CN206339563U - The detection means of analyte in a kind of detection liquid sample - Google Patents
The detection means of analyte in a kind of detection liquid sample Download PDFInfo
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- CN206339563U CN206339563U CN201620934696.XU CN201620934696U CN206339563U CN 206339563 U CN206339563 U CN 206339563U CN 201620934696 U CN201620934696 U CN 201620934696U CN 206339563 U CN206339563 U CN 206339563U
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
This practicality provides a kind of detection means for detecting analyte in liquid sample, it is characterized in that, the detection means of analyte in a kind of detection liquid sample, it is characterized in that, the detection means includes collecting chamber and test chamber, wherein, collecting chamber is located in test chamber, and collecting chamber forms described test chamber in vivo in detection；Wherein, the bottom of collecting chamber includes through hole, and test chamber carries out fluid connection by the through hole with collecting chamber, includes the hollow posts of a connecting detection chamber and ambient atmosphere environment in the bottom of test chamber, gas regulation material is provided with hollow posts.The air pressure in pattern detection chamber can be effectively adjusted using said structure, it is allowed to keep constant pattern detection liquid level, ensure that the stabilization of testing result, sample storage chamber (collecting chamber) is individually provided with addition, ensure that unnecessary sample, not by reagent contamination, is easy to secondary detection.
Description
Technical field
The utility model is related in the collection in a kind of detection means, especially quick diagnosis field and detection fluid sample
The device of analyte, such as urine detection and collection device.
Background technology
Be presently used for detection sample in whether the detection means containing analyte, be largely used to hospital or family
In, these detection means for being applied to quick diagnosis include one or more detection reagent bars, such as early pregnancy is detected, drug abuse
Detection etc..The detection means of this quick diagnosis is facilitated very much, can be at one minute, or at most ten minutes or so are detecting
Testing result is obtained on reagent strip.
Illicit drugs inspection is widely used, be usually used in prohibition of drug department, public security bureau, narcotic house, medical center, country conscription physical examination at
Etc. mechanism.Illicit drugs inspection wide variety, number of times frequently, can be automatically separated the illicit drugs inspection urine cup of remaining sample and detected sample
With the huge market demand, illicit drugs inspection urine cup in the market is after detection is completed, and sample in urine cup will be by
Second of confirmation detection can not be continued on for the pollution of detection reagent, such as United States Patent (USP) 7300633 is described.
Although in the conventional technology, detected sample can be allowed to be isolated with the sample collected, cost
Height, and do not allow easy to operate.Such as United States Patent (USP), the piston urine cup that the patent No. 7300633 is described, when the mistake for promoting piston-advance
Cheng Zhong, the fluid sample allowed in collecting chamber, such as urine is transferred to test chamber from collecting chamber, there is detection sample in test chamber
The testing element of middle analyte, and the fluid sample of collecting chamber is kept apart by piston, so that two local samples are not
It can obscure, so as to for later confirmation detection.Although the sample that can so keep apart the sample of detection and collect,
It is the urine cup high cost of this piston, and operation is not easy, and promotes piston to need than larger strength after all, because living
Plug needs reach transfer sample, and the wall being necessarily required to piston plays the effect of hydraulic seal, reach that the effect of sealing needs to allow
Piston and piston are closely combined by force.
For some above-mentioned technical problems, therefore need to make improvements that solved there is provided other approach can be with
The deficiency of existing conventional art, so as to reach that detection liquid and collection liquid are separated, reaches secondary detection purpose.
Utility model content
For above-mentioned situation, to overcome the defect of prior art, the purpose of this utility model is to provide a kind of energy automatically
The detection means of the remaining sample of separation and detected sample, the urine cup is a certain amount of while spiral cover after sample has been collected
Sample flowed into from interior cup by small sircle hole in the test chamber in outer cup, be automatically performed detection process, and unnecessary sample
It is stored in interior cup, the pollution from being detected reagent strip can be used for second of detection.
On the one hand, the utility model provides a kind of detection means, and the detection means includes a test chamber, the test chamber
Body include with a passage outside test chamber, the passage is not when having liquid, and test chamber carries out gas circulation with extraneous, when
When having liquid, gas circulation is not carried out with the external world.
The utility model provides a kind of detection means, and the detection means includes a test chamber, and allows test chamber
The passage that test chamber is connected with the external world, the passage is not when having liquid, and test chamber carries out gas circulation with extraneous, when
When having liquid, test chamber can not carry out gas circulation with the external world.
In some embodiments, test chamber is the cavity body structure of relative closure.It is preferred that, test chamber includes detection
Chamber, when having fluid sample to enter test chamber, can be contacted with the testing element (if there is) in test chamber,
So as to obtain the quantity that analyte in fluid sample whether there is or exist.
In some embodiments, a collecting chamber is also included in test chamber, collecting chamber passes through a through hole and detection
Chamber is in fluid communication.When collection has fluid sample in collecting chamber, fluid sample is entered in test chamber by the through hole.
In some embodiments, when collecting chamber is located in test chamber, the wall of collecting chamber and the wall of test chamber and bottom form this
The test chamber of utility model.In some embodiments, the channel design being in communication with the outside is located at the bottom of test chamber.
Or, in some embodiments, the detection means also includes a collection device, the collection device and test chamber
It is in fluid communication, so that the fluid in collecting chamber is entered in test chamber.The structure of fluid communication can include through hole, even
It is logical, jack and latch, irrigation canals and ditches, the mode such as channel carry out fluid communication therebetween.When collecting chamber or collection device and inspection
When surveying chamber contact, the liquid positioned at collecting chamber is flowed into test chamber.
In some preferred modes, there are a small slot structure or sunk structure in the bottom of test chamber, for collecting
Fluid sample in test chamber.It is preferred that, testing element is included in test chamber, the sample of testing element applies end and sulculus knot
Fluid sample contact in structure or sunk structure.
