CN110161270A - The collection and detection method of sample - Google Patents
The collection and detection method of sample Download PDFInfo
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- CN110161270A CN110161270A CN201810740202.8A CN201810740202A CN110161270A CN 110161270 A CN110161270 A CN 110161270A CN 201810740202 A CN201810740202 A CN 201810740202A CN 110161270 A CN110161270 A CN 110161270A
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-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
Abstract
The present invention provides the collection and detection method of a kind of sample, sample is first allowed to enter intracavitary, and chamber is divided to store in the sample for being used for initial detecting and the sample for being used for secondary-confirmation detection, after the completion of collecting sample, the sample for being used in secondary-confirmation detection first is individually isolated, and is then detected again to the sample for initial detecting.This method can separate the detection sample of initial detecting sample and secondary-confirmation, the initial sample being collected by the detection device, the first chamber and second intracavitary can be had respectively entered, then after the completion of initial detecting or before completing, second chamber can be separated with initial collection chamber, realize primary collection secondary detection, it will not be polluted between the sample of initial detecting and the sample of confirmation detection, the sample of confirmation detection is just sealed before the sample of initial detecting enters detection zone, ensure that the sample of secondary-confirmation detection will not be polluted by the detection liquid of primary detection, influence the effect of secondary-confirmation.
Description
Technical field
The present invention relates to a kind of method of collection and detection liquid sample, the especially collections and inspection in quick diagnosis field
The method for surveying analyte in liquid sample, such as urine collecting and detection method.
Background technique
Currently, for detect in sample whether the detection device containing analyte, be largely used to hospital or family
In, these detection devices for being applied to quick diagnosis include one or more detection reagent items, for example early pregnancy detects, drug abuse
Detection etc..The detection device of this quick diagnosis is very convenient, can be at one minute, or at most ten minutes or so are detecting
Testing result is obtained on reagent strip.
Illicit drugs inspection is widely used, be usually used in prohibition of drug department, public security bureau, narcotic house, medical center, country conscription physical examination at
Etc. mechanisms.Illicit drugs inspection wide variety, number is frequent, can be automatically separated the illicit drugs inspection urine cup of remaining sample Yu detected sample
With the huge market demand, after detection is completed, sample in urine cup will be by for illicit drugs inspection urine cup currently on the market
To detection reagent pollution and cannot continue on for second of confirmation detection, such as United States Patent (USP) 7300633 describe as.
Although detected sample in the conventional technology, can be allowed to be isolated with the sample of collection, cost
Height, and do not allow easy to operate.Such as United States Patent (USP), the piston urine cup that the patent No. 7300633 describes, when the mistake for pushing piston to advance
Cheng Zhong, allows liquid sample in collecting chamber, such as urine, is transferred to test chamber from collecting chamber, there is test sample in test chamber
The testing element of middle analyte, and the liquid sample of collecting chamber is kept apart by piston, so that two local samples are not
It can obscure, be detected so as to be used to later confirmation.Although can isolate out the sample of detection and the sample of collection in this way,
Be this piston urine cup it is at high cost, and operation is not easy, and pushes piston to need bigger strength after all, this is because living
Plug needs to reach transfer sample, is necessarily required to play the effect of hydraulic seal with the wall of piston, achievees the effect that sealing needs allow
Piston and plunger shaft closely combine.
For another example United States Patent (USP) 8992855 describes a kind of device for collecting liquid sample, which includes connecting with lid
The piston structure for being integrated and moving together with lid separates although can detecte sample and the sample of collection, when detection
It after sample enters test chamber, needs to overcome very big pressure just to can enter, and needs the size of sophisticated design lid and rim of a cup,
The piston being linked together in this way with lid can accurately be just inserted into disengagement chamber.
In addition, carrying out confirmation inspection if necessary to subsequent after the completion of the preliminary tests such as these traditional collections and detection device
It surveys, needing an entire collection and detection device to be transported to, the progress of confirmation testing agency is further to confirm detection, this just brings
Many problems, at least have a problem in that first, and major part liquid is collected at present and detection device is provided only with Preliminary detection
Chamber.When if necessary to subsequent confirmation detection, the whole device containing urine and detection reagent item can only be sent to confirmation detection machine
Structure is detected.Sample in urine cup is possible to the pollution by detection reagent.Second, whole device is sent to confirmation detection
When mechanism, since rim of a cup is larger, liquid has the risk of leakage during transportation, this is just needed more at allowing device to have originally
There is better seal effect, to reduce the risk of leakage to the greatest extent;Third, by whole device be transported to confirmation testing agency it
Afterwards, confirmation testing agency needs huge low temperature warehouse to store entire detection device, prevents liquid sample rotten, in order to it is subsequent can
Energy further confirms that detection is prepared, and confirmation testing agency (being properly termed as secondary detection mechanism) cost is caused substantially to rise in this way
It is high.
It for above-mentioned some technical problems, therefore needs to make improvements, other approach is provided and solves existing traditional skill
The deficiency of art.
Summary of the invention
For above situation, to overcome the shortcomings of existing technologies, technical problem to be solved by the invention is to provide one kind
The collection and detection device of sample, the device can separate the detection sample of initial detecting sample and secondary-confirmation, pass through the inspection
Survey the initial sample that is collected into of device, the first chamber and second intracavitary can be had respectively entered, then after the completion of initial detecting or
Before person completes, the second chamber can be separated with initial collection chamber (the first chamber), realize primary collection secondary detection, initial detecting
Sample and confirmation detection sample between will not pollute, confirm that the sample of detection enters detection in the sample of initial detecting
It is just sealed before area, it is ensured that the sample of secondary-confirmation detection will not be polluted by the detection liquid of primary detection, influence secondary-confirmation
Effect.
In order to solve the above technical problems, the present invention provides following content:
In a first aspect, the present invention provides the collection and detection device of a kind of sample, which includes for receiving
Collect the first chamber of liquid sample and detect the second chamber of liquid sample for collecting confirmation, the first chamber and the second chamber can combine or
Separation, that is to say, that the combination of the first chamber and the second chamber can be a kind of removable combination, can ensure the first chamber in this way
It can be separated under certain conditions with the second chamber.In some preferred embodiments, the first chamber and the second chamber are initial
It is to combine, also, the first chamber and the second chamber should be in fluid communication in bonding state under state, i.e., required collection
Liquid sample can also enter the second chamber while entering the first chamber, alternatively, also entering while entering the second chamber
To the first chamber, the primary collection can be realized in this way, without being collected respectively to the first chamber and the second chamber.?
In some preferred modes, the first chamber has external opening, and the opening of the second chamber is connected to the inside of the first chamber.
Since the first chamber and the second chamber have one from the process for being integrated to separation, some preferred during use
Mode in, need to be designed to be able to be partially disengaged the mode of the first chamber, such as a part of the second chamber in the shape of the second chamber
It can be exposed to the gabarit of the first chamber, further, in some preferred modes, with the separation of the second chamber and the first chamber,
The part that second chamber is exposed to the first chamber can be gradually backed out space where the first chamber.
When the first chamber and the second chamber are in bonding state, only one of chamber can be sealed, because of the two
It needs independently to be sealed the second chamber after the first chamber and the separation of the second chamber with common opening, it is therefore desirable to have individually
For the sealing device of the second chamber, when the first chamber and the second chamber are during separation, the first chamber will necessarily be due to the second chamber
It exits and generates a new opening that may leak out liquid other than original opening, be also required to be open to this at this time
It is sealed, prevents liquid sample from flowing out, it is therefore desirable to which one for the sealing device at separation.
In some preferred modes, the second chamber collects sample by the first chamber, and the second chamber can be detachable with the first chamber
Connection or combination, the second chamber during sample collection in conjunction with the first chamber, the second chamber energy after the completion of sample collection
It is enough by from the first intracavitary release.
In some preferred modes, the second chamber includes the second collection port for collecting sample, collects sample in the second chamber
This when, the second collection port can be with first intracavitary portion's fluid connections.The second chamber is set to the first chamber in some preferred modes
Bottom.In some preferred modes, the first chamber has the first collection port for collecting sample.In some preferred modes
In, the first collection port is consistent with the opening direction of the second collection port.
In some preferred modes, while to the first intracavitary loading liquid sample, liquid sample can enter naturally
Second is intracavitary.In some preferred modes, while to the first intracavitary loading liquid sample, liquid sample can be in outer masterpiece
It is intracavitary with lower entrance second.
In some preferred modes, the bottom of the first chamber is equipped with the channel that can assemble the second chamber.Some preferred
In mode, the second chamber can move in channel.In some preferred modes, the removable combination of the second chamber and channel or
Connection.In some preferred modes, first passage and first intracavitary portion's fluid connection.In some preferred modes, when
When sample is collected in two chamber channels, the second chamber is assemblied in channel.In some preferred modes, the second chamber completes sample collection
It afterwards, can be mobile to the direction separated with the first chamber under external force.
Second aspect, the present invention provide specific sealing structure, these sealing structures may include for sealing the second chamber
The second sealing element, and when the first chamber and the second chamber separate, to what is be sealed at the separation of the first chamber and the second chamber
Third sealing element.
It should be noted that first, second, and third in the present invention is not offered as the quantity of physical presence, for example, this
Invention can only include second and/or third, and be not necessarily intended to comprising first, alternatively, can also be only comprising first and/or the
Three, and be not necessarily intended to comprising second, alternatively, can also only include first and/or second, and be not necessarily intended to comprising third, institute
With the qualifier plus first, second or third, it is only for the correspondence of relationship between the convenience and accessory of statement, this
One, two and the three of place do not indicate the number or sequence carried out according to actual quantity.
In some preferred embodiments, the opening portion of the first sealing element and the first chamber by the first helicitic texture into
The opening of row sealing, the second sealing element and the second chamber is sealed by the second helicitic texture, third sealing element and separation
Place is sealed by third helicitic texture.In some preferred modes, these sealing structures can also include for sealing
First sealing element of the first chamber.
In some preferred modes, the first sealing element and the second sealing element are linkages, when the first sealing element
During being sealed to the first chamber, the second sealing element can also be sealed the second chamber, it is possible that and state is, when
When first sealing element completes sealing, the second sealing element is also completed to seal, alternatively, before the first sealing element completes sealing,
Sealing is completed in second sealing element.
In some preferred modes, the first sealing element and third sealing element are linkages, when the first sealing element
During being sealed to the first chamber, third sealing element can also be to being sealed at separation, it is possible that and state is, when
When first sealing element completes sealing, the second sealing element is also completed to seal, alternatively, before the first sealing element completes sealing,
Sealing is completed in third sealing element.
In some preferred modes, the second sealing element and third sealing element are linkages, when the second sealing element
During being sealed to the second chamber, third sealing element can also be to being sealed at separation, it is possible that and state is, when
When second sealing element completes sealing, third sealing element is also completed to seal, alternatively, before third sealing element completes sealing,
Sealing is completed in second sealing element.
Due to needing the relationship with linkage between the first sealing element, the second sealing element and third sealing element,
Therefore, between these sealing elements, it is necessary to which some linkage structures are set.
The third aspect, the present invention provide the linkage structure of sealing element, the sealing element including sample collection device, sealing
The linkage of seal process is realized between element by linkage element.
In some preferred modes, linkage structure includes the first sealing element for sealing the first chamber and for sealing
Second sealing element of the second chamber is linked between the first sealing element and the second sealing element by the first linkage element.One
In a little preferred modes, linkage structure includes that the first sealing element for sealing the first chamber and the third for sealed passage are close
Element is sealed, is linked between the first sealing element and third sealing element by the first linkage element.In some preferred modes,
Linkage structure includes the second sealing element for sealing the second chamber and the third sealing element for sealed passage, the second sealing
It is linked between element and third sealing element by the second linkage element.In some preferred modes, including for sealing the
First sealing element of one chamber, the second sealing element for sealing the second chamber and the third sealing element for sealed passage,
It is linked between first sealing element and the second sealing element by the first linkage element, the second sealing element and third sealing element
Between by the second linkage element link.In some preferred modes, including for sealing the first chamber the first sealing element,
For sealing the second sealing element of the second chamber and for the third sealing element of sealed passage, the first sealing element and second close
It seals between element and is linked by the first linkage element, pass through close-fitting or the company of fixation between the second sealing element and third sealing element
Connect linkage.
