CN106268392B - method for mixing at least two substances - Google Patents
method for mixing at least two substances Download PDFInfo
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- CN106268392B CN106268392B CN201510279882.4A CN201510279882A CN106268392B CN 106268392 B CN106268392 B CN 106268392B CN 201510279882 A CN201510279882 A CN 201510279882A CN 106268392 B CN106268392 B CN 106268392B
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Abstract
the invention relates to a method for mixing at least two substances, and provides a mixing device which comprises a base and a container connected with the base, wherein the base comprises a piston cavity and a piston, the piston at least comprises a first position and a second position in the piston cavity, a through hole is formed at the joint of the container and the base, and the outer surface of the piston is at least provided with a first area and a second area; the method comprises the following steps: a) depositing a first substance in the second region; b) the piston is arranged at a first position in the piston cavity, and a through hole at the communication part of the container and the base is connected with a first area on the outer surface of the piston body and is closed and sealed by the first area; c) storing a second substance in the container; d) moving the piston from the first position to a second position in the piston cavity, so that the through hole at the communication part of the container and the base is connected with a second area of the outer surface of the piston body and is closed and sealed by the second area; e) the first substance and the second substance are mixed. The invention realizes the function of storing first and then mixing immediately. Moreover, the method is simple and convenient to operate.
Description
Technical Field
The invention relates to a method for mixing at least two substances by means of a mixing device for storing and mixing liquids or solids, in particular a mixing device and a mixing method for storing and mixing a liquid and other liquids or solids.
Background
The following background is provided to aid the reader in understanding the present invention and is not admitted to be prior art.
The technology of detecting whether an analyte exists in a sample by using the principle of an immunological binding reaction is widely used in various fields. It can be used to detect analytes in various biological samples (saliva, blood, urine, serum, sweat, etc.) to monitor diseases and human health (early pregnancy, tumors, infectious diseases, drugs, etc.). The underlying principle of such detection techniques is to establish the ability to specifically bind between immune molecules, such as antibodies and antigens, haptens/antibodies, biotin and avidin, and the like. In addition, many such assays can be performed on solid media, such as conventional lateral flow reagent strips, in glass or plastic porous disks, immunochromatographic devices, and the like. Usually, some solid particles or chemical substances can be further combined on the immune specific binding molecules, so that the detection result can be qualitatively, quantitatively or semi-quantitatively obtained by naked eyes or other instrument devices.
test strips or devices that utilize these principles are found in the prior art, such as those described in the following patents: US 4857453; US 5073484; US 5119831; US 5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US 5654162; US 5656503; US 5686315; US 5766961; US 5770460; US 5916815; US 5976895; US 6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US 6306642; US 6352862; US 6372515; US 6379620; and US 6403383.
In the detection of such biological samples, it is often necessary to pre-treat the biological sample so that the components of the sample to be analyzed are released. Therefore, the pretreatment or buffer treatment of the sample becomes an essential key step for ensuring the accuracy or precision of the detection result.
in some assays, the assay sample is pretreated by adding a buffer solution. The buffer solution for buffering is generally composed of one substance or a mixture of 2 or more solid or liquid substances. In some detection, two substances are mixed to form a buffer solution to buffer a sample, but the two substances can react after being mixed in advance, or the two substances are not easy to store for a long time, or the buffer effect is greatly reduced after the two substances are stored for a long time, and even the subsequent detection is inaccurate. Therefore, it is necessary to be able to mix the samples immediately when they need to be buffered.
Disclosure of Invention
the invention provides a device for storing and instantly mixing liquid and solid and a method for mixing at least two substances by using the device.
The invention discloses a method for mixing at least two substances, which comprises the steps of providing a mixing device, wherein the mixing device comprises a base and a container connected with the base, the base comprises a piston cavity and a piston accommodated in the piston cavity, the piston at least comprises a first position and a second position in the piston cavity, a through hole communicated with the piston cavity is formed in the joint of the container and the base, and the outer wall surface of the piston is at least provided with a first area and a second area; the method comprises the following steps:
a) Depositing a first substance in a second region of the outer wall surface of the piston;
b) placing the piston at a first position in the piston cavity, wherein the through hole at the communication part of the container and the base is connected with a first area of the outer wall surface of the piston body and is closed and sealed by the first area;
c) Storing a second substance in the container;
d) Moving the piston from the first position to the second position in the piston cavity, so that the through hole at the communication part of the container and the base is connected with the second area of the outer wall surface of the piston body and is closed and sealed by the second area;
e) The first substance and the second substance are mixed.
