CN201662573U - Detecting device with movable push rod - Google Patents

Abstract

The utility model relates to a detecting device comprising a sample cavity, a testing cavity and a liquid sample transfer cavity, wherein the sample cavity is used for collecting or storing a liquid sample; the testing cavity is used for containing a tested element; the transfer cavity is internally provided with a piston capable of moving from a first position to a second position; and the liquid sample in the sample cavity is transferred into a detecting cavity by movement of the piston. The detecting device is characterized in that the piston also comprises a piston push rod which is movably connected with the piston and is provided with the first position and the second position.

Description

The pick-up unit that has movable push bar

Technical field

The invention belongs to the liquid sample assembling sphere, belong to the field of collecting liquid sample and detecting analyte in the sample especially, especially detect the metabolin that whether contains the drug abuse material in the sample or the quick diagnosis of women's gestation aspect and detect.

Background technology

In recent years, pick-up unit is made the body fluid that is used for detecting the people in a large number, urine for example, the analyte in saliva or the blood, for example indicator substance of drug abuse or disease.Traditional like this pick-up unit need be collected in liquid sample to a container usually, inserts testing element in the liquid then and then takes out and read test result on (with the naked eye see or read with machine) testing element.Might allow the operator by sample contamination like this.Use this pick-up unit except being used by professional testing staff, do not had the people of professional experiences to use by some gradually, for example use in the family, this just need provide a kind of operation simpler, and testing result is pick-up unit more accurately.

Summary of the invention

The present invention provides a kind of simple to operate in order to overcome the deficiency of existing product, the device for fast detecting that can allow ordinary consumer accept.

The invention provides a kind of pick-up unit, comprising: one is used to collect or the sample chamber of storaging liquid sample; A test chamber that is used to accommodate testing element; With a liquid sample transfer chamber; In transfer chamber, comprise a piston that can move to the second place from primary importance; By moving of piston the liquid sample in the sample chamber is transferred in the test chamber; It is characterized in that, on piston, also comprise a piston push rod that is in flexible connection and has the primary importance and the second place with piston.In a preferred mode, optionally, piston push rod comprises piston push rod head and push rod main body, and wherein the part main body is positioned at piston.

Optionally, piston comprises the card article that has dop; The push rod main body comprises the bayonet socket that dop is installed.

Optionally, piston and card article are connected as a single entity; Bayonet socket is positioned on the outer wall of push rod main body.Optionally, the push rod main body comprises first bayonet socket and second bayonet socket, and when piston push rod in primary importance the time, the dop on the piston is positioned on first bayonet socket; When piston push rod in the second place time, the dop on the piston is positioned on second bayonet socket.

Optionally, when piston push rod in primary importance the time, the piston push rod that is positioned at piston can be drawn out.

Optionally, when piston push rod the time in the second place, piston push rod and piston can not relative motion and with the piston structure that is connected as a single entity.

Optionally, piston and piston push rod all are cylindrical shape.Optionally, also comprise the passage that is communicated with the liquid sample chamber on the transfer chamber.

Optionally, when piston is in the second place and piston push rod when being in primary importance, piston push rod all is arranged in transfer chamber.

Optionally, to move to the second place from primary importance can be from left to right, from front to back, from top to bottom, from right to left, from back to front or from top to bottom to piston push rod; Moving of piston also can be from left to right, from front to back, from top to bottom, from right to left, from back to front or from top to bottom.

Test chamber is meant space or the compartment that contains testing element.In one embodiment, test chamber can be positioned on the lid.In other embodiment, test chamber can be separated with lid, but its functional equivalent is in the chamber that is positioned on the lid.For example, in the embodiment that substitutes, test chamber can be to be positioned at the sample chamber the inside, perhaps in the outside of sample chamber.A kind of light of " transparent " expression material that can see through, thus under general indoor light, people's bore hole can be seen the object of transparent material back, and use the people of this device can see test result under this transparency window." cup " not only refers to conventional circular or oval-shaped container, also refers to the container of Any shape.Therefore, cup also can be square, perhaps is suitable for realizing any configuration of cup function.Secondly, lid can include helicitic texture as herein described, but also can be the buckle structure that snaps into the top of cup, or a kind of cork that can be tucked into the cup room and be fixed to cup by its bulging force.When adopting helicitic texture, the degree of depth of screw thread is not what limit, as long as can be fixed to lid on the cup, screw thread can be multi-turn, a circle even less than one circle.But in some embodiments, cup and lid all are circular.