In some preferred modes, the linkage between the second sealing element and third sealing element, which can be, passes through fixation
Connection is to realize.In some preferred modes, the linkage between the first sealing element and third sealing element, which can be, to be passed through
It is fixedly connected to realize.
In some preferred modes, the first linkage element is interlocking bar.In some preferred modes, the second linkage member
Part is set bar.In some preferred modes, the linkage refers to synchronous rotation.It is described in some preferred modes
Linkage refer to it is synchronous to mobile close to the direction of sample interior.
In some preferred modes, the first linkage element is interlocking bar, and the both ends of interlocking bar are separately connected the first sealing
Element and third sealing element, make one of the first sealing element and third sealing element rotate when, be able to drive in addition one of with
Rotation, this rotate with it can be synchronous, be also possible to the drive of discontinuity, but it is this rotate with it is usually same
Direction.In some preferred modes, the interior capping of the first sealing element is equipped with axis hole, and interlocking bar is plugged on the axis hole
It is interior.In some preferred modes, the outer capping of third sealing element is equipped with axis hole, and interlocking bar is plugged in the axis hole.?
In some preferred modes, interlocking bar can pass through the first chamber and connect the first sealing element and third sealing element.
In some preferred modes, interlocking bar has certain shape, and usually this shape is not circular, can
To be such as rectangular, semicircle or triangle, correspondingly, the axis hole on the first sealing element and third sealing element is also
Same shape, then, circumferential limit is just carried out by this shape between interlocking bar and axis hole, opposite turn will not occur
Dynamic, therefore, interlocking bar can drive the first sealing element and third sealing element to be rotated by two axis holes, to realize
Linkage.In other possible modes, interlocking bar and axis hole are also possible to the circular hole of close-fitting, and the power to link at this time is from connection
Lever and axis hole are adjacent to the frictional force between face.In other possible modes, interlocking bar and axis hole are also possible to step-by-step movement
The relationship that is linked, it is this it is step-type be linked under relationship, interlocking bar or axis hole can independently rotate certain angle,
Then resynchronisation rotation, while rotation, the first sealing element can be sealed the first chamber, close in the first sealing element
During sealing the first chamber, third sealing element can be to being sealed at separation.
As another way of realization being linked, interlocking bar is equipped with axis hole, the first sealing element or third sealing
Element is equipped with the co-operating member to link with axis hole, and co-operating member is of similar shape with axis hole, this shape is to deviate connection
Lever axle center, or be non-round, so that interlocking bar and co-operating member can be realized linkage.Some preferred
In mode, interlocking bar can also with co-operating member is step-type is linked.
In some preferred modes, linkage structure can also include for the second sealing element and the third sealing member of linking
Second linkage element of part.Second linkage element is the short object of set bar or analogous shape, and it is close that set bar can be connected in second
It seals on one of element or third sealing element, and in one of other upper setting and the matched linkage hole of set bar, together
Sample, set bar and linkage hole also have certain shape, and this shape is similar with interlocking bar, can deviate the second sealing element
Perhaps it is for example rectangular, semicircle or three to be perhaps that non-round this shape can be for third sealing element rotation center
It is angular etc., one of in addition it is rotated with it so that set bar and/or linkage one of hole are able to drive, it is this to turn therewith
It is dynamic to can be synchronous, it is also possible to the drive of discontinuity, this rotation can be equidirectional, it is also possible to opposite direction,
While rotation, third sealing element can be to being sealed at separation, the process at third sealing element hermetic separation
In, the second sealing element can be sealed the second chamber.
As the specific implementation form being linked, setting linkage hole, set bar are inserted on the interior capping of third sealing element
It connects in the linkage hole, the other end is connected on the outer capping of the second sealing element, alternatively, on the outer capping of the second sealing element
Setting linkage hole, one end of set bar are plugged in the linkage hole, and the other end is connected on the interior capping of third sealing element.?
Under this implementation, the linkage of the second sealing element and the first sealing element is driven, also by third sealing element
To say, during the first sealing element seals the first chamber, third sealing element can to being sealed at separation, meanwhile,
Second sealing element can be sealed the second chamber.
In some preferred modes, the second sealing element and third sealing element can be not provided with the second linkage element,
But realize that linkage, such as the second sealing element are fixedly connected with some face of third sealing element by the structure of itself cooperation
Together, so that can be rotated synchronously between two sealing elements.
Fourth aspect, the present invention provide the concrete form at separation.In some preferred modes, one can be at separation
The form in kind channel, such as a kind of channel that can be sealed that the second chamber grafting can be allowed to be installed therein.Some preferred
Mode in, which is located at the bottom of the first chamber, and (namely the channel and the first chamber are used to collect the oral area of liquid sample and distinguish
Positioned at the both ends of the first chamber), in this way, usually upward by oral area, then channel is downward, this is conveniently when acquiring liquid sample
In liquid sample while entering the first chamber, since gravity operation of nature is directly entered the second chamber.In some preferred modes
In, the bottom of the first chamber can be set to the inclined-plane being slightly slanted at channel, then liquid sample can be flowed to along this inclined-plane
At channel, the angle being slightly slanted can be within 5 °.
In some preferred modes, in product before use, the second chamber is installed in channel, certainly, this peace
Dress mode must be removable, such as the second chamber is plugged in channel, the inner wall close-fitting in outer wall and channel.Some preferred
Mode in, the close-fitting between the second chamber and channel must be band sealing, and this sealing can be own material and pass through assembly
The sealing realized afterwards is also possible to add the sealing of seal member realization on a mating.
In some preferred modes, channel has an opening being connected to the first chamber, and the second chamber also has a receipts
The opening for collecting sample, after the second chamber is assemblied in channel, this opening on the second chamber must be with this opening one in channel
It causes, it is intracavitary that such liquid sample can be collected into second.Opening and channel in some preferred modes, on the second chamber
The surface of opening flush.In other preferred modes, the surface of the opening of the second chamber is slightly above the table of the opening in channel
Face.In other preferred modes, the opening of the second chamber and the open surfaces in channel form a smooth transition and by interior
And below tilting down outside.About the design and cooperation of opening structure, main effect is to avoid liquid sample as far as possible
The gap oral area to deposit between the second chamber and channel, because this siltation easilys lead to the second chamber and channel in isolated mistake
The leakage that liquid sample is generated in journey, is layered by height in structure, allows liquid sample that can flow to the along this structure
The other positions of one bottom of chamber portion, rather than deposit at the cooperation in the second chamber and channel, except through the sealing between mating surface
Except, it can also be designed by the structure of opening to reinforce sealing, avoid any leakage as far as possible.
In some preferred modes, need to limit the cooperation between the second chamber and channel, otherwise the second chamber can
Energy can be intracavitary by the slide-in first of this channel, and such case has to prevent, because of the not only exposed part of the second chamber
Into first it is intracavitary liquid sample can be polluted, moreover, channel itself be exactly for the first chamber one opening, originally
Second chamber can be used as a plug in channel, if the second chamber falls into first intracavitary, necessarily cause the loophole at channel, liquid
Sample can be leaked largely.In some preferred modes, mutually matched limit is arranged in the outer wall of the inner wall in channel and the second chamber
The extreme position that second chamber is installed is limited to the somewhere in channel by structure, this position limiting structure, once the second chamber is installed in place
Afterwards, it just will not inwardly continue to move to again.
As a kind of specific implementation of position limiting structure, a between outer land terrace is set on the inner wall in channel, between outer land
For terrace as line of demarcation, the internal diameter close to the part of the first chamber is bigger than the internal diameter close to external part, at the same time, the
The interior step surface of one with the cooperation of this between outer land terrace are set on the outer wall of two chambers, within step surface as line of demarcation, close the
The internal diameter of the part of one chamber is smaller than the internal diameter close to external part, then the cooperation of interior step surface and between outer land terrace, so that it may
It,, can not due to step surface card master when the second chamber is packed into match in chalaza the limit of the limit installation site of the second chamber at this
It is inwardly further mobile, realize the limit to the second chamber.
Channel is that the first chamber and the second chamber is allow to realize the structure of assembly, and channel can regard one of the first chamber as
Point, in some preferred modes, after the second chamber completes installation, the outer surface of the gabarit of the second chamber without departing from channel.This feelings
Condition can make the first chamber and the second chamber use one entirety of preceding formation, but in this case, it just can not be by the second chamber
It takes out, therefore, in some preferred modes, during sealing element is at the first chamber of sealing, the second chamber and separation, energy
It is enough gradually to eject the second chamber outward, when all seal process is (including the first sealing element to the sealing of the first chamber, second close
Seal element to the sealing of the second chamber and third sealing element to the sealing at separation) complete when, the second chamber a part stretch out
Except the gabarit of the first chamber, the second chamber can be separated from the first chamber by this part of stretching at this time, at separation
Two chambers are the cavitys for having completed sealing, in liquid sample can be used for secondary-confirmation detection, the second chamber is being detached from
It, can be by independent transport to secondary detection mechanism after first chamber.
5th aspect, the present invention provide a kind of testing element, and testing element setting is intracavitary first, and can be intracavitary first
There is a relatively independent space, such as a detection zone that can be isolated or be connected to the first chamber is set on the side wall of the first chamber
Domain, testing element are placed in the detection zone, and liquid sample initially enters the first chamber, then enter detection zone from the first chamber again
It reacts in domain with testing element, to be detected.
Why the main body chamber of detection zone and the first chamber is separated, be in order to which part sample and test is first
Part separates, so that it is guaranteed that at least a part of liquid sample is not in contact with testing element, this part is not
It can be tested component contamination, it is intracavitary for carrying out secondary detection confirmation that second can be collected into.
In some preferred modes, the location of testing element is visual.
6th aspect, the present invention provides a kind of barrier element, for obstructing or opening between the first chamber and test zone
Connected relation, when collecting the original state of sample, barrier element separates the first chamber and test zone, at this time liquid sample without
Method enters test zone, and testing element will not be in contact or react with liquid sample, when collection is to a certain extent or one
When timing machine, barrier element opens the entrance of the first chamber connection test zone, and a part of liquid sample is allowed to enter from entrance
In test zone, and initial survey is carried out by testing element, obtains a preliminary testing result.
In some preferred modes, the bottom of the first chamber is equipped with the entrance in a communication with detection region, and barrier element is set
It sets in inlet.In some preferred modes, barrier element and the linkage of the second sealing element, in the completion pair of the second sealing element
While the sealing of second chamber, the entrance that barrier element opens communication with detection region is touched, is completed at this time to the close of the second chamber
Envelope, it is ensured that the second intracavitary liquid sample will not have any contact with the sample in detection zone, guarantee the standard of secondary detection
True property.
In some preferred modes, barrier element and third sealing element linkage, third sealing element complete to point
While sealing from place, the entrance that barrier element opens communication with detection region is touched, due in the sealing point of third sealing element
During from place, the second sealing element has completed the sealing to the second chamber, therefore, when third sealing element is completed to separation
When the sealing at place, the sealing of the second chamber is formerly completed, therefore, opens the entrance of detection zone, the second intracavitary liquid at this time
Sample will not have any contact with the sample in detection zone, can guarantee the accuracy of secondary detection.
7th aspect, the present invention provide a kind of collection method for detecting sample, and this method is received using foregoing sample
Acquisition means, the device are used to collect the first chamber of liquid sample, for collecting the second chamber of confirmation detection liquid sample, the first chamber
It can combine or separate with the second chamber;The sample testing apparatus further includes the second sealing element for sealing the second chamber, and
When the first chamber and the second chamber separate, to the third sealing element being sealed at the separation of the first chamber and the second chamber.
It further include the first sealing element being sealed to the first chamber in some preferred modes.
In some preferred modes, for the first sealing element during sealing the first chamber, the second chamber can be by second
Sealing element sealing.
In some preferred modes, the first sealing element, can be by third at separation during sealing the first chamber
Sealing element sealing.
In some preferred modes, one of the second sealing element and third sealing element and the first sealing element link and
Second sealing element and third sealing element link;Or second sealing element and third sealing element with the first sealing element
Linkage.
In some preferred modes, which further includes for making the first sealing element and third seal member
First linkage element of part linkage.
In some preferred modes, which further includes for making the second sealing element and third seal member
Second linkage element of part linkage.