In a preferred embodiment, the first area and the second area comprise a first groove and a second groove for containing substances, and the grooves are communicated with the through hole at the bottom of the container and seal the through hole; the first substance is located in the second recess.
In another preferred form, the piston further comprises a pull rod which can have an initial position and an end position within the piston, the piston being of smaller size and the pull rod being movable relative to the piston when the pull rod is in the initial position and the piston being of larger size and the pull rod being immovable relative to the piston when the pull rod is in the end position.
Specifically, the pull rod comprises a handle part and a clamping structure extending out of the handle part, the piston body comprises a corresponding mechanism for accommodating the clamping structure of the pull rod, and when the pull rod is located at an initial position, the clamping structure of the pull rod and the corresponding mechanism of the piston body are in a non-clamping state and can move relatively; when the pull rod is located at the termination position, the buckling structure of the pull rod and the corresponding mechanism of the piston body are in a buckling state, and the pull rod and the corresponding mechanism cannot move relatively.
More specifically, the locking structure of the pull rod comprises two elastic arms, and a convex block is arranged on the outer side of the free end accessory of each elastic arm; the corresponding mechanism in the piston body comprises a channel for accommodating the elastic arm and a clamping hole corresponding to the lug, and when the pull rod is positioned at the initial position, the elastic arm and the lug of the pull rod are compressed and accommodated in the channel of the corresponding mechanism in the piston body; when the pull rod is located at the termination position, the convex block at the free end of the elastic arm of the pull rod is clamped in the clamping hole of the corresponding mechanism in the piston body.
In a preferred mode, a step f) is further included between the steps c) and d): moving the pull rod from an initial position to an end position.
in another preferred mode, a step g) is further included between the steps a) and b): placing a third substance in the first region of the piston outer surface; between said steps c) and f) a step h) is also included: mixing the third substance and the second substance.
More specifically, the third material is disposed in the first groove of the first region.
The invention also comprises a device for mixing at least two substances by the method, which comprises a base and a container connected to the base, wherein the base comprises a piston cavity and a piston positioned in the cavity; the bottom of the container is communicated with a piston cavity on the base and is sealed by a piston; the piston is movable within a piston chamber.
In a preferred mode, the bottom of the container comprises a through hole, and the container is communicated with the piston cavity through the through hole.
In another embodiment, the piston includes at least 2 sealing areas on the outer surface.
specifically, the through hole in the bottom of the container is located in and sealed by the sealing area.
In other preferred embodiments, each sealing region includes a recess therein, the recesses communicating with the through-hole in the bottom of the container. In the groove of the sealing area, substances to be mixed, such as liquids or solids, etc., may be placed in advance.
in some embodiments, the piston includes at least a first position and a second position in the piston cavity.
in a specific mode, when the piston is located at the first position, the first sealing area of the piston is located at the bottom of the container and seals the through hole at the bottom of the container. More specifically, the through hole in the bottom of the container is in communication with and sealed by the first groove in the first sealing region. The solid or liquid located in the recess is in communication with and mixes with the contents of the container.
In another specific mode, when the piston is located at the second position, the second sealing area of the piston is located at the bottom of the container and seals the through hole at the bottom of the container. Similarly, the through hole at the bottom of the container is communicated with the second groove in the second sealing area and is sealed by the groove. The solid or liquid located in the second recess is in communication with and mixes with the contents of the container.
In a preferred embodiment, the piston surface comprises a plurality of sealing rings and sealing lines, which divide the piston into at least 2 sealing areas.
in other embodiments, the piston includes a push rod located within the piston.
In some embodiments, the pushrod has an initial position and an end position within the piston.
In a preferred mode, when the push rod is located at the initial position, the piston cannot move relatively in the piston cavity; when the push rod is at the end position, the piston can move back and forth in the piston cavity under the pushing of the push rod.
in another preferred manner, when the pull rod is in the initial position, the piston has a smaller size and the pull rod is movable relative to the piston, and when the pull rod is in the end position, the piston has a larger size and the pull rod is not movable relative to the piston.
In one specific embodiment, the push rod comprises a rod handle and a buckle structure connected with the rod handle; the piston comprises a corresponding mechanism matched with the buckling structure.
