second lid is to close opening for the second chamber for covering Mouthful.The specific example of lid can lid as shown in figures 1-28 shape.Certainly, lid plays the role of being exactly to cover in fact The opening of the first chamber is closed, the first lid is not necessarily required to the opening of the first chamber of sealing.But the main function of the second lid is For sealing the opening of the second chamber, it is allowed not lead to the leakage of liquid sample.So the second lid is located in some modes On first lid, the second lid is removably combined with the first lid.For example, the second lid passes through screw thread or other grafting Mode combine, when needing to be sealed usually liquid with the second lid and sealing the opening of the second chamber, from the The second lid is removed on one lid to seal the second chamber.

Liquid Sample Method is collected in detection

The present invention also provides the method for collecting liquid sample, this method includes providing the dress above-mentioned for collecting liquid sample Set, which includes the first chamber and the second chamber, wherein the second chamber and the first chamber are that dismountable mode connects, with the first chamber come Liquid sample is collected, liquid sample is allowed to be flowed into the second chamber.In some preferred modes, the collection of the second cavity is waited to have liquid When body sample, the second chamber and the first chamber is allowed to separate, to close the opening of the second chamber with the second cover cap.Some preferred Mode in, before allowing the first chamber and chamber to separate, the first chamber is allowed not to be in the state being in fluid communication with the second chamber.Some In preferred mode, allow sealing element that the first chamber and the second chamber is isolated, so that the first chamber and the second chamber be allowed to be not at circulation shape State.

In some preferred modes, the first chamber and the second chamber is allowed to link together by interface channel, wherein allowing connection First opening in channel and the first chamber fluid connection allow the second of interface channel to be open and the second chamber fluid connection.By allowing Two chambers are separated with interface channel, so that the second chamber be allowed to separate with the first chamber；Alternatively, allowing the second chamber and interface channel with detachable Mode connect, and interface channel is not connect removably with the first chamber；Alternatively, allow the second chamber and interface channel with Dismountable mode connects, and interface channel is allowed also removably to connect with the first chamber.

In some modes, when the second chamber is removably connect with the first chamber by interface channel, make sealing first Part is tightly connected channel.So the device further includes sealing element in some preferred modes, when in the second chamber and first Before chamber separation, sealing element is allowed to be tightly connected channel.In some preferred modes, which further includes lid, lid and close Envelope element is linked together structure, and when allowing cover cap to close the first chamber opening, while lid band moving sealing element sealed connection is logical First opening in road.In some preferred modes, lid band moving sealing element is allowed to enter in interface channel.Some excellent In the mode of choosing, after allowing sealing element to be tightly connected channel, the second chamber is allowed to separate with the first chamber.In some preferred modes, The draining element for excluding partially liq in the second chamber is also set up on lid, allows lid that draining element is driven to enter the In two chambers.In some preferred modes, sealing element and draining element are set on lid, allow draining element prior to sealing member Part enters in the second chamber.In some preferred modes, which further includes lyophoby channel, and draining element is allowed to be discharged Liquid sample is rejected to outside the second chamber by the lyophoby channel.In some preferred modes, sealing element is allowed to enter In interface channel, the liquid that sealing element is discharged is rejected to outside interface channel by lyophoby channel.In some preferred modes In, the liquid for allowing sealing element or draining element to exclude is discharged in the first chamber by lyophoby channel.In some preferred sides In formula, accommodating chamber is set on lid, the accommodating chamber and lyophoby channel are in fluid connection, wherein allow sealing element or The liquid that person/and draining element exclude is discharged in accommodating chamber by lyophoby channel.

In some modes, lyophoby channel have liquid inlet and liquid outlet, allow sealing element and draining element exclude Liquid enter liquid inlet, then enter accommodating chamber by the liquid outlet in lyophoby channel.

In other mode, sealing element is provided on lid, when by lid lid close the first chamber opening, To be tightly connected channel with moving sealing element.In some modes, if the first lid leaves the opening of the first chamber again When, sealing element simultaneously stays in interface channel, and the latter, sealing element is separated with lid.

On the other hand, the present invention provides a kind of method for detecting and whether there is analyte in liquid sample, described Method includes the fluid collection device of any one above-mentioned mode, after waiting the collection of the first chamber to have liquid sample, uses testing element Liquid sample from the first chamber is detected.After obtaining testing result, the second chamber is allowed to separate with the first chamber, according to upper Arbitrary mode is stated to be separated.In some specific modes, device further includes the test chamber for accommodating testing element, It is in flow communication in test chamber and the first chamber, after the collection of the first chamber has liquid sample, liquid is flowed into test chamber.When When test chamber includes testing element, after waiting testing elements to complete detection, the second chamber is allowed to separate with the first chamber.Some In preferred mode, allow liquid sample from first it is intracavitary be introduced into test chamber, then enter back into the second chamber.It is such Structure designs structure as previously described, so that the liquid for avoiding enter into test chamber also enters the second chamber, to pollute The liquid sample of second chamber.

Test chamber

Test chamber in the present invention is divided for carrying out whether there is for analysis test to the liquid sample from the first chamber Analyse substance.It can include testing element, the testing element and liquid in test chamber without detection device, generally in test chamber Body sample carries out contacting the chemical examination or test carried out to liquid sample.In traditional product, generally in manufacture with detection When the device of chamber, typically first makes testing element or testing element is allowed to be arranged on carrier, then again test Element is inserted into test chamber, then sealing detection chamber again.In this case, generally there is test chamber an opening to allow survey Examination element can enter and leave into test chamber.Such as illustrated in figs 1 and 9, test chamber 105 is in the opening 1031 close to the first chamber 103 Position have one opening 1051, and be placed on test carrier 106 on testing element (not shown) be located at test carrier card 1061 in slot, then carrier 106 is allowed to be inserted into test chamber by the opening of test chamber.Under normal conditions, it is inserted into test chamber Afterwards, it needs to be sealed the opening 1051 of test chamber, this sealing effect and quality requirement are very high, as front is explained It states, entire detection device or collection device require to carry out transportation and packaging together, in order to avoid being located at the liquid of test chamber The liquid of body or the first chamber is unlikely to reveal, and needs strictly to seal any place there may be leakage, and every One product requires the detection of being sealed property, increases production cost in this way.But use this it is of the invention have it is secondary After second chamber of confirmation, these were considered with the place for needing sealing effect good can not have to deliberately go to consider in the past, it is this close Envelope only needs temporary sealing with regard to much of that, and does not need to require persistent sealing.Such as shown in figure 9, for detection limit Opening 1051 sealing just using conventional sealing can, such as heat-sealing sealing is carried out with film, as long as guaranteeing examining When survey, the diaphragm seal is airtight or no leakage can, after completing detection, the second chamber and the first chamber is allowed to divide From rear, the first chamber and test chamber can be used as discard processing, without entire detection device is stored and transported.

Examples of implementation 1

It is illustrated how detection device of the invention assembles presently in connection with specific implementation example, how to operate.

Such as device shown in such as Fig. 1-3,6-14, the device include the first chamber 103 and the second cavity 104, the first chamber It is used to import the opening 1031 of liquid sample in 103.As shown in Figure 1, the first chamber is surrounded by side wall and bottom, in the first chamber Bottom has an elevated regions, such as shown in figure 9, elevated regions are located at the center of entire bottom, in elevated regions setting one It is a opening 1091, have one section of interface channel 109, the interface channel 109 first opening 1091 with communicated in the first chamber 103, separately One opening 1092 is communicated with the opening 1042 of the second chamber.Groove is formed around the elevated regions in the first intracavitary portion, the groove type At liquid sample collection region 1035,1036 (such as Fig. 7).It opposes in the outside close to the second opening 1092 of interface channel 109 Wall on setting 110 on be arranged helicitic texture 1101, the second chamber 104 opening 1042 outer wall be arranged helicitic texture 1041, the screw thread 1101 on the screw thread and wall 110 forms rotatable engagement, thus allow the second chamber 104 by interface channel 109 with First chamber forms detachable cooperation.Meanwhile further including test chamber 105, which passes through through-hole 1038 and the first chamber shape At fluid connection.It include testing element in test chamber.Testing element is arranged in 1061 in the card slot of test carrier 106.One As, the sample applying zone of testing element is located at test carrier and examines the region in nearly second bottom of chamber portion, or examines nearly test chamber bottom 1051 place, and the suction zone of testing element is close to the other end of test chamber (close to one end of the first chamber opening 1031).