It include channel at separation in some preferred modes, before sample collection, which is sealed by the second chamber.
In some preferred modes, the second chamber can move in channel, and being equipped in channel prevents the second chamber from sliding into the
The position limiting structure of one chamber.
In some preferred modes, in seal process, the second chamber and the first chamber can occur relative movement and make second
A part of chamber intracavitary is pushed out from first.
In some preferred modes, first it is intracavitary be equipped with can prevent liquid sample flow into detection zone barrier element,
The entrance in the first chamber communication with detection area can be opened or be closed to the barrier element, to prevent or discharge liquid sample flow to enter to examine
Survey area;While third sealing element at separation by sealing, triggering barrier element opens detection zone entrance.
In some preferred modes, this method includes that the first chamber and the second chamber is allowed to pass through channel realization fluid connection, liquid
Body sample can flow into the second chamber from the first chamber by some oral area in the channel or the channel, so that, to the first chamber
While interior loading liquid sample, liquid sample can also naturally enter intracavitary to second.In some preferred modes, first
Before separation, which is sealed for chamber and the second chamber.In some preferred modes, the first chamber and the second chamber are in isolated mistake
Cheng Zhong, the channel are sealed.
In some preferred modes, this method includes the mistake being sealed to the first chamber and the second chamber that have collected sample
Journey, during sealing, relative movement can occur for the first chamber and the second chamber so that a part of the second chamber is from first
It is intracavitary to be pushed out.In some preferred modes, during sealing, a part of the second chamber is exposed to except the first chamber.
In some preferred modes, in the seal process of the first chamber along with the sealing to the second chamber.
In some preferred modes, this method includes the mistake being sealed to the channel of the first chamber of connection and the second chamber
Journey, during sealing, relative movement can occur for the first chamber and the second chamber so that a part of the second chamber is from first
It is intracavitary to be pushed out.In some preferred modes, during sealing, a part of the second chamber is exposed to except the first chamber.
In some preferred modes, to the seal process of the first chamber along with the sealing to channel.It is right in some preferred modes
The seal process in channel is after the seal process to the second chamber.It, will while sealing to channel in some preferred modes
Second chamber is pushed outwardly.
Eighth aspect, the present invention provide a kind of sample testing method, and the detection method is for detecting collected liquid
In sample whether there is analyte, the detection method include collected using above-mentioned collection device or collection method to
The sample of detection after being collected into a certain amount of sample to the first chamber, carries out primary detection to the first intracavitary sample.
In some preferred schemes, the second chamber for completing sample collection is sealed first, then passes through test again
Element detects the first intracavitary sample.
In some preferred schemes, the first chamber and the second chamber are separated first, then pass through testing element pair again
First intracavitary sample is detected.Since the second chamber liquid sample collected is for secondary detection, first to second
Chamber is separated, can be dirty by the testing element in primary detection to avoid the intracavitary liquid sample of second for secondary detection
Dye.
In some preferred schemes, the channel of the first chamber of connection and the second chamber is sealed first, is then passed through again
Testing element detects the first intracavitary sample.
In some preferred schemes, during collecting sample, detection zone and sample are received by barrier element
Collection region is isolated, after the completion of sample collection, release barrier element between test zone and sample collection region every
From making sample be able to enter detection zone.
In some preferred schemes, in the first intracavitary setting detection zone.In some preferred schemes, detection zone
Interior setting testing element.In some preferred schemes, enter between detection zone and the first chamber equipped with what can be connected to or close
Mouthful.In some preferred schemes, which can cooperate with barrier element, be blocked members block and close, or open
And communication with detection region and the first chamber.
Following manner should also be as being included in technical solution of the present invention:
For collecting the first chamber of liquid sample, for collecting the second chamber of confirmation detection liquid sample, the first chamber and the
Two chambers can be combined or be separated;The sample testing apparatus further includes the second sealing element for sealing the second chamber, and to
The third sealing element being sealed at the separation of one chamber and the second chamber.
In some preferred schemes, when the first chamber and the combination of the second chamber, the first chamber and the second chamber are at liquid
Connected state.
In some preferred schemes, after the second sealing element is sealed the second chamber, third sealing element is to separation
Place is sealed.
In some preferred schemes, after the second sealing element is completed to the sealing of the second chamber, third sealing element is completed
To the sealing at separation.
It further include the first sealing element being sealed to the first chamber in some preferred schemes.
In some preferred schemes, for the first sealing element during sealing the first chamber, the second chamber can be by second
Sealing element sealing.
In some preferred schemes, the first sealing element, can be by third at separation during sealing the first chamber
Sealing element sealing.
In some preferred schemes, one of the second sealing element and third sealing element and the first sealing element link and
Second sealing element and third sealing element link.
In some preferred schemes, the second sealing element and third sealing element link with the first sealing element.
In some preferred schemes, which further includes for making the first sealing element and third seal member
First linkage element of part linkage.
In some preferred schemes, the linkage refers to synchronous rotation.
In some preferred schemes, the linkage refers to synchronous to mobile close to the direction of sample interior.
It include channel at separation in some preferred schemes, the second chamber can move in channel.
In some preferred schemes, the position limiting structure of the second chamber is equipped in channel.
In some preferred schemes, after the second chamber is sealed, it can be moved along channel to the direction separated with the first chamber.
In some preferred schemes, the detection zone including initial collection sample, detection zone can be opened or close
It closes.
In some preferred schemes, when the second chamber does not collect sample or when collecting sample, detection zone is closed, when
The collection of second chamber is completed and is sealed, and sample is able to enter detection zone.
It further include barrier element, the detection entrance that barrier element can be opened or is closed in some preferred schemes.
In some preferred schemes, barrier element can link with third sealing element, and in third sealing element
Drive lower opening detection zone entrance.
In some preferred schemes, barrier element can link with the second sealing element, and in the second sealing element
Drive lower opening detection zone entrance.
In some preferred schemes, barrier element can link with the first sealing element, and in the first sealing element
Drive lower opening detection zone entrance.
A kind of collection method of sample, it is intracavitary that this method first allows sample to enter, and by be used for initial detecting sample and
Sample for secondary-confirmation detection divides chamber to store, and after the completion of collecting sample, is used in the sample of secondary-confirmation detection first
It is individually isolated, then the sample for initial detecting is detected again.
A kind of collection method of sample, this method provide a kind of sample collection device, which includes for collecting liquid
First chamber of sample, for collecting the second chamber of confirmation detection liquid sample, the first chamber and the second chamber can be combined or be separated;It should
Sample testing apparatus further includes the second sealing element for sealing the second chamber, and at the separation of the first chamber and the second chamber into
The third sealing element of row sealing.
In some preferred schemes, the first intracavitary loading sample is first allowed, then allow the second intracavitary loading sample.
In some preferred schemes, the first chamber and second intracavitary while being loaded into sample.
In some preferred schemes, when the first chamber and the combination of the second chamber, the first chamber and the second chamber are at liquid
Connected state.
In some preferred schemes, after the second chamber completes sample collection, the second chamber is carried out using the second sealing element
Sealing.
In some preferred schemes, after the sealing of the second chamber, using third sealing element to being sealed at separation.
In some preferred schemes, while to the sealing of the second chamber, carried out using third sealing element at separation
Sealing.
It further include the first sealing element being sealed to the first chamber in some preferred schemes.
In some preferred schemes, after the first chamber and the second chamber complete sample collection, using the first sealing element to the
One chamber is sealed.
It is close using second while being sealed using the first sealing element to the first chamber in some preferred schemes
Envelope element is sealed the second chamber.
It is close using third while being sealed using the first sealing element to the first chamber in some preferred schemes
Envelope element at separation to being sealed.
In some preferred schemes, the second sealing element and the linkage sealing of third sealing element.
In some preferred schemes, the first sealing element and the linkage sealing of the second sealing element.
In some preferred schemes, the first sealing element and the linkage sealing of third sealing element.
In some preferred schemes, the linkage refers to synchronous rotation.
In some preferred schemes, the linkage refers to synchronous to mobile close to the direction of sample interior.
It include channel at separation in some preferred schemes, the second chamber can move in channel.
In some preferred schemes, after the second chamber is sealed, keep its channel mobile to the direction separated with the first chamber.One
The detection method of kind sample, adopts and collects sample with the aforedescribed process, and including detection zone, detection zone can be opened or close
It closes.
In some preferred schemes, the second chamber does not collect sample or when collecting sample, detection zone is closed, when second
When the collection of chamber is completed and sealed, detection zone is opened, sample is allowed to enter and detect.
It further include barrier element, the detection entrance that barrier element can be opened or is closed in some preferred schemes.
In some preferred schemes, barrier element can link with third sealing element, and in third sealing element
Drive lower opening detection zone entrance.
In some preferred schemes, barrier element can link with the second sealing element, and in the second sealing element
Drive lower opening detection zone entrance.
In some preferred schemes, barrier element can link with the first sealing element, and in the first sealing element
Drive lower opening detection zone entrance.
The beneficial effects of the present invention are: using the above structure, have the characteristics that it is simple and reasonable, using the cost of material is low
It is honest and clean, function admirable;Convenient for secondary detection.Particularly, it when needing to carry out subsequent confirmation detection, does not need entire inspection
Survey device is sent to mechanism for testing and is detected, and is only that the second chamber is removed from device, is sent to detection structure, so not
Only safety, and space is saved, save the cost is more environmentally-friendly.
Detailed description of the invention
Fig. 1 is overall structure outline drawing of the invention.
Fig. 2 is the overall structure cross-sectional view after completion sealing of the invention.
Fig. 3 is overall structure of the explosion figure of the invention.
Fig. 4 is overall structure section view explosive view of the invention.
Fig. 5 is the overall structure outline drawing after the second chamber is sealed.
Fig. 6 is the overall structure cross-sectional view after the second chamber is sealed.
Fig. 7 is the overall structure cross-sectional view before sealing.
Fig. 8 is the overall structure cross-sectional view of the first stage of sealing.
Fig. 9 is the perspective view of the first chamber.
Figure 10 is the cross-sectional view of the first chamber.
Figure 11 is the structure chart of the first sealing element.
Figure 12 is the schematic diagram of the first linkage element.
Figure 13 is the cross-sectional view that the present invention conceals the second chamber, shows the position of Sealing shield ring.
Figure 14 is another implementation of sealing element.
Figure label: the first chamber 1, the second chamber 2, detection zone 3, sample entrance port 4, channel 5, the first collection port 6, second receives
Collect mouth 7, between outer land terrace 8, interior step surface 9, the first sealing element 10, the second sealing element 11, the first sealing position 12, second is close
Envelope position 13, shoulder 14, the opening 15 in channel 5, third sealing element 16, the first helicitic texture 17, the second helicitic texture 18, the
Three helicitic textures 19, the first linkage element 20, the second linkage element 21, interior capping 22, interior axis hole 23, outer capping 24, hole of linking
25, coupled axle-pin 26, the upper capping 27 of the second sealing element, the lower capping 28 of third sealing element, interior step surface 29, gap 30,
Barrier element 31, the entrance 32 of detection zone 3, baffle 33, protrusion 34, stop collar 35, between outer land terrace 36, Sealing shield ring 37.
Specific embodiment
Below in conjunction with attached drawing, the present invention is described in further detail, it is noted that embodiment is only to this hair
Bright specific descriptions, are not construed as limitation of the invention.
Structure of the present invention or used technical term are described further first, if do not referred in particular to
It is bright, understood and explained according to general technology term generally in the art.
Detection
Detection indicates chemical examination or tests a kind of substance or material to whether there is, for example, but it is not limited to this, chemical substance,
Organic compound, inorganic compound, metabolism product, drug or drug metabolite, organic organization or organic organization generation
Thank object, nucleic acid, protein or polymer.In addition, detection indicates the quantity of test substances or material.Furtherly, table is gone back in chemical examination
Show immune detection, chemical detection, enzyme detection etc..
Sample
The sample that detection device of the invention can detecte includes biofluid (such as casing fluids or clinical sample).