More specifically, when the push rod is located at the initial position, the buckling structure of the push rod and the corresponding mechanism of the piston are in a non-buckling state, and the push rod and the corresponding mechanism can move relatively; when the push rod is positioned at the termination position, the buckling structure of the push rod and the corresponding mechanism of the piston are in a buckling state, and the push rod and the corresponding mechanism can not move relatively
In a specific embodiment, the snap structure comprises two elastic arms and a protrusion located outside the free ends of the elastic arms.
in another specific embodiment, the corresponding mechanism on the piston comprises a channel for receiving the elastic arm and a clamping hole corresponding to the bump.
When the push rod is positioned at the initial position, the two elastic arms of the push rod and the convex block positioned at the outer sides of the free ends of the elastic arms are compressed and accommodated in the channel of the corresponding mechanism in the piston; when the push rod is at the end position, the lug at the free end of the elastic arm is clamped in the clamping hole of the corresponding mechanism in the piston. That is, when the push rod is pulled out on the piston, the elastic arm moves in the piston channel until the lug on the elastic arm reaches the clamping hole on the piston and is clamped by the clamping hole to reach the end position. At this time, the positions of the push rod and the piston are fixed by engagement.
in other embodiments, the piston further comprises a clamping groove and a limiting pin positioned in the clamping groove. When the piston is located at the first position, the limiting pin is located in the clamping groove, and the piston cannot move in the cavity; when the piston needs to move in the piston cavity, the limiting pin is pulled out, the piston is pushed into the piston cavity, the piston reaches the second position, and the movement of the piston in the cavity is completed.
Advantageous effects
The device and the method for mixing solid and liquid substances can realize the function of mixing liquid or solid, particularly mixing liquid and solid at any time when in use, and can also realize quantitative mixing. The problem of inaccurate to follow-up detection that uses after mixing earlier and storing is solved. And the operation is simple and the use is convenient.
Drawings
FIG. 1 is an exploded schematic view of the apparatus of the present invention;
FIG. 2 is a front view of the apparatus of the present invention;
FIG. 3 is a schematic cross-sectional view of the piston of the device in a first position and the pushrod in an initial position;
FIG. 4 is a schematic partial cross-sectional view of the position of FIG. 3;
FIG. 5 is a schematic partial cross-sectional view of the device with the piston in a first position and the push rod in an end position;
FIG. 6 is a schematic partial cross-sectional view of the device with the piston in the second position and the pushrod in the end position.
Description of reference numerals:
A mixing device 800; a container 100; container bottom and through hole 101; a base 200; a base piston cavity 201; a piston 300; a piston outer surface 310; a pushrod 320, a pushrod handle 321; a push rod spring arm 322; an upper spring arm projection 323; a first sealing region 311; a second sealing region 312; a first groove 313 in the first sealing region; a second groove 314 of the second sealing region; a passage 315 of the piston; a piston snap hole 316; a sealing ring 318 on the piston; seal line 317 on the piston; a lid 400 on the container; a liquid 600; solid 500
Detailed Description
the present invention will be further described with reference to the structures or terms used herein. In the following detailed description, reference is made to the accompanying drawings that form a part hereof, and in which is shown by way of illustration specific embodiments in which the invention may be practiced. It is not excluded that the invention can also be implemented in other embodiments and that the structure of the invention can be varied without departing from the scope of use of the invention.
As shown in FIG. 1, the device 800 of the present invention includes a base 200, and a container 100 attached to the base. Wherein, the container 100 and the base 200 can be fixedly connected together or detachably connected. In one embodiment, the base 200 is a unitary structure with the container 100. The top of the container 100 further includes a lid 400 for closing or sealing the container to prevent the volatilization or leakage of the contents stored in the container 100, as shown in fig. 2.
The base 200 includes a piston chamber 201 and a piston 300 accommodated in the piston chamber. Also, the piston 300 is relatively movable in the piston chamber 201. As shown in fig. 3, the space of the piston chamber 201 is larger than the volume of the piston 300, so that the piston 300 can move forward a certain distance in the piston chamber 201. As shown in fig. 1, the piston chamber 201 is located on the base 200, and the chamber 201 is connected to and communicates with the bottom 101 of the container 100. The piston 300 is located in the piston chamber 201 of the base and is in communication with the bottom 101 of the container. More specifically, the bottom 101 of the container is sealed by the piston 300 to ensure that the substance (liquid or solid) located therein does not leak from the bottom 101. The bottom 101 of the sealed container is also maintained during movement of the piston 300 within the piston chamber 201.
in a specific embodiment, the bottom of the container is connected with the base and is provided with a through hole 101, and the through hole 101 enables the container to be communicated with a piston cavity 201 of the base. More specifically, the through hole 101 is sealed by the piston 300.