Beneficial effect

Device provided by the invention can allow the pick-up unit operation simpler, is different from existing traditional proving installation.Especially, piston and piston push rod flexibly connect, promote piston with piston push rod and move to the second place from primary importance, need not painstakingly take off piston push rod, piston push rod is arranged in piston in packing in addition, need not as traditional pick-up unit, need packing piston push rod (for example Chinese patent 200420107950.6) separately, reduce production cost.

Description of drawings

Fig. 1 is the perspective view of pick-up unit in specific embodiment of device of the present invention;

The blast structural representation of Fig. 2 for installing shown in Fig. 1;

Fig. 3 A is the device among Fig. 2 of the present invention and Fig. 1, and through hole is at first state, and piston push rod is in primary importance, and piston is at the part section structural representation of primary importance; Fig. 3 B is in the device shown in Fig. 3 A, and through hole is at first state, and piston push rod is at the perspective structure synoptic diagram of primary importance;

Fig. 4 is in the device of specific embodiment of the present invention, and piston push rod is in the second place, and piston is in the perspective view of primary importance;

Fig. 5 is in the device of specific embodiment of the present invention, and piston is in the second place, and push rod is arranged in the perspective view of transfer chamber;

Fig. 6 A is the assembling cross-sectional view of piston shown in Fig. 6 C and piston push rod element; Fig. 6 B is another cross-sectional view of assembling of piston shown in Fig. 6 C and piston push rod element; Fig. 6 C is an assembling perspective view (piston push rod is a primary importance, and piston is a primary importance) of showing piston and piston push rod element;

Fig. 7 A is the assembling cross-sectional view of piston shown in Fig. 7 C and piston push rod element; Fig. 7 B is another cross-sectional view of assembling of piston shown in Fig. 7 C and piston push rod element; Fig. 7 C is an assembling perspective view (piston push rod is the second place, and piston is a primary importance) of showing piston and piston push rod element; Description of reference numerals:

Pick-up unit 10; Testing element 700; Lid 800; Test chamber 400; Cup 600; Collecting chamber 601; Cup base 602; Cup opening 605; Transfer chamber 500; Transfer chamber one end opening 501; Transfer chamber other end opening 502, the transfer chamber bottom sides is along 503; Passage 603; Nipple element 300; Bar 204; Masthead end 205; Piston 200; Piston outer wall 203; First O-ring seal 201; Second O-ring seal 202; First card article, 207, the first card article ends 208; Second card article 206; The second card article end, 209, the first bayonet sockets 105,105 '; Second bayonet socket 104,104 '; Piston push rod 100; Push rod head 101; Piston push rod main body outer wall 102; Piston push rod bar main body 103; The chamber 210 of piston 200.

Embodiment

In the following detailed description, the explanation of accompanying drawing and corresponding character only is the mode that illustrates that by way of example the present invention can actable specific concrete scheme.We do not get rid of the present invention can also be in any other embodiment in claim scope of the present invention.

On the one hand, the invention provides the pick-up unit of analyte in a kind of tracer liquid sample.This device can detect chemical examination and not pollute other remaining liquid samples liquid sample.And this detection is to finish in a step, does not need the complicated operations step.