Fluid sample or fluid sample can be from the samples of solid-state or semisolid, including excreta, biological tissue and food
Sample.The sample of solid-state or semisolid can be converted to fluid sample using any method appropriate, such as mix, smash to pieces,
It macerates, be incubated for, dissolving or (such as water, phosphate solution or other buffer solutions) are disappeared using enzymolysis in a suitable solution
Change solid sample." biological sample " includes deriving from animal, plant and food samples, for example including the urine for deriving from human or animal
Liquid, saliva, blood and its ingredient, spinal fluid, vaginal fluid, sperm, excrement, sweat, secretion, tissue, organ, tumor, tissue
With the culture of organ, cell culture and medium.It is preferred that biological sample is urine.Food samples include the substance of food processing,
Final products, meat, cheese, wine, milk and reference water.Plant sample includes being derived from any plant, plant tissue, plant cell training
Support object and medium." environmental sample " from environment (for example, from lake or the fluid sample of other water bodys, sewage sample,
Soil property sample, underground water, seawater and waste liquid sample).Environmental sample may also include sewage or other waste water.
Using the present invention and suitable detecting element, any analyte can detecte.Saliva is detected preferably by the present invention
Drugs small molecule in liquid, urine.Certainly, the sample of any of the above form, nothing can be collected using collection device of the invention
By being initially solid or liquid, as long as after these liquid or liquid sample are flowed into the first chamber, these liquid samples
The second chamber perhaps can be flowed into later since the second chamber can be combined or be separated with the first chamber simultaneously, initial collection sample
This when, the first chamber and the second chamber combine, and user can be completed by once collection movement to the first chamber and the second intracavity liquid
The collection of sample allows the second chamber to separate with the first chamber when needing to carry out subsequent confirmation detection, thus, the liquid of the first chamber can
To carry out primary detection, and the second chamber can carry out secondary detection.Optionally, the function status of the first chamber and the second chamber can also be with
It calls, that is to say, that the liquid of the second chamber can carry out primary detection, and the liquid of the first chamber can carry out secondary detection.
Testing element
Testing element can select the test strip of lateral flow, it can detect a variety of analytes.Certainly, other are closed
Suitable testing element can also be used in the present invention, all to can detecte sample or sample is whether to be divided containing interested
The element of analysis substance can be referred to as testing element, and this detection is either based on which kind of Yuan technical principle, immunology, change
, electricity, optics, physics etc. are ok.
Various testing elements can be grouped together and apply in the present invention.A kind of form is Test paper.For dividing
The Test paper of analyte (such as drugs or showing the metabolin of physical condition) in analysis sample can be various forms, such as exempt from
The form of epidemic disease measurement or chemical analysis.Test paper can be using non-competing method or the analytical model of competition law.Test paper packet
Water-absorbent material containing one with sample application zone, reagent area and test section.Sample-adding passes through capillarity originally to sample application zone
Flow to reagent area.In reagent area, if there is analyte, sample is in conjunction with reagent.Then sample continues to flow to detection zone.
Other reagents, such as molecule with analyte specific binding are fixed on detection zone.Being divided in these reagents and sample
Analysis object (if present) reacts and analyte is incorporated in the area, or in conjunction with some reagent of reagent area.For showing
Show that the marker of detection signal exists and reagent area or isolated mark zone.
Typical non-competing method analytical model is if containing analyte in sample, and signal will generate, if do not wrapped
Containing analyte, signal is not just generated.In competition law, if analyte is not present in sample, signal is generated, if deposited
In analyte, then signal is not generated.
Testing element is Test paper, the material that can be selected water suction or not absorb water.Test paper may include multiple material
It is transmitted for liquid sample.The material of one of Test paper can cover on another material, as filter paper is covered on nitric acid
On cellulose membrane.One area of Test paper can select one or more materials, and one kind that another area selects other different
Or multiple material.Test paper can be attached on certain support or hard surface and be affectedly bashful the strong of Test paper for improving
Degree.
Analyte is detected by signal generating system, such as utilizes one with this analyte generation specific reaction
Kind or a variety of enzymes, are fixed on the method on Test paper for specific combinating substance using such as aforementioned, one or more signals are sent out
The composition of raw system is fixed on the analyte detection zone of Test paper.Generate signal substance can in sample application zone, reagent area,
Or on detection zone, or entire Test paper, which can be full of on one or more materials of Test paper.Signal will be contained
The solution of object is added to the surface of test paper or one or more materials of test paper is immersed in the solution of the object containing signal.Make to be added and contain
The test paper of signal object solution is dry.
Each area of Test paper can arrange in the following manner: sample application zone, reagent area, detection zone, control zone determine sample
This whether adulterated area, liquid sample uptake zone.Control zone is located at after detection zone.All areas can be arranged at only with a kind of
On one test paper of material.It can also be not same district and use different materials.Each area can directly be contacted with liquid sample, or not
Direction arrangement of the same area according to liquid sample flowing, the end in each area is connected and is overlapped with the front end in another area.Used
Material can be the preferable material of water imbibition such as filter paper, glass or nitrocellulose filter etc..Test paper can also use it
His form.
General common reagent strip is nitrocellulose assay strip, i.e. detection zone includes nitrocellulose filter, in nitre
Specific binding molecule is fixed on acid cellulose film to show the result of detection;It can also be cellulose acetate film or nylon membrane etc.
Deng.Such as the description of the following patent reagent strip or device containing reagent strip: US 4857453;US 5073484;US
5119831;US 5185127;US 5275785;US 5416000;US 5504013;US 5602040;US 5622871;US
5654162;US 5656503;US 5686315;US 5766961;US 5770460;US 5916815;US 5976895;US
6248598;US 6140136;US 6187269;US 6187598;US 6228660;US 6235241;US 6306642;US
6352862;US 6372515;US 6379620;With US 6403383.It test-strips disclosed in patent documents above and has
The similar device of test-strips, which can be applied in testing element or detection device of the invention, carries out analyte
Detection, for example, in sample analyte detection.
Apply to lateral effluent reagent strip (the Lateral flow that detection reagent item of the invention can be known as
Test strip), the specific structure and testing principle of these detection reagent items are this field general technology people in the prior art
Technology well known to member.Common detection reagent item, including sample collection region, marked region, detection zone and suction zone, sample
This collecting zone includes sample receiving pad, and marked region includes label pad, and suction zone may include water absorption pad, wherein detection zone
It include that can detect whether the necessary chemical substance containing analyte, such as immunoreagent or enzymology reagent on domain.One
As common detection reagent item be nitrocellulose assay strip, i.e. detection zone includes nitrocellulose filter, in cellulose nitrate
Specific binding molecule is fixed on plain film to show the result of detection;It can also be cellulose acetate film or nylon membrane etc., certainly,
It can also include testing result control area in the downstream of detection zone, in general, with horizontal line in control area and detection zone
Form occurs, and is detection line or control line.Such detection reagent item is traditional reagent strip, certainly, can also be other benefits
The other types of reagent strip detected with capillarity.In addition, dry chemistry reagent ingredient is had on general detection reagent item,
Such as fixed antibody or other reagents, after encountering liquid, liquid is flowed with capillarity along reagent strip, with stream
It is dynamic, allow dry agent formulations to be dissolved in liquid, so that the dry reagent to next regional processing in the area reacts, thus into
The necessary detection of row.Liquid flowing mainly carries out through capillary action.These testing elements are shown in the description and note of following file
It carries: " regeneration treatment of nitrocellulose filter and its research of adhesion protein ability " of Li Fugang;The Ma Hongyan, " glue of Li Qiang etc.
The analysis of membrane material characteristic is chromatographed in body gold diagnostic kit ";A kind of " new colloidal gold immunochromatography of Wang Yong, Wang Luhai etc.
Test strips ".It can be applied in detection device of the invention, or be arranged in test chamber and liquid sample herein
Contact either whether there is or existing quantity for detecting analyte in the liquid sample entered in test chamber.
In addition to above-mentioned testing element is in the form of reagent strip, itself it is used to contact with the liquid of the first chamber 1 to test
Whether containing outside analyte in liquid sample, in some preferred modes, testing element can also be arranged on one
In the test card of concentration, there are many grooves, in the grooves, entire test card is arranged on detection to testing element in test card
In region 3, due to having the entrance 4 for being connected to the two between the first chamber 1 and detection zone 3, the liquid in the first chamber 1 is entered
Sample can be entered in detection zone 3 by entrance 4, so that the testing element on tested card is detected.Certainly, more than removing
Outside disclosed carrier, carrier in addition can also be applied to the carrier in the present invention as bearing test item.For example, some
In mode, the first chamber can first collect liquid sample, then with individually with test-strips or card or carrier with test-strips
It is inserted into the first chamber and is detected.Those of ordinary skill in the art are appreciated that documented according to the present invention, these surveys
Strip can be not provided on carrier, but be individually present, and detection zone 3 of the invention is also in some cases can be with
Lack, test-strips are also that can lack in some cases.
Analyte
It can include some small-molecule substances with the example of the analyte involved in the present invention, these small molecules include poison
Product (such as drug abuse)." drug abuse " (DOA) refers to that non-medical destination uses drug (usually playing paralysis nerve).
It abuses these drugs and will lead to body & mind and be damaged, generate dependence, addicted and/or dead.Drug abuse
Example includes cocaine;Amphetamine AMP is (for example, black beauty, white amphetamine tablet, dextroamphetamine, dextrorotation benzene are different
Propylamine tablet, Beans);Crystal methamphetamine MET (crank, meth, crystal, speed);Barbiturate BAR
(such as Valium, Roche Pharmaceuticals, Nutley, New Jersey);Sedative (i.e. sleep paramedicines);Wheat
Angle acid acyl diethylamine (LSD);Inhibitor (downers, goofballs, barbs, blue devils, yellow jackets,
Methaqualone);The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin);Diformazan methylenedioxymethamphetamine aniline
MDMA;Phencyclidine (PCP);Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc..);Opiate (i.e. morphine
MOP or opium, cocaine COC;, heroin, hydroxyl dihydrocodeinone);Anxiolytic and hypnotic sedative agent, anxiolytic
It is that one kind is mainly used for anxiety reduction, anxiety, fear, sets the mind at rest, have the drug of hypnosis sedation, including Benzodiazepine concurrently
Class BZO (benzodiazepines), it atypia BZ class, fusion phenodiazine NB23C class, benzene nitrogen Zhuo class, the ligand class of BZ receptor, opens
Ring BZ class, diphenylmethane derivatives, piperazine carboxylic acid salt, piperidine carboxylic acid salt, Kui oxazoline ketone, thiazine and thiazole,
Other heterocyclics, imidazole type calmness/anodyne (such as hydroxyl dihydrocodeinone OXY, methadone MTD), propanediol derivative-ammonia
Formate ester, aliphatic compound, anthracene derivative etc..It can be used for detection using detection device of the invention and belong to medicine
The detection of purposes but easy overdose, such as tricyclic antidepressant (imipramine or the like) and Paracetamol.This
A little drugs can be metabolized to small-molecule substance after being absorbed by the body, these small-molecule substances are present in blood, urine, saliva, sweat
In equal body fluid or part body fluid there are above-mentioned small-molecule substances.
For example, including but is not limited to creatinine, bilirubin, nitrite, albumen with the analyte that the present invention detects
(non-specificity), hormone (for example, human chorionic promotes sex hormone, luteinizing hormone, follicular stimulating hormone etc.), blood, white blood cell,
Sugar, heavy metal or toxin, bacterial components (albumen or glucide as being directed to specific bacterial, such as such as colon bacillus 0157:
H7, staphylococcus, salmonella, fusobacterium, Campylobacter, L.monocytogenes, vibrio or cactus bacillus) and urine
Substance relevant to physiological characteristic in sample, such as pH and specific gravity.Other any Clinical Urinary chemical analyses are all examined using lateral flow
Survey form cooperates apparatus of the present invention to be detected.
The combination of first chamber and the second chamber with separate
Sample testing apparatus of the invention, including two for collecting chamber the-the first chamber 1 and the second chamber 2 of liquid sample,
First chamber 1 is used to collect the liquid sample of initial detecting, and the second chamber 2 is used to collect the liquid sample of secondary-confirmation detection, and first
Chamber 1 and the second chamber 2 can be combined together, and can receive the liquid sample collected for the first time simultaneously, that is to say, that be used
Person is when using product of the invention, it is only necessary to primary collection operation, so that it may at the same it is all real to the first chamber 1 and the second chamber 2
The injection of existing liquid sample.