In some preferred modes, connecting detection chamber includes gas regulation material, such as sponge core with extraneous passage
Material, or other similar materials.Gas regulation material is in the environment of relatively dry or gas regulation material does not have
Contacted with liquid, or when without liquid is absorbed, the material can allow the passage to have the gas in gas circulation, i.e. test chamber
Can be entered by the material in ambient atmosphere, certainly or, the air in ambient atmosphere can be entered by the material
In test chamber.But, at the gas regulation material under environment very moist either gas regulation material contacted with liquid or
Draw when absorb liquid, the material can not allow the passage to have the gas in gas circulation, i.e. test chamber can not be by the material
Material enter in ambient atmosphere, certainly or, the air in ambient atmosphere cannot be also entered in test chamber by the material.
In some preferred modes, when collecting chamber is located in test chamber, the bottom of collecting chamber includes a through hole,
Should be by allowing test chamber to be in fluid communication with collecting chamber.In some preferred modes, include in test chamber bottom one it is raised
Structure, raised structure include groove either channel structure or as structure be called flow guiding structure, allow by through hole stream
Liquid the place contacted in test chamber with testing element is entered by flow guiding structure, so as to allow fluid sample and testing element
Contact.
In some preferred modes, multiple necks for being used to accommodate testing element are provided with the outer wall of collecting chamber.Or
Person, includes the test card of testing element in test chamber, the structure such as prod.
In some preferred modes, collecting chamber includes the opening for being used to collect fluid sample.It is preferred that, collecting chamber includes
Lid for sealing opening.It is preferred that, collecting chamber is located in test chamber, and the outer of collecting chamber opening seals opening for test chamber
Mouthful, so as to separate the space of a sealing in test chamber.It is preferred that, the test chamber of sealing passes through the passage with the external world and the external world
Atmosphere.
On the other hand, the utility model provides a kind of detection means for detecting analyte in liquid sample, its feature
It is that the detection means includes collecting chamber and test chamber, wherein, collecting chamber is located in test chamber, and collecting chamber is detecting internal shape
Into described test chamber；Wherein, the bottom of collecting chamber includes through hole, and test chamber carries out liquid company with collecting chamber by the through hole
It is logical, include the hollow posts of a connecting detection chamber and ambient atmosphere environment in the bottom of test chamber, gas is provided with hollow posts
Body adjusts material.
It is preferred that, in foregoing all embodiments, test chamber includes side wall and bottom and opening, in test chamber
There is an edge at opening；Collecting chamber includes opening, side wall and bottom, and the edge of collecting chamber opening is included at collecting chamber opening, is receiving
Collect chamber opening includes the loop configuration of projection along lower, and the edge of the loop configuration and test chamber is connected in the way of hermetic seal.
It is preferred that, in foregoing all embodiments, it is provided with the outer surface for the side wall for collecting body for bearing test
The neck of element.
It is preferred that, in foregoing all embodiments, annular groove is included in described test chamber, while testing element
Sample applying zone is located at the bottom of annular groove.
It is preferred that, in foregoing all embodiments, detection body bottom includes the loop configuration body raised up, the ring
Shape structure is raised to form described annular groove with partial sidewall.
It is preferred that, in foregoing all embodiments, loop configuration projection includes funnelform depression, depression correspondence
The through hole of collecting chamber bottom.
It is preferred that, in foregoing all embodiments, described test chamber also includes a groove, one end of groove with
Funnelform depression connection, the other end of the groove connects the bottom of annular groove.
In some specific embodiments, detection means includes edge in outer cup (8) and interior cup (10), the outer cup
(2) lower end with interior cup screw thread adapter (5) is formed with airtight connection；Interior cup (10) upper end and spiral cup lid (9) shape
It is sealed into sealing；Interior cup (10) outer surface is formed with neck (6)；Interior cup (10) bottom is formed with small sircle hole (7)；The cup
Body bottom is formed with pattern detection chamber (3)；The pattern detection chamber (3) is hollow provided with the inner and outer boundary's air of UNICOM's cup test chamber
Post (11)；Sponge core (4) of the hollow posts bottom provided with sealing hollow posts.
As a kind of preferred scheme of the present utility model, the interior cup cup and outer cup are welded into by ultrasonic bonding art
One, sample is flowed into the pattern detection chamber in outer cup by the bottom through-hole of interior cup.
As a kind of preferred scheme of the present utility model, the urine cup, which is collected, only needs upright place after spiral cover just may be used after sample
Sample liquid level constant in automatic detection result, reading after certain time, pattern detection chamber, ensure that testing result
It is stable.As a kind of preferred scheme of the present utility model, the urine cup body is plastic material.
On the other hand, the utility model provides a side for being used to collecting or detecting the analyte in liquid sample
Method, this method includes providing foregoing arbitrary collection device or detection means, so as to allow fluid to pass through through hole stream from collecting chamber
Enter into test chamber, you contact and detected the liquid that is flowed into a test chamber part with the test original cost in test chamber, separately
One with the gas regulation material in the connecting detection chamber and ambient atmosphere passage, so as to allow test chamber not enter with the external world
Promoting the circulation of qi body circulates.
It is preferred that, test chamber is not carried out after gas circulation with the external world, one closed space of test chamber formation, including one
Point gas in test chamber, entered back into so as to limit fluid sample from collecting chamber into test chamber, thus realize collection and
Detect the separation of sample.
Beneficial effect
Using said structure, with it is simple and reasonable the characteristics of, use lower cost for material, function admirable；Gas is adjusted
Material (for example, sponge core) is saved, with preventing the function of leakage, while the air pressure in pattern detection chamber also can be effectively adjusted,
It is allowed to keep constant pattern detection liquid level, ensure that the stabilization of testing result, sample storage chamber (collecting chamber) is individually provided with addition,
Ensure that unnecessary sample, not by reagent contamination, is easy to secondary detection.