In some specific embodiments, the outer surface 310 of the piston includes at least 2 regions: a first sealing area 311 and a second sealing area 312, which form a seal with the piston chamber 201. During the movement of the piston 300 in the piston chamber 201, one of these areas is located at the through hole 101 of the container 100 communicating with the piston chamber 201 for sealing the through hole 101 and thus the bottom of the container 100.
The piston 300 is movable within the piston chamber 201, and in particular embodiments, the piston 300 has at least 2 positions within the piston chamber 201: a first position and a second position. When the piston 300 is in the first position of the chamber, as shown in fig. 3, 4 or 5, the container bottom 101 is located on the first sealing area 311, and more specifically, the through hole 101 of the container bottom is located on the first sealing area 311, and the space formed by the first sealing area 311 and the piston chamber 201 is sealed, so that the through hole 101 of the container bottom and the bottom is sealed, and the solid or liquid located therein is not leaked to the outside of the piston chamber 201. Similarly, when the piston 300 is located at the second position of the piston chamber 201, as shown in fig. 6, the second sealing area 312 is located at the bottom 101 of the container, and the through hole 101 of the bottom is located in the second sealing area 312, and is sealed by the closed space formed by the second area 312 and the piston chamber 201. In some embodiments, the sealed region further comprises a groove therein, the first region 311 comprises a first groove 313 therein, and the second sealed region 312 comprises a second groove 314 therein. These recesses 313,314 are used to contain the solid or liquid that is the substance to be mixed in the present invention. In addition, the grooves 313 and 314 are used for sealing the through holes at the bottom of the container, when the grooves 313 and 314 are positioned at the through holes at the bottom of the container, the side walls of the grooves 313 and 314 seal the through holes 101, so that the grooves 313 and 314 are connected with the bottom of the container into a whole, and simultaneously, the solid substances 500 in the grooves are mixed with the liquid substances 600 in the container.
in some embodiments, the piston outer surface 310 includes a plurality of sealing rings 318 and sealing lines 317, the sealing rings 318 and sealing lines 317 dividing the piston outer surface 310 into at least 2 sealing regions. As shown in fig. 1, the first seal region 311 and the second seal region 312 are formed to be separated by the seal ring 318 and the seal line 317. The first sealing area 311 and the second sealing area 312 are both located below the bottom 101 of the container, and the sealing areas 311,312 can be brought to the bottom 101 of the container in sequence by translation of the piston 300 in the piston chamber 201. Likewise, the recesses 313,314 in the sealing area are also in communication with the through-hole 101 in the bottom of the container and seal the through-hole 101, respectively.
The sealing ring 318 and the sealing line 317 may separate a third area and a fourth area … … on the outer surface of the piston in addition to the first area 311 and the second area 312. The piston 300 reaches the fourth position by the piston 300 moving within the piston chamber 201 to the first position, the second position, the third position, the fourth position … …, etc., and the fourth sealing area on the piston outer surface 310 is located on the container bottom 101 and communicates with the container 100. Mixing of the solid or liquid in the region and/or in the recess of the region with the solid or liquid in the container 100 may be achieved.
the problem to be solved by the present invention is how to move the piston 300 in the piston cavity 201. in some embodiments, the piston 300 includes a push rod 320, the push rod 320 is located in the piston 300, and the piston 300 is pushed forward in the cavity 201 by pressing the push rod 320. In a more specific embodiment, the push rod 320 includes a handle 321 and a snap structure connected thereto; the piston 300 includes a corresponding mechanism thereon that mates with the snap feature. The push rod 320 can move relative to the piston 300 or can remain in a fixed relationship by the engagement of the snap structure with the corresponding mechanism.
specifically, the pushrod 320 has an initial position and an end position within the piston 300. When the push rod 320 is located at the initial position, the piston 320 has a small size and the push rod 320 is movable with respect to the piston 300, and when the push rod 320 is located at the final position, the piston 300 has a large size and the push rod 320 is immovable with respect to the piston 300. More specifically, when the push rod 320 is located at the initial position, the locking structure of the push rod 320 and the corresponding mechanism of the piston 300 are in a non-locking state, and the two can move relatively; when the push rod 320 is located at the end position, the snap structure of the push rod 320 and the corresponding mechanism of the piston 300 are in a snap state, and the two can not move relatively.