In some embodiments of the invention, as shown in Fig. 2,7,8, a channel 5, channel 5 is arranged in the bottom of the first chamber 1
One end be connected to the first chamber 1 inside, the other end is externally connected to, and the second chamber 2 can be assembled in the channel 5, the bottom of the second chamber 2
Sealing forms a plug to the channel 5, as previously described, because sample has certain mobility, then when user exists
When collecting sample, it will usually oral area will be collected upward, such as Fig. 9, shown in 10, the first collection port 6 upward, channel 5 (namely second
The oral area 7 of chamber 2) positioned at the lower section of the first collection port 6, user injects the sample of mobility from the first collection port 6 for location
This, sample can be flowed in the second chamber 2 due to gravity, the inner wall along the first chamber 1, thus collected by the second chamber 2, also
It is to say, the second chamber 2 in bottom can be preferentially packed into sample, and then the first chamber 1 will continue to be loaded into, until reaching one-time detection
Required amount.
Since the liquid sample in the first chamber 1 is used directly to detect, and the liquid sample in the second chamber 2 may be close
It is honored as a queen and is transported, enter confirmation testing agency and carry out secondary-confirmation detection, therefore, and the liquid sample in the first chamber 1 is
Passed through an initial detecting, become non-primary sample, then detect to the sample in the first chamber 1, secondary-confirmation is detected
As a result accuracy can have an impact, therefore, it is necessary to separate the first chamber 1 and the second chamber 2, furthermore, it is desirable to meet the first chamber 1 and
It can be individually formed the cavity of a sealing after the separation of two chambers 2, wherein by the liquid sample encapsulation respectively in it, while also to expire
During the first chamber 1 of foot and the second chamber 2 separate, sample will not be sealed from separation place, this is just to the structure and the at separation
One chamber and the respective sealing structure of the second chamber all require.
In some preferred modes, the second chamber 2 collects sample by the first chamber 1, and the second chamber 2 can with the first chamber 1
The connection or combination of disassembly, the second chamber 2 are combined during sample collection with the first chamber 1, and the second chamber 2 is complete in sample collection
It can be by from the first intracavitary release after.
In some preferred modes, the second chamber 2 includes the second collection port for collecting sample, collects sample in the second chamber
This when, the second collection port can be with first intracavitary portion's fluid connections.The second chamber is set to the first chamber in some preferred modes
Bottom.In some preferred modes, the first chamber 1 has the first collection port 37 for collecting sample.Some preferred
In mode, the first collection port 37 is consistent with the opening direction of the second collection port 38, in this way can utmostly by structure come
The collection efficiency of the second chamber 2 is improved, if the first collection port 37 is different with the direction of the second collection port 38, sample passes through the first chamber
It is smooth when just identical not as good as collection port direction when into the second chamber, it be easy to cause stagnant on surface or side wall
It stays, and due to direction difference, corner will necessarily be generated, sample is then possible on the corner to deposit, is unfavorable for collecting, siltation
Locating extra sample also can be in the possibility for increasing leakage, in addition, if collection port direction is different, it is likely that when will cause sealing
That links is not smooth.
In some preferred modes, while to the first intracavitary loading liquid sample, liquid sample can enter naturally
Second is intracavitary.In some preferred modes, while to the first intracavitary loading liquid sample, liquid sample can be in outer masterpiece
It is intracavitary with lower entrance second.
In some preferred modes, the bottom of the first chamber is equipped with the channel that can assemble the second chamber.Some preferred
In mode, the second chamber can move in channel.In some preferred modes, the removable combination of the second chamber and channel or
Connection.In some preferred modes, first passage and first intracavitary portion's fluid connection.In some preferred modes, when
When sample is collected in two chamber channels, the second chamber is assemblied in channel.In some preferred modes, the second chamber completes sample collection
It afterwards, can be mobile to the direction separated with the first chamber under external force.
At separation
For this purpose, the present invention also provides at the separation of a kind of first chamber 1 and the second chamber 2, as shown in fig. 7, this separation is sentenced
The form in channel 5 embodies, and when the first chamber 1 and the second chamber 2 combine, shows as the first chamber 1 and second again at this separation
One junction of chamber 2, the initial stage, sample collection device is not yet by use, the second chamber 2 is assemblied on the first chamber 1, at this time
As previously mentioned, the second chamber 2 prevents sample from leaking out at channel 5 when initial be packed into as a plug at channel 5,
Moreover, the second chamber 2 has to exit out of channel 5 without taking extra sample out of, this is just right after the completion of sample is packed into
Assembly between second chamber 2 and channel 5 and it is sealed with higher requirement, to allow inside of the liquid sample as far as possible to the second chamber 2
And the internal flow of the first chamber 1 other than channel 5, rather than deposit at the assembly in the second chamber 2 and channel 5.
For this purpose, devising following several forms:
It is possible, firstly, to the mode taken is, (i.e. the second chamber 2 is opened towards this in the first chamber 1 for the oral area 7 of the second chamber 2
Mouthful) must at least be flushed with the surface of channel 5 towards the first intracavitary opening 15, comparatively the face flushed is not easy to be formed
Deposit point, especially to be avoided, the surface of the opening in channel 5 is lower than the oral surfaces of the second chamber 2, in this case, no
It can avoid ground, liquid sample can enter in the gap between 2 oral area of channel 5 and the second chamber, thus when the second chamber 2 exits
It can flow out therewith.In addition it should be pointed out that since the second chamber 2 needs the second sealing of one and the second sealing element 11
Position 13, this second sealing position 13 may exceed its oral area 7, and be formed between the second sealing position 13 and oral area 7
One shoulder 14, as shown in figures 3 and 6, the guarantee that we need at this time to be shoulder 14 intracavitary open with channel 5 towards first
The surface of mouth 15 flushes.
Then, this form may also is that the second collection port 7 is slightly above the opening 15 in channel 5, alternatively, the shoulder of the second chamber
Portion 14 is slightly above the opening in channel 5, in this way, the liquid sample not being packed by the second chamber 2 would generally be along this from high to low
Layered structure flow in the first chamber 1 other than channel 5.
Or second collection port 7 and channel 5 opening 15 surface between form one and incline gradually downward from inside to outside
Oblique inclined-plane, alternatively, forming one between the surface of the opening 15 of the shoulder 14 and channel 5 of the second chamber from inside to outside gradually downward
Inclined inclined-plane, then the form on this inclined-plane can be more conducive to not leave entrance along it by the liquid sample that the second chamber 2 is packed into
Into the first chamber 1.
The form that channel 5 is sentenced in separation embodies, and channel 5 is the element of a both ends open, and one end connection is external, and one end connects
In logical first chamber 1, since the second chamber 2 can assemble wherein, then the second chamber 2 is possible to meeting along channel 5 in some cases
It enters in the first chamber 1, such case has to be absolutely avoided.On the one hand the leakage part of the second chamber 2 can pollute first
Liquid sample in chamber 1, second aspect, if the second chamber 2 is not clogged or is pulled out, channel 5 is just at the first chamber
One loophole, liquid sample can be from wherein a large amount of leakages, it is therefore necessary to the position limiting structure that the second chamber 2 moves inward be arranged.
As shown in Fig. 2,7,8 or 9, it is equipped with a between outer land terrace 8 in channel 5, is come with this between outer land terrace 8 for line of demarcation
It sees, channel 5 is less than between outer land terrace 8 close to this external side in internal diameter of the outer step surface 8 close to the part in 1 this direction of the first chamber
To part internal diameter, thus the inner wall in channel 5 forms inner small and outside big structure, and this between outer land terrace 8 is lucky
It is the line of demarcation of size, that is to say, that between outer land terrace 8 can be used as a position limiting structure.
In order to preferably be adapted to this position limiting structure, an interior step surface 9 can also be set on the outer wall of the second chamber 2,
Step surface 9 is as from the point of view of line of demarcation in using this, and the outer wall of the second chamber is in interior step surface 9 close to the portion of 1 internal direction of the first chamber
The internal diameter divided is less than the second cavity outer wall in interior step surface 8 close to the internal diameter of this external direction part, that is to say, that interior step surface
9 can form a cooperation between outer land terrace 8, to be limited to the inside movement of the second chamber 2, in original state, and second
Chamber 2 is assemblied in the first chamber 1, and interior step surface 8 and between outer land terrace 9 are usually to be engaged at this time, when interior 8 He of step surface
When between outer land terrace 9 is engaged, the bottom of the second chamber 2 is flushed with the oral surfaces of channel 5 outwardly.Later with sealing
It carries out, interior step surface 8 and between outer land terrace 9 will do it separation, and the second chamber 2 can be gradually rejected outward.
A kind of way of realization of above-mentioned only this position limiting structure, it should be appreciated that position limiting structure is that one kind can be into
The conventional mechanical structure of row extension and application all belongs to as long as can satisfy the structure for preventing the second chamber 2 from moving inward without limitation
In this column, for example, snap ring, elastic component etc., will not enumerate herein.
In some preferred modes, sealing structure, so-called dress can also be set on the fitting surface in the second chamber and channel
Refer to the outer surface of the second chamber and the inner surface in channel with face, sealing structure can use the form of Sealing shield ring 37, sealing
Retaining ring 37 can limit the assembly in the second chamber and channel, that is, play the role of it is identical with position limiting structure above-mentioned, can also be to
Sealing function is played in the separation of two chambers and channel.In some preferred modes, Sealing shield ring uses O-ring.Some preferred
Mode in, Sealing shield ring 37 use hair brush structure, hair brush structure can when the second chamber exits channel, scrape the second chamber table
Face, it would be possible to which the sample adhered to thereon strikes off, and certainly, O-ring can also function as described above.
In some preferred modes, sealing structure and position limiting structure can also be not arranged in the assembly in channel and the second chamber
On face, as long as can function as described above, the rigging position of structure is not the range of the invention to be limited.
The collection method of sample
The present invention provides a kind of method for collecting aforementioned sample, and this method, which uses, has the first chamber 1 above-mentioned and the second chamber 2
Sample collection device, the first chamber 1 is for collecting liquid sample, and the first chamber 1 has a sample entrance port 4, and the second chamber 2 is for receiving
Collection confirmation detection liquid sample, the detection opportunity and testing goal of the first chamber 1 and the second chamber 2 are different, but detect institute's needle
Pair be sample that same batch is collected into.In order to realize that same batch is collected and gradation detects, the first chamber 1 and the second chamber 2 were both
It can carry out being detected respectively after releasing with a batch of collection when combining in conjunction with can separate again, or
It is separated after detection, the second chamber 2 individually enters secondary detection program.Sample testing apparatus further includes for sealing the first chamber 1
The first sealing element 10, for sealing the second sealing element 11 of the second chamber 2, and the separation to the first chamber 1 and the second chamber 2
The third sealing element 16 that place is sealed, at separation, i.e., channel 5 above-mentioned.
In some preferred modes, for the first sealing element 10 during sealing the first chamber 1, the second chamber 2 can be by
The sealing of second sealing element 11.In some preferred modes, the first sealing element 10 leads to during sealing the first chamber 1
Road 5 can be sealed by third sealing element 16.In some preferred modes, the second sealing element 11 and third sealing element 16
One of with the linkage of the first sealing element 10 and the second sealing element 11 links with third sealing element 16;Or second sealing element
11 and third sealing element 16 with the first sealing element 10 link.In some preferred modes, in all seal process
Before, channel 5 is clogged by the second chamber 2, at this point, the first chamber 1 forms the entirety being internally connected to outer closure with the second chamber 2.
In some preferred modes, in seal process, the second chamber 2 is displaced outwardly relative to channel 5.
In some preferred modes, the collection method of sample includes that the first chamber 1 and the second chamber 2 is allowed to realize by channel 5
Fluid connection, liquid sample can be flowed by some oral area (such as opening 15) in the channel 5 or the channel 5 from the first chamber 1
Enter the second chamber 2, so that, while liquid sample is packed into the first chamber 1, liquid sample can also be naturally entered to second
In chamber 2.In some preferred modes, before separation, channel 5 is close by third sealing element 16 for the first chamber 1 and the second chamber 2
Envelope.In some preferred modes, during separation, channel 5 is close by third sealing element 16 for the first chamber 1 and the second chamber 2
Envelope.