Brief description of the drawings
Figure 1A is principle schematic of the present utility model.
Figure 1B be Figure 1A shown in principle schematic of the present utility model specific work process schematic diagram (collect, separate,
Detection process).
Fig. 2A is the structural representation of another specific embodiment of the utility model.
Fig. 2 B be Fig. 2A shown in principle schematic of the present utility model specific work process schematic diagram (collect, separate,
Detection process).
Fig. 3 is the structural representation of the test chamber in one embodiment of the utility model；
Fig. 4 is the bottom overlooking the structure diagram of the test chamber in one embodiment of the utility model；
Fig. 5 is the bottom overlooking the structure diagram of the test chamber in one embodiment of the utility model；
Fig. 6 is the structural representation of the collecting chamber in one embodiment of the utility model
Fig. 7 is structural representation (collecting chamber and the detection of the detection means in one embodiment of the utility model
The structural representation of chamber combination).
Embodiment
The structure being related to below to the utility model or these used technical terms are described further.
Detection
Detection represents chemical examination or tests a kind of material or material whether there is, such as, but is not limited to this, chemical substance,
The generation of organic compound, inorganic compound, metabolism product, medicine or drug metabolite, organic organization or organic organization
Thank thing, nucleic acid, protein or polymer.In addition, detection represents test substances or the quantity of material.Furtherly, table is gone back in chemical examination
Show immune detection, chemical detection, enzyme detection etc..
Sample
The signified sample of the utility model refers to those and can be used to detect, chemically examine or diagnose to be divided with the presence or absence of interested
Analyse material material, or pure broken meaning sample.Sample can be, for example, fluid sample, it is liquid-like that fluid sample, which can be,
This, liquid sample can include urine, blood, blood plasma, serum, urine, saliva and various juices, can also include solid-like
The liquid solution that this and semi-solid samples are formed after anticipating.Liquid sample can be the liquid-like without processing
This, can also include treated liquid solution sample etc..Collect the sample come and can be used for immune detection, chemistry inspection
Survey, the method such as enzyme detection detects whether to have analyte.
Testing element
Testing element can select the test strip of lateral flow, and it can detect a variety of analytes.Certainly, other are closed
Suitable testing element can also be used in the utility model.
Various testing elements can be grouped together and apply in the utility model.A kind of form is Test paper.With
The Test paper of analyte (such as drugs or show the metabolin of health) in analysis sample can be various forms,
Such as immunoassays or the form of chemical analysis.Test paper can be using non-competing method or the analytical model of competition law.Detection examination
Paper bag is containing an absorbent material with sample application zone, reagent area and test section.Sample-adding passes through capillary originally to sample application zone
Effect flows to reagent area.In reagent area, if there is analyte, sample is combined with reagent.Then sample continues to flow to inspection
Survey area.Other reagents, such as molecule with the Non-specific combination of analyte are fixed on detection zone.In these reagents and sample
Analyte (if present) is reacted and combines analyte to be combined in the area, or with some reagent of reagent area.With
Exist and reagent area or the mark zone separated in the label of display detection signal.
Typical non-competing method analytical model is that signal will be produced if containing analyte in sample, if do not wrapped
Containing analyte, signal is not just produced.In competition law, if analyte is not present in sample, signal is produced, if deposited
In analyte, then signal is not produced.
Testing element is Test paper, can be from water suction or the material not absorbed water.Test paper may include multiple material
For liquid sample transmission.The material of one of which Test paper can be covered on another material, as filter paper is covered in nitric acid
On cellulose membrane.One area of Test paper can be from one or more materials, and another area selects other different one kind
Or multiple material.Test paper, which can be attached on certain holder or hard surface, to be used for raising and is affectedly bashful the strong of Test paper
Degree.
Analyte is detected by signal generating system, such as utilizes one with this analyte generation specific reaction
Plant or a variety of enzymes, using such as foregoing method being fixed on specific combinating substance on Test paper, one or more signals are sent out
The composition of raw system is fixed on the analyte detection zone of Test paper.Produce signal material can in sample application zone, reagent area,
Or on detection zone, or whole Test paper, the material can be full of on one or more materials of Test paper.Signal will be contained
The solution of thing is added to the surface of test paper or one or more materials of test paper is immersed in the solution of the thing containing signal.Contain addition
The test paper of signal thing solution is dried.
Each area of Test paper can be arranged in the following manner：Sample application zone, reagent area, detection zone, control zone determines sample
This whether adulterated area, liquid sample uptake zone.Control zone is located at after detection zone.All areas can be arranged at only with a kind of
On one test paper of material.It may also be not same district and use different materials.Each area directly can be contacted with liquid sample, or not
The direction arrangement that same area is flowed according to liquid sample, the end in each area is connected and overlapped with the front end in another area.Used
Material can be the preferable material of water imbibition such as filter paper, glass or nitrocellulose filter etc..Test paper can also use it
His form.
Typically conventional reagent strip includes nitrocellulose filter for nitrocellulose assay strip, i.e. detection zone, in nitre
Specific binding molecule is fixed on acid cellulose film to show the result of detection；It can also be cellulose acetate film or nylon membrane etc.
Deng.The reagent strip of such as the following patent description or the device containing reagent strip：US 4857453；US 5073484；US
5119831；US 5185127；US 5275785；US 5416000；US 5504013；US 5602040；US 5622871；US
5654162；US 5656503；US 5686315；US 5766961；US 5770460；US 5916815；US 5976895；US
6248598；US 6140136；US 6187269；US 6187598；US 6228660；US 6235241；US 6306642；US
6352862；US 6372515；US 6379620；With US 6403383.Test-strips disclosed in patent documents above and carry
The similar device of test-strips, which can be applied in testing element of the present utility model or detection means, carries out analyte
The detection of material about being divided in the detection of matter, such as sample.