Lid 102 is also provided, connecting rod 1023 is connected in the center of lid, the end of connecting rod is provided with sealing Sealing ring 108 is arranged on sealing element for element 1028.Meanwhile draining element 1027 is set under sealing element, drain member Part 1027 and sealing element and connecting rod 1023 are formed as one, only the division of unused functional area.Generally, even The length of extension bar 1023 and sealing element 1038 and draining element 1027 will be less times greater than the opening 1031 with the first chamber 103 To the distance of the opening 1042 of the second chamber 104, in this way, draining element 1027 can be allowed to enter in the second chamber 104, to rise To the second intracavitary partially liq sample of exclusion.Meanwhile the inlet in the lower section of sealing element 1028 setting lyophoby channel 1025 (Fig. 2 and 3).The inlet 1025 can be between draining element 1027 and sealing element 1028.Meanwhile sealing member Part, draining element and connecting rod are hollow structure, and inside includes accommodating chamber 1029 to collect extra liquid sample.? When use, the opening of the first chamber is first allowed to collect liquid sample, with the entrance of liquid sample, is converged in the bottom of the first chamber Collection gets up, and is then entered in test chamber by through-hole 1038, into the sample of liquid sample and testing element in test chamber Reagent areas contact, to be chemically examined and be detected.The opening for passing through interface channel with the increase of liquid, liquid sample In 1091 the second chambers entered, then, liquid sample is gradually filled with the second chamber 104, and then flood interface channel first opens Mouth 1091, final liquid level are higher than the first opening 1091 of interface channel 109.This stops collecting liquid sample in time.Then, First lid 102 is covered the opening 1031 for closing the first chamber 103.As cover cap runs mouth 1031 jointly, the rotation lid of lid is closed, Band moving sealing element 1028, the inlet 1025 in draining element 1027 and lyophoby channel close to interface channel 109 opening (such as Figure 10,11 and 12).With the rotation of lid, draining element 1027 is first into interface channel 109, at this time sealing element Sealing ring not yet close to interface channel first opening 1091.Liquid can pass through draining element 1027 and interface channel Gap between 109 enters in the first chamber 103.With entering in interface channel 109 for sealing element, the liquid excluded at this time Body is entered in accommodating chamber 1029 by the inlet 1025 in lyophoby channel, to exclude extra liquid sample, is also mitigated Sealing element enters the pressure of interface channel, to be easier to obtain preferable sealing.Equal draining elements enter the second chamber In after, at this point, sealing element also seals interface channel 109.This when, the testing element of test chamber detect for the first time It completes, it is believed that it is necessary to retain after remaining sample carries out secondary-confirmation chemical examination, by rotating the second chamber, allow the second chamber and first Chamber separates, since sealing element seals interface channel, so, the liquid sample positioned at the first chamber will not leak. Then the opening 1042 of the second chamber 104 is sealed with the second lid 101 being arranged on the first lid 102 (such as the institute of Figure 14 and 13 Show).The second lid individually can be carried out storage or packed and transported in this way and carry out secondary-confirmation chemical examination to chemical examination mechanism.

Examples of implementation 2

Such as such as Figure 15-18, shown in 23-28, shown in device, which includes the first chamber 203 and the second cavity 204, It is used to import the opening 2031 of liquid sample in first chamber 203.As shown in figure 16, the first chamber is surrounded by side wall and bottom, The bottom of one chamber has an elevated regions, such as shown in figure 24, elevated regions are located at the center of entire bottom, in convex area An opening 2091 is arranged in domain, has one section of interface channel 209, the interface channel 209 first opening 2091 and the first chamber 203 It inside communicates, another opening 2092 is communicated with the opening 2042 of the second chamber.It is formed around the elevated regions in the first intracavitary portion recessed Slot, the groove form liquid sample collection region 2035,2034 (such as Figure 24).In interface channel 209 close to the second opening Helicitic texture 2101 is set in setting 210 on the wall of 2092 outside opposition, is set in the outer wall of the opening 2042 of the second chamber 204 Helicitic texture 2043 is set, the screw thread 2101 on the screw thread and wall 210 forms rotatable engagement, so that the second chamber 204 be allowed to pass through company It connects road 209 and the first chamber forms detachable cooperation.Meanwhile a kind of carrier 206 being provided, there is a plurality of one end close on carrier One or more of test-strips are arranged in envelope 2062, the channel of another end opening 2063 in the channel, and the sample of test-strips applies Region is located at one end of opening 2063, has one or more channels for accommodating test-strips in carrier 206, each channel is set A testing element is set, when with multiple channels, the test member of different analysis substances can be set in each channel Part, in this way, can detect multiple analytes using the same sample.This carrier 206 is placed on the first chamber In 203, there are two positive stop strips 2032 and 2033 on the wall of chamber 203, carrier 206 is inserted into or snaps fit onto two limits In slot, allow the one end 2065 in the channel with opening close to the bottom of the first chamber, one end 2064 with sealed passage is close The opening 2031 (Figure 16) of first chamber.When liquid sample is flowed into the first chamber by the opening 2031 of the first chamber, liquid sample It is just contacted with the sample applying zone of test-strips, to complete to detect.

Lid 202 is also provided, connecting rod 2023 is connected in the center of lid, the end of connecting rod is provided with sealing Sealing ring 208 is arranged on sealing element for element 2028.Meanwhile draining element 2027 is set under sealing element, drain member Part 2027 and sealing element 2028 and connecting rod 2023 are formed as one, only the division of unused functional area.One As, the length of connecting rod 2023 and sealing element 2028 and draining element 2027 will be less times greater than the opening with the first chamber 203 The distance of the opening 2042 of 2031 to the second chamber 204, in this way, draining element 2027 can be allowed to enter in the second chamber 204, from And it plays and excludes the second intracavitary partially liq sample.Meanwhile the feed liquor in the lower section of sealing element 2028 setting lyophoby channel 2025 (Figure 18 and 26) of mouth.The inlet 2025 can be between draining element 2027 and sealing element 2028.

Meanwhile sealing element, draining element and connecting rod are hollow structure, inside includes accommodating chamber 2029 to receive Collect extra liquid sample.When in use, the opening of the first chamber is first allowed to collect liquid sample, with liquid sample into Enter, collects in the bottom of the first chamber, contacted immediately with the applying zone of the testing element on carrier, chemically examined and examined It surveys.With the increase of liquid, in the second chamber that the opening 2091 that liquid sample passes through interface channel enters, then, liquid-like Originally it is gradually filled with the second chamber 204, then floods the first opening 2091 of interface channel, final liquid level is higher than interface channel 209 First opening 2091.Again once adding with liquid, the position of setting is reached, receptive liquid sample is stopped, this stops receiving in time Collect liquid sample.Then, the first lid 202 is covered the opening 2031 for closing the first chamber 203.As cover cap runs mouth 2031 jointly, The rotation lid of lid closes, band moving sealing element 2028, and the inlet 2025 in draining element 2027 and lyophoby channel is close to connection The opening (such as Figure 22, shown) in channel 209.With the rotation of lid, draining element 2027 is first into interface channel 209 In, the sealing ring of sealing element is not tightly connected the of channel not yet close to the first opening 2091 of interface channel at this time One opening 2091.Liquid can enter the first chamber 203 by the gap 809 between draining element 2027 and interface channel 209 In.As sealing element is into the sealing in interface channel 209 to interface channel, sealing element or draining element at this time The liquid of exclusion is entered in accommodating chamber 2029 by the inlet 2025 in lyophoby channel, so that extra liquid sample is excluded, The pressure that sealing element enters interface channel is also mitigated, to be easier to obtain preferable sealing.Equal draining elements enter After into the second chamber, at this point, sealing element also seals interface channel 209.This when, the testing element of test chamber is For the first time or primary detection is completed, it is believed that after retaining remaining sample progress secondary-confirmation chemical examination, passes through rotation second Chamber allows the second chamber to separate with the first chamber, since sealing element seals interface channel, so, positioned at the liquid of the first chamber Sample will not leak.Then the opening of the second chamber 204 is sealed with the second lid 201 being arranged on the first lid 202 2042 (such as Figure 24).It is secondary really to the progress of chemical examination mechanism the second cavity individually can be carried out storage or packed and transported in this way Recognize chemical examination.