In some preferred modes, the collection method of sample include to the first chamber 1 and the second chamber 2 for having collected sample into
The process of row sealing, during sealing, relative movement can occur for the first chamber 1 and the second chamber 2 so that the second chamber 2
A part is pushed out out of first chamber 1.In some preferred modes, during sealing, a part of the second chamber 2 is exposed
Except the first chamber 1.In some preferred modes, in the seal process of the first chamber 1 along with the sealing to the second chamber 2.
In some preferred modes, the collection method of sample include to connection the first chamber 1 and the second chamber 2 channel 5 into
The process of row sealing, during sealing, relative movement can occur for the first chamber 1 and the second chamber 2 so that the second chamber 2
A part intracavitary is pushed out from first.In some preferred modes, during sealing, a part of the second chamber 2 is exposed
Except the first chamber 1.In some preferred modes, to the seal process of the first chamber 1 along with the sealing to channel 5.One
In some preferred modes, to the seal process in channel 5 after the seal process to the second chamber 2.In some preferred modes,
Second chamber 2 is pushed outwardly while sealing to channel 5.
The detection method of sample
The present invention provides a kind of method that the sample to after collection is detected, and the detection method is collected for detecting
Liquid sample in whether there is analyte, the detection method include using above-mentioned collection device or collection method come
Sample to be detected is collected, after being collected into a certain amount of sample to the first chamber 1, the sample in the first chamber 1 is examined for the first time
It surveys.
In some preferred schemes, the second chamber 2 for completing sample collection is sealed first, then passes through test again
Element detects the sample in the first chamber 1.In some preferred schemes, the first chamber 1 and the second chamber 2 are divided first
From then being detected again by testing element to the sample in the first chamber 1.Since the liquid sample collected of the second chamber 2 is
For secondary detection, the second chamber is separated first, liquid sample that can be intracavitary to avoid second for secondary detection
By the testing element pollution in primary detection.In some preferred schemes, first to the logical of the first chamber 1 of connection and the second chamber 2
Road is sealed, and is then detected again by testing element to the first intracavitary sample.Channel is sealed, prevents from testing
Sample leaks.
In some preferred modes, the barrier element that liquid sample can be prevented to flow into detection zone is equipped in the first chamber 1
31, barrier member, 31 can open or be closed the entrance 32 in 1 communication with detection area of the first chamber, to prevent or discharge liquid-like
This inflow detection zone 3;While third sealing element 16 seals channel 5, triggering barrier element 31 opens detection zone
Entrance.In some preferred schemes, during collecting sample, detection zone 3 and sample are received by barrier element 31
Collection region (i.e. the inside of the first chamber) is isolated, and after the completion of sample collection, releases barrier element 31 to detection zone and sample
Isolation between this collecting zone, makes sample be able to enter detection zone.
In some preferred schemes, detection zone 3 is set in the first chamber 1, detection zone usually has externally visual
Characteristic, such as detection zone can using transparent material make.In some preferred schemes, setting is surveyed in detection zone 3
Try element.In some preferred schemes, the entrance 32 that can be connected to or close is equipped between detection zone 3 and the first chamber 1.?
In some preferred schemes, which can cooperate with barrier element 31, be blocked members block and close, or open and
Communication with detection region and the first chamber.
Sealing element
As previously described, when the first chamber 1 and the second chamber 2 are in bonding state, only one of chamber can be carried out
Sealing, because the two has common opening, and a channel by a channel 5 as both connections, when the first chamber 1
After the separation of the second chamber 2, need independently to be sealed the second chamber 2, such second chamber 2 can be independently to liquid-like therein
Originally it is sealed, it is therefore desirable to have the sealing device individually for the second chamber 2, when the first chamber 1 and the second chamber 2 are in isolated process
In, the first chamber 1 will necessarily generate one in addition to (this original opening can be by first for original opening due to the second exiting for chamber 2
Sealing element 10 is sealed) except the new opening (i.e. the outside opening 15 in channel 5) that may leak out liquid, also need at this time
This opening 15 is sealed, prevent liquid sample from flowing out, it is therefore desirable to which one for the sealing device at separation.
In view of above-mentioned reason, the present invention provides the specific sealing structure of the first chamber 1 and the second chamber 2, these specific sealings
Structure includes the first sealing element 10 for sealing the first chamber 1, for sealing the second sealing element 11 of the second chamber 2, and
When the first chamber 1 and the second chamber 2 separate, the third that (i.e. channel 5) is sealed at the separation of the first chamber 1 and the second chamber 2 is close
Seal element 16.
In some preferred modes, the oral area 6 of the first sealing element 10 and the first chamber 1 by the first helicitic texture 17 into
The oral area 7 of row sealing, the second sealing element 11 and the second chamber 2 is sealed by the second helicitic texture 18, third sealing element
16 and separation at (i.e. channel 5) be sealed by third helicitic texture 19.
Be as shown in Figure 7 whole device sealing before state, at this point, the first sealing element 10, the second sealing element 11 with
And third sealing element 16 does not start to seal, when user is collected into proper amount of liquid sample from the oral area 6 of the first chamber 1
Afterwards, device can be sealed, the first sealing element 10 lid is closed into the oral area 6 to the first chamber 1, the rotation of the first sealing element 10
Lid is closed onto the oral area 6 of the first chamber 1, is realized the sealing to the first chamber 1, is sealed in the first sealing element 10 to the first chamber 1
During, the second sealing element 11 is sealed the oral area 7 of the second chamber 2, or in the first sealing element 10 to the first chamber 1
During being sealed, third sealing element 16 is sealed channel 5, alternatively, in the first sealing element 10 to the first chamber 1
During being sealed, the second sealing element 11 and third sealing element 16 are respectively sealed the second chamber 2 and channel 5,
When the first sealing element 10 completes the sealing to the first chamber 1, the second sealing element 11 and third sealing element 16 have been distinguished
The sealing to the second chamber 2 and channel 5 is completed, alternatively, during the first sealing element 10 is sealed the first chamber 1, the
Two sealing elements 11 are sealed the second chamber 2 with the rotation of the first sealing element 10, at the same time, third sealing element 16
Also channel 5 is sealed rotating with it, the sequence for sealing completion is that the second sealing element 11 is completed first to the second chamber 2
Sealing, the second chamber 2 assembly at this time completes, although formed one it is whole be in the first chamber 1 actually with
Second sealing element 11 is separated into the state of an individual cavity, can be separated at any time from the first chamber 1, then third is close
And then envelope element 11 completes the sealing to channel 5, the first sealing element 1 continues to rotate until completing the sealing to the first chamber 1.
View of the above, it will be seen that the second sealing element 11 must be close first to the seal process of the second chamber 2
Envelope element 10 is to carrying out in the seal process of the first chamber 1, seal process of the third sealing element 16 to channel 5, it is also necessary to be
It is carried out in seal process of first sealing element 10 to the first chamber 1, and sealing of second sealing element 11 to the second chamber 2
Journey and third sealing element 16 can be what sequence successively carried out, are also possible to overlap to the seal process in channel 5
, it can also be fully synchronized.
Shown in Fig. 8 is a pilot process of sealing, and in state shown in Fig. 8, the second sealing element 11 is complete
At the sealing to the second chamber 2, third sealing element 16 will start the sealing to channel 5 at this time, and the first sealing element 1 is in
To in the seal process of the first chamber 1, that is to say, that for the length of screw thread, the length of the first helicitic texture 17 is equal to second
The sum of helicitic texture 18 and the length of third helicitic texture 19, be just able to achieve in this way the first sealing element 10 to the first chamber 1 into
During row sealing,
It should be pointed out that during this sealing, due to the first sealing element 1, the second sealing element 2 and third
Sealing element 3 is sealed in such a way that screw thread screws, therefore during being threadedly engaged, these sealing elements
Necessarily have the reduction in a height, the reduction in this height, from linkage it is upper for, will push the second chamber 2 towards being detached from the
The direction of one chamber 1 is ejected so that the second chamber 2 some be exposed to except the first chamber 1, consequently facilitating by the second chamber 2 from
It takes out in one chamber 1, will be described in detail in this linkage element below.
In some preferred modes, sealing element can also realize the sealing to each cavity by way of plug.
For example, the first sealing element 1, the second sealing element 2 and third sealing element 3 can use the form of sealing-plug.
In some preferred modes, Sealing shield ring can be set on the inner wall in channel or the outer wall of the second chamber.?
In some preferred modes, Sealing shield ring can use flexible structure or hair brush structure, and the effect of Sealing shield ring be can be the
When two chambers are exited out of channel, prevents the second chamber or isolated sample exudation.
In some preferred modes, sealing element only needs to include the second sealing element 11 for sealing the second chamber 2
With the third sealing element 16 for sealed passage 5, the second sealing element and third sealing element can be in linkage respectively to
Two chambers and channel are sealed.
In some preferred modes, the second sealing element 11 is first sealed the second chamber 2, then third sealing element
16 are again sealed channel 5.In some preferred modes, third sealing element 16 can make while sealed passage 5
Second chamber 2 is mobile to the direction isolated with the first chamber 1.In some preferred modes, the second chamber 2 only needs partly to exit
One chamber 1.
In some preferred modes, the second sealing element 11 is combined during sealing the second chamber 2 with the second chamber 2.
In some preferred modes, third sealing element 16 is combined during sealed passage 5 with channel 5, while compressing outward
Second chamber, combination here refer to that sealing element and the member distance sealed are more and more closer, or the case where having assembled
Under, it more closely assembles, this assembly can be such that the length of entire assembling structure or height further shortens, for example, spiral shell
Line structure, with the screw-in of screw thread, the height or length of whole device will be shorter.
In some preferred modes, the second sealing element 11 can and the second chamber 2 the removable combination or company of oral area
It connects, combination and combination above here is identical, and the second collection port refers to that the second chamber for collecting the collection port of sample, generally comes
It says, this collection port should also be as being that the second chamber is uniquely open, and after this opening is closed, the second chamber would be at sealed shape
State.
In some preferred modes, the second sealing element 11 is the second lid, and the second lid passes through the second helicitic texture
And the second collection port removable combination or connection.In some preferred modes, screw thread be can be set in the second accent portion
Outer wall and the second lid inner wall.In some preferred modes, screw thread can be set the second lid outer wall and
The inner wall in the second accent portion.Internal and external threads can select according to the actual needs, and the present invention is not limited to one kind shown in figure
Connection type.In some preferred modes, the second sealing element is the second cock body, and the second cock body can be with the second accent portion
Inner wall close-fitting inwardly squeezes and clogs oral area using the form of plug, also can achieve above-mentioned sealing effect, and plug exists
Also it can be realized the linkage between cock body during filling in.For the present invention, it the sealing of sealing element and sealed
The linkage of journey is that the present invention needs scheme to be protected.
In some preferred modes, third sealing element can and channel the removable combination or connection of oral area.?
In some preferred modes, third sealing element is third lid, and third lid passes through the oral area of third helicitic texture and channel
Removable combination or connection.In some preferred modes, third sealing element is third cock body, and third cock body can be with
The inner wall close-fitting of channel portal.Equally, the mode of connection or the combination of third sealing element and channel portal can also use
The structure similar with the preceding paragraph is also not necessarily limited to a kind of connection type shown in figure and may be used also in some cases in the present invention
As needed different lids are selected with different connection types, that is to say, that use knockdown connection type, it should also
Among protection scope of the present invention.
Linkage element
In order to realize the sealing sequence of the first chamber 1, the second chamber 2 and channel 5, need for the first sealing element, the second sealing
Linkage structure is arranged in element and third sealing element, and the effect of linkage structure is, when the first sealing element is close to the progress of the first chamber
During envelope, the second sealing element can also be sealed the second chamber, it is possible that state is, when the first sealing element is complete
When at sealing, the second sealing element is also completed to seal, alternatively, the second sealing element is before the first sealing element completes sealing
Complete sealing.
These linkage structures include the first linkage element for link the first sealing element 10 and third sealing element 16
20, and for link the second sealing element 11 and third sealing element or the second sealing element 11 and the first sealing element 10
Second linkage element 21.