The horizontal effluent reagent strip that detection reagent bar of the present utility model can be known as is applied to, these detection examinations
The concrete structure and Cleaning Principle of agent bar are technology known to persons skilled in the art in the prior art.Common detection
Reagent strip, including sample collecting zone, marked region, detection zone and suction zone, sample collecting zone receive including sample
Pad, marked region include label pad, suction zone can include adsorptive pads, wherein in detection zone include can detect whether containing
The necessary chemical substance of analyte, such as immunoreagent or enzymology reagent.Typically conventional detection reagent bar is nitre
Acid cellulose membrane reagent bar, i.e. detection zone include nitrocellulose filter, and specific binding molecule is fixed on nitrocellulose filter
To show the result of detection；Cellulose acetate film or nylon membrane etc. are can also be, certainly, can be with the downstream of detection zone
Including testing result control area, generally, occur on control area and detection zone in the form of horizontal line, be detection line or control
Line processed.Such detection reagent bar is traditional reagent strip, certainly or other using capillarity detected it is other
The reagent strip of type.In addition, dry chemistry reagent composition is carried on general detection reagent bar, such as fixed antibody or other examinations
Agent, after liquid is run into, liquid flows with capillarity along reagent strip, with flowing, allows dry agent formulations to be dissolved in
Liquid, so as to be reacted to dry reagent of next regional processing in the area, so as to carry out necessary detection.Liquid flowing master
To be carried out by capillarity.These testing elements are shown in the description and record of following file：Li Fu is firm《Nitrocellulose filter
Regeneration treatment and its adhesion protein ability research》；Ma Hongyan, Li Qiang etc.《Membrane material is chromatographed in colloidal gold diagnosis kit
Expect the analysis of performance》；Wang Yong, Wang Luhai's etc.《A kind of Novel colloidal gold immunity-chromatography test strip》.It can be transported herein
Use in detection means of the present utility model, be either arranged in test chamber contacted with liquid sample or for detect into
Enter the quantity that analyte whether there is or exist in the liquid sample in test chamber.
Analyte
Some haptens materials, these haptens bags can be included with the example for the analyte being related in the utility model
Include drugs (such as drug abuse)." drug abuse " (DOA) refers to that the work of paralysis nerve (is generally played in non-medical destination using medicine
With).Abusing these medicines can cause body ＆ mind to suffer damage, and produce dependence, addicted and/or death.Medicine is indiscriminate
Example includes cocaine；Amphetamine AMP is (for example, black beauty, white amphetamine tablet, dextroamphetamine, dextrorotation
Amphetamine tablet, Beans)；Crystal methamphetamine MET (crank, meth, crystal, speed)；Barbiturate
BAR (such as Valium, Roche Pharmaceuticals, Nutley, New Jersey)；Sedative (paramedicines of sleeping)；
Lysergic acid diethylamide (LSD)；Inhibitor (downers, goofballs, barbs, blue devils, yellow
Jackets, methaqualone)；The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin)；Two methylenedioxy groups
Methylaniline MDMA；Hog (PCP)；Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc..)；Opiate
(i.e. morphine MOP or, opium, cocaine COC；, heroin, hydroxyl dihydrocodeinone)；Anxiolytic and hypnotic sedative agent, resist
Anxiety medicine is that a class is mainly used in anxiety reduction, anxiety, fear, is set the mind at rest, and has the medicine of hypnosis sedation, including benzene concurrently
Diazepine BZO (benzodiazepines), atypia BZ classes, fusion phenodiazine NB23C classes, the tall and erect class of benzene nitrogen, the part of BZ acceptors
Class, open loop BZ classes, diphenylmethane derivatives, piperazine carboxylic acid salt, piperidine carboxylic acid salt, Kui oxazoline ketone, thiazine and thiazole spread out
Biology, other heterocyclics, imidazole type calmness/anodyne (such as hydroxyl dihydrocodeinone OXY, methadone MTD), propane diols derive
Thing-carbamates, aliphatic compound, anthracene derivative etc..Inspection is can be used for using detection means of the present utility model
Survey and belong to medical usage but the easily detection of overdose, such as tricyclic antidepressant (imipramine or the like) and acetyl ammonia
Base phenol etc..These medicines can resolve into different small-molecule substances after being absorbed by the body, these small-molecule substances be present in blood,
In the body fluid such as urine, saliva, sweat or part body fluid has above-mentioned small-molecule substance.
Detection means or collection device
Detection means refer to for detect in sample whether the device containing analyte.Collection device refers to carry out liquid
The collection and storage of body sample.Detection means can include collection device, and collection device can also include detection means, Huo Zheshou
Acquisition means are separated with detection means, and when detection, collection device and detection means are combined, so as to complete inspection
Survey.Can also be, the device that collection device and detection means are structure as a whole, once after collection liquid sample, it is possible at once
Detected, obtain test result, while detection sample is carried out with collecting the separation of sample, so as to carry out secondary detection
(if desired).
In some embodiments in the utility model, as seen in figs. 1 a-1b, detection means includes collection chamber
20 and test chamber 30, collection chamber is surrounded by opening 21 and side wall and bottom, test chamber also include opening and side wall and
Bottom is surrounded, herein, and the opening of test chamber is collected the sealing of chamber, and collection chamber is located in test chamber in addition, for example
Figure 1A, so that, collection chamber is in itself divided into test chamber by its side wall the cavity 60 of one sealing, the cavity of the sealing
It is properly termed as test chamber 60.Collection chamber is used for collecting liquid sample, such as urine.Collection chamber is located in test chamber, its
In, include through hole 22 in the bottom of collection chamber, the through hole 22 be through hole so that, allow test chamber 60 and collecting chamber
Collecting chamber 28 in body, which is in, to be in fluid communication.Certainly, in optional mode.The through hole may not be to be through at the very start
, but when detection is needed, by puncturing or other mechanisms allow through hole to open, so as to allow test chamber 60 and collecting chamber
Collecting chamber 28 in body, which is in, to be in fluid communication.There is a certain distance between the bottom 27 of collecting chamber and the bottom 36 of test chamber.