Fig. 1-7 is proving installation and the method in another embodiment of the present invention.As Fig. 1, this device comprises the flexible member 300 of a sample chamber 601 and a test chamber 400 and a nipple shape.Sample chamber 601 and nipple element 300 are positioned at cup 600, the opening 606 of cup is used for collecting liquid sample in sample chamber 601, comprise a passage 603 in the bottom of sample chamber 601, this passage and a transfer chamber 500 communicate, sample chamber 601 communicates with transfer chamber 500 by passage 603, the shared wall of the bottom of collecting chamber 601 and transfer chamber, passage 603 is positioned on this wall.The both ends open of transfer chamber 500 near nipple element 300 is installed on the opening 502 of test chamber, comprises a piston 200 near on away from the opening of test chamber, and piston is positioned at the cavity of transfer chamber, piston can be in transfer chamber move left and right.Comprise elastic sealing elements 201,202 on the piston 200, the sealing element is used for sealing the inwall of transfer chamber and the outer wall 203 of piston.Piston and nipple element 300 have limited a chamber 900 to transfer chamber, and this chamber receives partially liq sample from sample chamber by passage 603.

Referring to Fig. 1-5, the flexible member 300 of nipple shape comprises the part and the base part 301 of a projection, and the part of projection comprises that 302, one through holes of sidewall 304 and top 303 are opened on sidewall 304; Sidewall 304 and top 302 surround a nipple chamber 305.Comprise a groove 306 on the base part 301, the circular protrusion edge 503 of this groove and transfer chamber cooperates, and allows the nipple element be installed in hermetically on the end opening 502 of transfer chamber.When the flexible member 300 of nipple shape was positioned at first state, nipple chamber 305 was towards the right side, and this moment, through hole 303 was in self-sealing state (Fig. 4) because the elastic reaction in nipple chamber 305 self.When nipple chamber 305 shrink and in turn over after, when top 302 is positioned at the left side of base part 301, the through hole 303 that is in sealing or closure state be opened (Fig. 5).In a concrete mode, a push rod 204 is connected as a single entity with piston, and be positioned at the dead ahead at the top 302 of nipple shape flexible member 300, when driving push rod 204 from the primary importance on the right side when the second place on the left side moves in transfer chamber, piston moves from right to left, thereby push rod forces top 302 to move to the left side of pedestal 301 from the right of base part 301.

On piston 200, also comprise a piston push rod that is in flexible connection and has the primary importance and the second place with piston.When piston push rod in primary importance the time, the main body 103 of piston push rod is arranged in the chamber of piston and fixedly is connected as a single entity with piston; When the main body 103 of piston push rod moved to the second place from primary importance, the main body 103 that is in the piston of the second place was fixed with piston and is connected as a single entity.

In a mode, piston 200 is flexible connection with piston push rod 100.When needs push away stalk 100 and promote piston and move in transfer chamber 500 with piston when, piston push rod 100 is pulled out from piston 200, then by position limiting structure by no longer relative motion between piston 200 and the piston push rod 100, piston and piston push rod are connected as a single entity like this.When promoting piston push rod 100, piston moves with piston push rod, thereby drives bar 204 motions that are connected as a single entity with piston.Moving of push rod 204 positions can allow the nipple flexible member of first state that is in the closed or sealing of oneself change to second state like this.