First linkage element 20 is interlocking bar, and the both ends of interlocking bar are separately connected the first sealing element 10 and third sealing member
Part 16, make one of the first sealing element 10 and third sealing element 16 rotate when, be able to drive in addition one of rotate with it, it is this
Rotate with it and can be synchronous, be also possible to the drive of discontinuity, but it is this rotate with it is usually equidirectional, still
Also a possibility that being not excluded for opposite direction.
As the specific implementation form of interlocking bar, the first sealing element 10 is a kind of cup lid, opposed flattened with one
Interior capping 22, interior capping 22 be equipped with interior axis hole 23, the upper end of interlocking bar is plugged in the interior axis hole 23, such as the institute of Fig. 2,7,8
The part of the first sealing element 10 shown.In some cases, third sealing element 16 is also a kind of lid structure, has one
Opposed flattened outer capping 24, outer capping 24 are equipped with outer shaft hole, and the lower end of interlocking bar is plugged in the outer shaft hole, link in this way
Bar can be linked the first sealing element 10 and third sealing element 16 by inside and outside two axis holes, can be synchronized
Rotation, then user only needs to rotate the first sealing element 10 of outermost when in use, it will be able to which synchronous drive third is close
Envelope element 16 is sealed channel 5.
Alternatively, the part of third sealing element 16 is also possible to the appearance as shown in Fig. 2,7,8, the lower end of interlocking bar is equipped with
One linkage hole 25, a coupled axle-pin 26 is arranged on the outer capping 24 of third sealing element 16, and coupled axle-pin 26 is plugged on linkage hole
In 25, realize that the linkage of third sealing element 16 and interlocking bar can also reach so that the first sealing element in this manner
1 and third sealing element 16 rotate synchronously purpose, alternatively, the lower end of interlocking bar is just directly connected in third sealing element 16
On outer capping 24, in this case, removable point of the first linkage element 20 and third sealing element 16 cannot be realized
From and combine, but will not influence the present apparatus collect sample function.
Either above-mentioned any implementation, interlocking bar can all pass through the first chamber 1 and connect 10 He of the first sealing element
Third sealing element 16.Also, interlocking bar or thereon for the part shape that needs to have certain of connection, usually this
Kind of shape is not circular, be can be such as rectangular, semicircle or triangle, correspondingly, the first sealing element 10 and the
Interior outer shaft hole on three sealing elements 16 is also same shape, then, just pass through this shape between interlocking bar and interior outer shaft hole
Shape carries out circumferential limit, will not relatively rotate, and such interlocking bar can drive first sealing element by two axis holes
It is rotated with third sealing element, to realize linkage.In other possible modes, interlocking bar and interior outer shaft hole can also
To be the circular hole of close-fitting, the power to link at this time is adjacent to the frictional force between face from interlocking bar and interior outer shaft hole.At other
In possible mode, interlocking bar and axis hole are also possible to the step-type relationship that is linked, this step-type pass that is linked
Under system, interlocking bar or interior outer shaft hole can independently rotate certain angle, then resynchronisation rotation.
Correspondingly, linkage hole 25 and coupled axle-pin 26 can also use under the fit system of linkage hole 25 and coupled axle-pin 26
Above-mentioned similar shape is linked to realize, or is linked using similar principle to realize.
As another way of realization being linked, interlocking bar is equipped with axis hole, the first sealing element or third sealing
Element is equipped with the co-operating member to link with interior outer shaft hole, and co-operating member is of similar shape with axis hole, this shape is inclined
It from interlocking bar axle center, or is non-round, so that interlocking bar and co-operating member can be realized linkage.Some excellent
In the mode of choosing, interlocking bar can also with co-operating member is step-type is linked.
Second linkage element 21 can directly link the first sealing element 10 and the second sealing element 11, can also link
Two sealing elements 11 and third sealing element 16 and whose linkage are not the specific implementation of the invention to be limited, the present invention
Purpose be able to realize three sealing priority.The appearance as shown in Fig. 2,7,8, the second linkage element 21 are linkage
The short object of pin or analogous shape, the second linkage element 21 are connected on the upper capping 27 of the second sealing element, naturally it is also possible to Gu
It is connected on the lower capping 28 of third sealing element 16 (this mode is not shown in the figure), no matter the second linkage element 21 is to be connected in
Second sealing element 11 is still connected on third sealing element 16, and the second sealing element 11 and third sealing element 16 are in addition
One of the hole of setting and the cooperation of the second linkage element 21 in (second linkage element 21 that is not connected that), likewise, the
Two linkage elements 21 and matched hole also have certain shape, and this shape is similar with interlocking bar above-mentioned, both may be used
To deviate the second sealing element or third sealing element rotation center, it is also possible to non-round such as rectangular, semicircle
Or triangle etc., one of in addition the purpose is to be able to drive set bar and/or linkage one of hole to rotate with it,
This rotate with it can be synchronous, be also possible to the drive of discontinuity, and this rotation can be equidirectional, be also possible to
Opposite direction.
Second sealing element 11 with the first sealing element 10 when linking, with the rotation of the first sealing element 10, second
Sealing element 11 can be sealed the second chamber 2 by the second helicitic texture 18, and the second sealing element 11 is close with third
When sealing the linkage of element 16, since third sealing element 16 is linked with the first sealing element 10, then it is close also to will drive second
Envelope element 11 is sealed the second chamber 2.The direct linkage part of second sealing element 11 is the first sealing element 10 or
Three sealing elements 16 can be arranged to consider according to the structure of actual product, be selected as needed.
In some preferred modes, linkage structure includes the first sealing element for sealing the first chamber and for sealing
Second sealing element of the second chamber is linked between the first sealing element and the second sealing element by the first linkage element.One
In a little preferred modes, linkage structure includes that the first sealing element for sealing the first chamber and the third for sealed passage are close
Element is sealed, is linked between the first sealing element and third sealing element by the first linkage element.In some preferred modes,
Linkage structure includes the second sealing element for sealing the second chamber and the third sealing element for sealed passage, the second sealing
It is linked between element and third sealing element by the second linkage element.In some preferred modes, including for sealing the
First sealing element of one chamber, the second sealing element for sealing the second chamber and the third sealing element for sealed passage,
It is linked between first sealing element and the second sealing element by the first linkage element, the second sealing element and third sealing element
Between by the second linkage element link.In some preferred modes, including for sealing the first chamber the first sealing element,
For sealing the second sealing element of the second chamber and for the third sealing element of sealed passage, the first sealing element and second close
It seals between element and is linked by the first linkage element, pass through close-fitting or the company of fixation between the second sealing element and third sealing element
Connect linkage.
In some preferred modes, the linkage between the second sealing element and third sealing element, which can be, passes through fixation
Connection is to realize.In some preferred modes, the linkage between the first sealing element and third sealing element, which can be, to be passed through
It is fixedly connected to realize, that is to say, that as shown in figure 13, can be one between the second sealing element 11 and third sealing element 16
The connected mode of kind, is equivalent to the second sealing element 11 and third sealing element 16 is linked together, can be realized linkage naturally, this
Kind is connected, and can be and is inherently linked together, such as some surface of two sealing elements is fixedly connected or sticks together, can also
Being achieved a fixed connection by other components, such as connecting rod, the present invention does not limit connected mode, as long as can reach
To the effect for making it link.Equally, between the first sealing element and the second sealing element, the first sealing element and third are close
It seals between element, can also naturally realize linkage in this way.
In some preferred modes, the first linkage element is interlocking bar.In some preferred modes, the second linkage member
Part is set bar.In some preferred modes, the linkage refers to synchronous rotation.It is described in some preferred modes
Linkage refer to it is synchronous to mobile close to the direction of sample interior.In the present invention, especially seal process is synchronous, example for linkage
Such as, it rotates synchronously, synchronous rotation is particularly suitable for the connection type of helicitic texture, and for another example, synchronous to be packed into, synchronous be packed into especially is fitted
It for the connection type of plug, is being clamped, in the connection types such as knob, similar linkage structure can also be used.
Position limiting structure
As previously mentioned, channel 5 is a kind of way of realization at separation, effect is that 2 grafting of the second chamber can be allowed to be mounted on
Wherein, it and is sealed against, then as previously mentioned, need to limit the cooperation between the second chamber 2 and channel 5, otherwise second
Chamber 2 may be slid into the first chamber 1 by this channel 5, pollute or cause liquid sample at channel 5 to liquid sample
It can largely leak.Therefore, mutually matched position limiting structure is set in the inner wall in channel 5 and the outer wall of the second chamber 2, this limit knot
The extreme position that second chamber 2 is installed is limited to the somewhere in channel 5 by structure, after the second chamber 2 is installed in place, just will not again to
Inside continue to move to.
As shown in Fig. 2,7,8, a between outer land terrace 36 is set on the inner wall in channel 5, step surface 36 is as boundary in addition
Line, channel 5 is bigger than the internal diameter close to this external a part close to the internal diameter of this part of the first chamber 1, at the same time, such as
Shown in Fig. 5-6, on the outer wall of the second chamber 2 be arranged one with this between outer land terrace 36 cooperate interior step surface 29, within step
Face 29 is used as line of demarcation, the second chamber 2 close to this part of the first chamber 1 internal diameter than close to internal diameter of this external a part
It is small, then interior step surface 29 and between outer land terrace 36, which carry out cooperation, to limit the limit installation site of the second chamber 2 at this
It in chalaza, when the second chamber 2 is packed into, due to step surface card master, inwardly can not further move, realize the limit to the second chamber 2
Position.
Channel 5 is that the first chamber 1 and the second chamber 2 is allow to realize the structure of assembly, and channel 5 can regard the first chamber 1 as
A part, ideal state are, after the second chamber 2 completes installation, the gabarit (such as bottom surface) of the second chamber 2 is outer without departing from channel 5
Surface, such case can make the first chamber 1 and the second chamber 2 use one entirety of preceding formation, but if when using still
Such case, the second chamber 2 will be difficult to take out out of first chamber 1, and therefore, linkage structure of the invention can also be realized when sealing
Element sealing the first chamber 1, the second chamber 2 and during channel 5, can the gradually ejection outward by the second chamber 2, when all close
Envelope process is (including the first sealing element 10 to the sealing of the first chamber 1, the second sealing element 11 to the sealing of the second chamber 2 and
Sealing of three sealing elements 16 to channel 5) when completing, a part of the second chamber 2 stretches out in (such as Fig. 2 except the gabarit of the first chamber 1
It is shown), the second chamber 2 can be separated from the first chamber 1 by this part of stretching at this time, after the sealing of the second sealing element 11
The second chamber 2 be one completed sealing cavity, in liquid sample can be used for secondary-confirmation detection, the second chamber 2
It, can be by independent transport to secondary detection mechanism after being detached from the first chamber 1.
In order to realize the second chamber 2 as seal process is gradually pushed out, the length of helicitic texture and the length of linkage element
Need to meet certain requirement, for example, as previously described, being sealed first by the second sealing element 11 in the second chamber 2, then immediately
Channel 5 sealed by third sealing element 16, during the two is sealed, the first sealing element 11 always in sealing
The process of first chamber 1, ideal state are, while the first sealing element 11 completes sealing, third sealing element page 16 is just
Sealing is completed, in this case, the length of the first helicitic texture 17 is equal to the second helicitic texture 18 and third helicitic texture 19
The sum of length, the length of interlocking bar meets: when the first sealing element 1 is swung down to the second sealing element 11 just by second
When chamber 2 is fully sealed, the second chamber 2 and the relative position in channel 5 are constant, when third sealing element 16 starts sealed passage 5, the
Two chambers 2 start to be pushed out outward.That is, the first sealing element 11 passes through interlocking bar drive the in the initial stage that lid closes
Two sealing elements and the rotation of third sealing element, third sealing element is not the state in idle running at this time, not and other component
Contact, and the second sealing element has begun in the helicitic texture cooperation on the second chamber 2, after the completion of the sealing of the second chamber 2, continues
The first sealing element 11 is rotated, the first helicitic texture 17 continues to close up at this time, pushes down on third sealing element by interlocking bar
With the second chamber after sealing, while the beginning of the second chamber 2 is displaced outwardly along channel 5, third sealing element starts sealed passage
5, until channel 5 is fully sealed, the first chamber 1 is also sealed just and is completed by the first sealing element 11 at this time.
