BR9809113A - Novos intermediários e processo para sua preparação - Google Patents
Novos intermediários e processo para sua preparaçãoInfo
- Publication number
- BR9809113A BR9809113A BR9809113-1A BR9809113A BR9809113A BR 9809113 A BR9809113 A BR 9809113A BR 9809113 A BR9809113 A BR 9809113A BR 9809113 A BR9809113 A BR 9809113A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- new intermediaries
- thienyl
- intermediaries
- new
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- HVLUYXIJZLDNIS-UHFFFAOYSA-N 2-thiophen-2-ylethanamine Chemical compound NCCC1=CC=CS1 HVLUYXIJZLDNIS-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal cyanide Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Abstract
"NOVOS INTERMEDIáRIOS E PROCESSO PARA SUA PREPARAçãO" Trata-se de um processo para a preparação de [2 - (2 - tienil) -etil - amino] - (2 -halogeno-fenil) -acetonitrilas da fórmula genérica (I), a partir de 2 - (2 - tienil) -etil-amina, cianeto de metal alcalino e o-halogeno-benzaldeído. Os compostos da fórmula genérica (I) são internediários valiosos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9700886A HU225504B1 (en) | 1997-05-13 | 1997-05-13 | Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them |
HUP9700886 | 1997-05-13 | ||
PCT/HU1998/000046 WO1998051682A1 (en) | 1997-05-13 | 1998-05-11 | New intermediates and process for the preparation thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9809113A true BR9809113A (pt) | 2000-08-01 |
BR9809113B1 BR9809113B1 (pt) | 2010-03-09 |
Family
ID=89995121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9809113-1A BR9809113B1 (pt) | 1997-05-13 | 1998-05-11 | [2-(2-tienil) -etilamino] -(2-halogeno-fenil) -acetonitilas como intermediários e processo para sua preparação. |
Country Status (14)
Country | Link |
---|---|
US (1) | US6215005B1 (pt) |
EP (1) | EP0981525B1 (pt) |
JP (1) | JP4279903B2 (pt) |
AT (1) | ATE258551T1 (pt) |
AU (1) | AU7444698A (pt) |
BR (1) | BR9809113B1 (pt) |
CA (1) | CA2288637C (pt) |
DE (1) | DE69821347T2 (pt) |
DK (1) | DK0981525T3 (pt) |
ES (1) | ES2213900T3 (pt) |
HU (1) | HU225504B1 (pt) |
NO (1) | NO325305B1 (pt) |
PT (1) | PT981525E (pt) |
WO (1) | WO1998051682A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU226421B1 (en) * | 1998-11-09 | 2008-12-29 | Sanofi Aventis | Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides |
US6495691B1 (en) | 2001-07-06 | 2002-12-17 | Brantford Chemicals Inc. | Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives |
US6767913B2 (en) | 2001-12-18 | 2004-07-27 | Teva Pharmaceutical Industries Ltd. | Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms |
US7074928B2 (en) | 2002-01-11 | 2006-07-11 | Teva Pharmaceutical Industries, Ltd. | Polymorphs of clopidogrel hydrogensulfate |
HUP0200438A3 (en) * | 2002-02-06 | 2003-10-28 | Egis Gyogyszergyar Nyilvanosan | Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them |
IL166593A0 (en) | 2002-08-02 | 2006-01-15 | Racemization and enantiomer separation of clopidogrel | |
US6800759B2 (en) * | 2002-08-02 | 2004-10-05 | Teva Pharmaceutical Industries Ltd. | Racemization and enantiomer separation of clopidogrel |
EP1603920A1 (en) | 2003-03-12 | 2005-12-14 | Cadila Healthcare Ltd. | Polymorph and amorphous form of (s)-(+)-clopidogrel bisulfate |
US20040250673A1 (en) * | 2003-06-10 | 2004-12-16 | Salerno Paul Michael | Ergonomic pedal board |
GB0321256D0 (en) | 2003-09-11 | 2003-10-08 | Generics Uk Ltd | Novel crystalline compounds |
EP1680430B1 (en) | 2003-11-03 | 2010-01-20 | Cadila Healthcare Ltd. | Processes for preparing form i of (s)-(+)- clopidogrel bisulfate |
US20060154957A1 (en) * | 2004-09-21 | 2006-07-13 | Nina Finkelstein | Crystalline clopidogrel hydrobromide and processes for preparation thereof |
TW200640932A (en) * | 2005-02-24 | 2006-12-01 | Teva Pharma | Clopidogrel base suitable for pharmaceutical formulation and preparation thereof |