In some preferred modes, the through hole 22 of connection collecting chamber and test chamber can be located at Anywhere, as long as collecting chamber can be allowed
Liquid sample be flowed into by the through hole 22 in test chamber, this flowing can be because liquid Action of Gravity Field (such as Fig. 1
The position relationship of collecting chamber and test chamber) or non-gravity factor, such as other pressure or compressing, or again
The common results that power is acted on and other pressure are acted on.It is preferred that, it is from eminence to low based on liquid caused by gravity factor
The flowing at place.In some modes, one end pipeline 29 is additionally provided with the through hole 22 of collecting chamber bottom, pipeline one end connection is logical
Hole 22, the other end is located in collecting chamber, so as to play a kind of purpose of protection through hole.When this can reduce collection sample,
It is a small amount of due to the irregular flowing of liquid sample to be entered by through hole in test chamber, it can so allow collecting chamber to be collected into
When a certain amount of liquid, liquid is smoothly flow in test chamber by pipeline 29 and by through hole 22.In some modes
In, such as Figure 1A, the bottom of test chamber 60 includes a bulge-structure, and one is formed between the bulge-structure and the side wall of test chamber
Individual groove structure 31, groove structure, which can be played, collects liquid sample, so as to allow a small amount of liquid sample just can be in groove
In reach a certain height.Meanwhile, gas regulation material is also included at groove, the material, which is worked as, not to be contacted or do not have with liquid
When absorbing liquid, allow test chamber to carry out gas circulation or gas exchanges with ambient atmosphere, work as when the material and connect with liquid
When tactile or absorption has liquid, test chamber is allowed to be circulated with ambient atmosphere without gas or without gas exchanges.When
So, gas regulation material can be placed in the channel first at groove or the bottom of test chamber is provided with a hole or passage,
So as to play above-mentioned effect.Certainly, the position of gas regulation material can also arbitrarily be set as needed, as long as can contact
Just can be with to liquid sample, this contact can be liquid flowing on gas regulation material or naturally passively
Flow on gas regulation material, so as to allow the material to carry out mutual effect with liquid sample, this effect is probably that physics is made
With or chemical action, or physics and the common effect of chemistry, so as to change the physics or chemically of material
Matter, so as to play gas regulation effect.Or with gas regulation material, so as to moisten the material, so as to allow gas regulation
Material, which has, can be allowed when doing test chamber to carry out the circulation of gas (or air) with the external world or exchange, in moistening
When, the circulation of gas (or air) can not be carried out with the external world or is exchanged for test chamber.
Principle demonstration process schematic as shown in Figure 1B.For example, when detection is needed, liquid sample is injected first
Into collecting chamber 28, injection can be existing sample injection, or subject directly liquid sample (such as urine) directly
Urinate in collecting chamber.Once have urine in collecting chamber, urine is just flowed into test chamber due to Action of Gravity Field, this
When individual, because gas regulation material is in dry state, due to cavity of the test chamber 60 for sealing, with entering for liquid sample
Enter, the air or gas of the presence in test chamber certainly will be discharged, so, gas or air are just smoothly adjusted by gas
Section material is discharged in ambient atmosphere environment.As liquid sample further increases, collected in the bottom of test chamber, this
Sample, a part of sample may be contacted with being arranged on the testing element of test chamber in advance, so as to detect the quilt in liquid sample
Material is analyzed, another can flow to the contact that gas regulation material is in, so as to moisten gas regulation material, the material is general
It is wet, the property of gas regulation material changes, for example automatic expansion, expansion is so as to can breathe freely when allowing dry
Bore closure, so that test chamber and extraneous gas can not be allowed to swap, so as to allow test chamber to go completely into the state of sealing.By
Sealing is completely in test chamber, if liquid is continuously introduced to test chamber, then the gas pressure of test chamber just increases, with
The pressure gradually increased, the gravity that liquid can be overcome spontaneous, so that the liquid sample in collecting chamber is not just being continued to flow into
Into test chamber, so as to reach a kind of balance.So, the liquid positioned at test chamber positioned at remaining liquid in collecting chamber with being in
Separation physically, the two is not in contact with, if necessary to further detection, can directly take part to be located at the liquid of collecting chamber
Carry out two measurements or confirm measurement.
In this mode or in the latter's other modes, the size positioned at the through hole of collecting chamber can be designed arbitrarily, example
It can be such as 1-10 millimeters, 1-5 millimeters, 0.1-3 millimeters, 0.5-2 millimeters are all feasible.Through hole than it is larger when, liquid
Can because of Action of Gravity Field under flow in test chamber, if through hole is smaller, due to the work of capillary and surface tension
With, flowed under the more difficult nature of liquid in test chamber, can collecting chamber liquid surface apply pressure, force liquid sample to enter
Enter into test chamber, the liquid of entrance is as described above, a part is contacted with testing element, and another part can be subsequently or concurrently
With gas regulation material, gas regulation material is allowed to be changed into moistening from dry, from without allowing test chamber and ambient atmosphere environment
Carry out the exchange or circulation of gas.