Due to that can not be fully sealed between the second sealing element 11 and third sealing element 16, will necessarily have certain
Gap 30, this partial gap may enter liquid sample when the second sealing element 11 seals the second chamber, therefore, ideal
State be that after the second sealing element 11 completes sealing, third sealing element 16 still can dally a small distance, will be in gap
Liquid extrude, then channel 5 is sealed again, such that residual liquid sample is as few as possible in gap, is subtracted
The leakage of liquid sample when separating less, in this case, the length of the first helicitic texture 17 is just needed slightly larger than the second screw thread
The sum of structure 18 and the length of third helicitic texture 19, in practice, specific size can according to need to adjust, institute of the present invention
The main technical solution to be realized is, the interaction relation of sealing and the sequence of sealing.
Barrier element
In addition to the foregoing structure, carrying out the initial survey of sample using the device of the invention is also one aspect of the present invention,
So, the present invention is in the state of ideal, it is desirable to can complete in sample collection, be used for two in the second chamber 2 especially
After the liquid sample collection of secondary confirmation detection is completed and sealed, initial detecting, the detection sample of such secondary-confirmation are carried out
It will not be contaminated because of initial detecting, it is ensured that the accuracy of secondary detection, for this purpose, also a kind of barrier element 31 of the present invention, as before
Described, the effect of barrier element is temporarily by testing element and the liquid sample being collected into initial detecting chamber (i.e. the first chamber 1)
Partition, temporarily prevents liquid sample from entering detection zone 3, and certainly, barrier element can also discharge sample, therefore, resistance
Every the component that element is for obstructing or opening the connected relation between the first chamber 1 and detection zone 3, the initial of sample is being collected
When state, barrier element 31 separates the first chamber 1 with test zone 3, and liquid sample cannot be introduced into detection zone 3 at this time, test
Element will not be in contact or react with liquid sample, when collect to a certain extent or at certain opportunity, barrier element 31
The detection entrance 32 for opening 1 communication with detection region 3 of the first chamber allows a part of liquid sample to enter detection from detection entrance 31
In region 3, and initial survey is carried out by testing element, obtains a preliminary testing result.
As in Figure 2-4, barrier element 31 can be one and can rotate around the rotatable lamella of the axis rotation of the first chamber 1
A baffle 33 can be set on piece, and using preceding and collection sample original state, baffle 33 can block entrance 32, this
Even if when liquid sample enter in the first chamber 1 and the second chamber 2, it is also not possible to enter in detection zone 3, will not with test member
Part is in contact, and then barrier element 31 can be during sealing element rotates, on suitable opportunity and one of those
Sealing element interferes, to open entrance 32, the liquid sample of initial survey is allowed to enter in detection zone 3, carries out initial survey.
For example, barrier element 31 and the linkage of the second sealing element, complete the sealing to the second chamber in the second sealing element
Meanwhile the entrance that barrier element opens communication with detection region is touched, the sealing to the second chamber is completed at this time, it is ensured that second is intracavitary
Liquid sample will not have any contact with the sample in detection zone, guarantee the accuracy of secondary detection.
Alternatively, appearance as in Figure 2-4, barrier element 31 is set in the periphery in channel 5, and can rotate around it, third
Sealing element 16 is equipped with protrusion 34, protrusion 34 when third sealing element 16 and channel 5 seal, can drop to
In the height that baffle 33 is interfered, while third sealing element 16 completes the sealing to channel 5, protrusion 34 and baffle 33 are sent out
Raw interference, pushes baffle 33 that barrier element 31 is driven to rotate, and opens the entrance 32 in communication with detection region, due to sealing member in third
During at part hermetic separation, the second sealing element has completed the sealing to the second chamber, therefore, when third sealing element is complete
When sealing at pairs of separation, the sealing of the second chamber is formerly completed, therefore, opens the entrance of detection zone, the second chamber at this time
Interior liquid sample will not have any contact with the sample in detection zone, can guarantee the accuracy of secondary detection.
In some preferred modes, barrier element is used to open the detection zone detected to initial detecting sample,
When the second chamber does not collect sample or when collecting sample, detection zone is closed, when the collection of the second chamber is completed and is sealed, sample
Originally it is able to enter detection zone.
In some preferred modes, including the second sealing element for sealing the second chamber, the second sealing element can
Detection entrance is opened or closed, when the second sealing element completes the sealing to the second chamber, opens detection entrance.Some preferred
Mode in, the second sealing element and barrier element link, while the second sealing element completes the sealing to the second chamber, touching
Dynamic barrier element opens the entrance in communication with detection region.
In some preferred modes, the first chamber can be with detection zone fluid connection or partition.When detection entrance is opened
When, the first chamber and detection zone realize fluid connection, and when detection entrance is closed, the first chamber and detection zone are separated.?
In some preferred modes, the first sealing element and the second sealing element link, and the first sealing element can open or close inspection
Entrance is surveyed, when the second sealing element completes the sealing to the second chamber, the first sealing element is driven to open detection entrance.Some
In preferred mode, the first sealing element and barrier element link, and complete the same of the sealing to the second chamber in the second sealing element
When, the entrance that barrier element opens communication with detection region is touched by the first sealing element.
In some preferred modes, third sealing element and the second sealing element link, and third sealing element can be beaten
Detection entrance is closed on or off, when the second sealing element completes the sealing to the second chamber, third sealing element is driven to open detection
Entrance.In some preferred modes, third sealing element and barrier element link, and complete in the second sealing element to the second chamber
Sealing while, pass through third sealing element touch barrier element open communication with detection region entrance.
A kind of concrete implementation scheme
Before use, interlocking bar and the first sealing element 10, the second sealing element 11 and the equal energy of third sealing element 16
Enough states for being in separation or being partially separated, at this point, the first sealing element 10 under discrete state can be used for closing entirely
Device, the second sealing element 11, third sealing element 16 and interlocking bar under discrete state can be put into the first chamber 1
In, as a complete product packaging.
In use, opening the first sealing element 10, it is taken out accessory (including the second sealing element, third sealing element
And interlocking bar), in some cases, these accessories can also be placed individually using other packagings, and the present invention, which does not limit, to be matched
The manner of packing of part is inwardly packed into liquid sample from the first collection port, and a part of liquid sample can enter simultaneously simultaneously at this time
Second chamber, since the second chamber is located at the bottom of the first chamber, it is generally the case that the second chamber can preferentially be loaded into liquid sample,
Continue to be packed into liquid sample into device until reaching required amount.
After the completion of liquid sample collection, start to be sealed device, related accessory is connected according to appearance shown in Fig. 7
Together, the first sealing element 10 is then rotated, the first chamber is sealed, in this process, as shown in figure 8, interlocking bar
It drives the second sealing element and third sealing element to be moved downward to the second sealing element first to contact with the second collection port, into one
Step rotation, then the second sealing element can be sealed the second chamber, while being sealed to the second chamber, pass through linkage
The mobile whole sealing elements of interaction relation formation one of element integrally continue to move down, until the completion of the second sealing element is close
Envelope, further, the first sealing element continues to rotate down, and third sealing element starts to be sealed channel at this time, due to
Second sealing element and third sealing element or the first sealing element are in linkage status, therefore, the second sealing member
The second chamber that part will drive after sealing rotates one time on one side and moves down, at this time the second chamber move down with respect to channel to
It is pushed out outside, the bottom of the second chamber is gradually exposed except the bottom of the first chamber, also complete at this time until completing the sealing to channel
At the sealing to the first chamber, inordinate rotation, is additionally provided with a sealing limit element on the outside of the first collection port in order to prevent, this
A sealing limit element can be a stop collar 35, the periphery of this stop collar is than the first sealing as shown in Fig. 2,4,7 or 8
The periphery of element is big, therefore just cannot be further continued for downwards when the first sealing element is turned to and contacted with this stop collar
It moves, sealing position limiting structure can play a protective role to internal structure, prevent inordinate rotation from leading to the damage to internal structure
Wound.Certainly, this sealing limit element is also possible to a limited block or a buckle, alternatively, sealing position limiting structure can be with
It is realized by the terminal of screw thread, when the first sealing element goes to the terminal of the first helicitic texture, is limited naturally.
Claims (25)
1. a kind of collection method of sample, characterized in that it is intracavitary that this method first allows sample to enter, and will be used for initial detecting
Sample and the sample detected for secondary-confirmation divide chamber to store, and after the completion of collecting sample, are used in secondary-confirmation detection first
Sample be individually isolated, then the sample for initial detecting is detected again.
2. a kind of collection method of sample according to claim 1, characterized in that this method provides a kind of sample collection dress
It sets, which includes the first chamber for collecting liquid sample, for collecting the second chamber of confirmation detection liquid sample, the first chamber
It can combine or separate with the second chamber;The sample testing apparatus further includes the second sealing element for sealing the second chamber, and
To the third sealing element being sealed at the separation of the first chamber and the second chamber.
3. a kind of collection method of sample according to claim 1, characterized in that first allow the first intracavitary loading sample, then
Allow the second intracavitary loading sample.
4. a kind of collection method of sample according to claim 1, characterized in that the first chamber and second intracavitary while being filled
Enter sample.
5. a kind of collection method of sample according to claim 1, characterized in that when the first chamber and the second chamber combine,
First chamber and the second chamber are at fluid connection state.
6. a kind of collection method of sample according to claim 1, characterized in that after the second chamber completes sample collection, adopt
The second chamber is sealed with the second sealing element.
7. a kind of collection method of sample according to claim 6, characterized in that after the sealing of the second chamber, using
Three sealing elements at separation to being sealed.
8. a kind of collection method of sample according to claim 6, characterized in that while to the sealing of the second chamber, adopt
With third sealing element to being sealed at separation.
9. a kind of collection method of sample according to claim 1, characterized in that further include being sealed to the first chamber
First sealing element.
10. a kind of collection method of sample according to claim 9, characterized in that the first chamber and the second chamber complete sample
After collection, the first chamber is sealed using the first sealing element.
11. a kind of collection method of sample according to claim 10, characterized in that using the first sealing element to first
While chamber is sealed, the second chamber is sealed using the second sealing element.
12. a kind of collection method of sample according to claim 10, characterized in that using the first sealing element to first
While chamber is sealed, using third sealing element to being sealed at separation.
13. a kind of collection method of sample according to claim 1, characterized in that the second sealing element and third sealing
Element linkage sealing.
14. a kind of collection method of sample according to claim 9, characterized in that the first sealing element and the second sealing
Element linkage sealing.
15. a kind of collection method of sample according to claim 9, characterized in that the first sealing element and third sealing
Element linkage sealing.
16. a kind of collection method of sample described in any one of 3-15 according to claim 1, characterized in that the linkage
Refer to synchronous rotation.
17. a kind of collection method of sample described in any one of 3-15 according to claim 1, characterized in that the linkage
Refer to synchronous to mobile close to the direction of sample interior.
18. a kind of collection method of sample according to claim 1, characterized in that include channel, the second chamber energy at separation
It is enough to be moved in channel.
19. a kind of collection method of sample according to claim 18, characterized in that after the second chamber is sealed, keep it logical
Road is mobile to the direction separated with the first chamber.
20. a kind of detection method of sample, characterized in that collect sample using method described in any one of claim 1-19
This, and including detection zone, detection zone can be opened or closed.
21. a kind of detection method of sample according to claim 18, characterized in that the second chamber is not collected sample or received
When collecting sample, detection zone is closed, when the collection of the second chamber is completed and sealed, detection zone is opened, sample is allowed to enter
And it detects.
22. a kind of detection method of sample according to claim 21, characterized in that it further include barrier element, barrier member
The detection entrance that part can be opened or is closed.
23. a kind of detection method of sample according to claim 22, characterized in that barrier element can be sealed with third
Element linkage, and detection zone entrance is opened under the drive of third sealing element.
24. a kind of detection method of sample according to claim 22, characterized in that barrier element can be with the second sealing
Element linkage, and detection zone entrance is opened under the drive of the second sealing element.
25. a kind of detection method of sample according to claim 22, characterized in that barrier element can be with the first sealing
Element linkage, and detection zone entrance is opened under the drive of the first sealing element.
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CN201810717178 | 2018-06-29 |
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Cited By (1)
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CN113281107A (en) * | 2021-04-12 | 2021-08-20 | 玉屏侗族自治县环境监测站 | Multi-parameter analysis sample retention device |
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