EP1902058A2 (en) | 2005-07-12 | 2008-03-26 | RPG Life Sciences Limited | A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno(3,2-c)pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof |
KR20090013794A (ko) * | 2006-04-27 | 2009-02-05 | 인드-스위프트 래버러토리즈 리미티드 | 클로피도그렐 히드로겐 설페이트의 다형태의 제조방법 |
US20090247569A1 (en) * | 2006-08-03 | 2009-10-01 | Claude Singer | Process for Preparing Clopidogrel Bisulphate |
EP1980563A1 (en) | 2007-04-09 | 2008-10-15 | BATTULA, Srinivasa Reddy | Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate |
EP2346879A1 (en) * | 2008-10-24 | 2011-07-27 | Sandoz AG | A process for the preparation of s-clopidogrel |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2508455A1 (fr) | 1981-06-30 | 1982-12-31 | Sanofi Sa | Procede de preparation de derives des (thienyl-2)- et (thienyl-3)-2 ethylamines |
FR2530247B1 (fr) | 1982-07-13 | 1986-05-16 | Sanofi Sa | Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique |
FR2608607B1 (fr) | 1986-12-23 | 1989-04-28 | Sanofi Sa | Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues |
FR2623810B2 (fr) | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
FR2614619B1 (fr) | 1987-04-29 | 1989-09-15 | Sanofi Sa | Procede de preparation de n-((chloro-2)-benzyl) (thienyl-2)-2 ethylamine |
FR2652575B1 (fr) * | 1989-09-29 | 1992-01-24 | Sanofi Sa | Procede de preparation d'acides alpha-bromo phenylacetiques. |
FR2664596B1 (fr) * | 1990-07-10 | 1994-06-10 | Sanofi Sa | Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese. |
CA2265886A1 (en) * | 1996-09-12 | 1998-03-19 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Stereospecific preparation of chiral 1-aryl- and 1-heteroaryl-2-substituted ethyl-2-amines |
-
1997
- 1997-05-13 HU HU9700886A patent/HU225504B1/hu unknown
-
1998
- 1998-05-11 EP EP98921668A patent/EP0981525B1/en not_active Expired - Lifetime
- 1998-05-11 AU AU74446/98A patent/AU7444698A/en not_active Abandoned
- 1998-05-11 JP JP54895498A patent/JP4279903B2/ja not_active Expired - Lifetime
- 1998-05-11 DK DK98921668T patent/DK0981525T3/da active
- 1998-05-11 US US09/423,548 patent/US6215005B1/en not_active Expired - Lifetime
- 1998-05-11 AT AT98921668T patent/ATE258551T1/de active
- 1998-05-11 DE DE69821347T patent/DE69821347T2/de not_active Expired - Lifetime
- 1998-05-11 WO PCT/HU1998/000046 patent/WO1998051682A1/en active IP Right Grant
- 1998-05-11 CA CA002288637A patent/CA2288637C/en not_active Expired - Lifetime
- 1998-05-11 BR BRPI9809113-1A patent/BR9809113B1/pt not_active IP Right Cessation
- 1998-05-11 PT PT98921668T patent/PT981525E/pt unknown
- 1998-05-11 ES ES98921668T patent/ES2213900T3/es not_active Expired - Lifetime
-
1999
- 1999-11-12 NO NO19995531A patent/NO325305B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HUP9700886A2 (hu) | 1999-09-28 |
NO995531D0 (no) | 1999-11-12 |
AU7444698A (en) | 1998-12-08 |
US6215005B1 (en) | 2001-04-10 |
NO995531L (no) | 1999-12-13 |
NO325305B1 (no) | 2008-03-25 |
DE69821347D1 (de) | 2004-03-04 |
EP0981525B1 (en) | 2004-01-28 |
PT981525E (pt) | 2004-05-31 |
ES2213900T3 (es) | 2004-09-01 |
HU225504B1 (en) | 2007-01-29 |
DE69821347T2 (de) | 2004-12-02 |
WO1998051682A1 (en) | 1998-11-19 |
JP2001525817A (ja) | 2001-12-11 |
BR9809113B1 (pt) | 2010-03-09 |
EP0981525A1 (en) | 2000-03-01 |
CA2288637C (en) | 2005-11-15 |
DK0981525T3 (da) | 2004-05-10 |
CA2288637A1 (en) | 1998-11-19 |
ATE258551T1 (de) | 2004-02-15 |
JP4279903B2 (ja) | 2009-06-17 |
HU9700886D0 (en) | 1997-07-28 |
HUP9700886A3 (en) | 2000-06-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25G | Requested change of headquarter approved | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS (FR) Free format text: ALTERADO DE: SANOFI-SYNTHELABO |
|
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/03/2010, OBSERVADAS AS CONDICOES LEGAIS. |
|
B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 09.03.2020 |