ZA988954B - Novel dihydronaphthalene compound and production process of the same - Google Patents
Novel dihydronaphthalene compound and production process of the sameInfo
- Publication number
- ZA988954B ZA988954B ZA988954A ZA988954A ZA988954B ZA 988954 B ZA988954 B ZA 988954B ZA 988954 A ZA988954 A ZA 988954A ZA 988954 A ZA988954 A ZA 988954A ZA 988954 B ZA988954 B ZA 988954B
- Authority
- ZA
- South Africa
- Prior art keywords
- inhibiting activity
- same
- cancer
- production process
- sex hormone
- Prior art date
Links
- -1 dihydronaphthalene compound Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- KEIFWROAQVVDBN-UHFFFAOYSA-N 1,2-dihydronaphthalene Chemical class C1=CC=C2C=CCCC2=C1 KEIFWROAQVVDBN-UHFFFAOYSA-N 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 102000014654 Aromatase Human genes 0.000 abstract 1
- 108010078554 Aromatase Proteins 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 206010051482 Prostatomegaly Diseases 0.000 abstract 1
- 102000001854 Steroid 17-alpha-Hydroxylase Human genes 0.000 abstract 1
- 108010015330 Steroid 17-alpha-Hydroxylase Proteins 0.000 abstract 1
- 208000002495 Uterine Neoplasms Diseases 0.000 abstract 1
- 206010047486 Virilism Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 208000030270 breast disease Diseases 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003163 gonadal steroid hormone Substances 0.000 abstract 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 1
- 231100000794 masculinization Toxicity 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 206010046766 uterine cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28426397 | 1997-10-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA988954B true ZA988954B (en) | 1999-04-12 |
Family
ID=17676271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA988954A ZA988954B (en) | 1997-10-02 | 1998-10-01 | Novel dihydronaphthalene compound and production process of the same |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1028110B1 (xx) |
| KR (1) | KR20000069426A (xx) |
| CN (1) | CN1117732C (xx) |
| AT (1) | ATE264304T1 (xx) |
| AU (1) | AU743405B2 (xx) |
| CA (1) | CA2298527A1 (xx) |
| DE (1) | DE69823222T2 (xx) |
| DK (1) | DK1028110T3 (xx) |
| ES (1) | ES2218853T3 (xx) |
| FI (1) | FI20000207A (xx) |
| HU (1) | HUP0004037A3 (xx) |
| IL (1) | IL133483A0 (xx) |
| NO (1) | NO315044B1 (xx) |
| NZ (1) | NZ501822A (xx) |
| RU (1) | RU2203890C2 (xx) |
| WO (1) | WO1999018075A1 (xx) |
| ZA (1) | ZA988954B (xx) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100287366B1 (ko) | 1997-11-24 | 2001-04-16 | 윤순조 | 엠피이지 방식을 이용한 휴대용 음향 재생장치 및 방법 |
| US7001926B2 (en) | 2000-03-10 | 2006-02-21 | Oxigene, Inc. | Tubulin binding agents and corresponding prodrug constructs |
| TWI283669B (en) * | 1999-06-10 | 2007-07-11 | Allergan Inc | Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors |
| US6849656B1 (en) | 1999-09-17 | 2005-02-01 | Baylor University | Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents |
| JP4520012B2 (ja) * | 1999-10-22 | 2010-08-04 | 武田薬品工業株式会社 | １−置換−１−（１ｈ−イミダゾール−４−イル）メタノール類 |
| JP4616454B2 (ja) * | 1999-10-22 | 2011-01-19 | 武田薬品工業株式会社 | １−置換フェニル−１−（１ｈ−イミダゾール−４−イル）アルコール類、その製造法および用途 |
| AU7950100A (en) * | 1999-10-22 | 2001-05-08 | Takeda Chemical Industries Ltd. | 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof |
| US7091240B2 (en) | 2000-03-10 | 2006-08-15 | Oxigene, Inc. | Tubulin binding ligands and corresponding prodrug constructs |
| EP1263763B1 (en) | 2000-03-10 | 2007-07-25 | Baylor University | Tubulin binding ligands |
| KR20080002929A (ko) | 2000-11-17 | 2008-01-04 | 다케다 야쿠힌 고교 가부시키가이샤 | 신규 이미다졸 유도체, 이의 제조 방법 및 이의 용도 |
| US6960586B2 (en) | 2000-11-20 | 2005-11-01 | Takeda Pharmaceutical Company Limited | Imidazole derivatives, process for their preparation and their use |
| AU2002221080A1 (en) | 2000-12-08 | 2002-06-18 | Masami Kusaka | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparingthe same and use thereof |
| AU2002368473A1 (en) * | 2002-01-25 | 2004-09-09 | Pharmacia Corporation | Aldosterone blocker therapy to prevent or treat inflammation-related disorders |