Applying stressed mode has a lot, and a preferred mode is exactly to cover lid 9, because lid once covers collection
The opening that the opening of chamber is just sealed, with the rotation of lid, the gas volume that lid is just made way on the liquid level of collecting chamber reduces,
So as to increase the pressure for acting on liquid surface, it is flowed into so as to force liquid through through hole 22 in test chamber.Certainly, press
Pressure is a preferred mode, it is not absolutely required to complete.
In other modes, due to the easier flowing of the liquid that test chamber is flowed into by through hole 22, in test chamber
Inside also include drainage element, for example, flow guiding structure or structure can be any absorbent material or not practise absorbent material composition,
So as to guide the fluid from collecting chamber than more smoothly flowing to the place of test chamber preventing and treating testing element or flowing to gas
Adjust at material, so as to change the property of gas regulation material, for example, be changed into the state of moistening from dry state, so as to change gas
Such as body adjusts the ventilatory conditions of material, is ventilated when dry, stuffiness when moistening.
In other embodiment, such as Fig. 2A, it is to separate to collect body 200 with detection body 300, and collection chamber includes
Opening 201 and side wall and the collecting chamber of bottom 203, include on the wall of side one can either on or off passage 202, detect body bag
Include side wall, the test chamber 303 that bottom is surrounded includes gas regulation material in the bottom of test chamber, its allow test chamber simply by
The material carries out gas exchanges with ambient atmosphere.On the side wall of test chamber also include one can either on or off passage 301.Inspection
Testing element can be included by surveying in chamber.Before being detected, collect body 200 and be used for collecting liquid sample, now can either on or off
Passage 202 be close, so liquid will not flow.When detection is needed (such as Fig. 2 B), collection body is allowed with detecting body
Contact or coordinate so that collect on body can either on or off passage 202 with detection body on can either on or off passage 301
Coordinate, thus allow liquid sample 50 flow into test chamber 303, because at the beginning, gas regulation material is not in contact with liquid
Sample is dry state, is discharged into the liquid of test chamber and the air or gas that extrude by gas regulation material outer
In boundary's atmospheric environment, with the increase of liquid, a part is contacted with testing element, and another portion flow to setting gas regulation material
Place and the material, so as to moisten the material, change the physical property of the material, allow gas regulation material from ventilative
State is changed into impermeable gaseity.With the formation of impermeable gaseity, the cavity that test chamber formation one is fully sealed, according to foregoing
Principle (Figure 1A -1B) description, with continuing into for liquid, the increase of test chamber internal pressure consequently reaches balance, collecting chamber
Liquid sample be just no longer flowed into by passage 202 and 301 in test chamber.So as to allow the liquid of test chamber to keep fixed body
Product.When feeling to need secondary chemical examination or confirm chemical examination, collecting chamber directly is removed from test chamber 300, is now led to
Road 202 is closed, and then covers lid sealing opening 201, is routed directly to laboratory and is carried out secondary chemical examination or confirm detection.
It can be readily apparent that, the various embodiments of test chamber in figure ia can be applied to the inspection in Fig. 2A
Survey device in come carry out improve fluid circulation or collect fluid contacted to a specific position with testing element or and
With gas regulation material, so as to change the state of gas regulation material, sealed so as to allow detection means to be changed into complete.
In some preferred modes, position of the gas regulation material in test chamber is to pass through passage away from collecting chamber
202 or through hole 22, it can so allow liquid sample to reach after certain volume, with increasing, then flow to gas regulation material
The position of material, so as to allow test chamber to be fully sealed.Or, it is envisaged that obtain, in a preferred mode, in test chamber
The position of the gas regulation material of setting can allow the position that liquid sample is naturally flowed to, and so conveniently moisten dry gas and adjust
Material is saved, so as to complete the isolation of gas, so as to allow test chamber to be in the state of air seal.Certain gas regulation material can be with
Be arranged in hole, hole, groove, irrigation canals and ditches, passage, this some holes, hole, groove, irrigation canals and ditches, passage when no gas regulation material,
Allow test chamber freely to be connected with atmosphere, when gas regulation material is set in these structures, allow gas
Circulated by gas regulation material between test chamber and the environment of ambient atmosphere and either exchange or do not flow or not
Exchange.This unlatching circulation or immobilising process are one naturally, automatic process.
Quantity for setting gas regulation material can be one or more, can be based on also without specific limitation
Actual conditions are voluntarily selected.
Gas regulation material can have many selections, for example, select those ventilative when drying, and when moistening
Air-locked material just can be with.This so-called " drying " and " moistening " are a relative concepts, and drying can refer to the material
Material can more be moistened or moist with the change of gas permeability caused by the change of humidity, such as swap-in, and the material is more impermeable
Gas.Certainly opposite state can also, for example environment is drier, and the material is more airtight.Such material can be cork
Plug, rubber stopper or sponge core.
Sponge core can material selection main component be polyvinyl alcohol, be the tasteless solid of white, shape is generally cylinder, certainly
Various suitable surname Zhu shapes can be processed into, such as circular, figure of tablet is square, or other suitable shapes.Density is
0.8-1.6g/cm3.Sponge core can be used alone or is used in mixed way with other gas regulation materials.Typically, sponge core
Interior, with viscoplasticity, to be deformed containing warming particle because of temperature and pressure, the sponge core ventilative and hygroscopicity can be splendid, memory
Deformation being capable of sufficiently sealed space.When drying, the permeability is good, and test chamber can be allowed big by the material and the external world
Gas phase is same, and whenever moistening after (such as liquid sample moistens the material or the material is absorbed after liquid sample), the material is deformed,
Can sufficiently sealed space, so that test chamber and external environment air can not be allowed to carry out exchanging for gas or air, it is to avoid urine
Cup gas leak phenomenon.Optional sponge core is purchased in Hangzhou Bei Chi Science and Technology Ltd.s.The analog of other identical functions can also be used
Matter or material.
