ZA992407B - Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity. - Google Patents
Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity.Info
- Publication number
- ZA992407B ZA992407B ZA9902407A ZA992407A ZA992407B ZA 992407 B ZA992407 B ZA 992407B ZA 9902407 A ZA9902407 A ZA 9902407A ZA 992407 A ZA992407 A ZA 992407A ZA 992407 B ZA992407 B ZA 992407B
- Authority
- ZA
- South Africa
- Prior art keywords
- phenoxymethyl
- tetrazole
- derivatives
- acetic acid
- antitumor activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98105726A EP0947511A1 (en) | 1998-03-30 | 1998-03-30 | Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA992407B true ZA992407B (en) | 1999-09-30 |
Family
ID=8231677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9902407A ZA992407B (en) | 1998-03-30 | 1999-03-29 | Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0947511A1 (es) |
| JP (1) | JP2000063340A (es) |
| KR (1) | KR19990078366A (es) |
| CN (1) | CN1232028A (es) |
| AR (1) | AR018170A1 (es) |
| AU (1) | AU2250299A (es) |
| BR (1) | BR9901208A (es) |
| CA (1) | CA2267047A1 (es) |
| HR (1) | HRP990093A2 (es) |
| HU (1) | HUP9900804A3 (es) |
| ID (1) | ID22335A (es) |
| IL (1) | IL129191A0 (es) |
| MA (1) | MA26616A1 (es) |
| NO (1) | NO991526L (es) |
| NZ (1) | NZ334874A (es) |
| PE (1) | PE20000341A1 (es) |
| PL (1) | PL332273A1 (es) |
| SG (1) | SG81972A1 (es) |
| TR (1) | TR199900719A2 (es) |
| ZA (1) | ZA992407B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2841900B1 (fr) | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
| FR2841784B1 (fr) * | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
| FR2857361B1 (fr) * | 2003-07-08 | 2005-09-09 | Genfit S A | PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one |
| WO2005063774A1 (en) | 2003-12-22 | 2005-07-14 | Johns Hopkins University | Boronic acid aryl analogs |
| JP2007297283A (ja) * | 2004-07-28 | 2007-11-15 | Santen Pharmaceut Co Ltd | 新規桂皮酸関連化合物 |
| JP5399904B2 (ja) * | 2006-08-30 | 2014-01-29 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Ｍｄｍ２の小分子阻害剤およびその使用 |
| JP2010504298A (ja) | 2006-09-21 | 2010-02-12 | エフ．ホフマン−ラ ロシュ アーゲー | オキシンドール誘導体 |
| US7638548B2 (en) * | 2006-11-09 | 2009-12-29 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| US7553833B2 (en) | 2007-05-17 | 2009-06-30 | Hoffmann-La Roche Inc. | 3,3-spiroindolinone derivatives |
| US7928233B2 (en) | 2009-02-10 | 2011-04-19 | Hoffmann-La Roche Inc. | Spiroindolinone pyridine derivatives |
| US8217051B2 (en) | 2009-02-17 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| US8076482B2 (en) | 2009-04-23 | 2011-12-13 | Hoffmann-La Roche Inc. | 3,3′-spiroindolinone derivatives |
| US8017607B2 (en) | 2009-10-14 | 2011-09-13 | Hoffmann-La Roche Inc. | N-substituted-pyrrolidines as inhibitors of MDM2-P-53 interactions |
| US8088815B2 (en) | 2009-12-02 | 2012-01-03 | Hoffman-La Roche Inc. | Spiroindolinone pyrrolidines |
| US8288431B2 (en) | 2010-02-17 | 2012-10-16 | Hoffmann-La Roche Inc. | Substituted spiroindolinones |