| US7456214B2 (en) | 2004-05-03 | 2008-11-25 | Baylor University | Chromene-containing compounds with anti-tubulin and vascular targeting activity |
| AU2010264698C1 (en) | 2009-06-26 | 2013-05-16 | Novartis Ag | 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of CYP 17 |
| CN103124563B (zh) | 2010-08-04 | 2016-08-10 | 佩尔菲丘尔制药有限公司 | 用于前列腺癌治疗的联合治疗 |
| US8946260B2 (en) | 2010-09-16 | 2015-02-03 | Novartis Ag | 17α-hydroxylase/C17,20-lyase inhibitors |
| AU2012249421B9 (en) | 2011-04-28 | 2015-10-22 | Novartis Ag | 17alpha-hydroxylase/C17,20-lyase inhibitors |
| EP2968219B1 (en) | 2013-03-14 | 2019-04-24 | Pellficure Pharmaceuticals, Inc. | Novel therapy for prostate carcinoma |
| EP3191087A1 (en) | 2014-09-12 | 2017-07-19 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
| WO2018080933A1 (en) | 2016-10-24 | 2018-05-03 | Pellficure Pharmaceuticals Inc. | Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5681566A (en) * | 1979-12-05 | 1981-07-03 | Yoshitomi Pharmaceut Ind Ltd | Imidazole derivative |
| ZA825413B (en) * | 1981-08-26 | 1983-06-29 | Pfizer | Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them |
| US4540705A (en) * | 1983-03-14 | 1985-09-10 | Sterling Drug Inc. | Antidepressant imidazolines and related compounds |
| PH22076A (en) * | 1983-08-25 | 1988-05-20 | Daiichi Seiyaku Co | Benzocycloalkane derivative |
| JPS61186348A (ja) * | 1985-02-14 | 1986-08-20 | Dai Ichi Seiyaku Co Ltd | ナフタレン誘導体 |
| DE3508905A1 (de) * | 1985-03-13 | 1986-09-18 | Hoechst Ag, 6230 Frankfurt | Neue imidazolylverbindungen und verfahren zu ihrer herstellung |
| JPH06166674A (ja) * | 1992-12-01 | 1994-06-14 | Tokyo Tanabe Co Ltd | テトラリン化合物 |
| JP3338905B2 (ja) * | 1993-05-13 | 2002-10-28 | 帝国臓器製薬株式会社 | ６位置換ステロイド誘導体 |
| AU679119B2 (en) * | 1993-09-30 | 1997-06-19 | Yamanouchi Pharmaceutical Co., Ltd. | Azole derivative and pharmaceutical composition thereof |
| FR2787451B1 (fr) * | 1998-12-18 | 2001-01-26 | Adir | Nouveaux composes imidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
1998
- 1998-10-01 WO PCT/JP1998/004426 patent/WO1999018075A1/ja active Search and Examination
- 1998-10-01 ES ES98945556T patent/ES2218853T3/es not_active Expired - Lifetime
- 1998-10-01 DE DE69823222T patent/DE69823222T2/de not_active Expired - Fee Related
- 1998-10-01 NZ NZ501822A patent/NZ501822A/en unknown
- 1998-10-01 CN CN98808436A patent/CN1117732C/zh not_active Expired - Fee Related
- 1998-10-01 KR KR1019997005209A patent/KR20000069426A/ko not_active Application Discontinuation
- 1998-10-01 DK DK98945556T patent/DK1028110T3/da active
- 1998-10-01 AU AU92810/98A patent/AU743405B2/en not_active Ceased
- 1998-10-01 RU RU99127323/04A patent/RU2203890C2/ru not_active IP Right Cessation
- 1998-10-01 EP EP98945556A patent/EP1028110B1/en not_active Expired - Lifetime
- 1998-10-01 ZA ZA988954A patent/ZA988954B/xx unknown
- 1998-10-01 CA CA002298527A patent/CA2298527A1/en not_active Abandoned
- 1998-10-01 HU HU0004037A patent/HUP0004037A3/hu unknown
- 1998-10-01 AT AT98945556T patent/ATE264304T1/de not_active IP Right Cessation
- 1998-10-01 IL IL13348398A patent/IL133483A0/xx unknown
-
2000
- 2000-02-01 FI FI20000207A patent/FI20000207A/fi not_active Application Discontinuation
- 2000-03-10 NO NO20001289A patent/NO315044B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2298527A1 (en) | 1999-04-15 |
| EP1028110A4 (en) | 2001-05-23 |
| DE69823222T2 (de) | 2005-04-14 |
| KR20000069426A (ko) | 2000-11-25 |
| NO20001289D0 (no) | 2000-03-10 |
| RU2203890C2 (ru) | 2003-05-10 |
| AU743405B2 (en) | 2002-01-24 |
| ATE264304T1 (de) | 2004-04-15 |
| EP1028110B1 (en) | 2004-04-14 |
| IL133483A0 (en) | 2001-04-30 |
| CN1117732C (zh) | 2003-08-13 |
| EP1028110A1 (en) | 2000-08-16 |
| CN1268120A (zh) | 2000-09-27 |
| DK1028110T3 (da) | 2004-07-19 |
| ES2218853T3 (es) | 2004-11-16 |
| NO20001289L (no) | 2000-03-10 |
| FI20000207A (fi) | 2000-02-01 |
| AU9281098A (en) | 1999-04-27 |
| HUP0004037A2 (hu) | 2001-10-28 |
| WO1999018075A1 (fr) | 1999-04-15 |
| NZ501822A (en) | 2001-12-21 |
| NO315044B1 (no) | 2003-06-30 |
| DE69823222D1 (de) | 2004-05-19 |
| HUP0004037A3 (en) | 2002-03-28 |
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