Examples of implementation 3

Such as device as shown in figs. 25-30, which includes the first chamber 303 and the second cavity 304, in the first chamber 303 For importing the opening 3031 of liquid sample.As shown in figure 27, the first chamber is surrounded by side wall and bottom, in the bottom of the first chamber With an elevated regions, such as shown in figure 27, elevated regions are located at the center of entire bottom, are arranged one in elevated regions Opening 3091, have one section of interface channel 309, the interface channel 309 first opening 3091 with communicated in the first chamber 303, it is another Opening 3092 is communicated with the opening 3042 of the second chamber.Groove is formed around the elevated regions in the first intracavitary portion, which forms Liquid sample collection region 3035,3036 (such as Figure 27).It close to the second opening 3092 is smooth outer in interface channel 309 Wall and inner wall.With a support holder structure 1004, which has an internal screw thread 10041, the internal screw thread and the first chamber The external screw thread of bottom is threadedly engaged.

Second chamber 304 is located in a base tray 1004, and base tray 1004 is removably to connect with the first chamber It connects, and the also combination detachable with the base tray 1004 of the second chamber 304.Specifically, support holder structure 1004 has interior spiral shell The external screw thread 3031 that the bottom of line, the internal screw thread and the first chamber 303 extends cooperates, to realize support holder structure 1004 and first The detachable combination of chamber 303.In this way, if as shown in figure 27, interface channel 309 still can have there is also interface channel The first opening 3091 of liquid flowing is in the first chamber and the second opening 3092 of liquid flowing is in the second chamber, and Interface channel has one section of extended segment 3098, which is deep into 3052 the inside of opening of the second chamber, in opening 3041 Wall contact, can be connected together, it may be assumed that the outer diameter of elongated area and the internal diameter matching of opening 3041.Although the second chamber and first Chamber can also be by the clamping connection as shown in Figure 27 of interface channel 109, but this connection does not need firmly to connect very much It connects, does not need closely to be connected as Fig. 8-9 (by modes such as screw threads), this is because support holder structure 1004 passes through spiral shell The external screw thread 3031 of the extended segment of line 10041 and the first chamber 103 cooperates, and no matter how much the second chamber 304 collects liquid sample in this way Amount not will cause the leakage problem between interface channel 109 and the second chamber opening 1042.So interface channel 109 is interior Diameter can allow interface channel to be inserted into the opening 3042 of the second chamber in this way less than the internal diameter of the opening 1042 of the second chamber, this The mode of kind insertion can be easily plugged into (shown in Figure 27).And only in the opening outer of opening 3042, setting screw thread is used for The lid of second lid closes (such as Figure 27).This when, as long as the connection of the opening of interface channel and the second chamber guarantees collecting Do not revealed when liquid sample can, can allow liquid enter the second chamber can, without more Structure limitation.Can being clamped of this connection, the form of piston type, lock is ok.In fact, allowing the first chamber and the second chamber Dismountable combination, in conjunction with or engagement to be indirect mode complete.

Lid 302 is also provided, connecting rod 3023 is connected in the center of lid, the end of connecting rod is provided with sealing Sealing ring is arranged on sealing element for element 3028, and sealing ring and sealing element are same material, and are once to be molded into Type.Meanwhile draining element 3027, the draining element 3027 and sealing element and connecting rod 3023 are set under sealing element It is formed as one, only the division of unused functional area.Generally, connecting rod 3023 and sealing element 3038 and drain The length of element 3027 will be less times greater than at a distance from the opening 3042 of the 3031 to the second chamber of opening 304 of the first chamber 303, this Sample can allow draining element 3027 to enter in the second chamber 304, exclude the second intracavitary partially liq sample to play.Together When, the inlet 3025 (Figure 27) in the lower section of sealing element 3028 setting lyophoby channel.The inlet 3025 can be located at row Between liquid element 3027 and sealing element 3028, or it is located on draining element.Meanwhile sealing element, draining element and Connecting rod is hollow structure, and inside includes accommodating chamber 3029 to collect extra liquid sample.When in use, it first allows The opening of first chamber is collected liquid sample and is collected with the entrance of liquid sample in the bottom of the first chamber.With liquid Increase, in the second chamber that liquid sample is entered by the opening 1091 of interface channel, then, liquid sample is gradually filled with Second chamber 304, then floods the first opening 3091 of interface channel, and final liquid level is higher than the first opening of interface channel 309 3091.This stops collecting liquid sample in time.Then, the first lid 302 is covered the opening 3031 for closing the first chamber 303.With Cover cap run mouth 3031 jointly, the rotation lid of lid closes, band moving sealing element 3028, draining element 3027 and lyophoby channel Opening of the inlet 3025 close to interface channel 309.With the rotation of lid, it is logical that draining element 3027 is first into connection In road 309, the sealing ring of sealing element is not yet close to the first opening 3091 of interface channel at this time.Liquid can pass through row Gap between liquid element 3027 and interface channel 309 enters in the first chamber 303.As the connection that enters of sealing element is led to In road 309, the liquid excluded at this time is entered in accommodating chamber 3029 by the inlet 3025 in lyophoby channel, to exclude more Remaining liquid sample also mitigates the pressure that sealing element enters interface channel, to be easier to obtain preferable sealing. After equal draining elements enter in the second chamber, at this point, sealing element also seals interface channel 309.

The liquid of the first chamber can be allowed to do subsequent primary detection to use, it is believed that it is necessary to retain remaining sample this when After this progress secondary-confirmation chemical examination, by rotary-tray structure, support holder structure is allowed to be detached from the first chamber, thus drive the second chamber with The separation of first chamber allows the second chamber to separate with the first chamber, since sealing element seals interface channel, so, it is located at the The liquid sample of one chamber will not leak.Then second is sealed with the second lid 301 being arranged on the first lid 302 The opening 3042 (such as Figure 28) of chamber 304.Support holder structure and the second chamber can be encapsulated together this when be sent to chemical examination mechanism into The secondary chemical examination of row.Alternatively, removing the second chamber from pallet, it is packaged and is used as secondary-confirmation chemical examination with (Figure 29).This When, pallet continues again to be gone on the first chamber, and the structure (Figure 30) of completion is formed.

Present invention content below is also a part as technical solution of the present invention.

1. a kind of device for receiving liquid sample includes: the first chamber for collecting liquid sample；It is used for really with being used to collect Recognize the second chamber of detection liquid sample；Wherein, the first chamber and the second cavity removably combine, and combine or connect.

2. the apparatus according to claim 1, wherein the first chamber and the second chamber are in the state of liquid communication.

3. the apparatus according to claim 1, wherein when the second chamber does not leave the first chamber, the first chamber and Second chamber is in liquid communication state.

4. the apparatus according to claim 1, wherein before the second chamber leaves the first chamber, or will leave Before first chamber, the first chamber and the second chamber are not at liquid flowing state.

5. the apparatus according to claim 1, wherein first chamber and the second chamber is by detachable mode It fits together.

6. the apparatus according to claim 1, wherein second chamber is located at below the first chamber, alternatively, working as When collecting liquid, liquid is introduced into the first chamber, the second chamber is then entered back into, alternatively, the second chamber is under the first chamber Trip；Alternatively, liquid enters the first and second chambers simultaneously when collecting liquid；Alternatively, partially liq sample enters first Chamber, another part liquid sample enter the second chamber.