| US8217044B2 (en) | 2010-04-28 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone pyrrolidines |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3255241A (en) * | 1961-01-19 | 1966-06-07 | Merck & Co Inc | (2-alkylidene acyl)phenoxy-and (2-alkylidene acyl)phenylmercaptocarboxylic acids |
| NL300456A (es) * | 1962-11-13 | |||
| US3251064A (en) * | 1962-11-13 | 1966-05-10 | Everett M Schultz | beta-aminoacylphenoxy-and beta-aminoacylphenylmercapto-derivatives of monocarboxylicacids |
| US3994955A (en) * | 1975-01-20 | 1976-11-30 | G. D. Searle & Co. | Substituted phenoxydialkylacetic acids and esters |
| US4904697A (en) * | 1987-04-09 | 1990-02-27 | Merrell Dow Pharmaceuticals Inc. | Controlling the growth of certain tumor tissue with chalcone derivatives |
| JPH0624975A (ja) * | 1992-05-12 | 1994-02-01 | Dainippon Ink & Chem Inc | 制癌活性増強剤 |
| DE4327365A1 (de) * | 1993-08-14 | 1995-02-16 | Boehringer Mannheim Gmbh | Verwendung von Phenolen und Phenolderivaten als Arzneimittel mit fibrinogensenkender Wirkung |
-
1998
- 1998-03-30 EP EP98105726A patent/EP0947511A1/en not_active Withdrawn
-
1999
- 1999-03-26 IL IL12919199A patent/IL129191A0/xx unknown
- 1999-03-26 NZ NZ334874A patent/NZ334874A/xx unknown
- 1999-03-26 PE PE1999000244A patent/PE20000341A1/es not_active Application Discontinuation
- 1999-03-26 MA MA25510A patent/MA26616A1/fr unknown
- 1999-03-26 TR TR1999/00719A patent/TR199900719A2/xx unknown
- 1999-03-26 AR ARP990101366A patent/AR018170A1/es unknown
- 1999-03-26 ID IDP990274D patent/ID22335A/id unknown
- 1999-03-26 CA CA002267047A patent/CA2267047A1/en not_active Abandoned
- 1999-03-27 SG SG9901555A patent/SG81972A1/en unknown
- 1999-03-29 HR HR98105726.8A patent/HRP990093A2/hr not_active Application Discontinuation
- 1999-03-29 PL PL99332273A patent/PL332273A1/xx unknown
- 1999-03-29 NO NO991526A patent/NO991526L/no not_active Application Discontinuation
- 1999-03-29 ZA ZA9902407A patent/ZA992407B/xx unknown
- 1999-03-29 KR KR1019990010823A patent/KR19990078366A/ko not_active Application Discontinuation
- 1999-03-29 BR BR9901208-1A patent/BR9901208A/pt not_active Application Discontinuation
- 1999-03-29 HU HU9900804A patent/HUP9900804A3/hu unknown
- 1999-03-30 CN CN99104509A patent/CN1232028A/zh active Pending
- 1999-03-30 AU AU22502/99A patent/AU2250299A/en not_active Abandoned
- 1999-03-30 JP JP11087932A patent/JP2000063340A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ334874A (en) | 2000-08-25 |
| TR199900719A2 (xx) | 1999-10-21 |
| KR19990078366A (ko) | 1999-10-25 |
| NO991526L (no) | 1999-10-01 |
| ID22335A (id) | 1999-09-30 |
| BR9901208A (pt) | 2000-04-25 |
| JP2000063340A (ja) | 2000-02-29 |
| HUP9900804A2 (hu) | 1999-11-29 |
| AU2250299A (en) | 1999-10-14 |
| HUP9900804A3 (en) | 2001-08-28 |
| EP0947511A1 (en) | 1999-10-06 |
| PE20000341A1 (es) | 2000-05-08 |
| SG81972A1 (en) | 2001-07-24 |
| PL332273A1 (en) | 1999-10-11 |
| IL129191A0 (en) | 2000-02-17 |
| NO991526D0 (no) | 1999-03-29 |
| HRP990093A2 (en) | 2000-02-29 |
| MA26616A1 (fr) | 2004-12-20 |
| HU9900804D0 (en) | 1999-05-28 |
| CN1232028A (zh) | 1999-10-20 |
| CA2267047A1 (en) | 1999-09-30 |
| AR018170A1 (es) | 2001-10-31 |
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