In a concrete mode, referring to Fig. 6 A-6C and Fig. 7 A-7C, piston 200 is cylindrical, the cavity 210 that comprises hollow, have two grooves that seal element 201,202 is installed on the outer wall 203 of piston, an end of piston is for sealing and to rod shaped structure 204 of outer process.Piston push rod 100 comprise push rod main body 103 be connected with main body cut somebody's hair 101, on the outer wall 102 of push rod main body 103, comprise the bayonet socket of two teams' correspondence: first bayonet socket 105,105 ' with second bayonet socket 104,104 '.Bayonet socket is inverted "L" shaped.On the inwall of piston cavity 210, fix two card articles 207,206 respectively.One end of card article has reclinate end 208,209.When push rod main body 103 was positioned at plunger shaft 210, the part of two card article 207,206 bendings just can be positioned on first bayonet socket 105,105 ', and this moment, bayonet socket 104,104 ' was vacant not by the state of card article end clamping.During this time, piston head exposes to outside the proving installation, and piston and piston push rod are arranged in transfer chamber 500 (Fig. 1), and simultaneously, piston and piston push rod fixedly are connected as a single entity.When needs are operated, cut somebody's hair 101 with pulling out, allow push rod main body 103 from piston cavity 210, pull out, hear " coughing " one, the end 208,209 of expression card article 207,206 is respectively from first bayonet socket 105, move on 105 ' on second bayonet socket 104 and 104 ' on, and be connected to bayonet socket 104 and 104 on the push rod main body 103 '.In this time, piston still is in primary importance, and piston push rod is in the second place and is positioned at proving installation and exposes (Fig. 4), simultaneously in position upper piston and the piston push rod structure that still is fixed as one.Cut somebody's hair 101 then and since this moment push rod main body 103 to be connected as a single entity with piston 200 be not to be in relative active state, so piston is pushed to the second place by push rod main body 103 from primary importance.Like this, the bar 204 that is connected on the piston moves to the second place from primary importance, and the moving of push rod 204 positions can allow the nipple flexible member of first state that is in the closed or sealing of oneself change to second state of opening.At this moment, piston push rod is positioned at transfer chamber again, cuts somebody's hair and gets back to preliminary examination position (Fig. 5).

Describe the pick-up unit work principle in detail and the push rod of the flexible connection how to use below in conjunction with accompanying drawing.

Referring to Fig. 1-3, the top 302 of nipple flexible member is towards the right side, piston is positioned at transfer chamber (perhaps being called plunger shaft) 500 and limits a chamber 900 with the nipple flexible member, comprise passage 603 on the sidewall in this chamber 900, the seal element of piston, for example O- ring seal 201 and 202 allows the outer wall of piston and the inner wall sealing of transfer chamber 500.And piston blow-by passage 603 is shown in Fig. 1 and 3A-3B.At this moment, when collecting liquid sample with device, when liquid sample is full of sample chamber, the partially liq sample flow in the chamber 900 by passage 603, but because through hole 303 is in first state that the oneself is closed or seal on the nipple flexible member 300, liquid sample can not flow in the test chamber 400 by the through hole on the nipple flexible member.Though the liquid sample in the liquid sample chamber has produced certain pressure or pressure to the through hole on the nipple flexible member 300 303, perhaps the top 302 to nipple has also produced pressure simultaneously, and this pressure can't force the through hole of self-isolation or sealing to be opened.In addition, piston 200 has sealed the other end in the transfer chamber 500, so the volume of liquid sample is certain in chamber 900.Certainly, the volume in chamber can be selected arbitrarily, for example is the 1-5 milliliter, the 2-10 milliliter.

When in use, referring to Fig. 4, draw back the piston push rod 100 that flexibly connects with piston 200 and promote piston, allow piston 200 move to the second place from primary importance, in the process that moves, outer wall 203 seal channels 603 of piston allow top 302 on the top one end 205 contact nipple flexible members 300 of push rod 204 simultaneously.This moment, chamber 900 was all sealed, and it neither carries out fluid exchange with sample chamber, does not also exchange with test chamber.

Referring to Fig. 5, along with piston further moves, the chamber 305 that the push rod 204 that is connected as a single entity with piston forces the nipple element is from being turned to towards a left side towards the right side, allows the top of nipple element become and be positioned at test chamber 400 from being positioned at chamber 900.Because turning up of nipple element 300 sidewalls, the through hole 303 that be positioned on nipple element 300 sidewalls 304 this moment is in second state of opening, piston mobile forces the liquid sample in the chamber 900 to enter in the test chamber 400 by through hole 303 and contacts with testing element 700, thereby can detect whether comprise analyte in the liquid sample by testing element.At this moment, chamber 900 is a fluid connection with test chamber, but not with sample chamber 601 fluid connections.

This push rod that flexibly connects with piston not only can be used for the present invention's proving installation, can also be connected with piston separately and apply in other the proving installation.