In other specific embodiments, the utility model provides a kind of specific detection means, as in Figure 3-5
Structure.The detection means includes detection body 8 and collects body 10, wherein collecting body is located at detection in vivo, so that internal in detection
Form test chamber.Wherein, the bottom of collecting chamber includes through hole 7, and the through hole 7 allows test chamber to carry out fluid or liquid with collecting chamber
Connection, includes the hollow posts 11 of a connecting detection chamber and ambient atmosphere environment in the bottom of test chamber, is set in hollow posts
Gas regulation material, such as sponge core material, so that, adjust test chamber in different situations and ambient atmosphere is changed between part
Gas exchanges.
More specifically say, as shown in figure 3, detection body 8 includes side wall and bottom and opened, 37 cavitys surrounded
30, have one along 2 at opening.And constitute and collect the structure of body 10 for opening 21, side wall 23 and bottom, through hole is provided with bottom
7.There is the edge for collecting body opening at opening, along screw thread is above provided with, the screw thread of screw thread and lid 9 coordinates, so as to form sealing.In spiral shell
There is a raised loop configuration 5 under line, the loop configuration is tightly connected with detection body along 2, so that the opening of sealing detection body
37.Sample combination here is formed detection means as shown in Figure 5.Here be sealed into hermetic seal with loop configuration 5 along 2,
The mode of sealing can pass through ultra-sonic welded, bonding reagent bonding etc..It is preferred that, it is provided with the outer surface for the side wall for collecting body
Neck 6, the neck is used for bearing test element.When body and detection body assembling is collected, testing element is located in neck 6,
Sample applying zone is located at the bottom of neck simultaneously, and at annular groove 35, and contacted with annular groove bottom.
In some preferred modes, the loop configuration body 70 for including raising up in detection body bottom, the loop configuration
Raised to form annular groove 35 with partial sidewall, when having liquid to enter test chamber, a small amount of liquid is collected in annular groove,
So as to ensure the height of certain liquid, the sample application port position of convenient moistening testing element.It is preferred that, loop configuration projection 70 is wrapped
Include funnelform depression 71, the through hole 7 of depression correspondence collecting chamber bottom.In other embodiments, connected with depression 71
One groove 3, groove one end connection depression 71, one end connects the bottom of annular groove 35.When the liquid-like flowed down by through hole 7
Originally when collecting in recess, liquid sample enters the bottom of annular groove along groove 3, and in the bottom of annular groove gradually
Collect, and liquid level gradually height.In preferred mode, in order to allow the liquid for entering annular groove 35 under small size, liquid
Face can be divided into annular groove separation structure 72 each independent several parts, such as groove is located at a pair of separations with more higher
Between structure 72, and this pair of separation structure 72 is divided into annular groove 2 independent parts.When liquid from groove 3 enters annular
When groove 35, the liquid sample of such less volume can allow liquid level to reach certain height in annular.It is to be appreciated that ring
Liquid in shape groove reaches under certain height that the sample of testing element applies end or applying zone only has a small amount of liquid just
Liquid can be allowed to be flowed on the test strip by capillarity, so as to complete the detection of analyte in sample.Example again
Such as, as shown in figure 4, between a pair of separation structures 72 be annular groove 37 place, set hollow posts 11, set in hollow posts 11
Gas regulation material 4 is put, after the liquid sample from collecting chamber enters annular groove 35, on the one hand with the survey in annular groove
The first pole of examination likes that you contact, and the opposing party can flow to the place of circular column 11 to contact when gas regulation material 4, gas regulation material
The state of material changes, for example, be changed into moistening or dampness from dry state, so that test chamber can be entered with the external world
Row gas exchanges (such as dry state) can not carry out gas exchanges (for example moistening dampness) to test chamber with the external world, from
And close exchanging for test chamber and ambient atmos.Test chamber is so allowed as complete hermetic seal state.As before, by
It is complete gaseous state sealing state in test chamber, by the liquid sample of through hole due to the increase of test chamber internal pressure, reaches
After balance, more liquid samples are not had and are flowed into test chamber, so that, the liquid sample and testing element allowed in test chamber
Contact, without polluting the liquid sample being located in collecting chamber, so as to play a part of separation.In addition, the effect of gas pressure
Under, make the volume of the liquid sample flowed into test chamber constant in each different test chamber, detection can be quantified
The volume of sample.So, can be directly in collecting chamber when needing to carry out secondary detection or further confirm that chemical examination
Part sample is taken out, and the sample is sample contamination that is independent, not contacted with testing element.
In with upper type, the position of hollow posts 11 can also be arranged on the opposite side of separation structure 72, not positioned at ring
In shape groove 37, and in annular groove 38, as shown in Figure 5.So, a part of liquid from collecting chamber is entered by groove 3
Into annular groove 35, contacted with the testing element in annular groove 35.Another liquid from collecting chamber passes through groove 03
Enter in annular groove 38, flow to and pay contact on gas regulation material 4 in advance, so as to moisten the material 4.
In a preferred mode, lid 9 is used for sealing the opening of collecting chamber.In other modes, lid 9 can be with
Apply pressure to the liquid in collecting chamber while closed collecting chamber opening.Specially when lid covers collecting chamber opening
Wait, hermetically closed collecting chamber opening, closed one section of gas, rotates, gas when with lid between liquid surface and opening
Volume-diminished so that the liquid surface in collecting chamber applies certain pressure, such pressure can accelerate the liquid of collecting chamber
Body is flowed into test chamber by through hole.Equally, when gas regulation materials behavior changes, for example, from allowing test chamber
With it is extraneous carry out gas exchanges arrive allow test chamber can not with after the extraneous state for carrying out gas, in fact, test chamber is also as gas
Body sealing state, collecting chamber also turns into air seal state, but test chamber is liquid communication shape by through hole 22 with collecting chamber
State, so, after collecting chamber reaches balance with test chamber, liquid will not flow to test chamber, enter so as to complete quantitative liquid
To test chamber, while the separation of collecting chamber and test chamber liquid is also completed, mutually not in interference.
