ATE258551T1 - (2-(2-thienyl)-ethylamino)-(2-halophenyl)- acetonitrile als zwischenprodukte und verfahren zu ihrer herstellung - Google Patents

(2-(2-thienyl)-ethylamino)-(2-halophenyl)- acetonitrile als zwischenprodukte und verfahren zu ihrer herstellung

Info

Publication number
ATE258551T1
ATE258551T1 AT98921668T AT98921668T ATE258551T1 AT E258551 T1 ATE258551 T1 AT E258551T1 AT 98921668 T AT98921668 T AT 98921668T AT 98921668 T AT98921668 T AT 98921668T AT E258551 T1 ATE258551 T1 AT E258551T1
Authority
AT
Austria
Prior art keywords
thienyl
acetonitriles
ethylamino
halophenyl
production
Prior art date
Application number
AT98921668T
Other languages
German (de)
English (en)
Inventor
Alain Heymes
Bertrand Castro
Maria Bakonyi
Nagy Marianna Csatarine
Leventene Molnar
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Application granted granted Critical
Publication of ATE258551T1 publication Critical patent/ATE258551T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
AT98921668T 1997-05-13 1998-05-11 (2-(2-thienyl)-ethylamino)-(2-halophenyl)- acetonitrile als zwischenprodukte und verfahren zu ihrer herstellung ATE258551T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9700886A HU225504B1 (en) 1997-05-13 1997-05-13 Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
PCT/HU1998/000046 WO1998051682A1 (fr) 1997-05-13 1998-05-11 Nouveaux produits intermediaires et procede de preparation de ces derniers

Publications (1)

Publication Number Publication Date
ATE258551T1 true ATE258551T1 (de) 2004-02-15

Family

ID=89995121

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98921668T ATE258551T1 (de) 1997-05-13 1998-05-11 (2-(2-thienyl)-ethylamino)-(2-halophenyl)- acetonitrile als zwischenprodukte und verfahren zu ihrer herstellung

Country Status (14)

Country Link
US (1) US6215005B1 (fr)
EP (1) EP0981525B1 (fr)
JP (1) JP4279903B2 (fr)
AT (1) ATE258551T1 (fr)
AU (1) AU7444698A (fr)
BR (1) BR9809113B1 (fr)
CA (1) CA2288637C (fr)
DE (1) DE69821347T2 (fr)
DK (1) DK0981525T3 (fr)
ES (1) ES2213900T3 (fr)
HU (1) HU225504B1 (fr)
NO (1) NO325305B1 (fr)
PT (1) PT981525E (fr)
WO (1) WO1998051682A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226421B1 (en) * 1998-11-09 2008-12-29 Sanofi Aventis Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
EP1603920A1 (fr) 2003-03-12 2005-12-14 Cadila Healthcare Ltd. Polymorphes et forme amorphe de bisulfate de (s) - (+) -clopidogrel
US20040250673A1 (en) * 2003-06-10 2004-12-16 Salerno Paul Michael Ergonomic pedal board
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
EP1680430B1 (fr) 2003-11-03 2010-01-20 Cadila Healthcare Ltd. Procedes de preparation de forme i de (s)-(+)- clopidogrel bisulfate
US20060154957A1 (en) * 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof
TW200640932A (en) * 2005-02-24 2006-12-01 Teva Pharma Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
EP1902058A2 (fr) 2005-07-12 2008-03-26 RPG Life Sciences Limited Procede de preparation d'ester methylique de l'acide methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothienoý3,2-c¨pyridine-5(4h)-acetique ou de sels dudit acide ayant une purete chirale elevee et produits ainsi obtenus
KR20090013794A (ko) * 2006-04-27 2009-02-05 인드-스위프트 래버러토리즈 리미티드 클로피도그렐 히드로겐 설페이트의 다형태의 제조방법
US20090247569A1 (en) * 2006-08-03 2009-10-01 Claude Singer Process for Preparing Clopidogrel Bisulphate
EP1980563A1 (fr) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Procédure pour la préparation d'acétate de méthyle (+)-(S)-alpha-(O-chlorophényl)-6,7-dihydrothiéno-[3,2-C]pyridine-5(4H)
EP2346879A1 (fr) * 2008-10-24 2011-07-27 Sandoz AG Procédé de préparation de s-clopidogrel

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508455A1 (fr) 1981-06-30 1982-12-31 Sanofi Sa Procede de preparation de derives des (thienyl-2)- et (thienyl-3)-2 ethylamines
FR2530247B1 (fr) 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2608607B1 (fr) 1986-12-23 1989-04-28 Sanofi Sa Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues
FR2623810B2 (fr) 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2614619B1 (fr) 1987-04-29 1989-09-15 Sanofi Sa Procede de preparation de n-((chloro-2)-benzyl) (thienyl-2)-2 ethylamine
FR2652575B1 (fr) * 1989-09-29 1992-01-24 Sanofi Sa Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
CA2265886A1 (fr) * 1996-09-12 1998-03-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. Preparation stereospecifique de 1-aryl- et 1-heteroaryl-2-substituees ethyl-2-amines chirales

Also Published As

Publication number Publication date
HUP9700886A2 (hu) 1999-09-28
NO995531D0 (no) 1999-11-12
BR9809113A (pt) 2000-08-01
AU7444698A (en) 1998-12-08
US6215005B1 (en) 2001-04-10
NO995531L (no) 1999-12-13
NO325305B1 (no) 2008-03-25
DE69821347D1 (de) 2004-03-04
EP0981525B1 (fr) 2004-01-28
PT981525E (pt) 2004-05-31
ES2213900T3 (es) 2004-09-01
HU225504B1 (en) 2007-01-29
DE69821347T2 (de) 2004-12-02
WO1998051682A1 (fr) 1998-11-19
JP2001525817A (ja) 2001-12-11
BR9809113B1 (pt) 2010-03-09
EP0981525A1 (fr) 2000-03-01
CA2288637C (fr) 2005-11-15
DK0981525T3 (da) 2004-05-10
CA2288637A1 (fr) 1998-11-19
JP4279903B2 (ja) 2009-06-17
HU9700886D0 (en) 1997-07-28
HUP9700886A3 (en) 2000-06-28

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