" sample " that the present invention refers to refer to whether needs chemical examinations exists and (or) analyze any material of analyte concentration, maybe need to determine whether one or more samples exist and (or) material of the analyte of quantity, maybe need to carry out the material of qualitative evaluation.Sample can be liquid sample, for example liquid sample.Liquid sample comprises body fluid, such as blood, serum, blood plasma, saliva, urine, tears, seminal fluid and marrow; Liquid sample also can be a water sample, such as seawater, river, river etc., perhaps from domestic water, municipal water use or service water resource, runoff water or sewage; Sample can be a food sample, such as milk and wine.Mucus, semisolid or solid sample can be used for making liquid, eluate, suspending liquid or leachate equal samples.For example, throat or genitals sample may be dipped in and make sample in the liquid.Sample can comprise potpourri or any relevant potpourri of liquid, solid and gas, such as the cell suspending liquid in dilution or the solution.Sample comprises biological substance, such as cell, microorganism, organelle and biochemical complexes.Liquid sample can be from producing such as solid, semisolid or high-viscosity materials such as soil, ight soil, tissue, organ, biological fluid or other occurring in nature non-liquid samples.For example, these solids or semi-solid samples can be mixed with the suitable solution of dilution one class.Sample can be macerated, freezing and thaw, perhaps other extracting method form liquid samples.Remaining particulate material can use traditional method such as filtration or precipitation to remove.

The analyte that the present invention refers to can be " drug abuse " (DOA) or other have interested material in the sample." drug abuse " (DOA) is meant that the non-medical destination uses medicine (playing the paralysis nerve usually).Abuse these medicines and can cause body ﹠ mind to suffer damage, produce dependence, habit-forming and/or dead.The example of drug abuse comprises cocaine; Amphetamine (for example, black beauty, white amphetamine tablet, dextroamphetamine, dexie, Beans); Crystal methamphetamine (crank, meth, crystal, speed); Barbiturate (as Valium, RochePharmaceuticals, Nutley, New Jersey); Sedative (paramedicines of promptly sleeping); Lysergic acid diethylamide (LSD); Inhibitor (downers, goofballs, barbs, blue devils, yellow jackets, methaqualone); The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin); Hog (PCP); Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); Opiate (being morphine, opium, codeine, heroin, the hydroxyl dihydrocodeinone); Anxiolytic and hypnotic sedative agent, anxiolytic is that a class is mainly used in anxiety reduction, nervous, frightened, set the mind at rest, have the medicine of hypnosis sedation concurrently, comprise Benzodiazepines (benzodiazepines, BZ), atypia BZ class, merge phenodiazine NB23C class, the tall and erect class of benzene nitrogen, the part class of BZ acceptor, open loop BZ class, diphenylmethane derivatives, the piperazine carboxylic acid salt, the piperidine carboxylic acid salt, Kui azoles quinoline ketone, thiazine and thiazole, other heterocyclic, imidazole type calmness/anodyne, propanediol derivative-carbamates, fatty compound, anthracene derivative etc.Use this device also can be used to detect and belong to medical usage but the detection of overdose easily, as tricyclic antidepressant (imipramine or analog) and Paracetamol etc.Can resolve into different small-molecule substances after these medicines are absorbed by the body, these small-molecule substances are present in the body fluid such as blood, urine, saliva, sweat or there is above-mentioned small-molecule substance in part body fluid.

Testing element 700

Device of the present invention can adopt multiple test-strips, and this is according to the purpose of being disinclined to analyte to be checked and test.Test-strips can roughly be divided into two classes, detects test-strips and the anti-test-strips of mingling.Detect test-strips and comprise the material that is used for detecting sample composition to be checked.Prevent that mingling test-strips comprises the material that is used to detect the sample material characteristic.Two types test-strips all comprises sample application zone and detection zone.

Detect test-strips: multiple detection test-strips can be used among the present invention.Detect the test that test-strips comprises analyte in immune detection or chemical detection and the detection sample.These analytes comprise: the metabolin of drug abuse or hint health status.