In addition, when the push rod 320 is located at the initial position, the piston 300 cannot move relatively in the piston cavity 201; at this time, the push rod 320 is located in the piston 300 integrally, and is in a relative motion relationship with the piston 300, so that the piston 300 cannot move in the piston cavity 201, and at this time, the piston 300 is in the first position, as shown in fig. 4; after the push rod 320 is pulled out from the piston 300 from the initial position, when the push rod reaches the end position, the push rod 320 is fixed with the piston 300 in a buckling manner, as shown in fig. 5; the piston 300 can move back and forth in the piston cavity 201 under the pushing of the fixed push rod 320, so that the piston 300 reaches the second position, as shown in fig. 6.
In one embodiment, the latch structure on the push rod 320 includes a resilient arm 322 and a protrusion 323 located outside the free end of the resilient arm. The corresponding mechanism on the piston 300 includes a channel 315 for receiving the resilient arm and a snap hole 316 corresponding to the tab. When the push rod 320 is in the initial position, the elastic arm 322 and the projection 323 of the push rod are compressed and housed in the channel 315 of the corresponding mechanism in the piston 300; when the push rod 320 is in the end position, the protrusion 323 at the free end of the elastic arm 322 of the push rod is snapped into the snap hole 316 of the corresponding mechanism in the piston. When the push rod 320 is pulled out on the piston 300, the elastic arm 322 moves in the piston channel 315 until the protrusion 323 on the elastic arm reaches the latch hole 316 on the piston and is latched by the latch hole. At this time, the positions of the push rod 320 and the piston 300 are fixed by engagement.
The method of mixing at least two substances by the apparatus 800 of the present invention is described in detail below. The method comprises the following specific steps:
depositing a first substance (solid 500) in a second region 312 of the piston outer wall surface; more specifically, the solid 500 is stored in the second recess 314 of the second region;
the piston 300 with the solid 500 is arranged at a first position in the piston cavity 201, and the through hole 101 at the communication part of the container 100 and the base 200 is connected with a first area 311 on the outer wall surface of the piston body and is closed and sealed by the first area 311; specifically, the through hole 101 is located in the first groove 313, and is sealed and sealed by the first groove 313, and the first groove 313 is communicated with the container 100;
storing a second substance (liquid 600) in the container 100 of the device;
pulling the push rod 320 in the piston 300 out of the channel 315 of the piston 300, so that the push rod 320 reaches the end position from the initial position, that is, the push rod elastic arm 322 is pulled out of the piston channel 315, until the bump 323 at the free end of the elastic arm reaches the clamping hole 316 on the piston and is clamped and fixed;
Pushing the handle 321 of the push rod to move the piston 300 connected and fixed with the push rod 320 from the first position to the second position in the piston chamber 201, so that the through hole 101 where the container 100 and the base 200 communicate is connected with the second region 312 of the outer wall surface 110 of the piston body and is closed and sealed by the second region 312; at this time, the second sealing area further comprises a second groove 314, the solid is located in the second groove 314, and the through hole 101 is located in the second groove 314, and is sealed and sealed by the second groove 314;
The container 100 is shaken to mix the first substance (solid 500) and the second substance (liquid 600).
In another method for mixing 3 substances, the specific steps are as follows:
depositing a first substance (solid 500) in a second region 312 of the piston outer wall surface; more specifically, the solid 500 is stored in the second recess 314 of the second region;
Depositing a third substance in a first region 311 of the piston outer wall surface 310, more specifically, in a first recess 314 of the first region;
The piston 300 with the solid 500 and the third substance is arranged at the first position in the piston cavity 201, the through hole 101 where the container 100 and the base 200 are communicated is connected with the first area 311 of the outer wall surface of the piston body, and is closed and sealed by the first area 311; specifically, the through hole 101 is located in the first groove 313, and is sealed and sealed by the first groove 313, and the third substance in the first groove 313 is communicated with the container 100;
Storing a second substance (liquid 600) in the container 100 of the device;
Mixing the third substance and the second substance (liquid 600)
Pulling the push rod 320 in the piston 300 out of the channel 315 of the piston 300, so that the push rod 320 reaches the end position from the initial position, that is, the push rod elastic arm 322 is pulled out of the piston channel 315, until the bump 323 at the free end of the elastic arm reaches the clamping hole 316 on the piston and is clamped and fixed;
Pushing the handle 321 of the push rod to move the piston 300 connected and fixed with the push rod 320 from the first position to the second position in the piston chamber 201, so that the through hole 101 where the container 100 and the base 200 communicate is connected with the second region 312 of the outer wall surface 110 of the piston body and is closed and sealed by the second region 312; at this time, the second sealing area further comprises a second groove 314, the solid is located in the second groove 314, and the through hole 101 is located in the second groove 314, and is sealed and sealed by the second groove 314;
The container 100 is shaken to mix the mixture of the first substance (solid 500) and the second substance (liquid 600) with the third substance.