When needing to carry out secondary detection, simply need to open the lid of collecting chamber, when lid is taken away, though
Gas pressure (if there is) in right collecting chamber recovers consistent with extraneous, but is due to that test chamber is still within air-tight state, even
The liquid of individual chamber is also appointed will not so be flowed again.So as to directly take out segment fluid flow from collecting chamber and carry out secondary chemical examination (progress
The secondary detection same with testing element) or the chemical examination of progress secondary-confirmation (carry out and the different secondary detection of testing element,
For example testing element is detected using immunity principle, and secondary-confirmation chemical examination can be used and examined different from immune detection principle
Survey, such as gas-chromatography, liquid chromatogram etc.).
All patents and publication mentioned in the utility model specification all represent that these are the public technologies of this area,
The utility model can be used.All patents referred to herein and publication are all equally listed in bibliography, with each
Individual publication is specifically individually referenced the same.The utility model described here can lack any element or
Multiple element, is realized in the case of one kind limitation or a variety of limitations, and this limitation here is not particularly illustrated.For example it is each here
Term "comprising" in individual example, " essence by ... constitute " and " by ... constitute " remaining 2 term of one of both can be used
Instead of.Here describing mode carried out by the term and expression way used, and be not limited except as, also refer to here without any intention
These terms of bright this book description and explanation eliminate any equivalent feature, but it is recognised that can be in the utility model
Any suitably it is altered or modified with being done in the range of claim.It is appreciated that the examples of implementation described by the utility model
All it is some preferred embodiments and feature, any those of ordinary skill in the art can be described according to the utility model
Marrow under do some change and change, these change and change be recognized as belonging to scope of the present utility model and independent right
It is required that and in the range of appended claims limit.
Claims (10)
1. a kind of detection means for detecting analyte in liquid sample, it is characterised in that the detection means includes collecting chamber
And test chamber, wherein, collecting chamber is located in test chamber, and collecting chamber forms described test chamber in vivo in detection；Wherein, collecting chamber
Bottom include through hole, test chamber and collecting chamber carry out fluid connection by the through hole, include a company in the bottom of test chamber
The hollow posts of test chamber and ambient atmosphere environment are connect, gas regulation material is provided with hollow posts.
2. detection means according to claim 1, it is characterised in that test chamber includes side wall and bottom and opening,
There is an edge at the opening of test chamber；Collecting chamber includes opening, side wall and bottom, and collecting chamber opening is included at collecting chamber opening
Edge, includes raised loop configuration, the edge of the loop configuration and test chamber is in the way of hermetic seal in collecting chamber opening along lower
Connection.
3. detection means according to claim 2, it is characterised in that be provided with the outer surface for the side wall for collecting body for holding
Carry the neck of testing element.
4. detection means according to claim 3, it is characterised in that include annular groove in described test chamber, is surveyed simultaneously
The sample applying zone for trying element is located at the bottom of annular groove.
5. detection means according to claim 4, it is characterised in that detection body bottom includes the loop configuration raised up
Body, the loop configuration is raised to form described annular groove with partial sidewall.
6. detection means according to claim 5, loop configuration projection includes funnelform depression, depression correspondence is collected
The through hole in bottom of chamber portion.
7. detection means according to claim 6, it is characterised in that described test chamber also includes a groove, groove
One end connect with funnelform depression, the bottom of the other end of groove connection annular groove.
8. detection means according to claim 7, it is characterised in that described hollow posts are located in annular groove and and ring
Shape groove keeps liquid communication.
9. detection means according to claim 1, it is characterised in that described gas regulation material has dry when
Keep test chamber and ambient atmosphere to carry out gas circulation by the gas regulation material, do not allowed when moistening test chamber with it is big
The property that gas is in fluid communication by the gas regulation material.
10. the detection means according to one of claim 1-9, it is characterised in that described gas regulation material includes sea
Continuous material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620934696.XU CN206339563U (en) | 2016-08-24 | 2016-08-24 | The detection means of analyte in a kind of detection liquid sample |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620934696.XU CN206339563U (en) | 2016-08-24 | 2016-08-24 | The detection means of analyte in a kind of detection liquid sample |
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| Publication Number | Publication Date |
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| CN206339563U true CN206339563U (en) | 2017-07-18 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110161267A (en) * | 2018-02-13 | 2019-08-23 | 杭州博拓生物科技股份有限公司 | The detection device of analyte in a kind of detection sample |
| CN110174508A (en) * | 2019-06-12 | 2019-08-27 | 成都恩普生医疗科技有限公司 | A kind of multi-functional urine cup |
| CN110389049A (en) * | 2018-04-20 | 2019-10-29 | 艾博生物医药(杭州)有限公司 | A kind of sample collection detection device |
-
2016
- 2016-08-24 CN CN201620934696.XU patent/CN206339563U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110161267A (en) * | 2018-02-13 | 2019-08-23 | 杭州博拓生物科技股份有限公司 | The detection device of analyte in a kind of detection sample |
| CN110161265A (en) * | 2018-02-13 | 2019-08-23 | 杭州博拓生物科技股份有限公司 | A kind of device for collecting liquid sample |
| CN110389049A (en) * | 2018-04-20 | 2019-10-29 | 艾博生物医药(杭州)有限公司 | A kind of sample collection detection device |
| CN110174508A (en) * | 2019-06-12 | 2019-08-27 | 成都恩普生医疗科技有限公司 | A kind of multi-functional urine cup |
| CN110174508B (en) * | 2019-06-12 | 2024-05-28 | 成都恩普生医疗科技有限公司 | Multifunctional urine cup |
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