7. the apparatus according to claim 1, wherein the fluid communication between the first chamber and the second chamber includes One of following state is several: fluid circulation, fluid not circulation status.

8. the apparatus according to claim 1, wherein the first chamber and the second chamber are first in the state that liquid does not circulate, Then it is being in liquid communication state, again finally is being at liquid not circulation status.

9. the apparatus according to claim 1, wherein the first chamber and the second chamber are first in liquid communication state, then It again is at liquid not circulation status.

10. device described in one of -9 according to claim 1, wherein when the first chamber and the second chamber are in liquid communication shape When state, the first chamber and the second chamber are removably combined, alternatively, when the first chamber and the second chamber are in liquid and do not flow When logical state；First chamber and the second chamber can be separated or be had been separated from.

11. device according to claim 10, wherein when the first chamber and the second chamber are in the shape that liquid does not circulate State, the first chamber and the second chamber are removably combined.

12. device described in one of -11 according to claim 1, wherein the device further includes sealing element, sealing member Part can change the liquid communication state between the first chamber and the second chamber；Alternatively, the device further includes puncturing elements, this is punctured Element can allow the state not circulated in liquid to change into the state that liquid flows；Alternatively, the device further includes sealing element And puncturing elements, first allow puncturing elements that the first chamber and the second chamber is allowed to be in liquid communication state, then by sealing element by liquid Body is in the state not circulated.

13. device according to claim 12, wherein the sealing element before the second chamber leaves the first chamber, or Before the second chamber of person is separated with the first chamber or before will separating, the first chamber and the second chamber is allowed to be not at liquid communication state.

14. device described in one of -13 according to claim 1, the device further includes an interface channel, described The second chamber removably combine, combine or assemble with the first chamber by interface channel, or/and, second chamber and First chamber is in fluid connection by the interface channel or is not at fluid connection state.

15. device described in one of -13 according to claim 1, wherein the device further includes an interface channel； Second chamber and the first chamber is in fluid connection by the interface channel.

16. requiring the device according to right 15, wherein when the second chamber does not leave the first chamber, connection is logical Road is not sealed with；Alternatively, interface channel is sealed before or after the second chamber leaves the first chamber.

17. requiring the device according to right 16, wherein interface channel, which is sealed, to be sealed by sealing element.

18. device according to claim 15, wherein the device further includes sealing element, which is used for Sealed passage is not at liquid communication state to allow between the first chamber and the second chamber.

19. device described in one of -13 or one of 17-18 according to claim 1, wherein the device further includes Lyophoby channel, lyophoby channel have inlet.

20. device according to claim 19 is alternatively, the inlet is located under sealing element, alternatively, When sealing element carrys out sealed passage, the inlet, close to interface channel, is sealed prior to sealing element alternatively, working as When element enters interface channel, the inlet is located under the horizontal position of sealing element；Alternatively, when sealing member When part enters interface channel, the inlet enters interface channel prior to sealing element.

21. device according to claim 20, wherein the inlet is located on sealing element.

22. device according to claim 20, wherein the inlet is located on the side wall of interface channel.

23. device according to claim 20, wherein the lyophoby channel also has liquid outlet, and described goes out Liquid mouth and an accommodating chamber fluid connection.

24. device according to claim 23, wherein the accommodating chamber is located on sealing element.

25. device according to claim 20, wherein the lyophoby channel also has liquid outlet, and described goes out Liquid mouth and the first chamber are in fluid communication.

26. requiring the device according to one of right 1-25, wherein the device further includes for excluding second The draining element of partially liq sample in chamber.

27. device according to claim 26, wherein before the second chamber and the separation of the first chamber, the drain Element is located in second chamber or part is located in the second chamber.

28. device according to claim 26, wherein after the second chamber and the first chamber separate, described second Without containing draining element or without containing part draining element in chamber.

29. device described in one of 2-25 according to claim 1, wherein the device further includes for excluding second The draining element of partially liq sample in chamber；The draining element is located on sealing element or is linked as one with sealing element Body；.

30. device according to claim 29, wherein the draining element enters company prior to sealing element It connects in road or draining element enters in the second chamber prior to sealing element；Alternatively, when sealing element is located at interface channel When middle, draining element is located in the second chamber.

31. device according to claim 29, wherein the device further includes lyophoby channel, lyophoby channel tool There is inlet, the inlet is located on draining element；Alternatively, the device includes accommodating chamber, the accommodating chamber position In on draining element.

32. device according to claim 28, wherein the inlet and an accommodating chamber fluid connection, it is described Accommodating chamber be located in draining element.

33. device according to claim 17, wherein the partial region of the sealing element is as excluding the The draining element of two intracavitary partially liqs uses.

34. device according to claim 33, wherein the portion sealing element is used to be tightly connected channel, Portion sealing element is used to exclude the partially liq of the second chamber.

35. device according to claim 33, wherein the portion sealing element is used to be tightly connected channel, Portion sealing element is located in the second chamber.

36. device according to claim 29, wherein the vertical projection region of the draining element is located at close It seals in element upright view field.

37. device described in one of 2-19 or 17-18 according to claim 1, wherein the device further includes lyophoby Channel, lyophoby channel have inlet, and the vertical projection of the inlet is located in the vertical view field of sealing element.

38. device described in one of -11 according to claim 1, wherein the device further includes the first and second sealings member Part, first sealing or the second sealing element can change the liquid communication state between the first chamber and the second chamber.

39. the device according to claim 37, wherein described is logical for being tightly connected with the first sealing element Road, second seal are used to seal the opening of the second chamber, alternatively, the opening of the second chamber is sealed with the first sealing element, second Sealing element is used to be tightly connected first opening in channel.

40. the device according to claim 38, wherein when the opening for sealing the second chamber with the first sealing element Simultaneously or after sealing, the seat of the second chamber is allowed to change from first position to the second position；Or the second chamber is allowed to be detached from second Chamber.

41. device described in one of 7-39 according to claim 1, wherein the sealing element or draining element is joined It is dynamic to be moved.

42. device according to claim 41, wherein the linkage, which be used to cover, closes the first chamber opening lid It is moved.

43. according to device described in claim 41 or 42, wherein the movement is rotational motion.

44. a kind of method for collecting liquid sample, the method include:

A kind of collection device is provided, which includes for collecting the first chamber of liquid sample and collecting liquid sample Second chamber, wherein first chamber and the dismountable mode of the second chamber combines, combination or assembling；Collecting liquid sample Before, allow the first chamber and the second chamber to be in fluid connection state, so as to allow the liquid for entering the first chamber to flow in the second chamber.

45. according to the method for claim 44, wherein after the first chamber has collected liquid sample, allow the first chamber and Second chamber is not at liquid communication state.

46. according to the method for claim 45, wherein when the first chamber and the second chamber are not at liquid communication state When, the second chamber is separated from the first chamber, or the first chamber is allowed to separate with the second chamber.

47. according to the method for claim 44, wherein the liquid sample of the second chamber of entrance is allowed to derive from first Liquid sample in chamber；It allows and liquid while entering the first and second chambers；Alternatively, partially liq sample is allowed to enter first, another portion Liquid sample is divided to enter the second chamber.

48. according to the method for claim 44, first chamber and the second chamber are connected by interface channel, In, the second chamber removably combines with interface channel, combination or assembling；Alternatively, by the interface channel, allow the first chamber and Second chamber is in liquid communication state.

49. according to the method for claim 48, allowing the first chamber and the second chamber to be not at liquid communication state is to pass through It is realized with the sealing element sealing channel.

50. according to the method for claim 49, the channel has the first opening being in fluid communication with the first chamber With the second opening being in fluid communication with the second chamber, sealing element is allowed to be tightly connected first opening in channel.

51. according to the method for claim 50, wherein after allowing sealing element to be tightly connected first opening in channel, Portion sealing element is allowed to enter in channel.