Claims (8)
1. A method of mixing at least two substances, characterized by: providing a mixing device, wherein the mixing device comprises a base and a container connected with the base, the base comprises a piston cavity and a piston accommodated in the piston cavity, the piston at least comprises a first position and a second position in the piston cavity, a through hole communicated with the piston cavity is arranged at the joint of the container and the base, and the outer wall surface of the piston is at least provided with a first area and a second area; the method comprises the following steps:
a) Depositing a first substance in a second region of the outer wall surface of the piston;
b) Placing the piston at a first position in the piston cavity, wherein the through hole at the communication part of the container and the base is connected with a first area of the outer wall surface of the piston body and is closed and sealed by the first area;
c) Storing a second substance in the container;
d) moving the piston from the first position to the second position in the piston cavity, so that the through hole at the communication part of the container and the base is connected with the second area of the outer wall surface of the piston body and is closed and sealed by the second area;
e) The first substance and the second substance are mixed.
2. The method of claim 1, wherein the first and second regions include first and second recesses for holding substances therein, the recesses communicating with and sealing the through-hole of the container bottom; the first substance is located in the second recess.
3. The method of claim 2, wherein the piston further comprises a pull rod having an initial position and an end position within the piston, wherein when the pull rod is in the initial position, the piston has a smaller size and the pull rod is movable relative to the piston, and when the pull rod is in the end position, the piston has a larger size and the pull rod is not movable relative to the piston.
4. The method of claim 3, wherein the pull rod includes a handle and a snap structure extending from the handle, and the piston body includes a corresponding mechanism for receiving the snap structure of the pull rod, and when the pull rod is in the initial position, the snap structure of the pull rod and the corresponding mechanism of the piston body are in a non-snap state and are movable relative to each other; when the pull rod is located at the termination position, the buckling structure of the pull rod and the corresponding mechanism of the piston body are in a buckling state, and the pull rod and the corresponding mechanism cannot move relatively.
5. The method as claimed in claim 4, wherein the locking structure of the pull rod comprises two elastic arms, and a protrusion is provided on an outer side of a free end of each elastic arm; the corresponding mechanism in the piston body comprises a channel for accommodating the elastic arm and a clamping hole corresponding to the lug, and when the pull rod is positioned at the initial position, the elastic arm and the lug of the pull rod are compressed and accommodated in the channel of the corresponding mechanism in the piston body; when the pull rod is located at the termination position, the convex block at the free end of the elastic arm of the pull rod is clamped in the clamping hole of the corresponding mechanism in the piston body.
6. the method according to claim 5, further comprising, between said steps c) and d), a step f): moving the pull rod from an initial position to an end position.
7. the method according to claim 6, characterized in that between said steps a) and b) it further comprises a step g): placing a third substance in the first region of the piston outer surface; between said steps c) and f) a step h) is also included: mixing the third substance and the second substance.
8. The method of claim 7, wherein a third substance is placed in the first recess of the first region.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510279882.4A CN106268392B (en) | 2015-05-27 | 2015-05-27 | method for mixing at least two substances |
| PCT/CN2015/097374 WO2016188096A1 (en) | 2015-05-27 | 2015-12-15 | A mixing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510279882.4A CN106268392B (en) | 2015-05-27 | 2015-05-27 | method for mixing at least two substances |
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| Publication Number | Publication Date |
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| CN106268392A CN106268392A (en) | 2017-01-04 |
| CN106268392B true CN106268392B (en) | 2019-12-13 |
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| CN201510279882.4A Active CN106268392B (en) | 2015-05-27 | 2015-05-27 | method for mixing at least two substances |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201662573U (en) * | 2010-03-25 | 2010-12-01 | 艾博生物医药(杭州)有限公司 | Detecting device with movable push rod |
| CN102439717A (en) * | 2009-03-24 | 2012-05-02 | 芝加哥大学 | Slip chip device and method |
-
2015
- 2015-05-27 CN CN201510279882.4A patent/CN106268392B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102439717A (en) * | 2009-03-24 | 2012-05-02 | 芝加哥大学 | Slip chip device and method |
| CN201662573U (en) * | 2010-03-25 | 2010-12-01 | 艾博生物医药(杭州)有限公司 | Detecting device with movable push rod |
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| Publication number | Publication date |
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| CN106268392A (en) | 2017-01-04 |
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