For example above-described " drug abuse " be material (DOA).Be the legal medication of medical purpose, but incidental dosage is excessive, also can adopts test-strips of the present invention to detect.These medicines comprise: three rings anti-strongly fragrant dose (imipramine and its analog) and contain the OTC product (medicine of acenol is provided such as the trade mark that is positioned at the washingtonian McNeil-PPC of Pennsylvania, America company and provides) of acetaminophen.This detection can help patient that emergency rescue personnel judges stupor whether by accident excessive use a kind of in these medicines.

Can hint that the metabolin in the urine of health status includes but not limited to creatinine, cholerythrin, nitrite, protein (non-specific), hormone is (as human chorionic gonadotrophin, corpus luteum hormone, follicular stimulating hormone etc.), blood, leucocyte, sugar, heavy metal or toxin, the bacterium composition is (as specific protein or the carbohydrate of Special Category bacterium, such as colon bacillus 0157: H7, staphylococcus, salmonella, fusobacterium, Campylobacter, monocytosis kytoplasm base (L.monocytogenes), vibrio, or cactus bacillus) and physical property, as pH value and proportion.Any other clinical urine chemical analyte that can adopt the fast detecting mode can be applied in this device.

Detect test-strips various ways can be arranged.Generally speaking, test-strips is made up of absorbent material.This absorbent material comprises sample application zone, raw material district and test results zone.Sample is added to sample application zone and by capillary force wet raw material district.In the raw material district, the sample dissolving also mixes those and detects the necessary raw material of analysans (if existing in the sample).The sample that has mixed raw material continues moistening test result zone.Extra raw material is fixed on test result zone.The reaction of one of first group of raw material in these raw materials and analysans (if present) or raw material district.If there is analyte really in sample, a signal will appear in the test section, otherwise then signal can not occur.

Claims (10)

1. pick-up unit comprises: one is used to collect or the sample chamber (601) of storaging liquid sample; A test chamber (400) that is used to accommodate testing element; With a liquid sample transfer chamber (500); In transfer chamber, comprise a piston (200) that can move to the second place from primary importance; By moving of piston the liquid sample in the sample chamber is transferred in the test chamber by transfer chamber (500); It is characterized in that, comprise also that on piston one is in flexible connection with piston, and has the piston push rod (100) of the primary importance and the second place.

2. device according to claim 1 is characterized in that, described piston push rod comprises push rod main body (103), and wherein part piston push rod main body is positioned at plunger shaft.

3. device according to claim 2 is characterized in that, piston comprises the card article (207,206) that has dop (208,209); The push rod main body comprises bayonet socket that dop is installed (104,104 ', 105,105 ').

4. device according to claim 3 is characterized in that piston and card article are connected as a single entity; Bayonet socket is positioned on the outer wall (102) of push rod main body.

5. device according to claim 3 is characterized in that, the push rod main body comprises first bayonet socket and second bayonet socket, and when piston push rod in primary importance the time, the dop on the piston is positioned at (105,105 ') on first bayonet socket; When piston push rod in the second place time, the dop on the piston is positioned at (104,104 ') on second bayonet socket.

6. device according to claim 5 is characterized in that, when piston push rod in primary importance the time, the piston push rod that is arranged in piston can be drawn out from plunger shaft (210).

7. device according to claim 6 is characterized in that, when piston push rod the time in the second place, piston push rod and piston can not relative motion and with the piston structure that is connected as a single entity.

8. according to the described device of one of claim 1-7, it is characterized in that, when piston push rod at primary importance and piston the time in primary importance, piston push rod all is positioned at transfer chamber.

9. according to the described device of one of claim 1-7, it is characterized in that, also comprise the passage (603) that is communicated with the liquid sample chamber on the transfer chamber.

10. according to the described device of one of claim 1-7, it is characterized in that this device also comprises a nipple shape flexible member (300), this nipple shape flexible member comprises the through hole (303) of oneself's sealing.

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