DK0981525T3 - (2-(2-Thienyl)-ethylamino)-(2-halophenyl)-acetonitriler som mellemprodukter og fremgangsmåde til deres fremstilling - Google Patents

(2-(2-Thienyl)-ethylamino)-(2-halophenyl)-acetonitriler som mellemprodukter og fremgangsmåde til deres fremstilling

Info

Publication number
DK0981525T3
DK0981525T3 DK98921668T DK98921668T DK0981525T3 DK 0981525 T3 DK0981525 T3 DK 0981525T3 DK 98921668 T DK98921668 T DK 98921668T DK 98921668 T DK98921668 T DK 98921668T DK 0981525 T3 DK0981525 T3 DK 0981525T3
Authority
DK
Denmark
Prior art keywords
thienyl
acetonitriles
ethylamino
preparation
intermediates
Prior art date
Application number
DK98921668T
Other languages
English (en)
Inventor
Alain Heymes
Bertrand Castro
Maria Bakonyi
Nagy Marianna Csatarine
Leventene Molnar
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Application granted granted Critical
Publication of DK0981525T3 publication Critical patent/DK0981525T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
DK98921668T 1997-05-13 1998-05-11 (2-(2-Thienyl)-ethylamino)-(2-halophenyl)-acetonitriler som mellemprodukter og fremgangsmåde til deres fremstilling DK0981525T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9700886A HU225504B1 (en) 1997-05-13 1997-05-13 Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
PCT/HU1998/000046 WO1998051682A1 (en) 1997-05-13 1998-05-11 New intermediates and process for the preparation thereof

Publications (1)

Publication Number Publication Date
DK0981525T3 true DK0981525T3 (da) 2004-05-10

Family

ID=89995121

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98921668T DK0981525T3 (da) 1997-05-13 1998-05-11 (2-(2-Thienyl)-ethylamino)-(2-halophenyl)-acetonitriler som mellemprodukter og fremgangsmåde til deres fremstilling

Country Status (14)

Country Link
US (1) US6215005B1 (da)
EP (1) EP0981525B1 (da)
JP (1) JP4279903B2 (da)
AT (1) ATE258551T1 (da)
AU (1) AU7444698A (da)
BR (1) BR9809113B1 (da)
CA (1) CA2288637C (da)
DE (1) DE69821347T2 (da)
DK (1) DK0981525T3 (da)
ES (1) ES2213900T3 (da)
HU (1) HU225504B1 (da)
NO (1) NO325305B1 (da)
PT (1) PT981525E (da)
WO (1) WO1998051682A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226421B1 (en) * 1998-11-09 2008-12-29 Sanofi Aventis Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
EP1603920A1 (en) 2003-03-12 2005-12-14 Cadila Healthcare Ltd. Polymorph and amorphous form of (s)-(+)-clopidogrel bisulfate
US20040250673A1 (en) * 2003-06-10 2004-12-16 Salerno Paul Michael Ergonomic pedal board
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
EP1680430B1 (en) 2003-11-03 2010-01-20 Cadila Healthcare Ltd. Processes for preparing form i of (s)-(+)- clopidogrel bisulfate
US20060154957A1 (en) * 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof
TW200640932A (en) * 2005-02-24 2006-12-01 Teva Pharma Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
EP1902058A2 (en) 2005-07-12 2008-03-26 RPG Life Sciences Limited A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno(3,2-c)pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
KR20090013794A (ko) * 2006-04-27 2009-02-05 인드-스위프트 래버러토리즈 리미티드 클로피도그렐 히드로겐 설페이트의 다형태의 제조방법
US20090247569A1 (en) * 2006-08-03 2009-10-01 Claude Singer Process for Preparing Clopidogrel Bisulphate
EP1980563A1 (en) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate
EP2346879A1 (en) * 2008-10-24 2011-07-27 Sandoz AG A process for the preparation of s-clopidogrel

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508455A1 (fr) 1981-06-30 1982-12-31 Sanofi Sa Procede de preparation de derives des (thienyl-2)- et (thienyl-3)-2 ethylamines
FR2530247B1 (fr) 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2608607B1 (fr) 1986-12-23 1989-04-28 Sanofi Sa Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues
FR2623810B2 (fr) 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2614619B1 (fr) 1987-04-29 1989-09-15 Sanofi Sa Procede de preparation de n-((chloro-2)-benzyl) (thienyl-2)-2 ethylamine
FR2652575B1 (fr) * 1989-09-29 1992-01-24 Sanofi Sa Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
CA2265886A1 (en) * 1996-09-12 1998-03-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. Stereospecific preparation of chiral 1-aryl- and 1-heteroaryl-2-substituted ethyl-2-amines

Also Published As

Publication number Publication date
HUP9700886A2 (hu) 1999-09-28
NO995531D0 (no) 1999-11-12
BR9809113A (pt) 2000-08-01
AU7444698A (en) 1998-12-08
US6215005B1 (en) 2001-04-10
NO995531L (no) 1999-12-13
NO325305B1 (no) 2008-03-25
DE69821347D1 (de) 2004-03-04
EP0981525B1 (en) 2004-01-28
PT981525E (pt) 2004-05-31
ES2213900T3 (es) 2004-09-01
HU225504B1 (en) 2007-01-29
DE69821347T2 (de) 2004-12-02
WO1998051682A1 (en) 1998-11-19
JP2001525817A (ja) 2001-12-11
BR9809113B1 (pt) 2010-03-09
EP0981525A1 (en) 2000-03-01
CA2288637C (en) 2005-11-15
CA2288637A1 (en) 1998-11-19
ATE258551T1 (de) 2004-02-15
JP4279903B2 (ja) 2009-06-17
HU9700886D0 (en) 1997-07-28
HUP9700886A3 (en) 2000-06-28

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