52. the method according to one of claim 44-51, wherein in a device further include lyophoby channel, this is dredged Liquid channel includes inlet.

53. method according to claim 52, wherein close when allowing portion sealing element to enter in channel The liquid sample that envelope element excludes is rejected to outside interface channel or outside the second chamber by inlet, if liquid sample exists In the case where.

54. method according to claim 53, wherein the liquid sample that sealing element excludes passes through lyophoby channel It is rejected in accommodating chamber.

55. according to the method for claim 50, wherein it in a device further include lyophoby channel, lyophoby channel packet Inlet is included, inlet is allowed to enter in interface channel prior to sealing element.

56. the method according to one of claim 48-56, wherein in a device further include for excluding the second chamber In partially liq draining element.

57. method according to claim 56, wherein when with sealing element, allow draining element prior to Sealing element enters or examines closely into interface channel.

58. method according to claim 57, wherein allow draining element to enter in the second chamber, or allow part Draining element enters in the second chamber.

59. method according to claim 54, wherein after the second chamber is separated with the first chamber, allow the drain Element is not located in the second chamber.

60. method according to claim 57, wherein sealing element is allowed to be tightly connected first opening in channel When, it allows draining element to enter in the second chamber, alternatively, sealing element is allowed to enter interface channel, draining element is allowed to enter the second chamber In.

61. method according to claim 56, sealing element and draining element ganged movement are allowed.

62. method according to claim 61, the linkage is that the lid for closing the first chamber by lid is joined It is dynamic.

1. a kind of device for receiving liquid sample includes: the first chamber for collecting liquid sample；It is used for really with being used to collect Recognize the second chamber of detection liquid sample；Wherein, first chamber has the opening for receiving liquid sample, and the second chamber, which has, to be connect Receive the opening of the liquid sample in the first chamber.

2. the apparatus according to claim 1, wherein the device further includes support holder structure, and the second chamber quilt can The setting of detachable is on support holder structure, the support holder structure and the detachable combination of first chamber.

3. the apparatus of claim 2, wherein when support holder structure and the first chamber are combined, the Two chambers and the second chamber are in liquid communication state.

4. the device according to shown in claim 3, wherein first chamber includes a hole, the opening in the hole and the second chamber In liquid communication state；Alternatively, the liquid sample of the first chamber can be flowed into second by the gravity that liquid itself is subject to In chamber.

5. device according to claim 3, wherein the hole is open for the first of interface channel, and described second Chamber realizes the fluid communication between the first chamber by interface channel；Or the hole has a channel extended, described the Two chambers realize the fluid communication between the first chamber by the channel of the extension.

6. device according to claim 5, wherein the channel of the interface channel or extension has first Opening and the second opening, first opening are in fluid communication with the first chamber, and the second opening is in fluid communication with the second chamber.

7. according to device described in claim 5 or 6, wherein the device further includes logical for being tightly connected Road, the channel of extension or hole sealing element.

8. device according to claim 7, wherein the sealing element can by be tightly connected channel or First opening or portion sealing element in the channel that person extends enter the channel of interface channel or extension to seal.

9. device described in one of -7 according to claim 1, wherein the device further includes lyophoby channel.

10. device according to claim 9, wherein lyophoby channel includes inlet, and the inlet is located at Under sealing element, alternatively, when sealing element is to be tightly connected channel or extend channel, the inlet Perhaps extend channel alternatively, when sealing element enters interface channel or extends close to interface channel prior to sealing element When channel, the inlet is located under the horizontal position of sealing element；Alternatively, leading to when sealing element enters connection When road, the inlet enters interface channel prior to sealing element.

11. device described in -7 according to claim 1, wherein the device further includes lyophoby channel, and described dredges Liquid channel includes liquid inlet, and the view field of the liquid inlet is located within sealing element view field.

12. device described in 0 or 11 according to claim 1, wherein the inlet is located on sealing element.

13. according to claim 10 or the device, wherein the inlet is located at the side wall of interface channel On.

14. according to claim 13 or the device, wherein the inlet is lower than interface channel opening Position

15. the device according to one of claim 9-14, wherein the lyophoby channel also has liquid outlet, institute The liquid outlet and an accommodating chamber fluid connection stated.

16. device according to claim 15, wherein the accommodating chamber is located on sealing element.

17. the device according to one of claim 9-14, wherein the lyophoby channel also has liquid outlet, institute The liquid outlet stated and the first chamber are in fluid communication

18. device according to claim 7, wherein the device further includes lyophoby channel, the lyophoby Channel includes liquid inlet, and the partially liq forced by sealing element enters lyophoby channel by liquid inlet, to be excluded To channel and the second chamber except.

19. device described in -18 according to claim 1, wherein the device includes for excluding in the middle part of the second chamber Divide the draining element of liquid sample.

20. device according to claim 19, wherein the device further includes lyophoby channel, the lyophoby Channel includes liquid inlet, and the liquid inlet is located on draining element.

21. device according to claim 19, wherein the draining element and sealing element is linked together knot Structure, when with sealing element.

22. device according to claim 21, wherein when with sealing element come sealed passage, drain member Part enters in the second chamber prior to sealing element.

23. device described in one of -22 according to claim 1, wherein the lyophoby channel includes liquid outlet, described Liquid outlet and an accommodating chamber fluid connection.

24. device according to claim 23, wherein when the portion sealing element enters interface channel Come, the accommodating chamber, which is used to receive sealing element, enters the liquid sample that interface channel is discharged.

25. according to claim 24 or the device, wherein the accommodating chamber be located in sealing element or In draining element.

26. device according to claim 21, wherein the view field of the draining element is located at sealing member Within the vertical projection region of part.

27. device according to claim 26, wherein the trans D of the draining element is less than sealing member The trans D of part.

28. device according to claim 27, wherein the interface channel is cylindrical, described sealing Element is also cylindrical.

29. device described in one of -28 according to claim 1, wherein the device further includes closing first for covering First lid of chamber opening.

30. device according to claim 29, wherein the lid and sealing element ganged movement, the latter's lid Body and draining element ganged movement, alternatively, lid and sealing element and draining element ganged movement.

31. device according to claim 30, wherein described when the first cover cap closes the first chamber opening Sealing element with lid lid close and come seal the first of the interface channel opening or subelement enter company It connects in road.

32. device according to claim 30, wherein the device further includes draining element, the drain Element is connect with sealing element.

33. device according to claim 32, wherein the draining element is than sealing element far from described First lid.

34. device according to claim 30, wherein the sealing element passes through connecting rod and the first lid Connection.

35. device according to claim 34, wherein the sealing element is removably connect with connecting rod.

36. device described in one of -35 according to claim 1, wherein the device further includes lyophoby channel, described Lyophoby channel include liquid inlet, the view field of the liquid inlet is located within sealing element view field.

37. device according to claim 36, wherein the liquid inlet is than sealing element far from the first lid.

38. the device according to claim 37, wherein the liquid inlet is located on draining element.

39. the device according to claim 37, wherein when the sealing element is tightly connected channel, The draining element or part draining element is located in the second chamber.

1. a kind of method for collecting liquid: this method comprises:

A kind of device for collecting liquid sample is provided, wherein the device includes: the first chamber for collecting liquid sample, Wherein, first chamber has the opening for receiving liquid sample；With

For collecting the second chamber for confirming detection liquid sample, the second chamber, which has, to be received from liquid in the first chamber The opening of sample；

Support holder structure, the support holder structure include the second chamber, wherein support holder structure and the detachable combination of the first chamber are tied It closes or combines；

Liquid sample is collected with the first chamber, liquid sample is allowed to enter in a chamber by the opening of the first chamber.

2. the hole and the second chamber form liquid according to the method described in claim 1, wherein, the first chamber has a hole Body circulation.

3. according to the method described in claim 2, wherein, before carrying out liquid collection, making the first chamber and the second chamber logical It crosses the hole and forms fluid connection state.

4. when collecting liquid, liquid is allowed to enter the first chamber according to the method described in claim 2, wherein, Then liquid is allowed to be flowed into the second chamber from the first chamber by the hole automatically；Liquid while the first chamber and are entered alternatively, allowing Two chambers；Alternatively, partially liq is allowed to enter the first chamber, another liquid is allowed to enter in the second chamber.

5. according to the method described in claim 2, wherein, the hole has the extension channel extended, the part Extend channel to be located in the second chamber, alternatively, the opening of second chamber of part is located in the passage portion, thus shape At fluid connection.

6. according to the method described in claim 5, wherein, after the completion of liquid sample collection, a sealing element is allowed to seal The hole extends channel, thus, it is possible to which the second chamber and the first chamber is allowed to be not at fluid communication.

7. according to the method described in claim 6, wherein, after the second chamber and the first chamber are not at fluid communication, support is allowed Disk leaves the first cavity, so that the second chamber be driven to leave the first chamber.

8. according to the method described in claim 7, wherein, the second chamber is allowed to be detached from the pallet.

9. according to the method described in claim 8, wherein, before allowing the second chamber to be detached from the pallet after the latter, using Second cover cap closes the opening of second chamber, to form the second chamber of sealing.

10. method described in one of -9 according to claim 1, wherein the first lid that lid closes the first chamber opening is provided, The sealing element is set on the lid, lid and sealing element is allowed to carry out ganged movement.

11. according to the method described in claim 10, wherein, during the opening for closing the first chamber with lid, lid band The liquid that moving sealing element is formed between the first chamber and the second chamber does not circulate.

12. according to the method described in claim 10, wherein, lid seals the first chamber and second with moving sealing element Hole or extension channel between chamber.

13. according to the method described in claim 10, wherein, lid band moving sealing element allows portion sealing element to enter Into extension channel.

14. according to the method described in claim 10, wherein, the lid further includes draining element, the drain Element is than sealing element far from lid.

15. described dredges according to the method described in claim 10, further including lyophoby channel in the lid wherein Liquid channel includes liquid inlet, allows the position of liquid inlet than sealing element further from lid；Alternatively, allowing liquid inlet prior to sealing member Part, which enters, to be extended in channel.

16. according to the method for claim 15, wherein the view field of the liquid inlet is located at sealing element Within view field.

17. according to the method for claim 15, wherein the partially liq forced by sealing element is by entering liquid Mouth enters lyophoby channel, to be rejected to except channel and/or the second chamber.

18. method described in one of 4-17 according to claim 1, wherein the lyophoby channel includes liquid outlet, institute The liquid outlet and an accommodating chamber fluid connection stated.

19. according to the method for claim 18, wherein the accommodating chamber is located in sealing element or drain In element or in lid.

20. according to the method for claim 19, wherein when the portion sealing element enters interface channel Come, the accommodating chamber, which is used to receive sealing element, enters the liquid sample that interface channel is discharged.

21. according to the method for claim 19, wherein when draining element enters in the second chamber, the drain is first Also sample enters in accommodating chamber for the part that part excludes.

1. the detection device of analyte includes: the first chamber for collecting liquid sample in a kind of detection sample；With For collecting the second chamber for confirming detection liquid sample, wherein first chamber, which has, receives opening for liquid sample Mouthful, the second chamber has the opening for receiving the liquid sample in the first chamber, wherein the device further includes testing element.

2. the apparatus according to claim 1, wherein the device further includes support holder structure, the support holder structure It is removably connect with the first chamber, wherein second chamber is arranged on pallet, second chamber passes through the support Disk and dismountable combination with the first chamber, combination or connection.

3. the apparatus of claim 2, wherein second chamber by a channel realize with the first chamber it Between fluid communication.

4. the apparatus of claim 2, wherein the channel has the first opening and the second opening, described First opening with the first chamber be in fluid communication, second opening with the second chamber be in fluid communication.

5. device according to claim 4, wherein the device further includes for being tightly connected the close of channel Seal element.

6. device according to claim 5, wherein the sealing element in the sealed connection channel can pass through The first opening or portion sealing element of sealed passage enter interface channel to seal.

7. device according to claim 5, wherein the device further includes lyophoby channel, and the lyophoby is logical Road includes liquid inlet and liquid outlet, and the liquid inlet is located at the region under sealing element.

8. device according to claim 5, wherein the device further includes lyophoby channel, and the lyophoby is logical Road includes liquid inlet and liquid outlet, and the view field of the liquid inlet is located within sealing element view field.

9. device according to claim 5, wherein the device further includes for excluding part in the second chamber The draining element of liquid, the draining element and sealing element link together.

10. device according to claim 9, wherein the device further includes lyophoby channel, the lyophoby Channel includes liquid inlet, and the liquid inlet is located on draining element.

11. device according to claim 10, wherein the lyophoby channel includes liquid outlet, and described goes out liquid Mouth and accommodating chamber fluid connection, the accommodating chamber are used to the liquid that structure draining element excludes.

12. device according to claim 11, wherein when the portion sealing element enters channel, institute The accommodating chamber stated, which is used to receive sealing element, enters the liquid sample that interface channel is discharged.

13. according to claim 11 or the device, wherein the accommodating chamber be located in sealing element or In draining element.

14. device according to claim 9, wherein the view field of the draining element is located at sealing element Vertical projection region within.

15. device according to claim 14, wherein the trans D of the draining element is less than sealing member The trans D of part.

16. device according to claim 5, wherein the interface channel is cylindrical, described sealing Element is also cylindrical.

17. device according to claim 4, wherein the device further includes being open for covering the first chamber of conjunction First lid is provided with the sealing element on the lid, thus when the first cover cap closes the first chamber opening It waits, the sealing element is with the lid conjunction of lid and to seal the first of the interface channel the opening or subelement It enters in interface channel.

18. device according to claim 17, wherein the device further includes draining element, the drain Element is connect with sealing element.

19. device according to claim 18, wherein the draining element is than sealing element far from described First lid.

20. device according to claim 19, wherein the sealing element passes through connecting rod and the first lid Connection.

21. device according to claim 20, wherein the sealing element is removably connect with connecting rod.

22. device according to claim 18, wherein the device further includes lyophoby channel, the lyophoby Channel includes liquid inlet, and the view field of the liquid inlet is located within sealing element view field.

23. device according to claim 22, wherein the liquid inlet is than sealing element far from the first lid.

24. device according to claim 23, wherein the liquid inlet is located on draining element.

25. device according to claim 18, wherein described when the sealing element sealed passage Draining element or part draining element be located in the second chamber.

26. the apparatus according to claim 1, wherein the device further includes test chamber, the test chamber and the first chamber It is in fluid communication, the testing element is located in test chamber.

27. the apparatus according to claim 1, wherein the device further includes a carrier, includes more on carrier A channel for accommodating testing element, it is intracavitary that the carrier is located at first.

28. device according to claim 27, wherein the sample applying zone of the testing element is located at the The bottom of one chamber.

1. a kind of cavity for collecting liquid sample, which is characterized in that the cavity includes:

Side wall；

Bottom；And the opening for receiving liquid, wherein the bottom has one to allow into the liquid in cavity Sample flows to the hole outside cavity.

2. cavity according to claim 1, which is characterized in that have in the cavity bottom to cavity convex The region risen, the region of the protrusion and side wall form liquid sample collection region.

3. cavity according to claim 2, which is characterized in that the sample pooling region is provided for connecing Acceptance Tests carrier.

4. cavity according to claim 3, which is characterized in that include testing element on the test carrier.

5. cavity according to claim 2, which is characterized in that include the hole on the elevated regions.

6. cavity according to claim 5, which is characterized in that the hole has the channel extended.

7. cavity according to claim 6, which is characterized in that the channel extend into cavity and/or to Extend outside cavity.

8. cavity according to claim 6, which is characterized in that the channel extends to outside cavity.

9. cavity according to claim 5, which is characterized in that the elevated regions have one flat in the cavity Platform structure includes the hole on the platform structure.

10. according to cavity described in claim 7 or 8, which is characterized in that the cavity further includes in bottom The length of elongated area, the elongated area exceeds or equal to the length for extending channel.

11. cavity according to claim 6, which is characterized in that the position in the hole is higher than pooling zone bottom Position, alternatively, allowing liquid to arrive first pooling zone, then in inflow hole when collecting liquid.

1. a kind of lid, which is characterized in that the lid includes sealing element.

2. lid according to claim 1, which is characterized in that the lid is to close cavity hatch for covering Lid.

3. lid according to claim 1, which is characterized in that the lid further includes connection rod structure, described Connecting rod one end connect lid, the other end connection sealing element.

4. lid according to claim 3, which is characterized in that the sealing element is the end of part connecting rod End or sealing element are structure as a whole with connecting rod.

5. lid according to claim 3, which is characterized in that the sealing element is elastic material.

6. lid according to claim 3, which is characterized in that the sealing element and connecting rod is detachable Connection.

7. lid according to claim 3, which is characterized in that the sealing element and connecting rod grafting, spiral shell Line, buckle mode connect.

8. lid according to claim 3, which is characterized in that the sealing element and connecting rod is hollow Structure.

9. lid according to claim 3, which is characterized in that the sealing element and connection should be disposable Injection molding.

10. lid according to claim 3, which is characterized in that the sealing element includes sealing ring.

11. lid according to claim 10, which is characterized in that the material of the sealing ring and sealing element It is the same, or the sealing element containing sealing ring is one-time injection molding.

1. a kind of lid, which is characterized in that the lid includes sealing element and draining element.

3. lid according to claim 1, which is characterized in that the lid further includes connection rod structure, described Connecting rod one end connect lid ontology, the other end connection sealing element and draining element.

6. lid according to claim 3, which is characterized in that the sealing element is connect with draining element.

7. lid according to claim 6, which is characterized in that the draining element is than sealing element far from institute The ontology for the lid stated.

8. lid according to claim 7, which is characterized in that the vertical projection of the draining element is located at close It seals within the vertical projection region of element or is overlapped.

9. lid according to claim 7, which is characterized in that the trans D of the draining element is less than close Seal the trans D of element.

10. lid according to claim 7, which is characterized in that the cone shape of the draining element.

11. lid according to claim 3, which is characterized in that the sealing element, connecting rod, draining element One of include hollow cavity, alternatively, sealing element, connecting rod, draining element are all hollow structure.

1. a kind of lid, which is characterized in that the lid includes sealing element and draining element and accommodating chamber.

2. lid according to claim 1, which is characterized in that the lid further includes connection rod structure, described Connecting rod one end connect lid ontology, the other end connection sealing element and draining element.

3. lid according to claim 3, which is characterized in that the sealing element is the end of part connecting rod End or sealing element are structure as a whole with connecting rod.

4. lid according to claim 3, which is characterized in that the sealing element is elastic material.

5. lid according to claim 3, which is characterized in that the sealing element is connect with draining element.

6. lid according to claim 6, which is characterized in that the draining element is than sealing element far from institute The ontology for the lid stated.

7. lid according to claim 1, which is characterized in that the sealing element, connecting rod, draining element One of include hollow cavity, alternatively, sealing element, connecting rod, the hollow structure of draining element multidigit, the accommodating chamber Hollow cavity or hollow structure for part.

8. lid according to claim 7, which is characterized in that the trans D of the draining element is less than close Seal the trans D of element.

9. lid according to claim 7, which is characterized in that the cone shape of the draining element.

10. lid according to claim 1, which is characterized in that the accommodating chamber is located at connecting rod, sealing member In part or draining element.

1. a kind of lid, which is characterized in that the lid includes sealing element and lyophoby channel, and the lyophoby is logical Road includes liquid inlet and liquid outlet.

2. lid according to claim 1, which is characterized in that the lid further includes connection rod structure, described Connecting rod one end connect lid ontology, the other end connection sealing element.

3. lid according to claim 1 or 2, which is characterized in that the liquid inlet in the lyophoby channel is than close Seal ontology of the element far from lid.

4. lid according to claim 3, which is characterized in that the sealing element is connect with draining element.

5. lid according to claim 3, which is characterized in that the liquid inlet in the lyophoby channel is located at drain On element.

6. lid according to claim 3, which is characterized in that the sealing element includes sealing ring, described Ontology of the liquid inlet in lyophoby channel than sealing ring far from lid.

7. lid according to claim 3, which is characterized in that further include accommodating chamber on the lid, wherein The liquid outlet and accommodating chamber in the lyophoby channel are in fluid communication.

8. lid according to claim 1, which is characterized in that the sealing element, connecting rod, draining element One of include hollow cavity, alternatively, the structure that sealing element, connecting rod, draining element multidigit are hollow, the lyophoby is logical The liquid outlet in road is connected to the hollow cavity or hollow structural fluid.

9. lid according to claim 3, which is characterized in that the liquid outlet in the lyophoby channel is than sealing member Ontology of the part far from lid.

10. lid described in one of -9 according to claim 1, which is characterized in that the vertical projection of the draining element In the vertical projection region of sealing element or it is overlapped.

1. a kind of device for collecting liquid sample, which is characterized in that it includes the first cavity and the second cavity, wherein The cavity bottom has to the region of cavity internal projection, and the elevated regions form the sky relative to the first chamber protrusion Between, to form the space relative to bottom notch, second chamber of part is located in the sunk area.

2. sample collection device according to claim 1, intracavitary described first includes hole, the Kong Yu The opening of two chambers forms liquid communication state.

3. sample collection device according to claim 1, the device further includes interface channel, described Two chambers are by forming detachable combination, combination or assembling with interface channel.

4. the opening of sample collection device according to claim 3, second chamber includes external screw thread, connection Channel includes internal screw thread, and the external screw thread of second chamber and the internal screw thread of interface channel pass through screw thread combination, combination or group Dress.

5. sample collection device according to claim 3, the hole has one section of extension channel, and described prolongs Stretch a part that section is interface channel, wherein the extension channel is located in the dented space.

6. sample collection device according to claim 5, it is intracavitary positioned at second that the part extends channel.

7. sample collection device according to claim 6, the outer diameter that the part extends channel is equal to or small In the internal diameter of the second chamber opening.

8. sample collection device according to claim 6, described extends in channel insertion second chamber.

9. sample collection device according to claim 2, the device further includes interface channel, the hole For the first opening of interface channel, which is to be in fluid communication with the first chamber, the of second chamber and interface channel Two openings are fluid communication.

10. sample collection device according to claim 1, device further includes support holder structure, the second chamber quilt Detachable setting is on support holder structure, the support holder structure and the detachable combination of first chamber.

1. a kind of cavity for collecting fluid sample, which is characterized in that the cavity includes:

Side wall；

Bottom；And the opening for receiving liquid, wherein the bottom has one to allow into the liquid in cavity Sample flows to the opening outside cavity, wherein the device further includes the test chamber for placing testing element, the inspection It surveys chamber and cavity and fluid connection state is in by through-hole.

2. the position of cavity according to claim 1, the opening is higher than position or the aperture efficiency of through-hole Opening of the through-hole closer to cavity；Or through-hole is than being open closer to the bottom of cavity.

3. cavity according to claim 1, when cavity collects liquid sample, liquid is introduced into through-hole, so After enter back into opening, alternatively, partially liq sample enters into through-hole, partially liq sample enters opening.

4. cavity according to claim 1, the opening includes the channel extended outside bottom.

It, should 5. cavity according to claim 1 has in the cavity bottom to the region of cavity internal projection The region of protrusion and side wall form liquid sample collection region.

6. cavity according to claim 5, the collection region includes bottom, and the opening is higher than and collects The bottom position in area.

7. cavity according to claim 6, the bottom of the collection region is the bottom section of part cavity.

8. cavity according to claim 1, which is characterized in that the test chamber includes testing element.

9. cavity according to claim 8, which is characterized in that the testing element is located on carrier, described Carrier is located in the test chamber.

10. cavity according to claim 1, which is characterized in that the testing element includes being used to contact detection The sample applying zone of liquid sample in amount.

1. a kind of device for collecting liquid sample, which is characterized in that the device includes: for collecting liquid sample One chamber and the second chamber, second chamber further include the test chamber for primary detection being in fluid communication with the second chamber, wherein the The bottom of one chamber has opening, and the opening is sealed by a sealing element.

2. the apparatus according to claim 1, which is characterized in that first chamber and the second chamber is detachable Combination, combination or assembling.

3. the apparatus according to claim 1, which is characterized in that the sealing element is the sealing member that can be punctured Part.

4. device according to claim 3, which is characterized in that the sealing element plastic film, double-sided adhesive Band, one-faced tapes, one of aluminium foil or several.

5. the apparatus according to claim 1, which is characterized in that the opening has the outer channel extended outward, The channel includes the second opening with the second chamber for fluid communi.

6. the apparatus according to claim 1, which is characterized in that the device further includes for puncturing sealing member The puncturing elements of part and/or another sealing element.

7. device according to claim 6, which is characterized in that also another sealing element of the device, it is described Another sealing element is used to seal opening described in the sealing after puncturing elements puncture sealing element.

8. device according to claim 7, which is characterized in that the puncturing elements and another sealing element quilt It is arranged on the first lid, first lid is used to cover the opening for closing the first chamber.

9. device according to claim 8, which is characterized in that the puncturing elements are relative to another sealing member Ontology of the part far from lid.

10. device according to claim 8, which is characterized in that the puncturing elements and another sealing element this Sample setting, allows puncturing elements first to puncture the sealing element of sealed opening, then discharges partially liq into the second chamber, then allows Another sealing element sealing opening.

11. device according to claim 5, which is characterized in that the device further includes for sealed passage Second lid of the second opening.

The all patents and publications mentioned in description of the invention all indicates that these are the public technologies of this field, this Invention can be used.All patents referred to herein and publication are all equally listed in bibliography, with each publication Object is specifically individually referenced the same.The present invention described here can lack any element or multiple element, It is realized in the case where a kind of limitation or a variety of limitations, this limitation is not particularly illustrated here.Such as here in each example Term "comprising", " essence by ... form " and " by ... form " can be replaced with remaining 2 term of one of both.This In it is so-called "one" be merely representative of the meaning of " one ", and be not excluded for only only include one, can also indicate to include 2 More than a.Here describing mode carried out by the terms and expressions mode used, and be not limited except as, here also without any intention Any equivalent feature is eliminated to indicate these terms of this book description and explain, but it is recognised that can be in the present invention With any suitable be altered or modified is done in the scope of the claims.It is appreciated that examples of implementation described in the invention are all It is some preferred embodiment and feature, the essence that any those of ordinary skill in the art can describe according to the present invention Some changes and variation are done under marrow, these change and variation be recognized as belong to the scope of the present invention and independent claims with And in the range of appended claims limit.

Claims

1. a kind of device for receiving liquid sample includes: the first chamber for collecting liquid sample；It is examined with being used to collect for confirming Survey the second chamber of liquid sample；Wherein, first chamber has the opening for receiving liquid sample, and the second chamber, which has to receive, to be come from The opening of liquid sample in first chamber.

2. the apparatus according to claim 1, wherein the device further includes support holder structure, and second chamber is detachable The setting of formula is on support holder structure, the support holder structure and the detachable combination of first chamber.

3. the apparatus of claim 2, wherein when support holder structure and the first chamber are combined, the second chamber Liquid communication state is in the second chamber.

4. the device according to shown in claim 3, wherein first chamber includes a hole, and the hole and the opening of the second chamber are in liquid Circulation status；Alternatively, the liquid sample of the first chamber can be flowed into the second chamber by the gravity that liquid itself is subject to.

5. device according to claim 3, wherein the hole is the first opening of interface channel, and second chamber is logical Cross the fluid communication between interface channel realization and the first chamber；Or the hole has the channel extended, second chamber The fluid communication between the first chamber is realized by the channel of the extension.

6. device according to claim 5, wherein the channel of the interface channel or extension have first opening and Second opening, first opening are in fluid communication with the first chamber, and the second opening is in fluid communication with the second chamber.

7. according to device described in claim 5 or 6, wherein the device further includes for being tightly connected channel, extending Channel or hole sealing element.

8. device according to claim 7, wherein the sealing element can be by being tightly connected channel or extension Channel first opening or portion sealing element enter the channel of interface channel or extension to seal.

10. device according to claim 9, wherein lyophoby channel includes inlet, and the inlet is located at sealing member Under part, alternatively, the inlet is prior to sealing when sealing element is to be tightly connected channel or extend channel Element close to interface channel perhaps extends channel alternatively, when sealing element enters interface channel or when extending channel It waits, the inlet is located under the horizontal position of sealing element；Alternatively, when sealing element enters interface channel, The inlet enters interface channel prior to sealing element.

11. device described in -7 according to claim 1, wherein the device further includes lyophoby channel, the lyophoby channel Including liquid inlet, the view field of the liquid inlet is located within sealing element view field.

13. according to claim 10 or the device, wherein the inlet is located on the side wall of interface channel.

14. according to claim 13 or the device, wherein the inlet is lower than the position of interface channel opening.

15. the device according to one of claim 9-14, wherein the lyophoby channel also has liquid outlet, described Liquid outlet and an accommodating chamber fluid connection.

17. the device according to one of claim 9-14, wherein the lyophoby channel also has liquid outlet, described Liquid outlet and the first chamber are in fluid communication.

18. device according to claim 7, wherein the device further includes lyophoby channel, the lyophoby channel packet Liquid inlet is included, the partially liq forced by sealing element enters lyophoby channel by liquid inlet, to be rejected to channel With or the second chamber except.

19. device described in -18 according to claim 1, wherein the device includes for excluding partially liq in the second chamber The draining element of sample.

20. device according to claim 19, wherein the device further includes lyophoby channel, the lyophoby channel Including liquid inlet, the liquid inlet is located on draining element.

21. device according to claim 19, wherein the draining element and sealing element is linked together structure, when When with sealing element.

22. device according to claim 21, wherein when with sealing element come sealed passage, draining element is first It is entered in the second chamber in sealing element.

23. device described in one of -22 according to claim 1, wherein the lyophoby channel includes liquid outlet, and described goes out Liquid mouth and an accommodating chamber fluid connection.

24. device according to claim 23, wherein when the portion sealing element enters interface channel, institute The accommodating chamber stated, which is used to receive sealing element, enters the liquid sample that interface channel is discharged.

25. according to claim 24 or the device, wherein the accommodating chamber is located in sealing element or drain member In part.

26. device according to claim 21, wherein the view field of the draining element is located at the perpendicular of sealing element Within straight view field.

27. device according to claim 26, wherein the trans D of the draining element is less than the cross of sealing element To diameter.

28. device according to claim 27, wherein the interface channel is cylindrical, described sealing element It also is cylindrical.

29. device described in one of -28 according to claim 1, wherein the device further includes closing the first chamber opening for covering The first lid.

30. device according to claim 29, wherein the lid and sealing element ganged movement, the latter's lid with Draining element ganged movement, alternatively, lid and sealing element and draining element ganged movement.

31. device according to claim 30, wherein when the first cover cap closes the first chamber opening, described is close Envelope element enters connection and leads to as the lid of lid closes to seal the first of the interface channel the opening or subelement In road.

32. device according to claim 30, wherein the device further includes draining element, the draining element It is connect with sealing element.

33. device according to claim 32, wherein the draining element is than sealing element far from first lid Body.

34. device according to claim 30, wherein the sealing element is connect by connecting rod with the first lid.

36. device described in one of -35 according to claim 1, wherein the device further includes lyophoby channel, and described dredges Liquid channel includes liquid inlet, and the view field of the liquid inlet is located within sealing element view field.

39. the device according to claim 37, wherein described when the sealing element is tightly connected channel Draining element or part draining element be located in the second chamber.